@book{CTT100403837, author = {赤池敏宏}, title = {バイオテクノロジー教科書シリーズ12 生体機能材料学-人工臓器・組織工学・再生医療の基礎-}, publisher = {コロナ社}, year = 2005, } @book{CTT100538421, author = {伊勢裕彦 and 中森修子 and 赤池敏宏}, title = {バイオ人工肝臓}, publisher = {現代化学増刊  再生医学・再生医療 東京化学同人}, year = 2002, } @book{CTT100457375, author = {赤池敏宏}, title = {ハイブリッド人工臓器(バイオ人工臓器)設計の基礎}, publisher = {現代医学の基礎 岩波書店}, year = 2001, } @book{CTT100404471, author = {荻原一隆 and 長岡正人 and 赤池敏宏}, title = {ティッシュエンジニアリング2005・材料表面修飾とティッシュエンジニアリング-キメラタンパク質を用いた細胞接着応答の制御}, publisher = {日本医学館}, year = 2005, } @book{CTT100532949, author = {赤池敏宏}, title = {再生医療の基礎シリーズ4 再生医療のためのバイオエンジニアリング}, publisher = {コロナ社}, year = 2007, } @book{CTT100531355, author = {赤池敏宏 後藤光昭}, title = {先端医療シリーズ37「人工臓器・再生医療の最先端」人工肝臓}, publisher = {先端医療技術研究所}, year = 2005, } @book{CTT100386996, author = {赤池敏宏}, title = {特集「細胞の狩人と錬金術からの脱却をめざして」}, publisher = {日本再生医療学会雑誌}, year = 2004, } @book{CTT100386998, author = {丸山厚 and 赤池敏宏}, title = {ナノバイオエンジニアリング 生命と物質の融合をめざして II部ナノバイオで解析する 7章人工核酸シャペロン}, publisher = {化学フロンティア13 杉本直巳編 化学同人}, year = 2004, } @book{CTT100486750, author = {赤池敏宏}, title = {再生医療と人工臓器}, publisher = {「日本産業の推進力『先端技術』」一橋フォーラム}, year = 2003, } @book{CTT100486643, author = {T.Akaike and M.Nagaoka and S-H.Kim}, title = {Synthetically-and Genetically-Engineered Extracellular Matrices for Tissue Engineering.}, publisher = {Advanced in Biomaterials and Drub Delivery Systems,Princeton International Publishing Co.Ltd.}, year = 2002, } @book{CTT100458713, author = {赤池敏宏}, title = {細胞における受容体シンクロナイゼーション}, publisher = {バイオミメテイックスハンドブック 第8節 }, year = 2000, } @book{CTT100446911, author = {赤池敏宏 and 伊勢裕彦}, title = {再生医療、人工臓器開発と幹細胞システム-応用の鍵を握るバイオマテリアル}, publisher = {現代化学}, year = 2000, } @book{CTT100444477, author = {Masayuki Ishihara and Yoshio Saito and Hirohumi Yuta and Katsuaki Ono and Keiichi Ishikawa and Hidemi Hattori and Toshiro Akaike and Akira Kurita}, title = {Heparin-Carrying Polystyrene to Mediate Cellular Attachment and Growth via Interaction with Growth Factors}, publisher = {HCP to Cellular Attachment and Growth}, year = 2000, } @book{CTT100433025, author = {赤池敏宏 and 渡辺恵史 and 伊勢裕彦 and 味岡逸樹}, title = {人工肝臓 再生医学―基礎と治療への応用 西川伸,中村敏一編}, publisher = {日本医学会}, year = 1999, } @book{CTT100433318, author = {赤池敏宏 and 渡辺恵史 and 伊勢裕彦 and 味岡逸樹}, title = {ティッシュ・エンジニアリング 人工肝臓  上田実編}, publisher = {名大出版会}, year = 1999, } @book{CTT100446991, author = {Kazukiyo KOBAYASHI and Akira KOBAYASHI and Toshihiro AKAIKE}, title = {Culturing Hepatocytes on Lactose-Carrying Polystyrene Layer via Asialoglycoprotein Receptor-Mediated Interations}, publisher = {Methods in Enzymology}, year = 1994, } @book{CTT100434219, author = {Kazukiyo Kobayashi and Akira Kobayashi and Seishiro Tobe and Toshihiro Akaike}, title = {Neoglycoconjugates Carbohydrate-Containing Polystyrenes in Neoglycoconjugates-preparation and Applications(分担)}, publisher = {Academic Press}, year = 1994, } @article{CTT100404466, author = {K.Ogiwara and M.Nagaoka and C-S.Cho and T.Akaike}, title = {Constraction of a novel extracellular matrix using a new genetically engineered epidermal growth factor fused to IgG-Fc}, journal = {Biotechnology Letters}, year = 2005, } @article{CTT100404465, author = {E.H.Chowdhury and K.Kutsuzawa and T.Akaike}, title = {Designing smart nano-apatite composites: the emerging era of non-viral gene delivery}, journal = {Gene Therapy and Molecular Biology}, year = 2005, } @article{CTT100404464, author = {E.H.Chowdhury and M.Nagaoka and K.Ogiwara and F.T.Zohra and K.Kutsuzawa and S.Tada and C.Kitamura and T.Akaike}, title = {Integrin-Supported Fast Rate Intracellular Delivery of Plasmid DNA by Extracellular Matrix Protein Embedded Calcium Phosphate Complexes}, journal = {Biochemistry}, year = 2005, } @article{CTT100404461, author = {E.H.Chowdhury and T.Akaike}, title = {Rapid isolation of high quality, multimeric plasmid DNA using zwitterionic detergent}, journal = {J. Biotech.}, year = 2005, } @article{CTT100404460, author = {F.T.Zohra and E.H.Chowdhury and M.Nagaoka and T.Akaike}, title = {Drastic effect of nanoapatite particles on liposome-mediated mRNA delivery to mammalian cells}, journal = {Analytical Biochemistry}, year = 2005, } @article{CTT100404457, author = {E.H.Chowdhury and T.Akaike}, title = {Advances in Fabrication of Calcium Phosphate Nano-composites for Smart Delivery of DNA and RNA to Mammalian Cells}, journal = {Current Analytical Chemistry}, year = 2005, } @article{CTT100404456, author = {M.K.Yoo and H.K.Choi and T.H.Kim and Y.J.Choi and T.Akaike and M.shirakawa and C.S.Cho}, title = {Drug Release from Xyloglucan Beads Coated with Eudragit for Oral Drug Delivery.}, journal = {Arch.Pharm.Res.}, year = 2005, } @article{CTT100404453, author = {Y-I. Jeong and S-J.Seo and I-K.Park and H-C.Lee and I-C.Kang and T.Akaike and C-S.Cho}, title = {Cellular recognition of paclitaxel-loaded polymeric nanoparticles composed of poly(g-benzyl L-glutamate) and poly(ethylene glycol) diblock copolymer endcaped with galactose moiety.}, journal = {Inter.J.Pharmaceutics.}, year = 2005, } @article{CTT100404451, author = {S.E.Cook and I.K.Park and E.M.Kim and H.J.Jeong and T.G.Park and Y.J.Choi and T.Akaike and C.S.Cho}, title = {Galactosylated polyethlenimine-graft-poly(vinyl pyrrolidone) as a hepatocyte-targeting gene carrier}, journal = {J.Control.Release.}, year = 2005, } @article{CTT100404450, author = {T.H.Kim and S.I.Kim and T.Akaike and C.S.Cho}, title = {Synergistic effect of poly(ethylenimine) on the transfection efficiency of galactosylated chitosan/DNA complexes.}, journal = {J.Control.Release.}, year = 2005, } @article{CTT100404449, author = {J.S.Moon and H.M.Jeon and W.Meng and T.Akaike and I.K.Kang}, title = {Morphology and metabolism of hepatocytes microencapsulated with acrylic terpolymer-alginate using gelatin and poly(vinyl alcohol)as extracellular matrices.}, journal = {J.Biomater.Sci.Polymer Edn.}, year = 2005, } @article{CTT100404446, author = {C. Iitaka and K. Miyazaki and T. Akaike and N. Ishida}, title = {A Role for Glycogen Synthase Kinase-3b in the Mammalian Circadian Clock}, journal = {J.Biol. Chem.}, year = 2005, } @article{CTT100404444, author = {J.S.Lee and S.H.Kim and Y.J.Kim and T. Akaike and S.C.Kim}, title = {Hepatocyte Adhesion on a Poly[N-p-vinylbenzyl-4-O-b-D-galactopyranosyl-D-glucoamide]-Coated Poly(L-lactic acid )Surface}, journal = {Biomacromolecules}, year = 2005, } @article{CTT100404443, author = {W. Meng and K.-H.Jung and I-K. and Kang and O. H. Kwon and T. Akaike}, title = {Immobilization of Lactobionic Acid on Polyurethane Films and Their Interaction with Hepatocytes}, journal = {Macromolecular Research}, year = 2005, } @article{CTT100404441, author = {K-H.Park and T.Akaike}, title = {Probing of Specific Binding of Synthetic Sulfonylurea with thte Insulinoma Cell Line MIN6}, journal = {J.Biochem}, year = 2005, } @article{CTT100541858, author = {E.H.Chowdhury and T.Akaike}, title = {A Bio-Recognition Device Developed Onto Nano-Crystals of Carbonate Apatite for Cell-Targeted Gene Delivery}, journal = {Biotechnology and Bioengineering}, year = 2005, } @article{CTT100404433, author = {S-J.Seo and T.Akaike and Y-J. Choi and M. Shirkawa and I-K. Kang and C-S.Cho}, title = {Alginate microcapsules prepared with xyloglucan as a synthetic extracellular matrix for hepatocyte attachment}, journal = {Biomaterials}, year = 2005, } @article{CTT100404432, author = {Yu-ichi Sato and Yuki Kobayashi and Takayuki Kamiya and Hiromitsu Watanabe and Toshihiro Akaike and Kenichi Yoshikawa and Atsushi Maruyama}, title = {The effect of backbone structure on polycation comb-type copolymer/DNA interactions and the molecular assembly of DNA.}, journal = {Biomaterials}, year = 2005, } @article{CTT100404420, author = {A. Higuchi and M. Kuriharaa and K. Kobayashi and C-S. Cho and T. Akaike and M. Hara}, title = {Albumin and urea production by hepatocytes cultured on extracellular matrix proteins-conjugated poly(vinyl alcohol) membranes}, journal = {J. Biomat. Sci., Polym. Edn.,}, year = 2005, } @article{CTT100404418, author = {Kato R. and Maeda T. and Akaike, T. and Tamai I.}, title = {Nucleoside Transport at the Blood-Testis Barrier Studied with Primary-Cultured Sertoli Cells.}, journal = {J. Pharmacol. Exp.Ther.}, year = 2005, } @article{CTT100404023, author = {R.Takei and D.Suzuki and T.Hoshiba and M.Nagaoka and S.J.Seo and C.S.Cho and T. Akaike}, title = {Role of E-cadherin molcules in speroid formation of hepatocytes adhered on galactose-carring polymer as an artificial asialoglycoprotein model}, journal = {Biotechnology Letters}, year = 2005, } @article{CTT100404436, author = {R. Takei and S.J. Seo and C.S. Cho and Y. Okahata and T. Akaike}, title = {Adsorption behaviors of poly(N-p-vinylbenzyl-4-o-b-d-galactopyranosyl-[1→4]-d-gluconamide) by quartz-crystal microbalance}, journal = {Colloids and Surfaces B: Biointerfaces}, year = 2005, } @article{CTT100777822, author = {Nihad Adnan and M. Mie and A. Hague and S. Hossain and Yasumasa Mashimo and Toshihiro Akaike and EIRY KOBATAKE}, title = {Construction of a Defined Biomimetic Matrix for Long-Term Maintenance of Mouse Induced Pluripotent Stem Cells}, journal = {Bioconjugate Chemistry}, year = 2016, } @article{CTT100673922, author = {Kakon Nag and Naznin Sultana and Akira Kato and A Dranik and Nobuhiro Nakamura and Koichi Kutsuzawa and Shigehisa Hirose and Toshihiro Akaike}, title = {Ligand-induced internalization, recycling, and resensitization of adrenomedullin receptors depend not on CLR or RAMP alone but on the receptor complex as a whole}, journal = {Gen Comp Endocrinol}, year = 2015, } @article{CTT100721100, author = {Dragomirka Jovic and Asako Sakaue-Sawano and Takaya Abe and Chong-Su Cho and Masato Nagaoka and Atsushi Miyawaki and Toshihiro Akaike}, title = {Direct observation of cell cycle progression in living mouse embryonic stem cells on an extracellular matrix of E-cadherin}, journal = {SpringerPlus}, year = 2013, } @article{CTT100721109, author = {Dragomirka Jovic and Amranul Haque and Bayar Hexig and Masato Nagaoka and Toshihiro Akaike}, title = {Control of Singular Cell Cycle Synchronization of Mouse ES Cells for Hepatocyte Differentiation on E-Cadherin Substratum}, journal = {Journal of Biotechnology & Biomaterials}, year = 2011, } @article{CTT100531747, author = {H-L.Jiang and Y-K.Kim and R.Arote and J-W. Nah and M-H.Cho and Y-J.Choi and T.Akaike}, title = {Chitosan-graft-polyethylenimine as a gene carrier}, journal = {J.Controlled Release}, year = 2007, } @article{CTT100599860, author = {Sung Won Choi and Akaike T and Maruyama A}, title = {Cationic comb-type copolymers for boosting DNA-fueled nanomachines.}, journal = {Nano Lett.}, year = 2007, } @article{CTT100599859, author = {Md. Ezharul Chowdhury and Toshihiro Akaike}, title = {pH-Sensitive Inorganic Nano-Particles and Their Precise Cell Targetibility: An Efficient Gene Delivery and Expression System.}, journal = {Current Chemical Biology}, year = 2007, } @article{CTT100599858, author = {S-H Kim and 赤池敏宏}, title = {Epidermal growth factor signaling for matrix-dependent cell proliferation and differentiation in primary cultured hepatocyte.}, journal = {Tissue Engineering}, year = 2007, } @article{CTT100560598, author = {Toshihiro Akaike}, title = {Primary hepatocyte survival on non-integrin-recognizable matrices without the activation of Akt signaling.}, journal = {Biomaterials}, year = 2007, } @article{CTT100531746, author = {H-L.Jian and I-K.Park and M-L.Kang and H-S.Yoo and Y-J.Choi and T.Akaike and C-S.Cho}, title = {Immune stimulating activity of an atrophic rhinitis vaccine associated to pegylated chitosan microspheres in vitro}, journal = {Polym. Adv. Technol.}, year = 2007, } @article{CTT100531743, author = {K.Kutsuzawa and E.H.Chowdhury and M.Nagaoka and K.Maruyama and Y.Akiyama and T.Akaike}, title = {Surface functionalization of inorganic nano-crystals with fibronectin and E-cadherin chimera synergistically accelerates trans-gene delivery into embryonic stem cells.}, journal = {Biochem.Biophys.Res.Commun.}, year = 2006, } @article{CTT100560597, author = {Toshihiro Akaike}, title = {Alginate/Galactosylated Chitosan]Heparin Scaffold As a New Synthetic Extracellular Matrix for Hepatocytes.}, journal = {Tissue Engineering}, year = 2006, } @article{CTT100531728, author = {T.Hoshiba and C-S.Cho and A.Murakawa and Y.Okahata and T.Akaike}, title = {The effect of natural extracellular matrix deposited on synthetic polymers on cultured primary hepatocytes.}, journal = {Biomaterials}, year = 2006, } @article{CTT100531727, author = {K. Ogiwara and M. Nagaoka and C-S. Cho and T. Akaike}, title = { Effect of photo-immobilization of epidermal growth factor on the cellular behaviors.}, journal = {Biochem. Biophys. Res. Commun.,}, year = 2006, } @article{CTT100531724, author = {H.Zhang and M.Iwama and T.Akaike and D.W.Urry and A.Pattanaik and T.M.Parker and I.Konishi and T.Nikaido}, title = {Human amiotic cell sheet harvest uing a novel temperature-responsive culture surface coated with protein-based polymer.}, journal = {Tissue Engineering}, year = 2006, } @article{CTT100531723, author = {S.J.Seo and H.S. Moon and D.D. Guo and S.H.Kim and T.Akaike and C.S.Cho}, title = { Receptor-mediated delivery of all-trans-retinoic acid (ATRA) to hepatocytes from ATRM-loaded poly(N-p-vinylbenzyl-4-o-b-D-garactopyranosyl-D-gluconamide)nanoparticles}, journal = {Materials Science and Engineerig}, year = 2006, } @article{CTT100531658, author = {S.J.Seo and I.Y.Kim and S.H.Kim and Y.J.Choi and T.Akaike and C.S.Cho}, title = {Enhanced liver functions of Hepatocytes cocultured with NIH3T3 in the alignate/garactosylated chitosan scaffold}, journal = {Biomaterials}, year = 2006, } @article{CTT100531657, author = {C.S.Cho and S.J.Seo and I.K.Park and S.H.Kim and T.H.Kim and T.Hoshiba and I.Harada and T.Akaike}, title = {Galactose-carrying polymers as extracelllular matrices for liver tissue engineering}, journal = {Biomaterials}, year = 2006, } @article{CTT100531749, author = {M.Nagaoka and U.Koshimizu and S.Yuasa and F.Hattori and H.Chen and T.Tanaka and M.Okabe and K.Fukuda and T.Akaike.}, title = {E-cadherin-coated plates maintain pluripotent ES cells without colony formation}, journal = {PLoS ONE}, year = 2006, } @article{CTT100531730, author = {E.H.Chowdhury and A.Maruyama. A.Kano and M. Nagaoka and S.Hirose and M. Kunou and T. Akaike}, title = {pH-sensing nano-crystals of cabonate apatite: Effects on intracellular delivery and release of DNA for efficient expression into mammalian cells.}, journal = {Gene}, year = 2006, } @article{CTT100531748, author = {T.H.Kim and H-L.Jiang and I-Y.Park and Y-K.Kim and M.H.Cho and J.W.Nah and T.Akaike and C-S.Cho}, title = {Chemical Modifications of Chitosan as Gene Carriers}, journal = {Biomaterials Research}, year = 2006, } @article{CTT100531745, author = {K. Yamana and Y. Fukunaga and Y. Ohtania and S. Sato and M. Nakamura and W. J. Kim and T. Akaike and A. Maruyama}, title = {DNA mismatch detection using a pyrene–excimer-forming probe.}, journal = {Chem. Commun.}, year = 2005, } @article{CTT100383750, author = {I.K.Park and H.L.Jiang and C.H.Yun and Y.J.Choi and S.J.Kim and T.Akaike and S.I.Kim and C.S.Cho}, title = {Release of Newcastle Disease Virus Vaccine from Chitosan Microspheres In vitro and In vivo}, journal = {Asian-Aust. J. Anim. Sci.}, year = 2004, } @article{CTT100383754, author = {Chowdhury EH and Megumi K and Harada I and Kundu AK and Akaike T.}, title = {Dramatic effect of Mg(2+) on transfecting mammalian cells by DNA/calcium phosphate precipitates.}, journal = {Anal Biochem.}, year = 2004, } @article{CTT100383757, author = {S. W. Choi and Y. Sato and T. Akaike and A. Maruyama}, title = {Preparation of Cationic Comb-Type Copolymer Having Guanidino Moieties and its Interaction with DNAs}, journal = {J. Biomater. Sci. polymer Edn.}, year = 2004, } @article{CTT100383759, author = {K.H.Park and T.Akaike}, title = {Visualization of theSpecific Interaction of Sulfonylurea-Incorporated Polymer with Insulinoma Cell Line MIN6 }, journal = {J. Biochem.}, year = 2004, } @article{CTT100386971, author = {S.Takashima and H. Ise and P. Zhao and T. Akaike and T. Nikaido}, title = {Human Amniotic Epithelial Cells Possess Hepatocyte-like Characteristics and Functions}, journal = {Cell Structure and Function }, year = 2004, } @article{CTT100386973, author = {H-L. Jiang and I-K.Park and N-R.Shin and S-G.Kang and H-S.Yoo and S-I.Kim and S-B.Suh and T.Akaike and C-S.Cho}, title = {In vitro study of the immune stimulating activity of an athrophic rhinitis vaccine associated to chitosan microspheres}, journal = {European J. of Pharmaceutics and Biopharmaceutics }, year = 2004, } @article{CTT100386974, author = {Sung Won Choi and Yuichi Sato and Toshihiro Akaike and Atsushi Maruyama}, title = {Evaluation of comb-type copolymers with different cationic groups as artificial nucleic acid chaperones}, journal = {Nucleic acids symposium series }, year = 2004, } @article{CTT100386975, author = {Kazuya Hirata and Yuichi Sato and Kano Arihiro and Toshihiro Akaike and Atsushi Maruyama}, title = {Nucleation-synchronized strand displacement for highly sensitive DNA analysis}, journal = {Nucleic Acids Res. Suppl.}, year = 2004, } @article{CTT100386986, author = {Y.Takei and A.Maruyama and T.Akaike and et al}, title = {Targeted gene delivery to sinusoidal endothelial cells: DNA nanoassociate bearing hyaluronan-glycocalyx}, journal = {FASEB J.}, year = 2004, } @article{CTT100386987, author = {E.H.Chowdury and F.T.Zohra and S.Tada and C.Kitamura and T.Akaike}, title = {Fibronectin in collaboration with Mg2+ enhances transgene expression by calcioum phosphate coprecipitates}, journal = {Anal. Biochem.}, year = 2004, } @article{CTT100386992, author = {Jiang HL and Park IK and Shin NR and Yoo HS and Akaike T and Cho CS.}, title = {Controlled release of Bordetella bronchiseptica dermonecrotoxin (BBD) vaccine from BBD-loaded chitosan microspheres in vitro.}, journal = {Arch Pharm Res. 20}, year = 2004, } @article{CTT100386994, author = {S.J.Seo and I-K. Park and M-K. Yoo and M. Shirakawa and T.Akaike and C.S.Cho}, title = {Xyloglucan as a synthetic extracellular matrix for hepatocyte attachment}, journal = {J. Biomater. Sci. Polymer Edn.}, year = 2004, } @article{CTT100386995, author = {T-W. Chung and K-Y. Cho and H-C. Lee and J-W. Nah and J-H. Yeo and T. Akaike and C-S. Cho}, title = {Novel micelle-forming block copolymer composed of poly (e-caprolactone) and poly (vinyl pyrroridone)}, journal = {Polymer }, year = 2004, } @article{CTT100386997, author = {原田伊知郎 and 長岡正人 and 金相憲 and 笹川忠 and 赤池敏宏}, title = {再生医療今後の課題と生命理工学との交流}, journal = {学会新報 }, year = 2004, } @article{CTT100386999, author = {望月慎一 and 狩野有宏 and 赤池敏宏 and 丸山厚}, title = {バイオナノマテリアルとしての多糖コンジュゲート}, journal = {高分子論文集}, year = 2004, } @article{CTT100388504, author = {I-K. Park and H-L. Jiang and S-E. Cook and M-H. Cho and S-I. Kim and H-J. Jeong and T.Akaike and C-S.Cho}, title = {Galactosylated chitosan(GC)-graft-poly(vinyl pyrrolidone)(PVP) as hepatocyte-targeting DNA carrier: in vitro transfection}, journal = {Arch. Pharm. Res.}, year = 2004, } @article{CTT100388505, author = {S-J.Seo and T.Akaike and Y.J. Choi and M. Shirkawa and I-K. Kang and C-S.Cho}, title = {Alginate microcapsules prepared with xyloglucan as a synthetic extracellular matrix for hepatocyte attachment}, journal = {Biomaterials}, year = 2004, } @article{CTT100540056, author = {H. Ise and T. Nikaido and N. Negishi and N. Sugihara and F. Suzuki and T. Akaike and U. Ikeda}, title = {Effective Hepatocyte Transplantation Using Rat Hepatocytes with Low Asialoglycoprotein Receptor Expression.}, journal = {Am. J. Pathol.}, year = 2004, } @article{CTT100383760, author = {E.H. Chowdhury and M. Kunou and M. Nagaoka and A.K. Kundu and T. Hoshiba and T.Akaike}, title = {High-efficiency gene delivery for expression in mammalian cells by nanoprecipitates of Ca-Mg phosphate}, journal = {Gene}, year = 2004, } @article{CTT100386539, author = {S-H.Kim and T.Hoshiba and T.Akaike}, title = {Hepatocyte behavior on synthetic glycopolymer matrix: inhibitory effect of receptor-ligand binding on hepatocyte spreading}, journal = {Biomaterials}, year = 2004, } @article{CTT100404012, author = {S.J.Seo and S.H.Kim and T.Sasagawa and Y.J.Choi and T.Akaike and C.S.Cho}, title = {Delivery of all trans-retinoic acid (RA) to hepatocyte cell line from RA/galactosyl α-cyclodextrin i nclusion complex}, journal = {European J. of Pharmaceutics and Biopharmaceutics}, year = 2004, } @article{CTT100487160, author = {S-H.Kim and T.Hoshiba and T.Akaike}, title = {Effect of carbohydrates attached to polystyrene on hepatocyte morphology on sugar-derivated polystyrene matrices.}, journal = {J.Biomaterial Mater.Res. }, year = 2003, } @article{CTT100490663, author = {I-K. Park and T-H. Kim and S-I. Kim and T.Akaike and C-S.Cho}, title = {Chemical Modification of Chitosan for Gene Delivery}, journal = {J.of Disp. Sci. a nd Tech.}, year = 2003, } @article{CTT100487161, author = {赤池敏宏}, title = {基盤的再生医療研究としての生命理工学の発展をめざして}, journal = {再生医療}, year = 2003, } @article{CTT100487159, author = {H.Nonaka and H.Ise and N.Suhihara and S.Hirose and N.Negishi and Y.Kondo and T.Akaike}, title = {Development of Highly Functional Long-Term Culture Method of Liver Slice Embeded in Agarose Gel for Bioartificial Liver}, journal = {Cell Transplantation}, year = 2003, } @article{CTT100487158, author = {S.Shimojo and C-S.Cho and I-K.Park and M.Kunou and M.Goto and T.Akaike}, title = {Helical Structure of Sugar-carrying Polystyrene in Aqueous Solution by Circular Dichroism}, journal = {Carbohydrate Research }, year = 2003, } @article{CTT100486755, author = {S-H.Kim and J-H.Kim and T.Akaike}, title = {Regulation of cell adhesion signaling by synthetic glycopolymer matrix in primary cultured hepatocyte}, journal = {FEBS Letters}, year = 2003, } @article{CTT100486754, author = {I-K.Park and S-J.Seo and M.Akashi and T.Akaike and C-S.Cho}, title = {Controlled Release of Epidermal Growth Factor (EGF) from EGF-loaded Polymeric Nanoparticles Composed of Polystyrene as Core and Poly(methacrylic acid) as Corona in vitro}, journal = {Arch Pharm Res }, year = 2003, } @article{CTT100486753, author = {I-K. Park and D-W. Kang and T.Akaike and M-Y.Chang and C-S.Cho}, title = {Contact Angle of Water on langmuir-Blodgett Films of Poly(g-benzyl L-glutamate)/Poly(ethylene glycol)/poly(g-benzyl L-glutamate) Block Copolymer}, journal = {Biomaterials Research}, year = 2003, } @article{CTT100486752, author = {I-K.Kang and D.W.Lee and S.K.Lee and T.Akaike}, title = {Grafting of lactose-carrying styrene onto polystrene dishes using plasma glow discharge and their interaction with hepatocytes}, journal = {J.Materials Science: Materials in Medicine }, year = 2003, } @article{CTT100486751, author = {石原義久 後藤光昭 赤池敏宏}, title = {バイオハイブリッド型人工肝臓:肝組織の再構築化とバイオハイブリッド型人工肝臓}, journal = {最新医学6月増刊号 ”現代医療の最前線ー人工臓器とメディカル・エンジニアリングの進歩ー”}, year = 2003, } @article{CTT100486749, author = {K.Ishida and H.Nagahara and T.Kogiso and T.Aso and N.Hayashi and T.Akaike}, title = {Cell adhesion aside from integrin system can abrogate anoikis in rat liver cells by down-regulation of FasL expression, not by activation of PI-3K/Akt and ERK signaling pathway}, journal = {Biochem.Biophys.Res.Commun.}, year = 2003, } @article{CTT100486748, author = {赤池敏宏}, title = {バイオマテリアルから再生医療への期待}, journal = {未来材料}, year = 2003, } @article{CTT100486747, author = {A. Higuchi and Y. Takanashi and N. Tsuzuki and T.Asakura and C-S. Cho and T.Akaike and M.Hara}, title = {Production of interferon-b by fibroblast cells on membranes prepared with RGD-containing peptide}, journal = {J. Biomed. Mater.Res. }, year = 2003, } @article{CTT100486746, author = {笹川忠 and 伊勢裕彦 and 赤池敏宏}, title = {特集 バイオマテリアルと再生医療 肝再生 肝細胞の増殖・分化・組織化を目指して}, journal = {バイオマテリアルー生体材料}, year = 2003, } @article{CTT100486726, author = {I-K.Park and J.Yang and H-J.Jeong and H-S.Bom and I.Harada and T.Akaike and S-I.Kim and C-S.Cho}, title = {Galactosylated chiotosan as a synthetic extracellular matrix for hepatocytes attachment}, journal = {Biomaterials}, year = 2003, } @article{CTT100486725, author = {I-K.Park and T-H.Kim. S-I.Kim and Y-H.Park and W-J.Kim and T.akaike and C-S.Cho}, title = {Visualization of transfectionof hepatocytes by galactosylated chitosan-graft-poly(ethylene glycol)/DNA complexes by confocal laser scanning microscopy}, journal = {Internaional Journal of Pharmaceutics}, year = 2003, } @article{CTT100486724, author = {M.Nagaoka and T.Akaike}, title = {Single amino acid substitution in the mouse IgG1 Fc region induces drastic enhancement of the affinity to protein A}, journal = {Protein Engineering}, year = 2003, } @article{CTT100486723, author = {Y.Watanabe and O.Suzuki and T.Haruyama and T.Akaike}, title = {Interferon-γ Induces Reactive Oxygen Species and Endoplasmic Reticulum Stress at the Hepatic Apoptosis}, journal = {J.Cell.Biochem.}, year = 2003, } @article{CTT100486722, author = {Y.Watanabe and T.Haruyama and T.Akaike}, title = {Liver-Derived Matrix Metalloproteinase-9(Gelatinase B) Recruits Progenitor Cells from Bone Marrow into the Blood Circulation}, journal = {Biol.Pharm.Bull.}, year = 2003, } @article{CTT100486721, author = {赤池敏宏 and 長岡正人}, title = {再生・発生医工学ー新しい細胞マトリックス工学への期待ー}, journal = {化学装置}, year = 2003, } @article{CTT100486720, author = {E.H.Chowdhury and T.Sasagawa and M.Nagaoka and A.K.Kundu and T.Akaike}, title = {Transfecting mammalian cells by DNA/calcium phosphate precipitates:Effect of temperature and pH on precipitation}, journal = {Analytical Biochemistry}, year = 2003, } @article{CTT100486719, author = {H-Y.Kweon and M-K.Yoo and In-Kyu Park and T-H.Kim and H-C.Lee and H-S.Lee and J-S.Oh and T.Akaike and C-S.Cho}, title = {A novel degradable polycaprolactone networks for tissue engineering}, journal = {Biomaterials}, year = 2003, } @article{CTT100486718, author = {伊勢裕彦 and 高島誠司 and 趙鵬 and 赤池敏宏 and 二階堂敏雄}, title = {肝前駆様細胞の探索と単離-生体肝臓と胎盤付着物である羊膜組織中の肝前駆細胞を中心に-}, journal = {肝胆膵}, year = 2003, } @article{CTT100486717, author = {C.S. Cho and I.K.Park and J.W.Nah and T.Akaike}, title = {Preparation of Polymeric Self-assembly and Its Application to Biomaterial}, journal = {Macromolecular Reseach,}, year = 2003, } @article{CTT100486646, author = {I.K.Park and J.E.Ihm and Y.H.Park and Y.J.Choi and S.I.Kim and W.J.Kim and T.Akaike and C.S.Cho}, title = {Galactosylated chitosan (GC)-graft-poly(vinyl pyrrolidone) (PVP) as hepatocyte-targeting DNA carrier Preparetion physicochemical charactarization of GC-graft-PVP/DNA complex(1)}, journal = {J. Control. Release}, year = 2003, } @article{CTT100490665, author = {A.K.Kundu and M.Nagaoa and E.H.Chowdhury and S.Hirose and T.Sasagawa and T.Akaike}, title = {IGF-Indeuces Growth, Survival and Morphological Change of Primary Hepatocytes on a Galactose-bared Polymer through both MAPK and b-catenin Pathways}, journal = {Cell Structure and Function}, year = 2003, } @article{CTT100456506, author = {J.Yang and M.Goto and H.Ise and C-S.Cho and T.Akaike}, title = {Galactosylated Alginate as a Scaffold for Hepatocytes Entrapment}, journal = {Biomaterials}, year = 2002, } @article{CTT100496148, author = {R. Nishio and T. Akaike and M. Ikekita and K.Ishibashi and M. Obinata and Y.Watanebe}, title = {Establishment of different types of immortalized liver containing cell lines from temperature-sensitive SV40 large.}, journal = {Research Communications in Biochemistry, Cell & Molecular Biology, }, year = 2002, } @article{CTT100471009, author = {M.Nagaoka and H.Ise and T.Akaike}, title = {Immobilized E-cadherin Model Can Enhance the Cell Attachment and Differentiation of Primary Hepatocytes but not Proliferation.}, journal = {Biotech.Lett.}, year = 2002, } @article{CTT100479762, author = {T-W.Chung and J.Yang and T.Akaike and K-Y.Cho and J-W.Nah and S-I.Kim and C-S.Cho}, title = {Preparation of alginate/galactosylated chitosan scaffold for hepatocyte attachment}, journal = {biomaterials}, year = 2002, } @article{CTT100479785, author = {赤池敏宏 後藤光昭}, title = {肝再生医療の現状と将来展開}, journal = {再生医療}, year = 2002, } @article{CTT100486633, author = {伊勢裕彦 and 赤池敏宏}, title = {再生医療のための細胞分離と工学装置}, journal = {医科器械学}, year = 2002, } @article{CTT100479786, author = {G. Khan and H. B. Lee 訳:赤池敏宏 and 入山俊介}, title = {韓国における再生医療研究の近況}, journal = {再生医療}, year = 2002, } @article{CTT100467976, author = {I.Ajioka and T.Akaike and Y.Watanabe}, title = {Ethanolamine is a co-mitogenic factor for proliferation of primary hepatocytes.}, journal = {J.Cell.Biochem.}, year = 2002, } @article{CTT100486631, author = {K-H.Park and K.Na and T.Akaike}, title = {Probe of specific interaction between a dsimplified synthetic glycopolymer and erythrocytes as mediated by a glucose transporter (GLUT) on a cell membrane}, journal = {J. of Biomedical Materials Research}, year = 2002, } @article{CTT100486644, author = {A.Higuchi and T.Takanashi and T.Ohno and T.Asakura and C-S.Cho and T.Akaike and M.Hara}, title = {Pruduction of interferon-βby fibroblast cells on membranes prepared by extracellular matrix proteins.}, journal = {Cytotechnology}, year = 2002, } @article{CTT100470902, author = {N.Sugihara and H.Ise and N.Negishi and T.Nikaido and T. Akaike}, title = {Drug metabolic activity of cultured hepatocytes can synchronize with bile acid concentration in the medium}, journal = {Cell Biochem.Funct.}, year = 2002, } @article{CTT100470969, author = {渡辺恵史 and 赤池敏宏}, title = {再生医学へのアプローチ:第2の肝臓を作る}, journal = {ファルマシア 社団法人日本薬学会}, year = 2002, } @article{CTT100470973, author = {K-H.Park and S.C.Song and T.Akaike}, title = {Determination of specific Interaction between Sulfonylurea-Incorporated Polymer and rat Islet}, journal = {J. Biochem.}, year = 2002, } @article{CTT100470975, author = {M.Mikawa and T.Yokawa and N.Miwa and M.Brautigam and T.Akaike and A.Maruyama}, title = {An Intelligent MRI Contrst Agent for Tumor Sensing}, journal = {Acad. Radial.}, year = 2002, } @article{CTT100470979, author = {S.Shimojo and T.Akaike and M.Harra and A.Higuchi and I-K.Park and C-S.Cho}, title = {Difference in the attachment of hepatocytes between a poly(g-benzyl L-glutamate) (PBLG)/poly(N-isopropylacrylamide)(PNIPAAm)diblock copolymer cast surface and a PBLG/PNIPAAm Langmuir-Blodgett one}, journal = {J.Biomater.Sci.Polymer Edn}, year = 2002, } @article{CTT100470987, author = {伊勢裕彦 and 赤池敏宏}, title = {再生医療のための細胞分離と工学装置}, journal = {医科器械学 }, year = 2002, } @article{CTT100470991, author = {杉原伸宏 and 根岸直樹 and 赤池敏宏}, title = {臓器別の現状と工学技術の必要性ー肝臓の再生医療に必要な工学的視点ー}, journal = {医科器械学}, year = 2002, } @article{CTT100470995, author = {T. W. Chung and K.Y. Cho and J.W. Nah and T. Akaike and C.S. Cho}, title = {Chiral Recognition of Bilirubin by Polymeric Nanoparticles}, journal = {Langmuir}, year = 2002, } @article{CTT100470999, author = {S-G. Kim and T.Akaike and T.Sasagawa and Y.Atomi and H.Kurosawa}, title = {Gene Expression of Type I and Type III Collagen by Mechanical Stretch in Anterior Cruciate Ligament Cells}, journal = {Cell Structure and Function}, year = 2002, } @article{CTT100471003, author = {赤池 敏宏}, title = {再生医療の発展のためには理工学との連携が必要不可欠である  }, journal = {炎症・再生}, year = 2002, } @article{CTT100546809, author = {W.J.Kim and T.Akeike and A.Maruyama}, title = {DNA Strand Exchange Stimulated by Spontaneous Complex Formation with Cationic Comb-Type Copolymer}, journal = {J.AM.CHEM.SOC.}, year = 2002, } @article{CTT100471007, author = {J.H.Kim and S.H.Kim and H.K.Kim and T.Akaike and S.C.Kim}, title = {Adhesion and Growth of Endothelial Cell on Amphiphilic PU/PS IPN Surface: Effect of Amphiphilic Balance and Immobilized Collagen}, journal = {J.Biomed.Mater.Res.}, year = 2002, } @article{CTT100455812, author = {I.Ajioka and T.Akaike and Y.Watanabe}, title = {Ethanolamine is a Co-Mitogenic Factor for Proliferation of Primary Hepatocytes.}, journal = {J.Cell.Bioche., in press}, year = 2001, } @article{CTT100455811, author = {Y.Watanabe and k.Hirakawa and T.Haruyama and T.Akaike}, title = {Direct Production of an Activatedmatrix Metalloproteinase-9 (gelatinase B) from Mammalian Cells.}, journal = {FEBS Lett.}, year = 2001, } @article{CTT100455806, author = {渡辺恵史 and 渋谷功 and 赤池敏宏}, title = {DDSによる肝疾患治療}, journal = {Drug Delivery System}, year = 2001, } @article{CTT100455805, author = {I.Ajioka and R.Nishio and T.Akaike and M.Sasaki and J.Enami and Y.Watanabe}, title = {Establishment of Heterotropic Liver Tissue Mass with Direct Link to the Host Liver Following Implantation of Hepatocytes Transfected with Vascular Endothelial Growth Factor Gene in Mice.}, journal = {Tissue Engineering}, year = 2001, } @article{CTT100455804, author = {M.Goto and K.Kobayashi and A.Hachikawa and K.Saito and C-S.Cho and T.Akaike}, title = {Micellar Behavior of Sugar-Carrying Polystyrene in Aqueous Solution}, journal = {Macromol. Chem. Phys.}, year = 2001, } @article{CTT100455800, author = {S-H.Kim and M.Goto and C-S.Cho and T.Akaike}, title = {Specific Binding of Glucose-derivatized Polymers to the Asialoglycoprotein Receptor Mouse Primary Hepatocytes}, journal = {J. Biol. Chem.}, year = 2001, } @article{CTT100456903, author = {H.Ise and A.Ferdous and N.Sugihara and T.Nikaido N.Negishi and T.Akaike}, title = {Separation of mouse hepatocytes of distinct biological phenotypes on their asialogycoprotein receptor-mediated binding affinity to an artificial ligand}, journal = {J.Artif.Organs}, year = 2001, } @article{CTT100462588, author = {C-S.Cho and K-Y.Cho and I-K.Park and S-H.Kim and T.Sasagawa and M.Uchiyama and T.Akaike}, title = {Receptor-mediated delivery of all trans-retinoic acid to hepatocyte using poly(L-lactic acid) nanoparticles coated with galactose-carrying polystyrene.}, journal = {J.Cont. Rel.}, year = 2001, } @article{CTT100455799, author = {根岸直樹 and 赤池敏宏}, title = {代用臓器の開発・臨床応用と血栓形成の制御 d人工肝臓(特集 代用臓器と血栓)}, journal = {血栓と循環(Thrombosis and Circulation)}, year = 2001, } @article{CTT100462576, author = {根岸直樹 and 赤池敏宏}, title = {特集 代用臓器と血栓 3.代用臓器の開発・臨床応用と血栓形成の制御 d 人工肝臓}, journal = {血栓と循環 (株)メディカル レビュー社}, year = 2001, } @article{CTT100462575, author = {C-S.Cho and T-W.Chung and T.Akaike}, title = {Self-Assembled Polymeric Nanoparticles.}, journal = {Macromol. Chem. Symp.}, year = 2001, } @article{CTT100455798, author = {W.J.Kim and T.Ishihara and T.Akaike and A.Maruyama}, title = {Comb-Type Cationic Copolymer Expedites DNA Strand Exchange while Stabilizing DNA Duplex}, journal = {Chem.Eur.}, year = 2001, } @article{CTT100455788, author = {M.Nogawa and T.Ishihara and T.Akaike and A.Maruyama}, title = {Polyethylenimine/Arabinogalactan Conjugate as a Hepatocyte Specific Gene Carrier}, journal = {S.T.P.Pharma Sciences}, year = 2001, } @article{CTT100455781, author = {杉原伸宏 and 赤池敏宏}, title = {再生医工学としての細胞マトリックス工学}, journal = {Biotherapy}, year = 2001, } @article{CTT100455780, author = {赤池敏宏}, title = {高分子のここが面白いー細胞を認識し機能制御する高分子の魅力}, journal = {高分子 }, year = 2001, } @article{CTT100455779, author = {杉原伸宏 and 長岡正人 and 赤池敏宏}, title = {細胞機能制御を目指すマトリックス工学}, journal = {化学フロンテイア3 再生医療工学 2部 再生医療のための基礎工学技術 化学同人}, year = 2001, } @article{CTT100444476, author = {C-S.Cho and A.Kobayashi and R.Takei and T.Ishihara and A.Maruyama and T.Akaike}, title = {Receptor-Mediated Cell Modulator Delivery to Hepatocyte Using Nanoparticles Coated with Carbohydrate-Carrying Polymers}, journal = {Biomaterials}, year = 2001, } @article{CTT100455775, author = {赤池敏宏 and 根岸直樹}, title = {生命科学と材料科学との融合 新しい治療法の開発をめざして}, journal = {実験医学}, year = 2001, } @article{CTT100486603, author = {T.Sato and A.Kotake and M.Miura and T.Aota and Y.Ishikawa and M.Sato and K.Imai and N.Kojima and C.Mukai-Tateno and T.Akaike and R.Hata and K.Yoshizato and H.Senoo}, title = {Enhancement of Glucose utilization in isolated-liver cells by the rotary culture system}, journal = {Molecular Biology of The Cell}, year = 2001, } @article{CTT100462574, author = {S.Suzuki and A-J.Li and A.Ishisaki and X.Hou and M.Hasegawa and M.Fukumura and T.Akaike and T.Imamura}, title = {Feeding Suppression by Fibroblast Growth Factor-1 is Accompanied by Selective Induction of Heat Shock Protein 27 in Hypothalamic Astrocytes}, journal = {European J. Neurosci. }, year = 2001, } @article{CTT100470502, author = {赤池敏宏 and 根岸直樹}, title = {生命科学と材料科学との融合 新しい治療法を開発をめざして}, journal = {実験医学}, year = 2001, } @article{CTT100470499, author = {C-S.Cho and A.Kobayashi and R.Takei and T.Ishihara and A.Maruyama and T.Akaike}, title = {Receptor-mediated cell modulator delivery to hepatocyte using nanoparticles coated with carbohydrate-carrying polymers}, journal = {Biomaterials}, year = 2001, } @article{CTT100457273, author = {伊勢裕彦 and 高島誠司 and 赤池敏宏}, title = {人工肝臓研究ー最近の進歩・各装置の工夫 4.肝細胞スフェロイドと人工肝臓}, journal = {臨床雑誌「外科」 南江堂}, year = 2001, } @article{CTT100461221, author = {K.Na and H-K.Choi and T.Akaike and K-H.Park}, title = {Conjugation of Arg-Gly-Asp (RGD) Sequence in Copolymer Bearing Sugar Moiety for Insulinoma Cell Line (MIN6) Culture}, journal = {Biosci. Biotechnol. Biochem.}, year = 2001, } @article{CTT100461210, author = {K-H. Park and M.Goto and J.Miyazaki and C-S.Cho and T.Akaike}, title = {Incorporation of Sulfonylrea into Sugar-Carrying Polymers and Their Effects on Insulin Secretion from MIN6 Cells in a Solution State}, journal = {J.Biomater.Sci.}, year = 2001, } @article{CTT100462604, author = {S.Suzuki and A-J. Li and T.Akaike and T.Imamura}, title = {Intracerebroventricular Infusion of Fibroblast Growth Factor-1 Increases Fos Immuoreactivity in Periventricular Astrocytes in Rat Hypothalamus.}, journal = {Neuroscience Letters}, year = 2001, } @article{CTT100459694, author = {S.Hirose and H.Ise and M.Uchiyama and C-S.Cho and T.Akaike}, title = {Regulation of Asialoglycoprotein Receptor Expression in the Proliferative States of Hepatocytes}, journal = {Biochem. Biophys. Res. Commun.}, year = 2001, } @article{CTT100457274, author = {T.Uchida and T.Serizawa and H.Ise and T.Akaike and M.Akashi}, title = {Graft Copolymer Having Hydrophobic Backbone and Hydrophilic Branches.34.Interaction of Hepatocytes and Polystyrene Nanospheres Having Lactose-Immobilized Hydrophilic Polymers on Their Surfaces}, journal = {Biomacromolecules}, year = 2001, } @article{CTT100459568, author = {M.Goto and Y.Makino and K.Kobayashi and C-S.Cho and T.Akaike}, title = {Hepatocyte Attachment onto Thermosensitive Poly(N-isopropylacrylamide-co-N-p-vinylbenzyl-O-β-D-galactopyranosyl-(1→4)-D-gluconamide)}, journal = {J.Biomater.Sci.Polymer Edn.}, year = 2001, } @article{CTT100456902, author = {N.Sugihara and H.ise and N.Negishi and T.Nikaido and T.Akaike}, title = {Drug Metabolic Activity of Cultured Hepatocytes can Synchronize with Bile Acid Concentration in the Medium}, journal = {Cell Biochemistry and Function}, year = 2001, } @article{CTT100456898, author = {K.Na and H-K.Choi and D-W and Kim and T.Akaike and K.H.Park}, title = {Incorporation of Sulfonylurea into N-Isopropylacrylamide as an Extracellular Matrix for an Artificial Pancreas}, journal = {Biosci. Biotechnol. Biochem.}, year = 2001, } @article{CTT100456886, author = {J.Yang and T.W.Chung and M.Nagaoka and M.Goto and C-S.Cho and T.Akaike}, title = {Hepatocyte-Specific Porous Polymer-Scaffolds of Alginate/Galactosylated Chitosan Sponge for Liver-Tissue Engineering}, journal = {Biotech. Letters}, year = 2001, } @article{CTT100462599, author = {I-K.Park and T-H.Kim and Y-H.Park and B-A.Shin and E-S.Choi and E-H.Chowdhury and T.Akaike and C-S.Cho}, title = {Galactosylated chitosan-graft-poly(ethylene glycol) as hepatocyte-targeting DNA carrier.}, journal = {J.Control Release.}, year = 2001, } @article{CTT100456493, author = {H.Ise and N.Sugihara and N.Negishi and T.Nikaido and T.Akaike}, title = {Low Asialoglycoprotein Receptor Expression as Markers for Highly Proliferative Potential Hepatocytes}, journal = {Biochem. Biophys. Res. Commun.}, year = 2001, } @article{CTT100455828, author = {朝山章一郎 and 赤池敏宏 and 丸山厚}, title = {エンドソーム内pHに応答するDNAに応答するキャリヤーとしての異種塩基性セグメントを持つポリカチオングラフト共重合体}, journal = {高分子加工}, year = 2001, } @article{CTT100455827, author = {T.Takei and A.Maruyama and T.Akaike and S.Sato}, title = {Site-specific Gene Transfer with Polylysinecomb-type Copolymers, in Non-viral Vectors for Gene Therapy}, journal = {Methods in Molecular Medicine, M.A.Findeis,Ed., Humana Press Inc.}, year = 2001, } @article{CTT100455817, author = {A.Maruyama and M.Ueda and W.J.Kim and T.Akaike}, title = {Design of Polymer Materials Enhancing Nucleotide Hybridization for Anti-gene Technology}, journal = {Advance in Drug Delivery Systems, in press}, year = 2001, } @article{CTT100455816, author = {H.Torigoe and T.Akaike and A.Maruyama}, title = {Synergistic Stabilization of Triplex by Combination of Comb-type Cationic Copolymer and Oligo-N3'->P5' Phospharamidat}, journal = {Nucleic. Acids. Sym. Ser. in press}, year = 2001, } @article{CTT100455815, author = {W.J.Kim and T.Akaike and A.Maruyama}, title = {Polycation Graft Copolymers Accelerating DNA Strand Exchange: Involvement of Ionic Interaction}, journal = {Nucleic Acids Sym. Ser. in press}, year = 2001, } @article{CTT100455814, author = {K.Obara and T.Ishihara and T.Akaike and A.Maruyama}, title = {Protein/Oligonucleotide Conjugates as a Cell Specific PNA Carrier}, journal = {Nucleic Acids Sym. Ser., in press}, year = 2001, } @article{CTT100455813, author = {S.Asayama and T.Akaike and A.Maruyama}, title = {Bi-Phaseic Polycation for the DNA Carrier Responding to Endosomal pH}, journal = {Colloids Surf. B.}, year = 2001, } @article{CTT100446891, author = {Taek Woong Chung and Beom Jun Kim and Soo Youg Park and Toshihiro Akaike and Jae Woon Nah and Chong Su Cho}, title = {Induced Circular Dichroism of Disperse Red Dye in the Self-Assembled Nanoparticles Composed of Poly(γ-benzyl L-gulutamate )and Poly(N-Isopropylacrylamide) and Its Phase Transition by Temperature}, journal = {Macromolecules}, year = 2000, } @article{CTT100461698, author = {Y.Watanabe and X.Liu and I.Shibuya and T.Akaike}, title = {Functonal Evaluation of Poly-(N-p-vinylbenzyl-O-β-D-galactopyranosyl-[1-4]D-gluconamide)(PVLA) as a Liver Specific Carrier}, journal = {J.Biomater.Sci. Polymer Edn.}, year = 2000, } @article{CTT100461690, author = {雨宮 浩 and 赤池敏宏 and 福田恵一}, title = {移植と再生医学ー21世紀を占うー}, journal = {カレントテラピー}, year = 2000, } @article{CTT100459735, author = {石原務 and 丸山厚 and 赤池敏宏}, title = {遺伝子キャリヤーとバイオマテリアル}, journal = {Drug Delivery System (日本DDS学会編) }, year = 2000, } @article{CTT100459728, author = {A.Maruyama and W.J.Kim and T.Ishihara and M.Ueda and H.Torigoe and A.Ferdous and T.Akaike}, title = {Regulation of DNA Function by Cationic Graft Copolymers}, journal = {Biomaterials and Drug Delivery toward New Mellenium, Eds.K.}, year = 2000, } @article{CTT100459727, author = {M.Ueda and M.Saito and T.Ishihara and T.Akaike and A.Maruyama}, title = {Triplex formation Using ODN Conjugates with Polycation Comb-Type Copolymer}, journal = {Nucleic Acids Sys.Ser.}, year = 2000, } @article{CTT100459719, author = {I.Ajioka and T.Akaike and Y.Watanabe}, title = {Ethanolamine Regulates the Transition from G2 to M Phase of Primary Cultured Hepatocytes by Inducing Cyclin B Expression via Cytoskeletal Rearrangement.}, journal = {Mol.Biol.Cell}, year = 2000, } @article{CTT100459718, author = {T.W.Chung and J.W.Nah and T.Akaike and Y.H.Park and C-S.Cho}, title = {Induced Circular Dichroism of Merocyanine Dye in the Self-Assembled Polymeric Nanoparticles}, journal = {Polymer}, year = 2000, } @article{CTT100459717, author = {渡辺恵史 and 味岡逸樹 and 赤池敏宏}, title = {遺伝子操作と新素材を用いた臓器工学}, journal = {蛋白質核酸酵素}, year = 2000, } @article{CTT100459716, author = {I.Shibuya and T.Akaike and Y.Watanabe}, title = {Suppression of Fas-Mediated Hepaticd Apoptosis by Caspase Inhibitor-Encapsulated Nanoparticles Bearing Poly-(N-p-vinylbenzyl-O-β-D-galactopyranosyl-[1-4]-D-gluconamide).}, journal = {Biotech.Letters}, year = 2000, } @article{CTT100459715, author = {I.Shibuya and T.Akaike and Y.Watanabe}, title = {Design of Temporally and Spatially Controlled Drug Delivery System for the Treatment of Liver Diseases in Mice}, journal = {Hepatology}, year = 2000, } @article{CTT100459714, author = {T.Haruyama and I.Ajioka and T.Akaike and Y.Watanabe}, title = {Regulation and Significance of Hepatocyte-Derived Matrix Metalloproteinases (MMP) in Liver Remodeling}, journal = {Biochem.Biophys.Res.Commun.}, year = 2000, } @article{CTT100459703, author = {Y.Watanabe and X. Liu and I. Shibuya and T.Akaike}, title = {Functional Evaluation of Poly-N-Vinylbenzyl-D-Lactonamide(PVLA) as a Liver Specific Carrier}, journal = {J. Biomaterials Sci., Polymer Edn.}, year = 2000, } @article{CTT100459702, author = {M.Mikawa and N.Miwa and M.Brautigam and T.Akaike}, title = {Gd3+-loaded Polyion Complex for pH Depicition with Magnetic Resonance Imaging}, journal = {J.Biomed.Mater.Res.}, year = 2000, } @article{CTT100459701, author = {A.Ferdous and T.Akaike and A.Maruyama}, title = {Inhibition of Sequence-Specific Protein-DNA Interaction and Restricition Endonuclease Cleavage via Triplex Stabilization by Poly(L-Lysine)-Graft-Dextran Copolymer}, journal = {Biomacromolecules}, year = 2000, } @article{CTT100458712, author = {赤池敏宏}, title = {さまざまな高分子基盤上におけるPC12細胞の形態観察ー培養基盤表面の物理的特性との相関ー}, journal = {日本化学会誌}, year = 2000, } @article{CTT100546808, author = {M. Ishihara and K. Ono and K. Ishikawa and H. Hattori and Y. Saito and H. Yura and T. Akaikke and Y. Ozeki and S. Tanaka and H. Mochizuki and A. Kurita}, title = {Enhanced Ability of Heparin-CarringPolystyrene (HCPS) to Bind to Heparin-Binding Growth Factors and to Inhibit Growth Factor-Induced Endothelial Cell Growth}, journal = {J. Biochem.}, year = 2000, } @article{CTT100458711, author = {赤池敏宏}, title = {再生医療をめざす組織工学ー肝臓でのケーススタデイー}, journal = {診療と新薬}, year = 2000, } @article{CTT100446890, author = {S.H.Kim and M. Goto and C.S.Cho and T.Akaike}, title = {Specific adhesion of primary hepatocytes to a novel glucose-carrying polymer}, journal = {Biotechnology Letters}, year = 2000, } @article{CTT100444484, author = {Ferdous A and Akaike T and Maruyama A.}, title = {Mechanism of intermolecular purine-purine-pyrimidine triple helix stabilization by comb-type polylysine graft copolymer at physiologic potassium concentration}, journal = {Bioconjug Chem.}, year = 2000, } @article{CTT100444483, author = {T.Sasagawa and M.Hlaing and T.Akaike}, title = {Synergistic Induction of Apoptosis in Murine Hepatoma Hepa1-6 cells by IFN-gamma and TNF-alpha}, journal = {Biochem. Biophys. Res. Commun.}, year = 2000, } @article{CTT100444482, author = { Higuchi A and Tamiya S and Tsubomura T and Katoh A and Cho CS and Akaike T and Hara M}, title = {Growth of L929 cells on polymeric films prepared by Langmuir-Blodgett and casting methods}, journal = {J. Biomater Sci. Polym. Edn.}, year = 2000, } @article{CTT100444481, author = {Mayer J and Karamuk E and Akaike T and Wintermantel E}, title = {Matrices for tissue engineering-scaffold structure for a bioartificial liver support system.}, journal = {J Control Release.}, year = 2000, } @article{CTT100444479, author = {K-H. Park and M. Goto and R.Takei and A. Maruyama and K. Kobayashi and J. Miyazaki and C-S. Cho and T.Akaike}, title = {Enhanced effect of sulfoyurea (SU) in copolymer comprising a sugar moiety and SU derivative as double Ligands insulin secretion from MIN6 Cells}, journal = {J. Biomater.Sci.Polymer Edn}, year = 2000, } @article{CTT100444478, author = {Y.K. Park and Y.H. Park and B.A. Shin and E.S. Choi and Y.R. Park and T. Akaike and C-S.Cho}, title = {Galactosylated Chitosan-Graft-Dextran as Hepatocyte-Targeting DNA Carrier}, journal = {J. Contr. Rel.}, year = 2000, } @article{CTT100458710, author = {W.J.Kim and T.Ishihara and T.Akaike and A.Maruyama}, title = {Accelaration of DNA Strand Exchange by Polycation Comb-Type Copolymer}, journal = {Nucleic Acids Sym. Ser.}, year = 2000, } @article{CTT100459567, author = {A.Higuchi and S.Uchiyama and M.Demura and T.Asakura and C-S.Cho and T.Akaike and H.Takarada and M.Hara}, title = {Enhanced CEA Production Associated with Aspirin in a Culture of CW-2 Cells on Some Polymeric Films}, journal = {Cytotechnology}, year = 1999, } @article{CTT100434218, author = {Tatsuki Shinoda and Atsushi Maeda and Seiki Kojima and Seiya Kagatani and Yutaka Konno and Takashi Sonobe and Toshihiro Akaike}, title = {Nanosphere Coated with Lactosyl-Polystyrene Polymer as a Targeting Carrier to Hepatocytes}, journal = {Drug Delivery}, year = 1999, } @article{CTT100433022, author = {赤池敏宏 and 伊勢裕彦 and 味岡逸樹 and 渡辺恵史}, title = { 先端科学技術と人工臓器 ―新しいマトリックス工学と遺伝子工学の導入}, journal = {医学の歩み}, year = 1999, } @article{CTT100434217, author = {Hirohiko ISE and Seiji TAKASHIMA and Masato NAGAOKA and Anwarul FERDOUS and Toshihiro AKAIKE}, title = {Analysis of Cell Viability and Differential Activity of Mouse Hepatocytes under 3D and 2D Culture in Agarose Gel}, journal = {Biotechnology Letters}, year = 1999, } @article{CTT100433030, author = {赤池敏宏 and 丸山 厚}, title = {新しい材料システム構築のための分子シンクロナイゼーショム}, journal = {化学}, year = 1999, } @article{CTT100459692, author = {M.Kamijou and H.Uchiyama and Y.Hoshi and T.Akaike}, title = {Flow Cytometric Analysis of the Binding Pattern of Various Carbohydrates to Leukemic Cells}, journal = {Jikeikai Medical Journal}, year = 1998, } @article{CTT100461225, author = {Toshihiro Akaike}, title = {Receptor-mediated Regulation of Differentiation and Proliferation of Hepatocyte by Synthetic Polymer Model of Asaloglycoproteon}, journal = {J. Biomater. Sci., Polymer Edn.}, year = 1994, } @inproceedings{CTT100736196, author = {Dragomirka Jovic and Asako Sakaue-Sawano and Atsushi Miyawaki and Toshihiro Akaike}, title = {Direct Observation of Mouse ES cells on extracellular E-cadherin matrix}, booktitle = {}, year = 2012, } @inproceedings{CTT100736202, author = {Dragomirka Jovic and Asako Sakaue-Sawano and Atsushi Miyawaki and Toshihiro Akaike}, title = {Visualization of Mouse Embryonic Stem Cell Cycle with Fucci Proteins on E-cadherin Engineered matrix.}, booktitle = {}, year = 2011, } @inproceedings{CTT100736185, author = {Dragomirka Jovic and Asako Sakaue-Sawano and Atsushi Miyawaki and Toshihiro Akaike}, title = {Visualization of Mouse Embryonic Stem Cell Cycle with Fucci Proteins on E-cadherin Engineered matrix}, booktitle = {}, year = 2011, } @inproceedings{CTT100736201, author = {Jovic Dragomirka and Akaike Toshihiro}, title = {Mouse ES cell cycle regulation on Cadherin Engineered Matrix for Regenerative Medicine}, booktitle = {}, year = 2011, } @inproceedings{CTT100736200, author = {Jovic Dragomirka and Akaike Toshihiro}, title = {Regulation of mES cells cycles on E-cad-Fc protein to Induce differentiation of Hepatocytes}, booktitle = {}, year = 2010, } @inproceedings{CTT100736199, author = {Jovic Dragomirka and Akaike Toshihiro}, title = {The mES Cycles Synchronization for Regenerative Medicine}, booktitle = {}, year = 2010, } @inproceedings{CTT100736198, author = {Jovic Dragomirka and Akaike Toshihiro}, title = {Synchronization of mES cell cycles on E-cadherin using drugs for efficient cell differentiation}, booktitle = {}, year = 2010, } @inproceedings{CTT100736189, author = {Jovic Dragomirka and Akaike Toshihiro}, title = {Synchronization of mES cells on E-cad-Fc Matrix using drug to establish efficient cell differentiation}, booktitle = {}, year = 2009, } @inproceedings{CTT100736187, author = {Jovic Dragomirka and Akaike Toshihiro}, title = {Synchronization of mES cells on E-cad-Fc Matrix using drug to establish efficient cell differentiation}, booktitle = {}, year = 2009, } @inproceedings{CTT100736194, author = {Jovic Dragomirka and Akaike Toshihiro}, title = {Mouse ES cells differentiation using drug for cell differentiation}, booktitle = {}, year = 2009, } @inproceedings{CTT100736186, author = {Jovic Dragomirka and Akaike Toshihiro}, title = {Synchronization of mES cells on E-Cad-Fc matrix by drug treatment to establish efficient cell differentiation}, booktitle = {}, year = 2009, } @misc{CTT100404406, author = {赤池敏宏 and 荻原一隆 and 長岡正人}, title = {バイオハイブリッド工学の新展開ー再生医療をめざす細胞マトリックス工学}, year = 2005, } @misc{CTT100404401, author = {赤池敏宏 and 長岡正人 and 村上哲平 and 赤野恭子 and 太田宗宏 and 後藤光昭 and 石原義久}, title = {バイオ人工肝臓をめざす細胞マトリックス工学-肝細胞機能の制御}, year = 2005, } @misc{CTT100404396, author = {赤池敏宏 and 杉山雄一}, title = {医薬品開発における薬工連携への展望}, year = 2005, } @misc{CTT100404468, author = {E.H.Chowdhury and T.Akaike}, title = {Mammalian integrin-targeted gene delivery: A common approach for advanced viral and non-viral vectors}, year = 2005, } @misc{CTT100681436, author = {Sultana N and Nobuhiro Nakamura and Hirose Shige and Kutsuzawa K and Akaike T and Nag K}, title = {Congenital heart disease and biotechnology: Connecting by connexin}, year = 2014, } @misc{CTT100531741, author = {赤池敏宏 and 長岡正人}, title = {細胞とナノファイバー (展望 特集 ナノファイバー)}, year = 2006, } @misc{CTT100531729, author = {赤池敏宏}, title = {巻頭言 若者よ、バイオマテリアル研究の変革期をたくましく、かつオリジナルに生き抜け!}, year = 2006, } @misc{CTT100531732, author = {Chong-Su Cho and Toshihiro Akaike}, title = {Nanothechnology in synthetic glycopolymers}, year = 2006, } @misc{CTT100404409, author = {長岡正人 and 赤池敏宏}, title = {再生医療・組織工学のためのバイオマテリアル}, year = 2005, } @misc{CTT100404413, author = {田川陽一 and 赤池敏宏}, title = {ES細胞から肝臓の発生・再構築を目指して、その薬理学的応用}, year = 2005, } @misc{CTT100404011, author = {長岡正人 and 赤池敏宏}, title = {マトリックス工学による幹細胞の分化増殖制御}, year = 2004, } @misc{CTT100594550, author = {Toshihiro Akaike}, title = {The Stereochemistry of the Polymerization of N-Carboxy α-Amino Acids Anhydrides}, year = 1975, } @misc{CTT100698841, author = {赤池敏宏 and 石井 浩介 and 荒巻 博 and 上野 俊一郎 and 大原 宏明 and 成相 健太郎 and 森 美栄 and 山村 隼志}, title = {細胞培養装置}, howpublished = {登録特許}, year = 2017, month = {}, note = {特願2013-273602(2013/12/27), 特開2015-126719(2015/07/09), 特許第6247932号(2017/11/24)} } @misc{CTT100698839, author = {赤池敏宏 and 石井 浩介 and 村本 知哉}, title = {細胞培養方法および細胞培養装置}, howpublished = {公開特許}, year = 2015, month = {}, note = {特願2013-273605(2013/12/27), 特開2015-126720(2015/07/09)} } @misc{CTT100682123, author = {赤池敏宏 and 石井 浩介 and 森 美栄 and 山村 隼志}, title = {幹細胞培養装置、幹細胞培養方法}, howpublished = {登録特許}, year = 2016, month = {}, note = {特願2013-060669(2013/03/22), 特開2014-183770(2014/10/02), 特許第6054223号(2016/12/09)} } @misc{CTT100617083, author = {赤池敏宏 and 篠田 さやか and 後藤 光昭}, title = {組織撮像用MRI造影剤}, howpublished = {公開特許}, year = 2010, month = {}, note = {特願2009-055656(2009/03/09), 特開2010-208979(2010/09/24)} } @misc{CTT100607755, author = {赤池敏宏 and 賀喜 白乙 and 佐竹 真 and 福井 三由紀 and 兼子 博章}, title = {細胞培養用基材}, howpublished = {公開特許}, year = 2010, month = {}, note = {特願2008-233322(2008/09/11), 特開2010-063411(2010/03/25)} } @misc{CTT100573147, author = {赤池敏宏 and Ezharul Hoque Choudh and Fatema Tuj Zohra}, title = {物質導入担体、物質導入方法及び物質導入用キット}, howpublished = {公開特許}, year = 2007, month = {}, note = {特願2005-252057(2005/08/31), 特開2007-063194(2007/03/15)} } @misc{CTT100573466, author = {赤池敏宏 and Ezharul Hoque Chowdh}, title = {アパタイト粒子及びその作製方法、遺伝子-アパタイト粒子複合体及びその作製方法、並びに遺伝子導入方法及び遺伝子導入用キット}, howpublished = {公開特許}, year = 2007, month = {}, note = {特願2005-232504(2005/08/10), 特開2007-043972(2007/02/22)} } @misc{CTT100573448, author = {赤池敏宏 and Ezharul Hoque CHOWDH}, title = {プラスミドDNAの精製方法及びプラスミドDNA精製用キット}, howpublished = {公開特許}, year = 2007, month = {}, note = {特願2005-192605(2005/06/30), 特開2007-006799(2007/01/18)} } @phdthesis{CTT100594550, author = {Toshihiro Akaike}, title = {The Stereochemistry of the Polymerization of N-Carboxy α-Amino Acids Anhydrides}, school = {東京大学}, year = 1975, }