論文

• Akihiro Ohkubo, Shuuhei Nishizawa. Chemical synthesis and biochemical characterization of cyclic oligonucleotides containing acyl groups at both 5´- and 3´-terminal positions, Bioorg. Med. Chem., 28, 115799, Dec. 2020.
• Akihiro Ohkubo, Kousuke Mutou, Lintaro Watanabe, Shuuhei Nishizawa, Shugo Hisamatsu, Takashi Kanamori. Chemical synthesis and properties of modified oligonucleotides containing 5'-amino-5'-deoxy-5'-hydroxymethylthymidine residues, Bioorg. Med. Chem., 28, 115407, Apr. 2020.
• Akihiro Ohkubo, Tatsuya Ohnishi, Shuuhei Nishizawa, Yuri Nishimura, Shugo Hisamatsu. The ability of a triplex-forming oligonucleotide to recognize T-A and C-G base pairs in a DNA duplex is enhanced by incorporating N-acetyl-2,7-diaminoquinoline, Bioorg. Med. Chem., Vol. 28, 115350, Apr. 2020.
• Takashi Kanamori, Masaki Y, Oda Y, Ohzeki H, Ohkubo A, Sekine M, Seio K.. DNA triplex-based fluorescence turn-on sensors for adenosine using a fluorescent molecular rotor 5-(3-methylbenzofuran-2-yl) deoxyuridine, Org. Biomol Chem., Jan. 2019.
• Takeshi Inde, Shuhei Nishizawa, Yuusaku Hattori, Takashi Kanamori, Hideya Yuasa, Kohji Seio, Mitsuo Sekine, Akihiro Ohkubo. Synthesis of and triplex formation in oligonucleotides containing 2’-deoxy-6-thioxanthosine, July 2018.
• Tanasak Kaewsomboon, Shuhei Nishizawa, Takashi Kanamori, Hideya Yuasa, Akihiro Ohkubo. pH-Dependent Switching of Base Pairs Using Artificial Nucleobases with Carboxyl Groups, J. Org. Chem., Vol. 83, No. 3, pp. 1320-1327, Jan. 2018.
• Takashi Kanamori, Takashi Sawamura, Tatsumi Tanaka, Izumi Sotokawa, Ryota Mori, Kotaro Inada, Akihiro Ohkubo, Shun-Ichiro Ogura, Yasutoshi Murayama, Eigo Otsuji, Hideya Yuasa. Coating lanthanide nanoparticles with carbohydrate ligands elicits affinity for HeLa and RAW264.7 cells, enhancing their photodamaging effect., Bioorg. Med. Chem., Vol. 25, pp. 743-749, Jan. 2017.
• Takashi Kanamori, Akihiro Takamura, Nobuhiro Tago, Yoshiaki Masaki, Akihiro Ohkubo, Mitsuo Sekine, Kohji Seio. Fluorescence enhancement of oligodeoxynucleotides modified with green fluorescent protein chromophore mimics upon triplex formation., Org. Biomol. Chem., Vol. 15, pp. 1190-1197, Jan. 2017.
• Yoshiaki Masaki, Hugo Itou, Yuki Oda, Kazufumi Yamazaki, Nobuhiro Tago, Kentaro Ohno, Nozomi Ishii, Hirosuke Tsunoda, Takashi Kanamori, Akihiro Ohkubo, Mitsuo Sekine, Kohji Seio. Enzymatic synthesis and reverse transcription of RNAs incorporating 2'-O-carbamoyl uridine triphosphate, Chemical Communications, Sept. 2016.
• Yu Ito, Yoshiaki Masaki, Takashi Kanamori, Akihiro Ohkubo, KOHJI SEIO, MITSUO SEKINE. Synthesis of 5-[3-(2-aminopyrimidin-4-yl)aminopropyn-1-yl]uracil derivative that recognizes Ade-Thy base pairs in double-stranded DNA, Bioorg. Med. Chem. Lett., Vol. 26, pp. 194-196, Jan. 2016.
• Nobuhiro Tago, Yoshiaki Masaki, Takashi Kanamori, Akihiro Ohkubo, KOHJI SEIO, MITSUO SEKINE. A New Microfluidic Phase-Transfer Reaction Using HPLC Guard Columns as the Reactor for the N3 Protection of Uridine Derivatives, SYNLETT, Vol. 26, pp. 2578-2582, Nov. 2015.
• Takashi Sawamura, Tatsumi Tanaka, hiroyuki ishige, masayuki Iizuka, yasutoshi murayama, Eigo Otsuji, Akihiro Ohkubo, Shun-ichiro OGURA, HIDEYA YUASA. The Effect of Coatings on the Affinity of Lanthanide Nanoparticles to MKN45 and HeLa Cancer Cells and Improvement in Photodynamic Therapy Efficiency, International Journal of Molecular Sciences, Vol. 16, pp. 22415-22424, Sept. 2015.
• Ohkubo, Kenji Yamada, Yu Ito, Kiichi Yoshimura, Koichiro Miyauchi, Takashi Kanamori, Yoshiaki Masaki, KOHJI SEIO, HIDEYA YUASA, Mitsuo. Synthesis and Triplex-forming Properties of Oligonucleotides Capable of Recognizing Corresponding DNA Duplexes Containing Four Base Pairs, Nucleic Acids Res., Vol. 43, No. 12, pp. 5675-5686, May 2015.
• Takahito Tomori, Yuya Miyatake, Takashi Kanamori, Yoshiaki Masaki, Akihiro Ohkubo, KOHJI SEIO, MITSUO SEKINE. Synthesis of peptide nucleic acids containing pyridazine derivatives as cytosine and thymine analogs, and their duplexes with complementary oligodeoxynucleotides, ORG. LETT., Vol. 17, 6, pp. 1609-1612, Mar. 2015.
• munefumi tokugawa, Kazuhei Kaneko, Masanori Saito, Takashi Kanamori, Yoshiaki Masaki, Akihiro Ohkubo, KOHJI SEIO, MITSUO SEKINE. Synthesis of responsive fluorescent Nucleobases 7-(Benzofuran-2-yl)-7- deazahypoxanthine and 7-(benzofuran-2-yl)-7-deazaguanine using cross-coupling reaction, CHEM. LETT., Vol. 44, pp. 64-66, Jan. 2015.
• Takashi Kanamori, Hiroki Ohzeki, Yoshiaki Masaki, Akihiro Ohkubo, MITSUO SEKINE, KOHJI SEIO. Controlling the fluorescence of benzofuran-modified uracil residues in oligonucleotides by triple-helix formation, Chembiochem, Vol. 16, 1, pp. 167-176, Jan. 2015.
• Junji Takeuchi, Akihiro Ohkubo, Hideya Yuasa. A Ring-Flippable Sugar as a Stimuli-Responsive Component of Liposomes, Chemistry—An Asian Journal, Vol. 10, No. 3, pp. 586–594, Jan. 2015.
• Masaki Yoshiaki, Yamada Takeshi, Saneyoshi Hisao, Ohkubo Akihiro, Seio Kohji, Sekine Mitsuo. Synthesis and Exon-Skipping Activity of Chemically Modified RNAs, Chemical Biology of Nucleic Acids: Fundamentals and Clinical Applications, pp. 497-510, Mar. 2014.  公式リンク  
  
• K. Yamada, Y. Masaki, H. Tsunoda, A. Ohkubo, K. Seio, M. Sekine. A new modified cytosine base capable of base pairing with guanine using four hydrogen bonds, ORGANIC & BIOMOLECULAR CHEMISTRY, Vol. 12, No. 14, pp. 2255-2262, 2014.
• Y. Masaki, R. Miyasaka, K. Hirai, T. Kanamori, H. Tsunoda, A. Ohkubo, K. Seio, M. Sekine. Properties of 5- and/or 2-modified 2 '-O-cyanoethyl uridine residue: 2 '-O-cyanoethyl-5-propynyl-2-thiouridine as an efficient duplex stabilizing component, ORGANIC & BIOMOLECULAR CHEMISTRY, Vol. 12, No. 7, pp. 1157-1162, 2014.
• T. Yamada, Y. Masaki, N. Okaniwa, T. Kanamori, A. Ohkubo, H. Tsunoda, K. Seio, M. Sekine. Synthesis and properties of oligonucleotides modified with 2 '-O-(2-carboxyethyl)nucleotides and their carbamoyl derivatives, ORGANIC & BIOMOLECULAR CHEMISTRY, Vol. 12, No. 33, pp. 6457-6464, 2014.
• K. Seio, M. Tokugawa, H. Tsunoda, A. Ohkubo, F. Arisaka, M. Sekine. Assembly of pyrene-modified DNA/RNA duplexes incorporating a G-rich single strand region, BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, Vol. 23, No. 24, pp. 6822-6824, Dec. 2013.
• Y. Iijima, S. Kojima, E. Kodama, S. Kurohagi, T. Kanamori, Y. Masaki, A. Ohkubo, M. Sekine, K. Seio. Modified oligodeoxynucleotide primers for reverse-transcription of target RNAs that can discriminate among length variants at the 3 '-terminus, ORGANIC & BIOMOLECULAR CHEMISTRY, Vol. 11, No. 47, pp. 8276-8282, Dec. 2013.
• A. Ohkubo, Y. Kondo, M. Suzuki, H. Kobayashi, T. Kanamori, Y. Masaki, K. Seio, K. Nagai, M. Sekine. Chemical synthesis of U1 snRNA derivatives, ORGANIC LETTERS, Vol. 15, No. 17, pp. 4386-4389, Sept. 2013.
• K. Seio, T. Kanamori, M. Tokugawa, H. Ohzeki, Y. Masaki, H. Tsunoda, A. Ohkubo, M. Sekine. Fluorescent properties of oligonucleotides doubly modified with an indole-fused cytosine analog and 2-aminopurine, BIOORGANIC & MEDICINAL CHEMISTRY, Vol. 21, No. 11, pp. 3197-3201, June 2013.
• K. Yamada, A. Ohkubo, Y. Esaka, T. Kanamori, Y. Masaki, K. Seio, M. Sekine. Base recognition of gap sites in DNA-DNA and DNA-RNA duplexes by short oligonucleotides, BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, Vol. 23, No. 11, pp. 3448-3451, June 2013.
• K. Yamada, Y. Hattori, T. Inde, T. Kanamori, A. Ohkubo, K. Seio, M. Sekine. Remarkable stabilization of antiparallel DNA triplexes by strong stacking effects of consecutively modified nucleobases containing thiocarbonyl groups, BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, Vol. 23, No. 3, pp. 776-778, Feb. 2013.
• K. Seio, M. Tokugawa, T. Kanamori, H. Tsunoda, A. Ohkubo, M. Sekine. Synthesis and properties of cationic 2 '-O- N-(4-aminobutyl)carbamoyl modified oligonucleotides, BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, Vol. 22, No. 7, pp. 2470-2473, Apr. 2012.
• T. Harakawa, H. Tsunoda, A. Ohkubo, K. Seio, M. Sekine. Development of an efficient method for phosphorodiamidate bond formation by using inorganic salts, Bioorganic & Medicinal Chemistry Letters, Vol. 22, No. 3, pp. 1445-1447, Feb. 2012.
• A. Ohkubo, N. Tago, A. Yokouchi, ; Y. Nishino, K. Yamada, H. Tsunoda, K. Seio, M. Sekine. Synthesis of 5 '-terminal capped oligonucleotides using O-N phosphoryl migration of phosphoramidite derivatives, ORGANIC LETTERS, Vol. 14, No. 1, pp. 10-13, Jan. 2012.
• T. Kanamori, Y. Masaki, M. Mizuta, H. Tsunoda, A. Ohkubo, M. Sekine, K. Seio. DNA duplexes and triplex-forming oligodeoxynucleotides incorporating modified nucleosides forming stable and selective triplexes, ORGANIC & BIOMOLECULAR CHEMISTRY, Vol. 10, No. 5, pp. 1007-1013, 2012.
• Y. Masaki, R. Miyasaka, K. Hirai, H. Tsunoda, A. Ohkubo, K. Seio, M. Sekine. Prediction of the stability of modified RNA duplexes based on deformability analysis: Oligoribonucleotide derivatives modified with 2 '-o-cyanoethyl-5-propynyl-2-thiouridine as a promising component, CHEMICAL COMMUNICATIONS, Vol. 48, No. 58, pp. 7313-7315, 2012.
• A. Ohkubo, Y. Nishino, Y. Ito, H. Tsunoda, K. Seio, M. Sekine. Formation of new base pairs between inosine and 5-methyl-2-thiocytidine derivatives, ORGANIC & BIOMOLECULAR CHEMISTRY, Vol. 10, No. 10, pp. 2008-2010, 2012.
• K. Seio, S. Kurohagi, E. Kodama, Y. Masaki, H. Tsunoda, A. Ohkubo, M. Sekine. Short-RNA selective binding of oligonucleotides modified using adenosine and guanosine derivatives that possess cyclohexyl phosphates as substituents, ORGANIC & BIOMOLECULAR CHEMISTRY, Vol. 10, No. 5, pp. 994-1006, 2012.
• A. Ohkubo, A. Yokouchi, K. Yamada, H. Tsunoda, K. Seio, M. Sekine. Synthesis and properties of oligonucleotides having 5 '-terminal 2,2,7-trimethylguanosine cap analogues, NUCLEIC ACID THERAPEUTICS, Vol. 21, No. 5, pp. A39-A40, Oct. 2011.
• T. Yamada, N. Okaniwa, H. Saneyoshi, A. Ohkubo, K. Seio, T. Nagata, Y. Aoki, S. Takeda, M. Sekine. Synthesis of 2 '-O- 2-(N-methylcarbamoyl)ethyl ribonucleosides using oxa-michael reaction and chemical and biological properties of oligonucleotide derivatives incorporating these modified ribonucleosides, JOURNAL OF ORGANIC CHEMISTRY, Vol. 76, No. 9, pp. ç, May 2011.
• H. Tsunoda, T. Kudo, Y. Masaki, A. Ohkubo, K. Seio, M. Sekine. Biochemical behavior of N-oxidized cytosine and adenine bases in DNA polymerase-mediated primer extension reactions, NUCLEIC ACIDS RESEARCH, Vol. 39, No. 7, pp. 2995-3004, Apr. 2011.
• S. Q. Cao, I. Okamoto, H. Tsunoda, A. Ohkubo, K. Seio, M. Sekine. Synthesis and triplex-forming properties of oligonucleotides containing thio-substituted C-nucleoside 4-thiopseudoisocytidine, TETRAHEDRON LETTERS, Vol. 52, No. 3, pp. 407-410, Jan. 2011.
• M. Sekine, Y. Oeda, Y. Iijima, H. Taguchi, A. Ohkubo, K. Seio. Synthesis and hybridization properties of 2 '-O-methylated oligoribonucleotides incorporating 2 '-O-naphthyluridines, ORGANIC & BIOMOLECULAR CHEMISTRY, Vol. 9, No. 1, pp. 210-218, 2011.
• A. Ohkubo, Y. Nishino, A. Yokouchi, Y. Ito, Y. Noma, Y. Kakishima, Y. Masaki, H. Tsunoda, K. Seio, M. Sekine. Stable triplex formation using the strong stacking effect of consecutive thionucleoside moieties, CHEMICAL COMMUNICATIONS, Vol. 47, No. 46, pp. 12556-12558, 2011.
• H. Tsunoda, T. Kudo, A. Ohkubo, K. Seio, M. Sekine. Synthesis of oligodeoxynucleotides using fully protected deoxynucleoside 3 '-phosphoramidite building blocks and base recognition of oligodeoxynucleotides incorporating N-3-cyano-ethylthymine, MOLECULES, Vol. 15, No. 11, pp. 7509-7531, Nov. 2010.
• K. Yamada, H. Taguchi, A. Ohkubo, K. Seio, M. Sekine. Synthesis and biochemical properties of oligodeoxynucleotides acylated by the chemically stable 2-(trimethylsilyl)benzoyl (TMSBz) group at the 5 ' or 3 ' terminus, Tetrahedron letters, Vol. 51, No. 39, pp. 5173-5176, Sept. 2010.
• A. Ohkubo, T. Sakaue, H. Tsunoda, K. Seio, M. Sekine. Synthesis and hybridization properties of oligonucleotides incorporating bi- and tricyclic cytosine derivatives, Chemistry letters, Vol. 39, No. 7, pp. 726-727, July 2010.
• A. Ohkubo, Y. Kuwayama, Y. Nishino, H. Tsunoda, K. Seio, M. Sekine. Oligonucleotide synthesis involving deprotection of amidine-type protecting groups for nucleobases under acidic conditions, ORGANIC LETTERS, Vol. 12, No. 11, pp. 2496-2499, June 2010.
• Y. Masaki, R. Miyasaka, A. Ohkubo, K. Seio, M. Sekine. Linear relationship between deformability and thermal stability of 2 '-O-modified RNA hetero duplexes, JOURNAL OF PHYSICAL CHEMISTRY B, Vol. 114, No. 7, pp. 2517-2524, Feb. 2010.
• Y. Masaki, A. Ohkubo, K. Seio, M. Sekine. Synthesis of 6-N-(benzothiazol-2-yl)deoxyadenosine and its exciton-coupled circular dichroism, BIOORGANIC & MEDICINAL CHEMISTRY, Vol. 18, No. 2, pp. 567-572, Jan. 2010.
• Magat Juan, E.C., Shimizu, S., Ma, X., Kurose, T., Haraguchi, T., Zhang, F., Tsunoda, M., Akihiro Ohkubo, Sekine, M., Shibata, T., Millington, C.L., Williams, D.M., Takénaka, A.. Insights into the DNA stabilizing contributions of a bicyclic cytosine analogue: Crystal structures of DNA duplexes containing 7,8-dihydropyrido [2,3-d]pyrimidin-2-one, Nucleic Acids Research, Vol. 38, No. 19, pp. 6737-6745, 2010.
• K. Seio, M. Shiraishi, E. Utagawa, A. Ohkubo, M. Sekine. Synthesis of oligodeoxynucleotides using the oxidatively cleavable 4-methoxytritylthio (MMTrS) group for protection of the 5 '-hydroxyl group, NEW JOURNAL OF CHEMISTRY, Vol. 34, No. 5, pp. 984-992, 2010.
• Y. Oeda, Y. Iijima, H. Taguchi, A. Ohkubo, K. Seio, M. Sekine. Microwave-Assisted Synthesis of 2 '-O-Aryluridine Derivatives, ORGANIC LETTERS, Vol. 11, No. 24, pp. 5582-5585, Dec. 2009.
• K. Seio, R. Tawarada, T. Sasami, M. Serizawa, M. Ise, A. Ohkubo, M. Sekine. Synthesis and hybridization of 2 '-O-methyl-RNAs incorporating 2 '-O-carbamoyluridine and unique participation of the carbamoyl group in U-G base pair, BIOORGANIC & MEDICINAL CHEMISTRY, Vol. 17, No. 20, pp. 7275-7280, Oct. 2009.
• Seio Kohji, Miyazaki Kazuya, Kurohagi Sayako, Masaki Yoshiaki, Tsunoda Hirosuke, Ohkubo Akihiro, Sekine Mitsuo. Synthesis and properties of terminally modified oligonucleotides capable of short-RNA selective hybridization., Nucleic acids symposium series (2004), No. 53, pp. 13-4, Sept. 2009.  公式リンク  
  
• K. Yamada, H. Taguchi, A. Ohkubo, K. Seio, M. Sekine. Synthesis and properties of nucleoside derivatives acylated by chemically stable 2-(trimethylsilyl)benzoyl group, Bioorganic & Medicinal Chemistry, Vol. 17, No. 16, pp. 5928-5932, Aug. 2009.
• A. Ohkubo, K. Sasaki, Y. Noma, H. Tsunoda, K. Seio, M. Sekine. Efficient solid-phase synthesis of oligodeoxynucleotides having a 5 '-terminal 2,2,7-trimethylguanosine pyrophosphate linkage, BIOORGANIC & MEDICINAL CHEMISTRY, Vol. 17, No. 13, pp. 4819-4824, July 2009.
• M. Mizuta, K. Seio, A. Ohkubo, M. Sekine. Fluorescence Properties of Pyrimidopyrimidoindole Nucleoside dC(PPI) Incorporated into Oligodeoxynucleotides, JOURNAL OF PHYSICAL CHEMISTRY B, Vol. 113, No. 28, pp. 9562-9569, July 2009.
• T. Sasami, R. Tawarada, A. Ohkubo, M. Sekine, K. Seio. Computational evaluation of the stability of 2 '-O-methyl-RNA/RNA duplexes incorporating 3-deazaguanine derivatives by ab initio calculations and a molecular dynamics simulation, JOURNAL OF MOLECULAR STRUCTURE-THEOCHEM, Vol. 899, No. 1-3, pp. 54-60, Apr. 2009.
• A. Ohkubo, Y. Noma, K. Aoki, H. Tsunoda, K. Seio, M. Sekine. Introduction of 3 '-Terminal Nucleosides Having a Silyl-Type Linker into Polymer Supports without Base Protection, JOURNAL OF ORGANIC CHEMISTRY, Vol. 74, No. 7, pp. 2817-2823, Apr. 2009.
• T. Sasami, Y. Odawara, A. Ohkubo, M. Sekine, K. Seio. Synthesis of oligodeoxynucleotides incorporating 2-N-carbamoylguanine and evaluation of the hybridization properties, BIOORGANIC & MEDICINAL CHEMISTRY, Vol. 17, No. 3, pp. 1398-1403, Feb. 2009.
• K. Miyata, R. Tamamushi, H. Tsunoda, A. Ohkubo, K. Seio, M. Sekine. Synthesis and Triplex Formation of Oligonucleotides Containing 8-Thioxodeoxyadenosine, Organic Letters, Vol. 11, No. 3, pp. 605-608, Feb. 2009.
• A. Ohkubo, R. Kasuya, K. Miyata, H. Tsunoda, K. Seio, M. Sekine. New thermolytic carbamoyl groups for the protection of nucleobases, ORGANIC & BIOMOLECULAR CHEMISTRY, Vol. 7, No. 4, pp. 687-694, 2009.
• K. Seio, Y. Takaku, K. Miyazaki, S. Kurohagi, Y. Masaki, A. Ohkubo, M. Sekine. Synthesis of terminally modified oligonucleotides and their hybridization dependence on the size of the target RNAs, ORGANIC & BIOMOLECULAR CHEMISTRY, Vol. 7, No. 11, pp. 2440-2451, 2009.
• K. Seio, M. Mizuta, K. Tasaki, K. Tamaki, A. Ohkubo, M. Sekine. Hybridization-dependent fluorescence of oligodeoxynucleotides incorporating new pyrene-modified adenosine residues, BIOORGANIC & MEDICINAL CHEMISTRY, Vol. 16, No. 17, pp. 8287-8293, Sept. 2008.
• A. Ohkubo, Y. Kuwayama, T. Kudo, H. Tsunoda, K. Seio, M. Sekine. O-selective condensation using P-N bond cleavage in RNA synthesis without base protection, Organic letters, Vol. 10, No. 13, pp. 2793-2796, July 2008.
• M. Mizuta, J. I. Banba, T. Kanamori, R. Tawarada, A. Ohkubo, M. Sekine, K. Seio. New nucleotide pairs for stable DNA triplexes stabilized by stacking interaction, JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, Vol. 130, pp. 9622-+, July 2008.
• A. Ohkubo, R. Kasuya, K. Aoki, A. Kobori, H. Taguchi, K. Seio, M. Sekine. Efficient synthesis of functionalized oligodeoxyribonucleotides with base-labile groups using a new silyl linker, BIOORGANIC & MEDICINAL CHEMISTRY, Vol. 16, No. 9, pp. 5345-5351, May 2008.
• H. Saneyoshi, K. Tamaki, A. Ohkubo, K. Seio, M. Sekine. Synthesis and hybridization properties of 2 '-O-(tetrazol-5-yl)ethyl-modified oligonucleotides, TETRAHEDRON, Vol. 64, No. 19, pp. 4370-4376, May 2008.
• A. Ohkubo, R. Kasuya, K. Sakamoto, K. Miyata, H. Taguchi, H. Nagasawa, T. Tsukahara, T. Watanobe, Y. Maki, K. Seio, M. Sekine. 'Protected DNA Probes' capable of strong hybridization without removal of base protecting groups, NUCLEIC ACIDS RESEARCH, Vol. 36, No. 6, pp. 1952-1964, Apr. 2008.
• H. Tsunoda, A. Ohkubo, H. Taguchi, K. Seio, M. Sekine. Synthesis and properties of DNA oligomers containing 2 '-deoxynucleoside N-oxide derivatives, JOURNAL OF ORGANIC CHEMISTRY, Vol. 73, No. 4, pp. 1217-1224, Feb. 2008.
• M. Sumino, A. Ohkubo, H. Taguchi, K. Seio, M. Sekine. Synthesis and properties of oligodeoxynucleotides containing 5-carboxy-2'-deoxycytidines, BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, Vol. 18, No. 1, pp. 274-277, Jan. 2008.
• A. Ohkubo, K. Tanaka, H. Taguchi, K. Seio, H. Nagasawa, T. Tsukahara, M. Sekine. An effective method for the in situ synthesis of DNA-CPG conjugates using chemical ligation technology as tools for SNP analysis, BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, Vol. 17, No. 21, pp. 5969-5973, Nov. 2007.
• Saneyoshi Hisao, Okamoto Itaru, Masaki Yoshiaki, Ohkubo Akihiro, Seio Kohji, Mitsuo. Facile synthesis of 2 '-O-cyanoethyluridine by ring-opening reaction of 2,2 '-anhydrouridine with cyanoethyl trimethylsilyl ether in the presence of BF3 center dot Et2O, Tetrahedron Letters, Vol. 48, No. 48, pp. 8554-8557, Nov. 2007.  公式リンク  
  
• E. Utagawa, A. Ohkubo, M. Sekine, K. Seio. Synthesis of branched Oligonucleotides with three different sequences using an oxidatively removable tritylthio group, JOURNAL OF ORGANIC CHEMISTRY, Vol. 72, No. 22, pp. 8259-8266, Oct. 2007.
• A. Ohkubo, H. Taguchi, K. Seio, H. Nagasawa, T. Tsukahara, M. Sekine. A new hydrophobic linker effective for the in situ synthesis of DNA-CPG conjugates as tools for SNP analysis, TETRAHEDRON LETTERS, Vol. 48, No. 29, pp. 5147-5150, July 2007.
• T. Sasami, Y. Odawara, A. Ohkubo, M. Sekine, K. Seio. Synthesis and hybridization properties of oligodeoxynucleotides incorporating 2-N-carbamoylguanine derivatives as guanine analogs, TETRAHEDRON LETTERS, Vol. 48, No. 30, pp. 5325-5329, July 2007.
• K. Seio, T. Sasami, A. Ohkubo, K. Ando, M. Sekine. Highly selective recognition of cytosine over uracil and adenine by a guanine analogue, 2-N-Acetyl-3-deazaguanine, in 2 '-O-Methyl-RNA/RNA and DNA duplexes, JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, Vol. 129, No. 5, pp. 1026-1027, Feb. 2007.
• K. Miyata, R. Mineo, R. Tamamushi, M. Mizuta, A. Ohkubo, H. Taguchi, K. Seio, T. Santa, M. Sekine. Synthesis and fluorescent properties of bi- and tricyclic 4-N-carbamoyldeoxycytidine derivatives, JOURNAL OF ORGANIC CHEMISTRY, Vol. 72, No. 1, pp. 102-108, Jan. 2007.
• M. Mizuta, K. Seio, K. Miyata, A. Ohkubo, H. Taguchi, M. Sekine. A pyrimidopyrimidoindole nucleoside (dC(PPI)): Photophysical properties and thermal stability of the modified DNA duplexes, NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS, Vol. 26, No. 10-12, pp. 1335-1338, 2007.
• K. Seio, T. Terada, M. Mizuta, A. Ohkubo, H. Taguchi, M. Sekine. Synthesis and hybridization properties of oligodeoxynucleotides with long-chain linkers, HELVETICA CHIMICA ACTA, Vol. 90, No. 10, pp. 1946-1965, 2007.
• K. Miyata, R. Tamamushi, A. Ohkubo, H. Taguchi, K. Seio, T. Santa, M. Sekine. Synthesis and properties of a new fluorescent bicyclic 4-N-carbamoyldeoxycytidine derivative, ORGANIC LETTERS, Vol. 8, No. 8, pp. 1545-1548, Apr. 2006.
• H. Taguchi, A. Ohkubo, M. Sekine, K. Seio, H. Kakeya, H. Osada, T. Sasaki. Synthesis and biological properties of new phosmidosine analogs having an N-acylsulfamate linkage, NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS, Vol. 25, No. 4-6, pp. 647-654, 2006.
• M. Sekine, M. Aoyagi, M. Ushioda, A. Ohkubo, K. Seio. Chemically stabilized phenylboranylidene groups having a dimethoxytrityl group as a colorimetrically detectable protecting group designed for cis-1,2-diol functions of ribonucleosides in the solid-phase synthesis of m(2)(2,2)G5 ' ppT, JOURNAL OF ORGANIC CHEMISTRY, Vol. 70, No. 21, pp. 8400-8408, Oct. 2005.
• A. Ohkubo, Y. Ezawa, K. Seio, M. Sekine. O-selectivity and utility of phosphorylation mediated by phosphite triester intermediates in the N-unprotected phosphoramidite method, JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, Vol. 126, No. 35, pp. 10884-10896, Sept. 2004.
• Akihiro Ohkubo. A New Strategy for the Synthesis of Oligodeoxynucleotides Directed toward Perfect O-Selective Internucleotidic Bond Formation without Base Protection, Tetrahedron letters, Vol. 45, pp. 363, 2004.
• Akihiro Ohkubo. O-Selectivity and Utility of Phosphorylation Mediated by a Phosphite Intermediate in N-Unprotected Phosphoramidite Method, Journal of the American Chemical Society, Vol. 126, No. 35, pp. 10884, 2004.
• Akihiro Ohkubo. A New Approach for Pyrophosphate Bond Formation Starting from Phosphoramidite Derivatives by Use of 6-Trifluoromethyl-1-hyroxybenzotriazole-Mediated O-N Phosphoryl Migration, Tetrahedron letters, Vol. 45, pp. 979, 2004.
• 大窪章寛. 精密ゲノム遺伝子解析法を指向した新技術の展開, 蛋白質　核酸　酵素, Vol. 49, No. 17, pp. 2978, 2004.
• Akihiro Ohkubo. Synthesis and Hybridization Affinty of Oligodeoxyribonucleosides Incorporating 4-N-(N-arylcarbamoyl)deoxycytidine Derivatives, Tetrahedron letters, Vol. 45, pp. 9365, 2004.
• Akihiro Ohkubo. Proton-Block Strategy for the Synthesus of Oligodeoxynucleotides without Base Protection, Capping Reaction, and P-N Bond Cleavage Reaction, Journal of Organic Chemistry, Vol. 68, No. 14, pp. 5478, 2003.

著書

• Yoshiaki Masaki, Akihiro Ohkubo, Kohji Seio, Mitsuo Sekine. Effects of 2'-O-Modifications on RNA Duplex Stability, Synthesis of Therapeutic Oligonucleotides, Springer, Jan. 2018.
• 清尾康志, 大窪章寛. 塩基部無保護ホスホロアミダイト法による核酸合成, 中分子創薬に資するペプチド・核酸・糖鎖の合成技術： 千葉一裕 監修, シーエムシー出版, 2018.
• KOHJI SEIO, Takashi Kanamori, Akihiro Ohkubo, MITSUO SEKINE. Synthesis and Fluorescence Properties of Nucleosides with Pyrimimidine-Type Base Moieties, Fluorescent Analogs of Biomolecular Building Blocks, July 2016.
• 大窪章寛. オリゴヌクレオチドの固相合成, 有機合成実験法ハンドブック第２版, pp. 741-755, 2015.
• Ohkubo Akihiro, Okamoto Itaru, Kasuya Rintaro, Sakamoto Kazushi, Sasami Takeshi, Odawara Yoko, Masaki Yoshiaki, Sakaue Toshiyuki, Nagasawa Hiroshi, Tsukahara Toshifumi, Seio Kohji, Sekine Mitsuo. Protected DNA probes (PDP): A new strategy for gene detection, Chemistry of Nucleic Acid Components, Vol. 10, pp. 94-102, 2008.  公式リンク  

国際会議発表 (査読なし・不明)

• Shuhei Nishizawa, Tatsuya Ohnishi, Lintaro Watanabe, Takashi Kanamori, Hideya Yuasa, Akihiro Ohkubo. Synthesis and properties of triplex-forming oligonucleotides containing modified sugar moieties and nucleobases, The 45th International Symposium on Nucleic Acids Chemistry, Nov. 2018.
• Ritsu Hashimoto, Shuhei Nishizawa, Yu Miyake, Takashi Kanamori, Hideya Yuasa, Akihiro Ohkubo. Synthesis and properties of cyclic oligonucleotides containing acyl groups at the 5'- and 3'- terminal sites, The 45th International Symposium on Nucleic Acids Chemistry, Nov. 2018.
• Shuhei Nishizawa, Tanasak Kaewsomboon, Takashi Kanamori, Hideya Yuasa, Akihiro Ohkubo. Synthesis and Properties of Modified Oligonucleotides Containing Benzoic Acid Derivatives as Nucleobases, The 44th International Symposium on Nucleic Acids Chemistry, Nov. 2017.
• Tomohiro Aoyama, Kosuke Muto, Lintaro Watanabe, Takashi Kanamori, Hideya Yuasa, Akihiro Ohkubo. Synthesis and properties of new modified oligonucleotides containing amino groups at the 5ʼ-positions of ribose moieties, The 44th International Symposium on Nucleic Acids Chemistry, Nov. 2017.
• Tanasak Kaewsomboon, Shuhei Nishizawa, Ritsu Hashimoto, Yu Miyake, Takashi Kanamori, Hideya Yuasa, Akihiro Ohkubo. Synthesis and Properties of Cyclic Oligonucleotides Containing Acyl Groups, The 44th International Symposium on Nucleic Acids Chemistry, Nov. 2017.
• Takuma Shiraiwa, Kousuke Ikeda, Hirotomo Tanaka, Takashi Kanamori, HIDEYA YUASA, Akihiro Ohkubo. Synthesis and properties of 3ʼ-O-protected nucleoside 5ʼ-triphosphate derivatives, The 44th International Symposium on Nucleic Acids Chemistry, Nov. 2017.
• Yoshiaki Masaki, Ryuta Miyasaka, Keishi Yamamoto, Keita Yoshida, Akihiro Ohkubo, Mitsuo Sekine, Kohji Seio. Deformability analysis of chemically modified RNA and its applicability for estimation of RNA duplex stability, The 43rd International Symposium on Nucleic Acids Chemistry, Sept. 2016.
• Yu Ito, Takashi Kanamori, Yoshiaki Masaki, Akihiro Ohkubo, Kohji Seio, Mitsuo Sekine. Synthesis of deoxyuridine derivatives modified with 2,4-diaminopyrimidine moiety for the development of high affinity triplex forming oligonucleotides, The 42nd International Symposium on Nucleic Acids Chemistry 2015, Sept. 2015.

国内会議発表 (査読なし・不明)

• 大窪章寛, 緒方大介, 西澤周平. 三重鎖形成能を向上できる2,6-ジアミノ-1,8-キノリンおよび5'-アミノチミジン誘導体を含むアンチパラレル型三重鎖形成核酸の開発, June 2021.
• 大窪章寛. 次世代の核酸テクノロジーを支える新規核酸合成法の開発, 核酸医薬学会 第6回年会, June 2021.
• 大窪章寛, 宮﨑祐宇, 三宅優, 池田黄介, 吉田蒼馬, 西澤周平, 伊藤優. 固相担体に導入した HOBt 誘導体による核酸縮合反応の高効率化, 日本化学会 第101回春季年会, Mar. 2021.
• Akihiro Ohkubo, Shuuhei Nishizawa, Daisuke Ogata, Gaohong Tu, Yu Ito. Development of the artificial triplex-forming oligonucleotides containing chemically modified nucleobases or sugar moieties, 日本化学会 第101回春季年会, Mar. 2021.
• 大窪章寛, 久恒一賜, 宗像功太郎, 西澤周平, 伊藤優. ビニル基のリボヌクレオシド2´-水酸基高選択的な導入と核酸合成への応用, 日本化学会 第101回春季年会, Mar. 2021.
• 大窪章寛, 伊藤優. 板状ポーラスガラス上で光分解性保護基を利用した新規核酸合成法の開発, 日本化学会 第101回春季年会, Mar. 2021.
• Akihiro Ohkubo, Yu Miyake, Kousuke Ikeda, Yu Miyazaki, Saaya Akazawa. Development of A New Method for Chemical Synthesis of Genomic DNAs, 本化学会 第100回春季年会, Mar. 2020.
• 大窪章寛, 明瀬友輝. 2-アミノキノリン誘導体を有するアンチパラレル型三重鎖形成 核酸の合成と性質, 本化学会 第100回春季年会, Mar. 2020.
• 金森功吏, 大西達也, 渡辺凛太郎, 西澤周平, 湯浅英哉, 大窪章寛. 糖部および塩基部修飾核酸を用いた三重鎖形成核酸の合成と性質, 日本核酸医薬学会 第4回年会, July 2018.
• 西澤 周平, 橋本 律, 三宅 優, 金森 功吏, 湯浅 英哉, 大窪 章寛. アシル基を有する環状オリゴヌクレオチドの合成と性質, 日本核酸医薬学会 第4回年会, July 2018.
• 渡辺 凜太郎, 青山 知寛, 武藤 功甫, 金森 功吏, 湯浅 英哉, 大窪 章寛. 5'-アミノ-5'-ヒドロキシメチルチミジン誘導体を含むオリゴヌクレオチドの合成と性質, 日本化学会 第98回春季年会, Mar. 2018.
• KAEWSOMBOON Tanasak, Kousuke Ikeda, Shuhei Nishizawa, Takashi Kanamori, Hideya Yuasa, Akihiro OHKUBO. Synthesis of the modified oligonucleotide containing o-chlorobenzoic acid and its pH dependence of hybridization properties, 日本化学会 第98回春季年会, Mar. 2018.
• 大西 達也, 西村 ゆり, 金森 功吏, 湯浅 英哉, 大窪 章寛. 2-アミノキノリン誘導体を含む新規三重鎖形成核酸の合成と性質, 日本化学会 第98回春季年会, Mar. 2018.
• 西澤 周平, 橋本 律, 三宅 優, 金森 功吏, 湯浅 英哉, 大窪 章寛. アシル基を有する環状オリゴヌクレオチドの合成と性質, 日本化学会 第98回春季年会, Mar. 2018.
• 稲田宏太郎, 金森功吏, 大窪章寛, 小倉俊一郎, 湯浅英哉. GFP色素誘導体を用いた糖鎖受容体のturn-on型蛍光プローブの設計と合成, 日本化学会第98春季年会, Mar. 2018.
• 西澤周平, 橋本律, 三宅優, 金森功吏, 湯浅英哉, 大窪章寛. 5’および3’末端にアシル基を有する環状オリゴヌクレオチドの合成と性質, 第11回バイオ関連化学シンポジウム, Sept. 2017.
• 大西達也, 西村ゆり, 金森功吏, 湯浅英哉, 大窪章寛. 2-アミノキノリン誘導体を含む三重鎖形成核酸の合成と性質, 第11回バイオ関連化学シンポジウム, Sept. 2017.
• Takashi Kanamori, Satoshi Kuwabara, Shun-ichiro Ogura, Akihiro Ohkubo, Hideya Yuasa. In silico screening and synthesis of carbohydrate-modified fluorescent probes for the detection of selectins, 日本化学会 第97春季年会(2017), Mar. 2017.
• 西村 ゆり, Tanasak Kaewsomboon, 金森 功吏, 湯浅 英哉, 大窪 章寛. イソフタル酸誘導体を有する新規修飾核酸の合成と 性質, 日本薬学会 第137回春季年会, Mar. 2017.
• 細谷輝, 金森 功吏, 湯浅 英哉, 大窪 章寛. U1 snRNA 誘導体の合成, 日本薬学会 第137回春季年会, Mar. 2017.
• 西澤周平, 橋本 律, 金森功吏, 湯浅 英哉, 大窪章寛. 5´および 3´末端にアシル基を有する環状オリゴヌクレオチ ドの合成, 日本化学会 第97春季年会(2017), Mar. 2017.
• 小田雄貴, 伊藤比佑吾, 金森功吏, 大窪章寛, 正木慶昭, 関根光雄, 清尾康志. 塩基性条件下不安定なヌクレオシド三リン酸の新規合成法の開発, 日本化学会 第96春季年会, Mar. 2016.

その他の論文・著書など

• 大窪章寛. 精密有機合成を駆使した核酸化学の新展開, 化学と工業 = Chemistry and chemical industry, Vol. 63, No. 8, pp. 653, Aug. 2010.

特許など

• 大窪章寛, 久恒一賜. ２’－ビニルＲＮＡホスホロアミダイトユニットの開発. 特許. 公開. 国立大学法人東京工業大学. 2022/03/08. 特願2022-035609. 2023/09/21. 特開2023-130982. 2023.
• 大窪章寛, 伊藤優, 赤澤紗彩. ３’－エキソヌクレアーゼを用いた長鎖核酸の精製法. 特許. 公開. 国立大学法人東京工業大学. 2021/11/01. 特願2021-178735. 2023/05/16. 特開2023-067467. 2023.
• 大窪章寛, 伊藤優. 光透過性を向上させたポーラスガラス上での光制御型核酸フロー合成. 特許. 公開. 国立大学法人東京工業大学. 2021/03/03. 特願2021-033892. 2022/09/15. 特開2022-134635. 2022.
• 大窪章寛, 池田黄介, 三宅優. 核酸合成用固相担体及びそれを用いた核酸の製造方法. 特許. 登録. 国立大学法人東京工業大学. 2019/02/25. 特願2019-031683. 2020/08/31. 特開2020-132604. 特許第7298866号. 2023/06/19 2023.
• 関根光雄, 清尾康志, 大窪章寛, 角田浩佑, 正木慶昭, 金森功吏, 山田　希, 山崎一史, 伊藤比祐吾. 2'-0-カルバモイル修飾ヌクレオシド三リン酸. 特許. 登録. 国立大学法人東京工業大学. 2013/07/23. 特願2013-152578. 2015/02/02. 特開2015-020994. 特許第6261027号. 2017/12/22 2017.
• 関根光雄, 清尾康志, 大窪章寛, 角田　浩佑, 工藤　智美. ヌクレオシドトリホスフェート誘導体. 特許. 公開. 国立大学法人東京工業大学. 2008/03/07. 特願2008-057295. 2009/09/24. 特開2009-215171. 2009.
• 関根光雄, 清尾康志, 大窪章寛, 田中　邦彦. オリゴヌクレオチド固定化固相担体. 特許. 公開. 国立大学法人東京工業大学. 2006/03/10. 特願2006-066396. 2009/07/16. 特開2009-153381. 2009.
• 関根光雄, 清尾康志, 大窪章寛, 坂本　一石, 佐々見　武志. オリゴヌクレオチド誘導体、遺伝子検出用プローブ及びＤＮＡチップ. 特許. 登録. 国立大学法人東京工業大学. 2006/02/28. 特願2007-505962. 2008/08/07. 再表2006-093157. 特許第4882074号. 2011/12/16 2011.
• 関根光雄, 清尾康志, 大窪章寛. 固体支持体及びDNAチップ. 特許. 公開. 国立大学法人東京工業大学. 2005/09/12. 特願2005-263722. 2007/03/29. 特開2007-078399. 2007.
• 関根光雄, 清尾康志, 大窪章寛, 粕谷　林太郎. トリチル型化合物. 特許. 公開. 国立大学法人東京工業大学. 2005/03/10. 特願2005-066555. 2006/09/21. 特開2006-248956. 2006.

学位論文

• 水酸基高選択的な塩基部無保護ホスホロアミダイト法の開発,  本文,  Doctor of Science,  Tokyo Institute of Technology,  2004/--/--, 

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