Since the Great East Japan Earthquake, the number of high-rise base-isolated buildings has been increased. However, with the increase of the height of the building, the influence of wind acting on the base-isolated layer will also increase, which will lead to the plasticization of the steel damper, resulting in residual deformation. In the existing wind resistant design, the commonly used 10-minute wind force with the wind speed and direction fixed is not enough to evaluate the residual deformation of the base-isolated layer. Compared with the wind force considering the change of wind speed and direction, the 10-minute wind force cannot take the occurrence of the wind force in the opposite direction to the deformation of the base-isolated layer into account, so there is a possibility that the residual deformation of the base-isolated layer may be overestimated. Therefore, based on the typhoon simulation, this paper will analyze the residual deformation of the base-isolated layer of the multi-degree-of-freedom model to discuss the design information that is closer to the actual situation.