Humans abstract water from various sources to sustain their livelihood and society. Some global hydrological models (GHMs) include explicit schemes of human water management, but the representation and performance of these schemes remain limited. We substantially enhanced the human water management schemes of the H08 GHM by incorporating the latest data and techniques. The model enables us to estimate water abstraction from six major water sources, namely, river flow regulated by global reservoirs (i.e., reservoirs regulating the flow of the world’s major rivers), aqueduct water transfer, local reservoirs, seawater desalination, renewable groundwater, and nonrenewable groundwater. All the interactions were simulated in a single computer program and the water balance was always strictly closed at any place and time during the simulation period. Using this model, we first conducted a historical global hydrological simulation at a spatial resolution of 0.5 x 0.5 degree to specify the sources of water for humanity. The results indicated that, in 2000, of the 3628 km3yr-1 global freshwater requirement, 2839 km3yr-1 was taken from surface water and 789 km3yr-1 from groundwater. Streamflow, aqueduct water transfer, local reservoirs, and seawater desalination accounted for 1786, 199, 106, and 1.8 km3yr-1 of the surface water, respectively. The remaining 747 km3yr-1 freshwater requirement was unmet, or surface water was not available when and where it was needed in our simulation. Renewable and nonrenewable groundwater accounted for 607 and 182 km3yr-1 of the groundwater total, respectively. Second, we evaluated the water stress using our simulations and contrasted it with earlier global assessments based on empirical water scarcity indicators, namely, the Withdrawal to Availability ratio and the Falkenmark index (annual renewable water resources per capita). We found that inclusion of water infrastructures in our model diminished water stress in some parts of the world, on the other hand, daily evaluation of water supply and demand highlighted the temporal/seasonal water deficit due to their variations. The enhanced model is potentially useful for quantitative understanding of the global hydrological cycles including human activities and advancement of global water resources assessment.