論文

• X.Li, Y.Bian, Y.Takizawa, T.Hashiomoto, N.Kitamura, T.Ikoma, J.Tanaka, Y.Inagaki, M.Komada, T.Tanaka. ERK-dependent downregulation of Skp2 reduces Myc activity with HGF, leading to inhibition of cell proliferation through a decrease in Id1 expression., Molecular Cancer Research, vol. 11, pp. 1437-1447, 2013.
• Tomofumi Fujino, Airi Takeuchi, Akiko Maruko-Ohtake, Yosuke Ohtake, Junichi Satoh, Tomonori Kobayashi, Toshiaki Tanaka, Haruka Ito, Ryosuke Sakamaki, Ryo Kashimura, Ken Ando, Tomoko Nishimaki-Mogami, Yasuhito Ohkubo, Naomi Kitamura, Ryuichiro Sato, Kiyomi Kikugawa, Makio Hayakawa.. Critical role of farnesoid X receptor (FXR) for hepatocellular carcinoma cell Proliferation., Journal of Biochemistry, vol. 152, pp. 577-586, 2012.
• D.Susuki, S.Kimura, S.Naganuma, K.Tsuchiyama, T.Tanaka, N.Kitamura, S.Fujieda, H.Itoh.. Regulation of microRNA expression by hepatocyte growth factor in human head and neck squamous cell carcinoma., Cancer Science, vol. 102, pp. 2164-2171, 2011.
• T. Hashimoto, M. Kato, T. Shimomura, and N. Kitamura. TMPRSS13, a type II transmembrane serine protease, is inhibited by hepatocyte growth factor activator inhibitor type 1 and activates pro-hepatocyte growth factor, FEBS J., in press, 2010.
• J. Sugatani, M. Osabe, M. Kurosawa, N. Kitamura, A. Ikari, and M. Miwa. Induction of UGT1A1 and CYP2B6 by an antimitogenic factor in HepG2 cells is mediated through suppression of cyclin-dependent kinase 2 activity: Cell-cycle dependent expression, Drug Metab. Dispos., Vol. 38, p. 177-186, 2010.
• A. Endo, N. Kitamura, and M. Komada. Nucleophosmin/B23 regulates ubiquitin dynamics in nucleoli by recruiting a deubiquitylating enzyme USP36, J. Biol. Chem., Vol. 284, p. 27918-27923, 2009.
• Kazutaka Ushio, Tomio Hashimoto, Naomi Kitamura, Toshiaki Tanaka. ID1 is down-regulated by hepatocyte growth factor via ERK-dependent and -independent signaling pathways, leading to increased expression of p16INK4a in hepatoma cells., Mol. Cancer Res., vol. 7, pp. 1179-88, 2009.
• Asuka Kondo, Hirayama Naoki, Sugito Yasuko, M. Shono, Toshiaki Tanaka, NAOMI KITAMURA. Coupling of Grb2 to Gab1 mediates hapatocyte growth factor-induced high intensity ERK signal required for inhibition of HepG2 hapatoma cell proliferation., J. Biol. Chem., Vol. 283, pp. 1428-1436, Jan. 2008.
• Erika Shirako, Naoki Hirayama, Yu-ich Tsukada, Toshiaki Tanaka, NAOMI KITAMURA. Up-regulation of p21CIP1 expression mediated by ERK-dependent and –independent pathways contributes to hepatocyte growth factor-induced inhibition of HepG2 hapatoma cell proliferation, J.Cell.Biochem., Wiley Inter Science, Vol. 104, pp. 176-188, 2008.
• A. Mukai, E. Mizuno, K. Kobayashi, A. Yamamoto, M. Matsumoto, K. Nakayama, N. Kitamura, M. Komada. Dynamic regulation of ubiquitylation and deubiquitylation at the central spindle during cytokinesis, J. Cell Sci., 2008.
• E. Shirako, N. Hirayama, Y. Tsukada, T. Tanaka, N. Kitamura. Up-regulation of p21CIP1 expression mediated by ERK-dependent and -independent pathways contributes to hepatocyte growth factor-induced inhibition of HepG2 hepatoma cell proliferation, J. Cell. Biochem., 2008.
• E. Mizuno, N. Kitamura, M. Komada. 14-3-3-dependent inhibition of the deubiquitinating activity of UBPY and its cancellation in the M phase, Exp. Cell Res., Vol. 313, pp. 3624-3634, 2007.
• M. Nakamura, N. Tanaka, N. Kitamura, M. Komada. Clathrin anchors deubiquitinating enzymes, AMSH and AMSH-like protein, on early endosomes, Genes to Cells, Vol. 11, pp. 593-606, 2006.
• A. Yamasaki, K. Tani, A. Yamamoto, N. Kitamura, M. Komada. The Ca2+-binding protein ALG-2 is recruited to ER exit sites by Sec31A and stabilizes the localization of Sec31A, Mol. Biol. Cell, Vol. 17, pp. 4876-4887, 2006.
• E. Mizuno, K. Kobayashi, A. Yamamoto, N. Kitamura, M. Komada. A deubiquitinating enzyme UBPY regulates the level of protein ubiquitination on endosomes, Traffic, Vol. 7, pp. 1017-1031, 2006.
• J.Han, Y.Tsukada, E.Hara, N.Kitamura, T.Tanaka.. Hepatocyte growth factor induces redistribution of p21CIP1 and p27KIP1 through ERK-dependent p16INK4a up-regulation, leading to cell cycle arrest at G1 in HepG2 hepatoma cells., J.Biol.Chem., Vol. 280, pp. 31548-31556, 2005.
• J. Han, Y. Tsukada, E. Hara, N. Kitamura, T. Tanaka. Hepatocyte growth factor induces redistribution of p21CIP1 and p27KIP1 through Erk-dependent p16INK4a up-regulation, leading to cell cycle arrest at G1 in HepG2 hepatoma cells, J. Biol. Chem., Vol. 280, pp. 31548-31556, 2005.
• E. Mizuno, T. Iura, A. Mukai, T. Yoshimori, N. Kitamura, M. Komada. Regulation of EGF receptor downregulation by UBPY-mediated deubiquitination at endosomes, Mol. Biol. Cell, Vol. 16, pp. 5163-5174, 2005.
• H. Kakinuma, H. Inomata, N Kitamura. Enhanced JNK activation by NESK without kinase activity upon caspase-mediated cleavage during apoptosis, Cell. Signal., Vol. 17, pp. 1439-1448, 2005.
• M. Komada, N. Kitamura. The Hrs/STAM complex in the downregulation of receptor tyrosine kinases, J. Biochem., Vol. 137, pp. 1-8, 2005.
• H. Tanaka, K. Nagaike, N. Takeda, H. Itoh, K. Kohama, T. Fukushima, S. Miyata, S. Uchiyama, S. Uchinokura, T. Shimomura, K. Miyazawa, N. Kitamura, G. Yamada, H. Kataoka. Hepatocyte growth factor activator inhibitor type 1 (HAI-1) is required for branching morphogenesis in the chorioallantonic placenta, Mol. Cell. Biol., Vol. 25, pp. 5687-5698, 2005.
• Y. Tsukada, T. Tanaka, K. Miyazawa, N. Kitamura. Involvement of down regulation of Cdk2 activity in hepatocyte growth factor-induced cell cycle arrest at G1 in the human hepatocellular carcinoma cell line HepG2, J. Biochem., Vol. 136, pp. 701-709, 2004.
• T. Inoue, H. Kataoka, K. Goto, K. Nagaike, K. Igami, D. Naka, N. Kitamura, K. Miyazawa. Activation of c-Met (hepatocyte growth factor receptor) in human gastric cancer tissue, Cancer Sci., Vol. 95, pp. 803-808, 2004.
• T. Hori, A, Ido, H. Uto, S. Hasuike, A. Moriuchi, K. Hayashi, S. Nakagawa, K. Miyazawa, N. Kitamura, H. Tsubouchi. Activation of hepatocyte growth factor in monkey stomach following gastric mucosal injury, J. Gastroenterology, Vol. 39, pp. 133-139, 2004.
• C. Morino, M. Kato, A. Yamamoto, E. Mizuno, A. Hayakawa, M. Komada, N. Kitamura. A role for Hrs in endosomal sorting of ligand-stimulated and unstimulated epidermal growth factor receptor, Exp. Cell Res., Vol. 297, pp. 380-391, 2004.
• E. Mizuno, K. Kawahata, A. Okamoto, N. Kitamura, M. Komada. Association with Hrs is required for the early endosomal localization, stability, and function of STAM, J. Biochem, Vol. 135, pp. 385-396, 2004.
• H. Itoh, S. Naganuma, N. Takeda, S. Miyata, S. Uchinokura, T. Fukushima, S. Uchiyama, H. Tanaka, N. Kitamura, M. Koono, H. Kataoka. Regeneration of injured intestinal mucosa is impaired in hepatocyte growth factor activator-deficient mice, Gastroenterology, Vol. 127, pp. 1423-1435, 2004.
• T. Kaneko, T. Kumasaka, T. Ganbe, T. Sato, K. Miyazawa, N. Kitamura, N. Tanaka. Structural insight into modest binding of a non-PXXP ligand to the STAM2 SH3 domain, J. Biol. Chem., Vol. 278, pp. 48162-48168, 2003.
• E. Mizuno, K. Kawahata, M. Kato, N. Kitamura, M. Komada. STAM proteins bind ubiquitinated proteins on the early endosome via the VHS domain and ubiquitin-interacting motif, Mol. Biol. Cell, Vol. 14, pp. 3675-3689, 2003.
• K. Nakano, M. K.-Azuma, Y. Kanai, K. Moriyama, K. Yazaki, Y. Hayashi, N. Kitamura. Cofilin phosphorylation and actin polymerization by NRK/NESK, a member of the germinal center kinase family, Exp. Cell Res., Vol. 287, pp. 219-227, 2003.
• H. Inomata, Y. Nakamura, A. Hayakawa, H. Takata, T. Suzuki, K. Miyazawa, N. Kitamura. A scaffold protein JIP-1b enhances amyloid precursor protein phosphorylation by JNK and its association with kinesin light chain 1, J. Biol. Chem., Vol. 278, pp. 22946-22955, 2003.
• K. Denda, T. Shimomura, T. Kawaguchi, K. Miyazawa, N. Kitamura. Functional characterization of Kunitz domains in hepatocyte growth factor activator inhibitor type 1, J. Biol. Chem., Vol. 277, pp. 14053-14059, 2002.
• M. Kaibori, T. Inoue, M. Oda, D. Naka, T. Kawaguchi, N. Kitamura, K. Miyazawa, AH. Kwon, Y. Kamiyama, T. Okumura. Exogenously administered HGF activator augments liver regeneration through the production of biologically active HGF, Biochem. Biophys. Res. Commun., Vol. 290, pp. 475-481, 2002.
• H. Kataoka, H. Itoh, Y. Nuki, R. Hamasuna, S. Naganuma, N. Kitamura, T. Shimomura. Mouse hepatocyte growth factor (HGF) activator inhibitor type 2 lacking the first Kunitz domain potently inhibits the HGF activator, Biochem. Biophys. Res. Commun., Vol. 290, pp. 1096-1100, 2002.
• K.Takeuchi, S. Shibamoto, K. Nagamine. I. Shigemori, S. Omura. N. Kitamura, F. Ito. Signaling pathways leading to transcription and translation cooperatively regulate the transient increase in expression of c-Fos protein, J. Biol. Chem., Vol. 276, pp. 26077-26083, 2001.
• H. Itoh, H. Kataoka, J. Y. Meng, R. Hamasuna, N. Kitamura, M. Koono. Mouse hepatocyte growth factor activator inhibitor type 1 (HAI-1) and type 2 (HAI-2) /placental bikunin genes and their promoters, Biochim. Biophys. Acta., Vol. 1519, pp. 92-95, 2001.
• D. Goto, H. Nakajima, Y. Mori, K. Kurasawa, N. Kitamura, I. Iwamoto. Interaction between smad anchor for receptor activation (SARA) and smad3 is not essential for TGF-b/smad3-mediated signaling, Biochem. Biophys. Res. Commun., Vol. 281, pp. 1100-1105, 2001.
• M. Komada, N. Kitamura. Hrs and Hbp: possible regulators of endocytosis and exocytosis, Biochem. Biophys. Res. Commun., Vol. 281, pp. 1065-1069, 2001.
• K. Nagata, S. Hirono, A. Ido, H. Kataoka, A. Moriuchi, T. Shimomura, T. Hori, K. Hayashi, M. Koono, N. Kitamura, H. Tsubouchi. Expression of hepatocyte growth factor activator and hepatocyte growth factor activator inhibitor type 1 in human hepatocellular carcinoma, Biochem. Biophys. Res. Commun, Vol. 289, pp. 205-211, 2001.
• S. Hirono, K. Nagata, A. Moriuchi, M. Onaga, H. Fujiwara, T. Hori, A. Ido, T. Shimomura, K. Hayashi, N. Kitamura, H. Tsubouchi. HGF-related proteins in hepatocellular carcinoma, Liver Cirrhosis, pp. 87-92, 2001.
• H. Itoh, H. Kataoka, M. Yamauchi, S. Naganuma, Y. Akiyama, Y. Nuki, T. Shimomura, K. Miyazawa, N. Kitamura, M. Koono. Identification of hepatocyte growth factor activator inhibitor type 2 (HAI-2) related small peptide (H2RSP): Its nuclear localization and generation of chimeric mRNA transcribed from both HAI-2 and H2RSP genes, Biochem. Biophys. Res. Commun., Vol. 288, pp. 390-399, 2001.
• Y. Tsukada, K. Miyazawa, N. Kitamura. High-intensity ERK signal mediates hepatocyte growth factor-induced proliferation inhibition of the human hepatocellular carcinoma cell line HepG2, J. Biol. Chem., Vol. 276, pp. 40968-40976, 2001.
• K. Nakano, J. Yamauchi, K. Nakagawa, H. Itoh, N. Kitamura. NESK, a member of the germinal center kinase family that activates the c-Jun N-terminal kinase pathway and is expressed during the late stages of embryogenesis, J. Biol. Chem., Vol. 275, pp. 20533-20539, 2000.
• H. Itoh, R. Hamasuna, H. Kataoka, M. Yamauchi, K. Miyazawa, N. Kitamura, M. Koono. Mouse hepatocyte growth factor activator gene: its expression not only in the liver but also in the gastrointestinal tract, Biochim. Biophys. Acta., Vol. 1491, pp. 295-302, 2000.
• H. Itoh, H. Kataoka, M. Tomita, R. Hamasuna, Y. Nawa, N. Kitamura, M. Koono. Upregulation of hepatocyte growth factor activator inhibitor type 1 but not type 2 along with regeneration of intestinal mucosa, Am. J. Physiol., Vol. 278, pp. G635-G643, 2000.
• S. Murai, N. Kitamura. Involvement of Hrs binding protein in IgE receptor-triggered exocytosis in RBL-2H3 mast cells, Biochem. Biophys. Res. Commun., Vol. 277, pp. 752-756, 2000.
• H. Kataoka, R. Hamasuna, H. Itoh, N. Kitamura, K. Nabeshima, M. Koono. Activation of Hepatocyte growth factor/scatter factor in colorectal carcinoma, Cancer Res., Vol. 60, pp. 6148-6159, 2000.
• M. Kato, K. Miyazawa, N. Kitamura. A de-ubiquitinating enzyme UBPY interacts with the SH3 domain of Hrs binding protein via a novel binding motif Px(V/I)(D/N)RxxKP, J. Biol. Chem., Vol. 275, pp. 37418-37487, 2000.
• S. Urbe, I. G. Mills, H. Stenmark, N. Kitamura, M. J. Clague. Endosomal localisation and receptor dynamics determine tyrosine phosphorylation of Hepatocyte growth factor-regulated tyrosine kinase substrate, Mol. Cell. Biol., Vol. 20, pp. 7685-7692, 2000.
• Y. Uehara, C. Mori, T. Noda, K. Shiota, N. Kitamura. Rescue of embryonic lethality in hepatocyte growth factor/scatter factor knockout mice, Genesis, Vol. 27, pp. 99-103, 2000.
• A. Hayakawa, N. Kitamura. Early endosomal localization of Hrs requires a sequence within the proline- and glutamine-rich region, but not the FYVE finger, J. Biol. Chem., Vol. 275, pp. 29636-29642, 2000.
• H. Itoh, M. Yamauchi, H. Kataoka, R. Hamasuna, N. Kitamura, M. Koono. Genomic structure and chromosomal localization of the human　hepatocyte growth factor activator inhibitor type 1 and 2 genes, Eur. J. Biochem., Vol. 267, pp. 3351-3359, 2000.
• H. Takata, M. Kato, K. Denda, N. Kitamura. A Hrs binding protein having a Src homology 3 domain is involved in intracellular degradation of growth factors and their receptors, Genes to Cells, Vol. 5, pp. 57-69, 2000.
• H. Kataoka, H. Itoh, H. Uchino, R, Hamasuna, N. Kitamura, K. Nabeshima, M. Koono. Conserved expression of hepatocyte growth factor activator inhibitor type-2/placental bikunin in human colorectal carcinomas, Cancer Lett., Vol. 148, pp. 127-134, 2000.
• NAOMI KITAMURA. Hepatocyte growth factor activator inhibitor, a novel Kunitz-type serine protease inhibitor, Journal of Biological Chemistry, Vol. 272, pp. 6370-6376, 1997.
• NAOMI KITAMURA. Purification and cloning of hepatocyte growth factor activator inhibitor type 2, a Kunitz-type serine protease inhibitor., J. Biol. Chem., Vol. 272, pp. 27558-27564, 1997.
• NAOMI KITAMURA. Hrs, a tyrosine kinase substrate with a conserved double zinc finger domain, is localized to the cytoplasmic surface of early endosomes., J. Biol. Chem., Vol. 272, pp. 20538-20544, 1997.
• NAOMI KITAMURA. Induction of hepatocyte growth factor activator mRNA in the liver following tissue injury and acute inflammation., Hepatology, Vol. 25, pp. 97-102, 1997.
• NAOMI KITAMURA. Activation of Hepatocyte Growth Factor in the Injured Tissues is Mediated by Hepatocyte Growth Factor Activator, J.Biol.Chem., Vol. 271, pp. 3615-3618, 1996.
• NAOMI KITAMURA. Growth Factor-Induced Tyrosine Phosphorylation of Hrs, A Novel 115-Kilodaltor Protein with a Structurally Consevved Putative Zinc Finger Domain, Mol.Cell.Biol., Vol. 15, pp. 6213-6221, 1995.
• NAOMI KITAMURA. Placental defect and embryonic lethality in mice lacking hepatocyte growth factor/scatter factor, Nature, Vol. 373, pp. 702-705, 1995.
• NAOMI KITAMURA. Regulatory role of major tyrosine autophosphorylation site of kinase domain of c-Met receptor (scatter factor/hepatocyte growth factor receptor), J. Biol. Chem., Vol. 269, pp. 16131-16136, 1994.
• NAOMI KITAMURA. Proteolytic activation of hepatocyte growth factor in response to tissue injury, J. Biol. Chem., Vol. 269, pp. 8966-8970, 1994.
• NAOMI KITAMURA. The cell dissociation and motility triggered by scatter factor/hepatocyte growth factor are mediated through the cytoplasmic domain of the c-Met receptor, Oncogene, Vol. 8, pp. 2381-2390, 1993.
• NAOMI KITAMURA. Activation of the zymogen of hepatocyte growth factor activator by thrombin, J. Biol. Chem., Vol. 268, pp. 22927-22932, 1993.
• NAOMI KITAMURA. Molecular cloning and sequence analysis of the cDNA for a human serine protease responsible for activation of hepatocyte growth factor-Structural similarity of the protease precursor to blood coagulation factor XII, J. Biol. Chem., Vol. 268, pp. 10024-10028, 1993.
• NAOMI KITAMURA. Expression of a human hepatocyte growth factor/scatter factor cDNA in MDCK epithelial cells influences cell morphology, motility and anchorage-independent growth, J. Cell Biology, Vol. 117, pp. 889-894, 1992.
• NAOMI KITAMURA. Functional characterization of human hepatocyte growth factor mutants obtained by deletion of structural domains, Biochemistry, Vol. 31, pp. 9555-9561, 1992.
• NAOMI KITAMURA. Activation of hepatocyte growth factor by proteolytic conversion of a single-chain form to a heterodimer, J. Biol. Chem., Vol. 267, pp. 20114-20119, 1992.
• NAOMI KITAMURA. Structural organization and the transcription initiation site of the human hepatocyte growth factor gene, Biochemistry, Vol. 30, pp. 9170-9176, 1991.

著書

• 喜多村直実, 田中利明. 肝細胞増殖因子によるがん細胞の増殖制御機構, バイオ研究のフロンティア３ー医療・診断をめざす先端バイオテクノロジー、工学図書株式会社, Oct. 2009.

国内会議発表 (査読有り)

• 田中利明, 喜多村直実. ツメガエル初期発生過程における母性CyclinE蛋白質の分解による形態形成の制御, 第30回日本分子生物学会年会・第80回日本生化学会大会合同大会, Dec. 2007.
• 田中利明, 韓俊宏, 原英二, 束田裕一, 喜多村直実. 肝癌細胞株HepG2におけるHGFによる癌抑制遺伝子p16INK4aの発現誘導と細胞増殖抑制機構, 第64回日本癌学会学術総会 ワークショップ, Sept. 2005.
• 田中利明, 韓俊宏, 原英二, 束田裕一, 喜多村直実. 肝癌細胞株HepG2におけるHGFによる癌抑制遺伝子p16INK4aの発現誘導と細胞増殖抑制機構, 第64回日本癌学会学術総会 ワークショップ, Sept. 2005.

国際会議発表 (査読なし・不明)

• Toshiaki Tanaka, Naomi Kitamura. Timed proteolysis of cylcin E regulates posterior body formation in Xenopus., The Toin International Symposium on Biomedical Engineering, Nov. 2007.
• Kazutaka Ushio, Naomi Kitamura, Toshiaki Tanaka. Mechanism of HGF-induced upregulation of p16INK4a in HepG2 hepatoma cells., The Toin International Symposium on Biomedical Engineering, Nov. 2007.

国内会議発表 (査読なし・不明)

• 仁禮綾香, 戸井田英俊, 喜多村直実, 田中利明. ツメガエル初期発生過程における新規Cdkインヒビター Ink4X の形態形成への係わりの解析, 第33回日本分子生物学会年会, Dec. 2010.
• 仁禮綾香, 戸井田英俊, 喜多村直実, 田中利明. ツメガエル初期発生過程における新規Cdkインヒビター Ink4X の解析, 第32回日本分子生物学会年会, Dec. 2009.
• 潮和敬, 喜多村直実, 田中利明. 肝癌細胞株HepG2における肝細胞増殖因子HGFによるp16INK4a発現制御の分子機構, 第30回日本分子生物学会年会・第80回日本生化学会大会 合同大会, Dec. 2007.
• 杉戸寧子, 田中利明, 喜多村直実. 肝細胞増殖因子 (HGF) による肝癌細胞株HpeG2の増殖抑制作用に関わるERK活性の制御機構の解析, 日本分子生物学会2006フォーラム, Dec. 2006.
• 白子絵里香, 平山直樹, 田中利明, 喜多村直実. HGFによる肝癌細胞株HepG2の増殖抑制におけるp21CIP1の役割, 日本分子生物学会2006フォーラム, Dec. 2006.
• Jun-hong Han, Yu-ichi Tsukada, Eiji Hara, 喜多村 直実, 田中 利明. 肝細胞増殖因子HGFによる肝癌細胞株HepG2の増殖停止誘導におけるp16INK4a の役割, 第28回日本分子生物学会年会, Dec. 2005.
• 近藤飛鳥, 平山直樹, 荘野道宏, 田中利明, 喜多村直実. 肝細胞増殖因子HGFによるHepG2細胞の増殖停止におけるHGF受容体c-Met とGrb2 の相互作用の役割, 第78回日本生化学会大会, Oct. 2005.
• Junhong Han, 束田裕一, 喜多村直実, 田中利明. 肝細胞増殖因子（HGF）によるヒト肝癌細胞HepG2におけるp16INK4a発現増加の制御機構, 第77回日本生化学会大会, Oct. 2004.

学位論文

• In vitroでのtRNA生合成に関する研究,  本文,  Doctor of Pharmaceutical Science,  東京大学,  1976/--/--, 

[ BibTeX 形式で保存 ]    [ 論文・著書をCSV形式で保存 ]    [ 特許をCSV形式で保存 ]