"Nobuaki Shiraki","Methionine and Zinc: Key Regulators of Pluripotent Stem Cell Fate","Cardiovascular Bioengineering",,,,,,2024,May "Dhimas Agung Kurniawan,Sylvia Leo,Mutsumi Inamatsu,Sohei Funaoka,Taichi Aihara,Mizuno Aiko,Inoue Rei,Takeshi Sakura,Hiroshi Arakawa,Yukio Kato,Tomoaki Matsugi,Katsuhiro Esashika,Nobuaki Shiraki,Shoen Kume,Kenta Shinha,Hiroshi Kimura,Masaki Nishikawa,Yasuyuki Sakai","Gut-liver microphysiological systems revealed potential crosstalk mechanism modulating drug metabolism",,"PNAS Nexus",,,,,2024,Feb. "Kenta Ouchi,Kaori Isono,Yuki Ohya,Nobuaki Shiraki,Masayoshi Tasaki,Yukihiro Inomata,Mitsuharu Ueda,Takumi Era,Shoen Kume,Yukio Ando,Hirofumi Jono","Characterization of heterozygous ATTR Tyr114Cys amyloidosis-specific induced pluripotent stem cells",,"Heliyon",,"Vol. 10","No. 2","Page e24590",2024,Jan. "木村莉瑠,西藤巧,渡邊輝彦,長田優菜,白木伸明,粂昭苑","共培養系を用いた iPS-小腸細胞と肝細胞との相互作用の解析","第 46 回 ?本分??物学会",,,,,,2023,Dec. "富永成海,上船史弥,井上愛?,板?勇輝,徳間啓,??伸明,坂野?介,粂昭苑","膵臓β細胞における不均?なドーパミン合成能の?理学的役割の解明","第 46 回 ?本分??物学会",,,,,,2023,Dec. "岸本 恵理子,徳間 啓,井上 愛里,白木 伸明,坂野 大介,粂 昭苑","HSVTK-GCV スイッチを利用した iPS 細胞由来β細胞における造腫瘍抑制","第 46 回 ?本分??物学会",,,,,,2023,Dec. "鈴木秀宜,小倉俊一郎,白木伸明,粂昭苑","5-アミノレブリン酸を用いた光線力学療法のヒト iPS 膵臓分化誘導への応用","第 46 回 日本分子生物学会年会",,,,,,2023,Dec. "図師菜々美,田熊 めぐみ,Yumeng Wu,遠藤 貴南,粂 昭苑,白木 伸明,藤枝 俊宣","多孔質高分子ナノシートの積層によるタンパク質透過性の制御","第45回日本バイオマテリアル学会大会",,,,,,2023,Nov. "白木 伸明,粂昭苑","メチオニンと亜鉛は多能性幹細胞の多能性および分化を制御する",,"生化学","公益社団法人日本生化学会","Vol. 95","No. 5","pp. 655-659",2023,Sept. "Hiyoshi N,Enomoto T,Uefune F,Kato Y,Wu Y,Araki K,Sakano D,Shiraki N,Kume S.","A specific plasma amino acid profile in the Insulin2Q104del Kuma mice at the diabetic state and reversal from hyperglycemia.",,"Biochem. Biophys. Res. Commun.",,"Vol. 679",,"pp. 58-65",2023,Aug. "Tokuma H,Sakano D,Shiraki N,Kume S","Selective proteasome degradation of the C-terminally-truncated human WFS1 mutants in the pancreatic beta cells.",,"FEBS Open Bio.",,"Vol. 13",,"pp. 1391-1540",2023,Aug. "Helena Aprilia Grace,Teruhiko Watanabe,Kato Y,Shiraki N,Kume S.","Activation of cAMP(EPAC2) signaling pathway promotes hepatocyte attachment.",,"Scientific Reports",,"Vol. 13",,"pp. 12352",2023,July "Nobuaki Shiraki,Erinn Zixuan Sim,Takayuki Enomoto,Nao Furuta,Soshiro Kashio,Taiho Kambe,Tomonori Tsuyama,Akihiro Arakawa,Hiroki Ozawa,Mizuho Yokoyama,Masayuki Miura,Shoen Kume","Methionine metabolism regulates pluripotent stem cell through zinc mobilization","ISSCR ANNAUL MEETING",,,,,,2023,June "Sylvia Leo,Yusuke Kato,Yumeng Wu,Mutsumi Yokota,Masato Koike,Shiro Yui,Kiichiro Tsuchiya,Nobuaki Shiraki,Shoen Kume","The effect of Vitamin D3 and Valproic Acid on the maturation of human induced pluripotent stem cell-derived enterocyte-like cells.",,"Stem Cells",,,,,2023,May "白木伸明","幹細胞制御におけるメチオニンと亜鉛のクロストーク","第77回日本栄養・食糧学会大会",,,,,,2023,May "Zixuan Erinn Sim,Takayuki Enomoto,Nobuaki Shiraki,Shoen Kume","Protocol to generate human PSC-derived pancreatic beta-cells through methionine and zinc deprivation.",,"STAR Protocols",,,,,2023,Apr. "Yukihiro Shimaya,Nobuaki Shiraki,Shoen Kume","Promoting pancreatic β cell proliferation: a powerful key for realizing regenerative therapy for diabetes. hionine and zinc deprivation.",,"J Diabetes Investig",,,,,2023,Apr. "白木伸明,粂昭苑","ヒト多能性幹細胞由来膵β細胞の成熟化","第22回日本再生医療学会総会",,,,,,2023,Mar. "門倉瑶乃,荒川哲大,山崎淳子,Erinn Zixuan Sim,白木伸明,粂昭苑","多能性幹細胞の未分化および分化状態における細胞内亜鉛動態解析","第22回日本再生医療学会総会",,,,,,2023,Mar. "渡邊輝彦,Grace A. Helena,白木伸明,粂昭苑","浮遊型初代ヒト肝細胞を培養容器に接着させる培地の開発とそのアプリケーション","日本薬学会 第143年会",,,,,,2023,Mar. "Marwa ALI Ahmed,Yusuke Kato,Nobuaki Shiraki,Shoen Kume","Generation of induced pluripotent stem cell-derived beta-cells in blood amino acids-like medium.",,"Biology Open",,"Vol. 12",,,2023,Mar. "Marwa Ali,Yusuke Kato,Nobuaki Shiraki,Shoen Kume","Generation of induced pluripotent stem cell-derived Beta cells in blood amino acids-like medium","22nd IUNS-ICN International Congress of Nutrition",,,,,,2022,Dec. "Dwina Juliana Warman,Takami Watanabe,Nobuaki Shiraki,Shoen Kume,Huijuan Jia,Hisanori Kato","Effects of two-day prenatal methionine deficiency on pancreatic development in newborn rats","22nd IUNS-ICN International Congress of Nutrition",,,,,,2022,Dec. "Naoya Hiyoshi,Takayuki Enomoto,Airi Inoue,Yusuke Kato,Daisuke Sakano,Kimi Araki,Nobuaki Shiraki,Shoen Kume","Investigation of metabolite profile in plasma from Kuma mice using LC-MS/MS","MBSJ2022",,,,,,2022,Nov. "Leo Sylvia,Kato Yusuke,Wu Yumeng,Shiraki Nobuaki,Kume Shoen","The effect of Vitamin D3 and Valproic Acid on the maturation of human induced pluripotent stem cell-derived enterocyte-like cells","MBSJ2022",,,,,,2022,Nov. "渡邊輝彦,白木伸明,粂昭苑","ad-MEDビトリゲル2とciKIC IEC MMを用いて構築したヒトiPS細胞由来腸管上皮モデルの消化管吸収評価モデルとしての有用性","日本薬物動態学会第37回年会",,,,,,2022,Nov. "金子 知代,榎本 孝幸,小島 慧理果,白木 伸明,粂 昭苑","メチオニン制限を組み込んだ新規iPS細胞膵臓分化方法の開発","日本アミノ酸学会第16回学術大会",,,,,,2022,Nov. "白木伸明,小澤弘樹,神戸梓沙,粂 昭苑","メチオニンは亜鉛代謝を介して多能性幹細胞を制御する","第33回日本微量元素学会学術集会",,,,,,2022,Sept. "Shiraki Nobuaki,Shoen Kume","Characterization of heterozygous ATTR Y114C amyloidosis-specific iPS cells","XVIII International Symposium on Amyloidosis ? ISA 2022",,,,,,2022,Aug. "Shiraki Nobuaki,Shoen Kume","Characterization of heterozygous ATTR Y114C amyloidosis-specific iPS cells","XVIII International Symposium on Amyloidosis ? ISA 2022",,,,,,2022,Aug. "Zixuan Erinn Sim,Takayuki Enomoto,Nobuaki Shiraki,Nao Furuta,Azusa Kambe,Hiroki Ozawa,Masayuki Miura,Shoen Kume","Methionine metabolism regulates pluripotent stem cell pluripotency and differentiation through zinc mobilization.",,"Cell Reports",,"Vol. 40",,"pp. 111120",2022,July "Kato Yusuke,Shiraki Nobuaki,Shoen Kume","Generation of functional pancreatic beta cells derived from human induced pluripotent Stem Cell-with physiological cell culture medium","ISSCR",,,,,,2022,June "白木伸明","メチオニン代謝制御による分化誘導の安定化","第21回日本再生医療学会総会",,,,,,2022,Mar. "小澤弘樹,神戸梓沙,日比滉大,木村宏,白木伸明,粂 昭苑","メチオニン除去培養によるエピジェネティック変化を伴うヒトiPS細胞分化促進","第44回日本分子生物学会",,,,,,2021,Dec. "Grace Aprilia Helena,Nobuaki Shiraki,Shoen Kume","Improvement of Primary Human Hepatocyte Cell Attachment","第44回日本分子生物学会",,,,,,2021,Dec. "滝波那拓,榎本孝幸,白木 伸明,粂 昭苑","ヒ膵島移植に用いるための免疫隔離カプセルの評価","第20回日本再生医療学会",,,,,,2021,Mar. "Nobuaki Shiraki","Coculture with hiPS-derived intestinal cells enhanced human hepatocyte functions in a pneumatic-pressure-driven two-organ microphysiological system",,"Scientific Reports",,"Vol. 11","No. 1",,2021,Mar. "白木 伸明,粂 昭苑","コラーゲンビトリゲル膜と新規培地で培養したヒトiPS細胞由来小腸細胞の有用性","第20回日本再生医療学会",,,,,,2021,Mar. "萩本隆之介,LeoSylvia Han Yun,白木 伸明,粂 昭苑","吸収腸上皮細胞への分化を促進する低分子化合物のスクリーニング","第20回日本再生医療学会",,,,,,2021,Mar. "白木 伸明","細胞の分化と栄養 (特集 食・栄養から健康を拓く生化学)",,"生化学","日本生化学会","Vol. 93","No. 1","pp. 59-66",2021,Feb. "Nobuaki Shiraki","Generation of Human-Induced Pluripotent Stem Cell-Derived Functional Enterocyte-Like Cells for Pharmacokinetic Studies",,"Stem Cell Reports",,"Vol. 16","No. 2","pp. 295-308",2021,Feb. "白木伸明","ヒト肝細胞の接着性向上とMPSへの応用","細胞アッセイ研究会シンポジウム",,,,,,2021,Jan. "Nobuaki Shiraki","Recent progress in pancreatic islet cell therapy",,"Inflammation and Regeneration",,"Vol. 41","No. 1",,2021,Jan. "Nobuaki Shiraki","VMAT2 Safeguards β-Cells Against Dopamine Cytotoxicity Under High-Fat Diet?Induced Stress",,"Diabetes",,"Vol. 69","No. 11","pp. 2377-2391",2020,Nov. "吉田晋平,本荘貴之,白木 伸明,粂 昭苑","薬物動態評価モデルとしてのヒトiPS細胞由来小腸上皮細胞の開発","第5回トランスポーター研究会関東部会",,,,,,2020,Nov. "白木 伸明,粂 昭苑","臓器チップに要求される細胞組織ソースと細胞共用培地 (特集 創薬におけるMPS技術の開発)",,"細胞","ニューサイエンス社","Vol. 52","No. 4","pp. 174-177",2020,Apr. "Nobuaki Shiraki","Detailed analysis at a single‐cell level of cells undergoing pancreatic differentiation",,"Journal of Diabetes Investigation",,"Vol. 11","No. 1","pp. 20-21",2020,Jan. "Nobuaki Shiraki","Plasticity of histone modifications around Cidea and Cidec genes with secondary bile in the amelioration of developmentally-programmed hepatic steatosis",,"Scientific Reports",,,,,2019,Dec. "五日市 実侑,白木 伸明,伊東 宏晃,粂 昭苑","iPS細胞肝臓分化誘導系を用いたDOHaDの検証",,"DOHaD研究","日本DOHaD学会事務局","Vol. 8","No. 3","pp. 46-46",2019,Aug. "Nobuaki Shiraki","Fetal androgen signaling defects affect pancreatic β-cell mass and function, leading to glucose intolerance in high-fat diet-fed male rats.",,"American journal of physiology. Endocrinology and metabolism",,,,,2019,July "Nobuaki Shiraki","Collagen vitrigel promotes hepatocytic differentiation of induced pluripotent stem cells into functional hepatocyte-like cells.",,"Biology open",,,,,2019,July "Nobuaki Shiraki","A culture substratum with net-like polyamide fibers promotes the differentiation of mouse and human pluripotent stem cells to insulin-producing cells.",,"Biomedical materials (Bristol, England)",,,,,2019,June "白木 伸明","多能性幹細胞の未分化維持や分化におけるアミノ酸の役割の解明 (第12回学術大会(JSAAS2018)) -- (日本アミノ酸学会 科学・技術賞受賞講演)",,"アミノ酸研究 = Amino acid research","日本アミノ酸学会","Vol. 12","No. 2","pp. 99-104",2019,Mar. "柴田 伊真,下道 隆広,渡邊 輝彦,山口 宏之,白木 伸明,粂 昭苑","メチオニン除去培地とコラーゲンビトリゲル薄膜を用いて分化誘導したヒト iPS 細胞由来肝臓細胞を利用した薬物毒性試験系の構築","細胞アッセイ研究会2019",,,,,,2019,Jan. "小田 雄一,篠原 満利恵,飯生 啓太,新谷 華梨,進 和美,佐藤 琢,荒川 大,白木 伸明,立野 知世,杉浦 慎治,粂 昭苑,加藤 将 夫,金森 敏幸,木村 啓志,酒井 康行","二臓器連結モデル型 Microphysiological System を用いた新鮮ヒト肝細胞とヒト iPS 細胞由来腸管上皮細胞の灌流共培養","細胞アッセイ研究会",,,,,,2019,Jan. "nobuaki shiraki","Methionine metabolism regulates ESCs/iPSCs Differentiation","APNNO 2018 Biennial Conference",,,,,,2018,Dec. "小田 雄一,篠原 満利恵,飯生 啓太,新谷 華梨,進 和美,佐藤 琢,荒川 大,白木 伸明,立野 知世,杉浦 慎治,粂 昭苑,加藤 将 夫,金森 敏幸,木村 啓志,酒井 康行","二臓器連結?圧力駆動型Microphysiological Systemを用いたヒト肝細胞とヒトiPS細胞由来腸管上皮細胞のリアルタイム灌流共培養","日本動物実験代替法学会 第31回大会",,,,,,2018,Nov. "本荘 貴之,飯生 啓太,前田 和哉,渡邊 輝彦,石川 晶也,楠原 洋之,白木 伸明,粂 昭苑","ヒトiPS細胞から機能的な小腸吸収上皮細胞への新規分化誘導系の構築","第41回 日本分子生物学会年会",,,,,,2018,Nov. "日比 滉大,秋山 智彦,洪実,白木 伸明,粂 昭苑","メチオニン除去培養によるヒトiPS細胞分化促進の機序解明","第41回 日本分子生物学会年会",,,,,,2018,Nov. "白木伸明","多能性幹細胞の未分化維持や分化におけるアミノ酸の役割の解明","日本アミノ酸学会第12回学術大会",,,,,,2018,Oct. "Nobuaki Shiraki","Induced Pluripotent Stem Cell Elimination in a Cell Sheet by Methionine-Free and 42°C Condition for Tumor Prevention.",,"Tissue engineering. Part C, Methods",,,,,2018,Oct. "Zixuan Erinn Sim,Nobuaki Shiraki,Shoen Kume","Insulin supplement is essential in differentiating human induced pluripotent stem cells into pancreatic beta cells","AOCE 2018",,,,,,2018,Sept. "白木 伸明,粂昭苑","ES/iPS細胞から膵β細胞への分化制御と糖尿病再生医療の現状と展開 (特集 代謝関連疾患と合併症の再生医療の最前線)",,"内分泌・糖尿病・代謝内科 = Endocrinology, diabetology & metabolism","科学評論社","Vol. 47","No. 1","pp. 7-11",2018,July "白木伸明","ヒトES細胞の維持・分化におけるメチオニン代謝の役割の解明",,"生化学",,"Vol. 89","No. 6","pp. 903-906",2017,Dec. "白木伸明","ヒト多能性幹細胞の分化および未分化維持におけるメチオニン代謝の役割","ConBio2017",,,,,,2017,Dec. "Nobuaki Shiraki","Androgen signaling expands β-cell mass in male rats and β-cell androgen receptor is degraded under high-glucose conditions.",,"American journal of physiology. Endocrinology and metabolism",,,,,2017,Nov. "Nobuaki Shiraki","Methionine metabolism regulates stem cell pluripotency","第76回日本癌学会学術総会",,,,,,2017,Sept. "Erinn Sim Zixuan,Saeko Momma,Nobuaki Shiraki,Shoen Kume","A NOVEL 3D SPHEROID CULTURE SYSTEM FOR GENERATING FUNCTIONAL PANCREATIC beta CELLS DERIVED FROM HUMAN INDUCED PLURIPOTENT STEM CELLS","ISSCR 2017 Annual Meeting",,,,,,2017,June "Hiraku Tokuma,Zixuan Erinn Sim,Fumiya Uefune,Daisuke Sakano,Nobuaki Shiraki,Shoen Kume","Establishment and analysis of hiPSC that visualize the INSULIN producing cells","第89回日本細胞生物学会大会",,,,,,2017,June "門馬紗英子,白木伸明,粂昭苑","多能性幹細胞から膵臓β細胞への分化誘導過程におけるアミノ酸要求性","第71回日本栄養・食糧学会大会",,,,,,2017,May "nobuaki shiraki","Amino acids regulate pancreatic differentiation of human pluripotent stem cells","the 50th annual meeting of JSDB",,,,,,2017,May "Hiraku Tokuma,Erinn Sim Zixuan,Fumiya Uefune,Daisuke Sakano,Nobuaki Shiraki,Shoen Kume.","Generation and Characterization of an INSULIN promoter driven mCherry Reporter Human iPS Cell Lines Using CRISPR/Cas9 system","日本発生生物学会第50回大会",,,,,,2017,May "Nobuaki Shiraki","Erythropoietin facilitates definitive endodermal differentiation of mouse embryonic stem cells via activation of ERK signaling.",,"American Journal of Physiology - Cell Physiology",,,,,2017,May "白木伸明","多能性幹細胞から膵臓β細胞への分化誘導","第16回日本再生医療学会総会",,,,,,2017,Mar. "Nobuaki Shiraki","Mild electrical stimulation with heat shock guides differentiation of embryonic stem cells into Pdx1-expressing cells within the definitive endoderm.",,"BMC biotechnology",,,,,2017,Feb. "Nobuaki Shiraki","METHIONINE METABOLISM REGULATES THE FUNCTIONS OF HUMAN PLURIPOTENT STEM CELLS",,"ANNALS OF NUTRITION AND METABOLISM","KARGER","Vol. 71",,"pp. 141-141",2017, "白木伸明","幹細胞におけるアミノ酸代謝の役割","第37回日本トリプトファン研究会学術集会",,,,,,2016,Dec. "神戸梓沙,白木伸明,木村宏,粂昭苑","ヒトiPS細胞におけるメチオニン代謝とヒストン修飾の役割","第39回日本分子生物学会年会",,,,,,2016,Dec. "古田奈央,荒川哲大,岩畑大悟,白木伸明,粂昭苑","未分化iPS細胞および分化過程おける亜鉛の役割","第39回日本分子生物学会年会",,,,,,2016,Dec. "白木伸明","多能性幹細胞から膵臓β細胞への分化誘導","幹細胞の培養法・培養工学のためのコンソーシアム第1回シンポジウム",,,,,,2016,Oct. "白木伸明","幹細胞の維持および分化におけるメチオニン代謝の役割","日本農芸化学会平成28 年度関西支部大会",,,,,,2016,Sept. "白木伸明","多能性幹細胞におけるメチオニン代謝の役割","第4回がんと代謝研究会",,,,,,2016,July "Sakano D,Choi S,Kataoka M,Shiraki N,Uesugi M,Kume K,Kume S","Dopamine D2 Receptor-Mediated Regulation of Pancreatic β Cell Mass.",,,,,,,2016,July "Daisuke Sakano,Choi S,Kataoka M,Shiraki N,Uesugi M,Kume K,Shoen Kume","Dopamine D2 Receptor-Mediated Regulation of Pancreatic β Cell Mass.",,"Stem cell reports",,"Vol. 7","No. 1","pp. 95-109",2016,July "門馬紗英子,白木伸明,及川彰,粂昭苑","幹細胞の未分化維持及び分化におけるメチオニン代謝の役割","第68回日本細胞生物学会大会",,,,,,2016,June "白木伸明","アミノ酸代謝制御による 幹細胞の未分化性維持と分化促進","JBA "未来へのバイオ技術" 勉強会 「幹細胞の創薬利用と産学連携」",,,,,,2016,May "Tomonori Tsuyama,Nobuaki Shiraki,Shoen Kume","Definitive Endoderm Differentiation of Human Embryonic Stem Cells Combined with Selective Elimination of Undifferentiated Cells by Methionine Deprivation.",,"Methods in molecular biology (Clifton, N.J.)",,"Vol. 1341",,"pp. 173-80",2016,Apr. "白木 伸明","ヒトiPS細胞膵臓分化系を用いた生活習慣病胎児期起源説の検証",,"バイオ クリニカ",,"Vol. 31","No. 5",,2016,Apr. "Soichiro Ogaki,Hisayoshi Omori,Mayu Morooka,Nobuaki Shiraki,Seiichi Ishida,Shoen Kume","Late stage definitive endodermal differentiation can be defined by Daf1 expression",,"BMC Developmental Biology",,"Vol. 16",,,2016,Mar. "白木伸明,粂昭苑","iPS細胞と肝胆膵疾患ー膵臓・肝臓への分化ー",,"G.I.Research",,"Vol. 24","No. 2","pp. 94-100",2016,Feb. "白木伸明,粂昭苑","アミノ酸代謝によるヒト多能性幹細胞の維持・分化誘導",,"Medical Science Digest",,"Vol. 42","No. 2","pp. 52-53",2016,Feb. "Ogaki S,Omori H,Morooka M,Shiraki N,Ishida S,Kume S","Late stage definitive endodermal differentiation can be defined by Daf1 expression.",,,,,,,2016, "白木伸明,門馬紗英子,粂昭苑","幹細胞分化におけるアミノ酸代謝の役割","第9回日本アミノ酸学会学術大会",,,,,,2016, "Nakashima R,Shiraki N,Daisuke Sakano,Ogaki S,Kume K,Shoen Kume","Neural cells play an inhibitory role in pancreatic differentiation of pluripotent stem cells.",,"Genes to Cells",,"Vol. 20",,"p. 1028-1045",2015,Oct. "白木伸明","幹細胞維持と分化におけるメチオニン代謝","第8回Symphony",,,,,,2015,Sept. "白木伸明","ES/iPS細胞分化制御におけるアミノ酸代謝","第96回日本栄養?食糧学会関東支部大会",,,,,,2015,Sept. "白木伸明,粂昭苑","iPS細胞の内胚葉系への誘導",,"日本臨牀",,"Vol. 73",,"pp. 107-114",2015,June "白木伸明,粂昭苑","幹細胞維持と分化におけるメチオニン代謝",,"日本臨牀",,"Vol. 73","No. 5","pp. 765-772",2015,May "白木 伸明,粂昭苑","糖尿病の再生医療 (第5土曜特集 糖尿病のすべて) -- (糖尿病対策と将来の根治・予防)",,"医学のあゆみ","医歯薬出版","Vol. 252","No. 5",,2015,May "白木 伸明,粂 昭苑","幹細胞維持と分化におけるメチオニン代謝 (特集 がん幹細胞 : 新しい医療を求めて)",,"日本臨床","日本臨床社","Vol. 73","No. 5","pp. 765-772",2015,May "Daisuke Sakano,Nobuaki Shiraki,Shoen Kume","Pancreatic differentiation from murine embryonic stem cells",,"Methods in Molecular Biology",,"Vol. 1341",,"pp. 417-423",2015,Mar. "白木伸明,粂昭苑","糖尿病の再生医学",,"医学のあゆみ",,"Vol. 252","No. 5","pp. 647-653",2015,Jan. "白木伸明,粂昭苑","ES/iPS細胞からの膵臓β細胞への分化誘導",,"糖尿病学2015","診断と治療社",,," 1-9",2015, "白木 伸明,粂昭苑","iPS細胞研究最前線 : 疾患モデルから臓器再生まで(Vol.10)ES/iPS細胞を用いた内胚葉細胞(膵,肝,小腸)への分化誘導",,"医学のあゆみ","医歯薬出版","Vol. 251","No. 12",,2014,Nov. "Yamazoe T,Shiraki N,Shoen Kume","Hepatic Differentiation from Murine and Human iPS Cells Using Nanofiber Scaffolds.",,"Methods in Molecular Biology",,,,,2014,Nov. "Umeda K,Shiraki N,Shoen Kume","Hepatic Differentiation from Human Ips Cells Using M15 Cells.",,"Methods in Molecular Biology",,,,,2014,Nov. "Shahjalal HM,Shiraki N,Daisuke Sakano,Kikawa K,Ogaki S,Baba H,Kume K,Shoen Kume","Generation of insulin-producing β-like cells from human iPS cells in a defined and completely xeno-free culture system.",,"Journal of Molecular Cellular and Biology",,"Vol. 6",,"p. 394-408",2014,Oct. "Kazuhide Kikawa,Daisuke Sakano,Nobuaki Shiraki,Tomonori Tsuyama,Kazuhiko Kume,Fumio Endo,Shoen Kume","Beneficial Effect of Insulin Treatment on Islet Transplantation Outcomes in Akita Mice",,"Plos One",,"Vol. 9","No. 4",,2014,Apr. "Hakim, Farzana,Kaitsuka, Taku,Raeed, Jamiruddin Mohd,Wei, Fan-Yan,Nobuaki Shiraki,Akagi, Tadayuki,Yokota, Takashi,Shoen Kume,Kazuhito Tomizawa","High Oxygen Condition Facilitates the Differentiation of Mouse and Human Pluripotent Stem Cells into Pancreatic Progenitors and Insulin-producing Cells*",,"Journal of Biological Chemistry",,"Vol. 289","No. 14","pp. 9623-9638",2014,Apr. "Nobuaki Shiraki,Yasuko Shiraki,Tomonori Tsuyama,Fumiaki Obata,Masayuki Miura,Genta Nagae,Hiroyuki Aburatani,Kazuhiko Kume,Fumio Endo,Shoen Kume","Methionine Metabolism Regulates Maintenance and Differentiation of Human Pluripotent Stem Cells",,"Cell Metabolism",,"Vol. 19","No. 5","pp. 780-794",2014,Apr. "Nobuaki Shiraki,Soichiro Ogaki,Shoen Kume","Profiling of embryonic stem cell differentiation.",,"The review of diabetic studies : RDS",,"Vol. 11","No. 1","pp. 102-14",2014,Apr. "Kaitsuka, Taku,Noguchi, Hirofumi,Nobuaki Shiraki,Kubo, Takuya,Wei, Fan-Yan,Hakim, Farzana,Shoen Kume,Kazuhito Tomizawa","Generation of Functional Insulin-Producing Cells From Mouse Embryonic Stem Cells Through 804G Cell-Derived Extracellular Matrix and Protein Transduction of Transcription Factors",,"Stem Cells Translational Medicine",,"Vol. 3","No. 1","pp. 114-127",2014,Apr. "Isono, Kaori,Jono, Hirofumi,Ohya, Yuki,Nobuaki Shiraki,Taiji Yamazoe,Sugasaki, Ayaka,Era, Takumi,Fusaki, Noemi,Tasaki, Masayoshi,Ueda, Mitsuharu,Shinriki, Satoru,Inomata, Yukihiro,Shoen Kume,Ando, Yukio","Generation of familial amyloidotic polyneuropathy-specific induced pluripotent stem cells",,"Stem Cell Research",,"Vol. 12","No. 2","pp. 574-583",2014,Apr. "Daisuke Sakano,Shiraki N,Kikawa K,Yamazoe T,Kataoka M,Umeda K,Araki K,Mao D,Matsumoto S,Nakagata N,Andersson O,Stainier D,Endo F,Kume K,Uesugi M,Shoen Kume","VMAT2 identified as a regulator of late-stage β-cell differentiation.",,"Nature Chemical Biology",,"Vol. 10","No. 2","pp. 141-148",2014,Feb. "白木 伸明","ES/iPS細胞分化制御におけるアミノ酸代謝",,"アミノ酸研究 = Amino acid research","日本アミノ酸学会","Vol. 8","No. 1",,2014, "木川 和英,坂野大介,白木 伸明","Akitaマウスに対するインスリン治療が膵島移植の成績に与える効果 (特集 小児内分泌学の進歩2014) -- (糖尿病・糖代謝異常)",,"ホルモンと臨床","医学の世界社","Vol. 61","No. 12",,2013,Dec. "坂野大介,白木 伸明,粂昭苑","多能性幹細胞から膵β細胞への分化 (特集 発生・分化・再生と代謝関連臓器)",,"内分泌・糖尿病・代謝内科","科学評論社","Vol. 35","No. 2",,2013,Aug. "Ogaki S,Shiraki N,Kume K,Shoen Kume","Wnt and Notch signals guide embryonic stem cell differentiation into the intestinal lineages.",,"Stem Cells",,"Vol. 31",,"p. 1086-1096",2013,June "Iwashita, Hidefumi,Nobuaki Shiraki,Daisuke Sakano,Ikegami, Takashi,Shiga, Masanobu,Kazuhiko Kume,Shoen Kume","Secreted Cerberus1 as a Marker for Quantification of Definitive Endoderm Differentiation of the Pluripotent Stem Cells",,"Plos One",,"Vol. 8","No. 5",,2013,Apr. "Taiji Yamazoe,Nobuaki Shiraki,Toyoda, Masashi,Kiyokawa, Nobutaka,Okita, Hajime,Miyagawa, Yoshitaka,Akutsu, Hidenori,Umezawa, Akihiro,Sasaki, Yutaka,Kazuhiko Kume,Shoen Kume","A synthetic nanofibrillar matrix promotes in vitro hepatic differentiation of embryonic stem cells and induced pluripotent stem cells",,"Journal of Cell Science",,"Vol. 126","No. 23","pp. 5391-5399",2013,Apr. "Kahoko Umeda,Suzuki, Keiichiro,Taiji Yamazoe,Nobuaki Shiraki,Higuchi, Yuichiro,Tokieda, Kumiko,Kazuhiko Kume,Mitani, Kohnosuke,Shoen Kume","Albumin gene targeting in human embryonic stem cells and induced pluripotent stem cells with helper-dependent adenoviral vector to monitor hepatic differentiation",,"Stem Cell Research",,"Vol. 10","No. 2","pp. 179-194",2013,Apr. "山添 太士,白木 伸明,佐々木 裕,粂昭苑","肝臓の再生医療 (特集 再生医療)",,"日本医師会雑誌","日本医師会","Vol. 142","No. 4",,2013,Apr. "Kataoka M,Kawamuro Y,Shiraki N,Miki R,Daisuke Sakano,Yoshida T,Yasukawa T,Kume K,Shoen Kume","Recovery from diabetes in neonatal mice after a low-dose streptozotocin treatment.",,,,,,,2013,Jan. "白木 伸明,粂 昭苑","ES/iPS細胞から膵臓への分化誘導",,"ファルマシア","公益社団法人 日本薬学会","Vol. 48","No. 9","pp. 852-856",2012,Sept. "白木 伸明,粂昭苑","ES/iPS細胞から膵臓への分化誘導(最前線,<特集>躍進する幹細胞研究)",,"ファルマシア","公益社団法人日本薬学会","Vol. 48","No. 9",,2012,Aug. "坂野大介,白木 伸明,粂昭苑","1型糖尿病治療の新しい知見 6.iPS細胞による糖尿病医療研究のこれから",,"糖尿病","THE JAPAN DIABETES SOCIETY","Vol. 54","No. 4",,2011,Sept. "Nagae G,Isagawa T,Shiraki N,Fujita T,Yamamoto S,Tsutsumi S,Nonaka A,Yoshiba S,Matsusaka K,Midorikawa Y,Ishikawa S,Soejima H,Fukayama M,Suemori H,Nakatsuji N,Shoen Kume,Aburatani H","Tissue-specific demethylation in CpG-poor promoters during cellular differentiation.",,"Human Molecular Genetics",,"Vol. 20",,"p. 2710-2721",2011,July "Higuchi Y,Shiraki N,Shoen Kume","In vitro models of pancreatic differentiation using embryonic stem or induced pluripotent stem cells.",,"Congenital Anomalies",,"Vol. 51",,"p. 21-25",2011,Mar. "坂野大介,白木 伸明,粂昭苑","iPS細胞による糖尿病医療研究のこれから",,"糖尿病","日本糖尿病学会","Vol. 54","No. 4",,2011,Mar. "Shiraki N,Yamazoe T,Qin Z,Ohgomori K,Mochitate K,Kume K,Shoen Kume","Efficient differentiation of embryonic stem cells into hepatic cells in vitro using a feeder-free basement membrane substratum.",,"Plos One",,"Vol. 6",,,2011, "Isagawa T,Nagae G,Shiraki N,Fujita T,Sato N,Ishikawa S,Shoen Kume,Aburatani H","DNA methylation profiling of embryonic stem cell differentiation into the three germ layers.",,"PLoS ONE",,"Vol. 6",,,2011, "Ogaki S,Harada S,Shiraki N,Kume K,Shoen Kume","An expression profile analysis of ES cell-derived definitive endodermal cells and Pdx1-expressing cells.",,"BMC Developmental Biology",,"Vol. 11",,,2011, "Higuchi Y,Shiraki N,Yamane K,Qin Z,Mochitate K,Araki K,Senokuchi T,Yamagata K,Hara M,Kume K,Shoen Kume","Synthesized basement membranes direct the differentiation of mouse embryonic stem cells into pancreatic lineages.",,"Journal of Cell Sciences",,"Vol. 123",,"p. 2733-2742",2010,Aug. "Katsumoto K,Shiraki N,Miki R,Shoen Kume","Embryonic and adult stem cell systems in mammals: ontology and regulation.",,"Development Growth Differentiation",,"Vol. 52",,"p. 115-129",2010,Jan. "山添 太士,白木 伸明,粂昭苑","ES細胞由来分化肝細胞の創出 (AYUMI ヒト幹細胞による薬物代謝・トランスポート・副作用予測--iPS・ES細胞・間葉系細胞を用いた新たな創薬スクリーニング)",,"医学のあゆみ","医歯薬出版","Vol. 232","No. 2",,2010, "Shiraki N,Harada S,Ogaki S,Kume K,Shoen Kume","Identification of DAF1/CD55, a novel definitive endoderm marker.",,"Cell Structure Function",,"Vol. 35",,"p. 73-80",2010, "梅田 香穂子,白木 伸明,粂昭苑","最新医学講座 iPS細胞(9)ES細胞やiPS細胞からの膵臓分化誘導と臨床への応用",,"臨床検査","医学書院","Vol. 53","No. 10",,2009,Oct. "Yoshida T,Murata K,Shiraki N,Kume K,Shoen Kume","Analysis of gene expressions of embryonic stem-derived Pdx1-expressing cells: implications of genes involved in pancreas differentiation.",,"Development Growth Differentiation",,"Vol. 51",,"p. 463-472",2009,May "樋口 裕一郎,白木 伸明,粂昭苑","iPS細胞を用いた膵臓細胞の作製と, その移植医療への応用",,"移植",,"Vol. 44","No. 3",,2009,May "Shiraki N,Higuchi Y,Harada S,Umeda K,Isagawa T,Aburatani H,Kume K,Shoen Kume","Differentiation and characterization of embryonic stem cells into three germ layers.",,"Biochemical and Biophysical Research Communications",,"Vol. 381",,"p. 694-699",2009,Apr. "Shiraki N,Umeda K,Sakashita N,Takeya M,Kume K,Shoen Kume","Differentiation of mouse and human embryonic stem cells into hepatic lineages.",,"Genes to Cells",,"Vol. 13",,"p. 731-746",2008,July "Yoshida T,Shiraki N,Baba H,Goto M,Fujiwara S,Kume K,Shoen Kume","Expression patterns of epiplakin1 in pancreas, pancreatic cancer and regenerating pancreas.",,"Genes to Cells",,"Vol. 13",,"p. 667-678",2008,July "Shiraki N,Yoshida T,Araki K,Umezawa A,Higuchi Y,Goto H,Kume K,Shoen Kume","Guided differentiation of embryonic stem cells into Pdx1-expressing regional-specific definitive endoderm.",,"Stem Cells",,"Vol. 26",,"p. 874-885",2008,Apr. "白木 伸明,粂昭苑","再生医療・遺伝子治療 ES細胞を用いた膵臓の再生医学 (新時代の糖尿病学(3)病因・診断・治療研究の進歩) -- (糖尿病治療学の進歩)",,"日本臨床","日本臨床社","Vol. 66","No. 7",,2008, "粂昭苑,白木 伸明","膵の発生分化と幹細胞系を用いた膵の再生医学",,"臨床病理 = THE OFFICIAL JOURNAL OF JAPANESE SOCIETY OF LABORATORY MEDICINE","日本臨床検査医学会事務所","Vol. 54","No. 4",,2006,Mar. "Shiraki N,Okamura K,Tokunaga J,Ohmura T,Yasuda K,Kawaguchi T,Hamada A,Nakano M","Bromocriptine reverses P-glycoprotein-mediated multidrug resistance in tumor cells.",,,,,,,2002,Feb. "白木 伸明,岡村 恵子,徳永 仁,濱田 哲暢,中野 眞汎","Bromocriptineによる抗癌薬の多剤耐性克服",,"薬物動態 = Xenobiotic metabolism and disposition",,"Vol. 16",,,2001,Aug. "徳永 仁,岡村 恵子,濱田 哲暢,白木 伸明,宮本 晋治,藤井 淳子,有森 和彦,中野 眞汎","マクロライド系抗生物質による消化管粘膜傷害の基礎的検討",,"医療薬学","日本医療薬学会","Vol. 27","No. 4",,2001,July "Shiraki N,Hamada A,Ohmura T,Tokunaga J,Oyama N,Nakano M","Increase in doxorubicin cytotoxicity by inhibition of P-glycoprotein activity with lomerizine.",,,,,,,2001,May