論文

• Kyra See, Tetsuya Kadonosono, Yumi Ota, Kotaro Miyamoto, Wanaporn Yimchuen, Shinae Kizaka-Kondoh. Reconstitution of an anti-HER2 antibody paratope by grafting dual CDR-derived peptides onto a small protein scaffold, Biotechnology Journal, e2000078, Sept. 2020.
• Wanaporn Yimchuen, Tetsuya Kadonosono, Yumi Ota, Shinichi Sato, Maika Kitazawa, Tadashi Shiozawa, Takahiro Kuchimaru, Masumi Taki, Yuji Ito, Hiroyuki Nakamura, Shinae Kizaka-Kondoh. Strategic design to create HER2-targeting proteins with target-binding peptides immobilized on a fibronectin type III domain scaffold, RSC Advances, Vol. 10, pp. 15154-15162, Apr. 2020.  公式リンク  
  
• Tetsuya Kadonosono, Wanaporn Yimchuen, Yumi Ota, Kyra See, Tadaomi Furuta, Tadashi Shiozawa, Maika Kitazawa, Yu Goto, Akash Patil, Takahiro Kuchimaru, Shinae Kizaka-Kondoh. Design Strategy to Create Antibody Mimetics Harbouring Immobilised Complementarity Determining Region Peptides for Practical Use, Sci. Rep., vol. 10, pp. 891, Jan. 2020.
• T. Kadonosono, W. Yimchuen, T. Tsubaki, T. Shiozawa, Y. Suzuki, T. Kuchimaru, Y. Sato, S. Kizaka-Kondoh. Domain architecture of vasohibins required for their chaperone-dependent unconventional extracellular release, Protein Sci, Vol. 26, No. 3, pp. 452-463, Mar. 2017.

著書

• Tetsuya Kadonosono, Yumi Ota, Wanaporn Yimchuen, Kyra See, Tadaomi Furuta, Takahiro Kuchimaru, Shinae Kondoh. Creation of High Performance Antibody Drug Alternatives Harboring Constrained CDR Peptides, PEPTIDE SCIENCE 2017 (I. Fujii (ed.)), The Japanese Peptide Society, Osaka, pp. 126-127, Mar. 2018.

国際会議発表 (査読有り)

• Tetsuya Kadonosono, Wanaporn Yimchuen, Kyra See, Shinae Kizaka-Kondoh. Strategic design to create clinically applicable HER2-targeting small proteins with immobilized target-binding peptides, Pacifichem 2021, Dec. 2021.
• Tetsuya Kadonosono, Wanaporn Yimchuen, Kyra See, Shinae Kizaka-Kondoh. A design strategy for developing practical antibody mimetic small proteins for cancer therapy, 25th Symposium of Young Asian Biological Engineers’ Community (YABEC2019), Nov. 2019.
• Wanaporn Yimchuen, Tetsuya Kadonosono, Shinichi Sato, Takahiro Nomoto, Kyra See, Hiroyuki Nakamura, Nobuhiro Nishiyama, Shinae Kizaka-Kondoh. Development of photoimmunotherapy probe using a small antibody mimetic with structurally constrained anti-HER2 CDR peptides, 11th International Peptide Symposium, June 2019.
• Tetsuya Kadonosono, Kyra See, Wanaporn Yimchuen, Shinae Kizaka-Kondoh. A design strategy for creating a small and high-affinity antibody mimetics by double-CDR grafting, 11th International Peptide Symposium, June 2019.
• Wanaporn Yimchuen, Tetsuya Kadonosono, Shinichi Sato, Kyra See, Takahiro Kuchimaru, Hiroyuki Nakamura, Shinae Kizaka-Kondoh. Creation of a small antibody mimetic immunoprobe with structurally constrained anti-HER2 CDR peptides, 10th International Peptide Symposium, Dec. 2018.
• Tetsuya Kadonosono, Wanaporn Yimchuen, Kyra See, Yumi Ota, Marina Katsumi, Takahiro Kuchimaru, Shinae Kizaka-Kondoh. A design strategy for creating practical middle-molecular-mass antibody mimetics having structurally constrained HER2-binding peptides, 10th International Peptide Symposium, Dec. 2018.
• Kyra See, Tetsuya Kadonosono, Wanaporn Yimchuen, Takahiro Kuchimaru, Shinae Kizaka-Kondoh. Production of a small and high-affinity HER2-binding protein by double-CDR grafting, 10th International Peptide Symposium, Dec. 2018.

国内会議発表 (査読有り)

• Kyra See, Tetsuya Kadonosono, Kotaro Miyamoto, Wanaporn Yimchuen, Shinae Kizaka-Kondoh. Development of small HER2-binding proteins by paratope reconstitution, 第79回日本癌学会学術集会, Oct. 2020.
• Kyra See, Tetsuya Kadonosono, Wanaporn Yimchuen, Shinae Kizaka-Kondoh. Double-CDR grafting for the development of small HER2-targeting proteins, 第20回日本蛋白質科学会年会, July 2020.
• 本間 滉也, 門之園 哲哉, YIMCHUEN WANAPORN, 近藤 科江. Development of a bioluminescent imaging probe for detecting KISS1R-expressing cancers in vivo, 第20回日本蛋白質科学会年会, July 2020.
• See Kyra, Kadonosono Tetsuya, Yimchuen Wanaporn, Shinae Kondoh. Development of a small anti-HER2 antibody mimetic by double-CDR grafting, 第56回ペプチド討論会, Oct. 2019.
• See Kyra, Kadonosono Tetsuya, Yimchuen Wanaporn, Shinae Kondoh. Design of a small and high-affinity anti-HER2 antibody mimetic by double-CDR grafting, 第78回日本癌学会学術総会, Sept. 2019.
• 門之園 哲哉, Wanaporn Yimchuen, 太田 優美, Kyra See, 口丸 高弘, 近藤 科江. 転写因子HIF活性を抑制するHER2結合小型タンパク質の創製, 第16回がんとハイポキシア研究会, Nov. 2018.
• Wanaporn Yimchuen, Tetsuya Kadonosono, Takahiro Kuchimaru, Shinae Kondoh. Functional analysis of high-affinity antibody mimetics with structurally constrained CDR peptides for tumor imaging, 第77回日本癌学会学術集会, Sept. 2018.
• Wanaporn Yimchuen, Tetsuya Kadonosono, Kyra See, Takahiro Kuchimaru, Shinae Kondoh. Development of high-affinity tumor imaging probes with structurally constrained CDR peptides, 第13回日本分子イメージング学会総会・学術集会, June 2018.
• 門之園 哲哉, Wanaporn Yimchuen, Kyra See, 太田 優美, 口丸 高弘, 近藤 科江. 抗体CDRペプチドの構造ゆらぎ制御による小型抗体代替分子の創製, 2017年度生命科学系学会合同年次大会, Dec. 2017.
• 門之園 哲哉, Kyra See, 勝見 茉莉奈, 太田 優美, Wanaporn Yimchuen, 相田 一希, 口丸 高弘, 近藤 科江. 腫瘍悪性化促進因子の活性を中和する抗体代替分子の創製, 第15回がんとハイポキシア研究会, Nov. 2017.
• 門之園 哲哉, 太田 優美, YIMCHUEN WANAPORN, Kyra See, 古田 忠臣, 口丸 高弘, 近藤 科江. Creation of high performance antibody drug alternatives harboring constrained CDR peptides, 第54回ペプチド討論会, Nov. 2017.
• YIMCHUEN WANAPORN, 門之園 哲哉, Kyra See, 古田 忠臣, 口丸 高弘, 近藤 科江. Development of anti-HER2 antibody mimetics with structurally constrained CDR peptides, 第54回ペプチド討論会, Nov. 2017.
• 門之園 哲哉, 太田 優美, YIMCHUEN WANAPORN, 口丸 高弘, 近藤 科江. A screening system for identifying biocompatible low-molecular-mass scaffold proteins to develop small antibody mimetics, The 76th Annual Meeting of the Japanese Cancer Association, Sept. 2017.
• Yumi Ota, Tetsuya Kadonosono, Wanaporn Yimchuen, Takahiro Kuchimaru, Shinae Kondoh. Development of high affinity anti-HER2 antibody mimetics by use of human fibronectin type III domain, The 76th Annual Meeting of the Japanese Cancer Association, Sept. 2017.
• YIMCHUEN WANAPORN, 門之園 哲哉, 古田 忠臣, 口丸 高弘, 近藤 科江. Development of high-affinity tumor imaging probes based on constrained target-binding peptides, 第12回日本分子イメージング学会学術集会, May 2017.
• 北澤 舞花, 門之園 哲哉, 塩澤 唯, Yimchuen Wanaporn, 口丸 高弘, 近藤 科江. 構造ゆらぎを抑制した高親和性HER2標的結合分子スクリーニング技術の開発, 第39回日本分子生物学会年会, Dec. 2016.
• 塩澤 唯, 門之園 哲哉, 北澤 舞花, Yimchuen Wanaporn, 口丸 高弘, 瀧 真清, 伊東 祐二, 近藤 科江. 標的結合ペプチドの構造ゆらぎ抑制による高親和性PD-1結合タンパク質の創製, 第39回日本分子生物学会年会, Dec. 2016.
• 北澤 舞花, 門之園 哲哉, 塩澤 唯, YIMCHUEN WANAPORN, 口丸 高弘, Masumi Taki, Yuji Ito, 近藤 科江. Development of fibronectin-based small protein harboring a structurally constrained HER2-binding peptide, 第53回ペプチド討論会, Oct. 2016.
• 塩澤 唯, 門之園 哲哉, 北澤 舞花, Wanaporn Yimchuen, 口丸 高弘, 近藤 科江. ゆらぎ抑制標的結合ペプチドによるPD-1結合低分子量タンパク質の創製, 第75回日本癌学会学術総会, Oct. 2016.
• YIMCHUEN WANAPORN, 門之園 哲哉, 塩澤 唯, 北澤 舞花, 口丸 高弘, 近藤 科江. Development of antibody mimetics with constrained target-binding peptide for cancer therapy, 第75回日本癌学会学術総会, Oct. 2016.
• 塩澤 唯, 門之園 哲哉, 北澤 舞花, YIMCHUEN WANAPORN, 口丸 高弘, Masumi Taki, Yuji Ito, 近藤 科江. Development of a high-affinity anti-PD-1 small protein harboring a constrained PD-1-binding peptide, 第53回ペプチド討論会, Oct. 2016.
• 門之園 哲哉, YIMCHUEN WANAPORN, 塩澤 唯, 北澤 舞花, 太田 優美, 口丸 高弘, 近藤 科江. A protein-engineering method for identifying a scaffold making peptides structurally constrained in order to develop high-affinity antibody mimetics, 第53回ペプチド討論会, Oct. 2016.
• 門之園 哲哉, Wanaporn Yimchuen, 塩澤 唯, 北澤 舞花, 太田 優美, 口丸 高弘, 近藤 科江. 標的結合ペプチドのゆらぎ制御による抗体代替分子の創製法, 第75回日本癌学会学術総会, Oct. 2016.
• 門之園 哲哉, Wanaporn Yimchuen, 塩澤 唯, 北澤 舞花, 口丸 高弘, 近藤 科江. 標的結合ペプチドの「構造ゆらぎ」抑制による高性能な腫瘍イメージングプローブの開発, 第11回日本分子イメージング学会総会・学術集会, May 2016.

国内会議発表 (査読なし・不明)

• Wanaporn Yimchuen, Tetsuya Kadonosono, Kyra See, Takahiro Kuchimaru, Shinae Kondoh. Functional analysis of high-affinity antibody mimetics with structurally constrained CDR peptides for tumor imaging, In vivo イメージングフォーラム2018, Oct. 2018.
• 門之園 哲哉, Wanaporn Yimchuen, 塩澤 唯, 北澤 舞花, 太田 優美, 口丸 高弘, 近藤 科江. 「構造ゆらぎ」制御による高性能な抗体医薬品代替分子の創製, 第5回 次世代がん治療推進専門家養成プランシンポジウム, Dec. 2016.
• 塩澤 唯, 門之園 哲哉, 北澤 舞花, Wanaporn Yimchuen, 口丸 高弘, 瀧 真澄, 伊東 祐二, 近藤 科江. 標的結合ペプチドの構造ゆらぎ抑制による高親和性抗PD-1タンパク質の創製, 第5回次世代がん治療推進専門家養成プランシンポジウム, Dec. 2016.
• YIMCHUEN WANAPORN, 門之園 哲哉, 古田 忠臣, 塩澤 唯, 北澤 舞花, 口丸 高弘, 櫻井 実, 近藤 科江. Development of IgG-based antibody mimetics with a constrained target-binding peptide, 第39回日本分子生物学会年会, Nov. 2016.
• 門之園 哲哉, Wanaporn Yimchuen, 塩澤 唯, 北澤 舞花, 太田 優美, 口丸 高弘, 近藤 科江. 腫瘍悪性化促進因子活性を中和する分子標的薬創製に向けた抗体代替分子設計, 第14回がんとハイポキシア研究会, Nov. 2016.
• YIMCHUEN WANAPORN, 門之園 哲哉, 古田 忠臣, 塩澤 唯, 北澤 舞花, 口丸 高弘, 櫻井 実, 近藤 科江. Evaluation of immunoglobulin-based antibody mimetics with a constrained target-binding peptide, 第53回ペプチド討論会, Oct. 2016.

学位論文

• Development of HER2-targeting small proteins by immobilization of binding-peptides in scaffold proteins,  Thesis,  Doctor (Engineering),  Tokyo Institute of Technology,  2020/06/30,   
• Development of HER2-targeting small proteins by immobilization of binding-peptides in scaffold proteins,  Exam Summary,  Doctor (Engineering),  Tokyo Institute of Technology,  2020/06/30,   
• Development of HER2-targeting small proteins by immobilization of binding-peptides in scaffold proteins,  Summary,  Doctor (Engineering),  Tokyo Institute of Technology,  2020/06/30,   

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