8-Oxo-7,8-dihydro-2'-deoxyguanosine produces a long-lived charge-separated state during the photosensitized one-electron oxidation of DNA resulting in efficient and exclusive degradation
英文:
8-Oxo-7,8-dihydro-2'-deoxyguanosine produces a long-lived charge-separated state during the photosensitized one-electron oxidation of DNA resulting in efficient and exclusive degradation
The kinetics and efficiency of oxidative degradation of 8-oxo-7,8-dihydro-2'-deoxyguanosine (8-oxodGuo) in DNA during the photosensitized one-electron oxidation of DNA was investigated. The presence of 8-oxodGuo was shown to increase the lifetime of the charge-separated state in DNA by serving as a "hole sink" resulting in efficient and exclusive degradation