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Title
Japanese: 
English:Asymmetric Reductive Amination of α-Keto Acids Using Ir-Based Hydrogen Transfer Catalysts: An Access to Unprotected Unnatural α-Amino Acids 
Author
Japanese: 矢島 隆明, 片山 彰人, 伊藤 翼, 川田 拓馬, 藪下 絢矢, 安田 俊尚, 太田 岳, 片山 武明, 内海 典之, 榧木 啓人, 桑田 繁樹.  
English: Takaaki Yajima, Akito Katayama, Tsubasa Ito, Takuma Kawada, Kenya Yabushita, Toshihisa Yasuda, Takeshi Ohta, Takeaki Katayama, Noriyuki Utsumi, Yoshihito Kayaki, Shigeki Kuwata.  
Language English 
Journal/Book name
Japanese: 
English:Organic Letters 
Volume, Number, Page Vol. 26    Issue 7    pp. 1426–1431
Published date Feb. 9, 2024 
Publisher
Japanese: 
English:American Chemical Society 
Conference name
Japanese: 
English: 
Conference site
Japanese: 
English: 
Official URL https://achs-prod.acs.org/doi/full/10.1021/acs.orglett.3c04378
 
DOI https://doi.org/10.1021/acs.orglett.3c04378
Abstract A direct asymmetric reductive amination of α-keto acids catalyzed by Cp*Ir complexes bearing a chiral N-(2-picolyl)sulfonamidato ligand is described. The combined use of optically active 2-phenyglycinol as an aminating agent is effective for the chemo- and stereoselective transfer hydrogenation using formic acid. The subsequent elimination of the hydroxyethyl moiety by orthoperiodic acid can afford various unprotected α-amino acids in satisfactory isolated yields (20 examples) with excellent optical purities (up to >99% ee).

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