This study was conducted to evaluate the blood compatibility and tissue responsiveness of methylsiloxane
(MS)-coated inorganic (glass and metal) substrates both in vitro and in vivo. MS was prepared from methyltriethoxysilane
(MTES) through hydrolysis of a sol–gel solution at 80 °C. The adhesive strength of the
MS coating was evaluated by using a tear-off test, revealing that the MS strongly adhered to the surface of
the inorganic substrates. Blood compatibility was evaluated by assessing platelet adhesion and blood plasma
coagulation time. The platelet aggregation ratio of the MS-coated glass tube was reduced to 10%, which was
much smaller than that of the coating-free glass tubes (99%) and conventional blood-compatible polystyrene
(PS) tubes (18%). Coagulation time was measured by active partial thromboplastin time (APTT) test, which
showed that MS coating is as inert as PS in activating blood coagulation factor XII. Tissue responsiveness to
the bulk MS sample, evaluated by animal test, showed a desirable compatibility comparable to that of the
control titanium sample. This study indicated that MS coating is readily available to convert inorganic materials
to useful biomaterials that have suitable mechanical strength and are compatible with blood and tissue.
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