The Imperial College of Engineering (Kobu-Daigakko) in Tokyo, founded in 1873 under the auspices of the Ministry of Public Works, was one of the most prominent modern institutions of engineering education in early Meiji Japan. The college offered seven (later eight) subdivided courses in engineering. The students were encouraged to work for the Ministry. This paper examines chemistry and practical education at the college by drawing on the official records of the Ministry, reports by Edward Divers and Henry Dyer, and student memoirs. It reveals that the college had many inconsistencies and difficulties. Chemistry, for example, was at a disadvantage compared to other courses, such as civil and mechanical engineering. Contrary to the educational ideals of Principal Dyer, Professor Divers was against having students work off-campus and at the sites of the Ministry, because he believed that analytical chemistry was more important for education than for manufacturing. Moreover, the college had very high standards for conferring a degree. In chemistry, until 1886, only four out of twenty-five students were able to score high enough to obtain a degree.