@book{CTT100501593, author = {石川智久}, title = {ファーマコゲノミクス:薬物トランスポーターの遺伝子多型と薬剤応答性}, publisher = {ゲノムと疾患 村松正実編(南山堂)}, year = 2004, } @book{CTT100501031, author = {石川智久}, title = {ゲノム創薬}, publisher = {図解バイオ活用技術のすべて 東京工業大学大学院生命理工学研究科編(工業調査会)}, year = 2004, } @book{CTT100532107, author = {石川智久}, title = {CMCテクニカルライブラリー DNAチップの開発II・第4章 薬物トランスポーターに基づく創薬分子デザイン -21世紀ゲノム創薬にむけた産学連携の提案-}, publisher = {シーエムシー出版}, year = 2006, } @book{CTT100532108, author = {Susan P.C. Cole and Ian F. Tannock 【訳=石川智久】}, title = {がんのベーシックサイエンス・第18章 薬剤耐性}, publisher = {メディカル・サイエンス・インターナショナル}, year = 2006, } @book{CTT100532110, author = {石川智久 and 櫻井亜季 and 田村藍 and 大西裕子 and 宝田裕 and 橋本幸蔵 and 川瀬三雄}, title = {『バイオ解析・診断技術のテーラーメイド医療への応用』・第2章 薬物トランスポーターの遺伝子多型:機能バリデーション法の国際標準化とSNP診断システムの開発}, publisher = {シーエムシー出版}, year = 2006, } @book{CTT100532109, author = {蔵田敦夫 and 櫻井亜季 and 大西裕子 and 平野弘之 and 石川智久}, title = {毒性質問箱<医薬品副作用予測の最前線> 安全性評価研究会編集企画委員会編・ 薬物性胆汁鬱滞の予測:胆汁酸トランスポーター(ABCB11/BSEP/sPGP)の高速スクリーニングと定量的幸蔵活性相関(QSAR)解析}, publisher = {サイエンティスト社}, year = 2006, } @book{CTT100395616, author = {石川智久}, title = {ゲノム創薬:予防医学事典}, publisher = {朝日書店}, year = 2005, } @book{CTT100397081, author = {T.Ishikawa}, title = {YOKOHAMA The Life Science and Biotechnology City for the Future}, publisher = {PORTSIDE}, year = 2005, } @book{CTT100483353, author = {Toshihisa Ishikawa}, title = {Multidrug Resistance: Genetics of ABC Transporters}, publisher = {In: Nature Encyclopedia of the Human Genome Cooper, D.N. (ed.) Nature Publishing Group, London, UK}, year = 2003, } @book{CTT100488309, author = {石川智久}, title = {ファーマコゲノミクスの概念と方法論は猛烈なスピードで進化している}, publisher = {HAB Newsletter}, year = 2003, } @book{CTT100483363, author = {石川智久}, title = {ゲノム創薬と未来産業:バイオテクノロジー・ビジネスクラスターの形成へ(石川智久 著)}, publisher = {エルゼビア・ジャパン}, year = 2003, } @book{CTT100483362, author = {石川智久}, title = {トキシコゲノミクスと遺伝子多型-ゲノム創薬から個の医療に向けて}, publisher = {次世代ゲノム創薬(日本薬学会編)中山書店}, year = 2003, } @book{CTT100476639, author = {石川智久}, title = {わかりやすいゲノム創薬 第6回新規鎮痛剤開発のターゲットは多様である}, publisher = {ミクス}, year = 2002, } @book{CTT100476430, author = {石川智久(監訳)}, title = {ファーマコゲノミクス:21世紀のゲノム創薬と個の医療(監訳 石川智久)}, publisher = {テクノミック}, year = 2002, } @book{CTT100472114, author = {Ishikawa, T. and Yoshikawa, M.}, title = {ABC transporters: a new approach to toxicogenomics.}, publisher = {In Toxicogenomics T.Inoue and W.D.Pennie (eds), Springer,}, year = 2002, } @book{CTT100472072, author = {石川智久}, title = {わかりやすいゲノム創薬 第5回 骨形成・骨代謝に核内受容体群の果たす役割の重要さ}, publisher = {ミクス}, year = 2002, } @book{CTT100472071, author = {石川智久}, title = {わかりやすいゲノム創薬 第4回 免疫抑制剤は転写因子を標的とした薬剤開発の始まり}, publisher = {ミクス}, year = 2002, } @book{CTT100471708, author = {石川智久 and 堀江透(編集)}, title = {創薬サイエンスのすすめ:ポストゲノム時代へのパラダイムシフト(石川智久、堀江透 編集)}, publisher = {共立出版}, year = 2002, } @book{CTT100472067, author = {石川智久}, title = {わかりやすいゲノム創薬 第2回 最大限の薬理効果・副作用は最小限の分子ターゲットの選択}, publisher = {ミクス}, year = 2002, } @book{CTT100477618, author = {石川智久}, title = {グルタチオン[輸送]GS-XポンプからABCトランスポーターへの新展開}, publisher = {ビタミン}, year = 2002, } @book{CTT100477616, author = {石川智久}, title = {ファーマコゲノミクス:癌の薬剤応答性とABCトランスポーター}, publisher = {けんさ}, year = 2002, } @book{CTT100476646, author = {石川智久}, title = {わかりやすいゲノム創薬 第12回トキシコゲノミクス、毒性評価のパラダイムシフト}, publisher = {ミクス}, year = 2002, } @book{CTT100472057, author = {藪内光 and 石川智久}, title = {ヒトゲノム機能解析から創薬へ―ABCトランスポーターに基づく創薬分子デザイン―}, publisher = {医学の歩み}, year = 2002, } @book{CTT100472069, author = {石川智久}, title = {わかりやすいゲノム創薬 第3回 ターゲット分子「G-蛋白共役型受容体」をめぐる創薬戦争}, publisher = {ミクス}, year = 2002, } @book{CTT100476645, author = {石川智久}, title = {わかりやすいゲノム創薬 第11回薬の体内動態に関係する各種薬物トランスポーター}, publisher = {ミクス}, year = 2002, } @book{CTT100476644, author = {石川智久}, title = {わかりやすいゲノム創薬 第10回 制癌剤を細胞外に排出するABCトランスポーターの発見}, publisher = {ミクス}, year = 2002, } @book{CTT100476643, author = {石川智久}, title = {わかりやすいゲノム創薬 第9回薬剤応答性の遺伝的差異を診断する分子技術の開発}, publisher = {ミクス}, year = 2002, } @book{CTT100476641, author = {石川智久}, title = {わかりやすいゲノム創薬 第8回遺伝子タイピングで薬理効果がより高く安全な薬剤医療へ}, publisher = {ミクス}, year = 2002, } @book{CTT100476640, author = {石川智久}, title = {わかりやすいゲノム創薬 第7回ファーマコゲノミクス研究、遺伝子多型を医療に役立てる}, publisher = {ミクス}, year = 2002, } @book{CTT100453605, author = {石川智久}, title = {Techno Online 大学の社会貢献「産業界からの人材登用を」}, publisher = {日経産業新聞}, year = 2001, } @book{CTT100453604, author = {石川智久}, title = {ハイテクうらばなし 分子を見分ける生体の“眼”29 「薬剤輸送機構に基づく創薬分子デザイン戦略」}, publisher = {日刊工業新聞}, year = 2001, } @book{CTT100453606, author = {石川智久 and 藪内光}, title = {創薬分子デザインの新戦略-ABCトランスポーターの遺伝子多型と薬剤応答性 特集SNPが変える疾患研究と新薬開発}, publisher = {Bioベンチャー}, year = 2001, } @book{CTT100453608, author = {石川智久}, title = {薬物輸送機構に基づく創薬 21世紀の創薬手法}, publisher = {化学と教育}, year = 2001, } @book{CTT100453609, author = {石川智久 and 藪内光 and 笠松志保 and 吉川恵美 and 池上洋二}, title = {医薬品開発研究におけるファーマコゲノミクスの利用}, publisher = {薬物動態 Xenobio. Metabol. and Dispos.}, year = 2001, } @book{CTT100453643, author = {石川智久}, title = {ゲノム創薬になにが必要か}, publisher = {現代化学}, year = 2001, } @book{CTT100460852, author = {石川智久}, title = {ハイテクうらばなし ヒトゲノム解読 創薬研究の大転回7 「Genomics と Proteomics」}, publisher = {日刊工業新聞}, year = 2001, } @book{CTT100453611, author = {石川智久}, title = {ヒトゲノムからSNP解析へ~薬剤応答性の差違を解明}, publisher = {OHM BULLETIN}, year = 2001, } @book{CTT100444503, author = {石川智久 and Allikmets, R. and Dean, M. and Higgins, C. and Ling and V. Wain, M.H.}, title = {ヒトABCトランスポーター遺伝子の新命名法}, publisher = {薬物動態}, year = 2000, } @book{CTT100443761, author = {Ishikawa, T. and Furuta, K. and Suzuki, M.}, title = {Is Transport Mechanism-based Drug Molecular Design Possible? Molecular Design of Biochemical Probes Targeting MRP1/GS-X Pump.}, publisher = {Control and Diseases of Sodium Dependent Transport Proteins and Ion Channels. Carafoli, E., Ladzunski, M., Mikoshiba, K., Okada, Y., Suketa, Y. and Wright, E.M. (eds.) Elsevier Science Publication, Amsterdam}, year = 2000, } @book{CTT100443762, author = {Ishikawa, T and Kuo, M.T. and Furuta, K. and Suzuki, M.}, title = {A Novel Aspect on Glutathione-associated Biological Function of MRP/GS-X Pump and Its Gene Expression.}, publisher = {Multiple Drug Resistance in Cancer, Clynes, M. (ed.), Kluwer Academic Publishers, Drodrecht}, year = 1998, } @book{CTT100443763, author = {Akimaru, K. and Nakanishi, M. and Furuta, M. and Suzuki, R. and Noyori, R. and Ishikawa, T.}, title = {Cell Growth Inhibition by Antitumor Prostaglandins and Its Modulation by MRP/GS-X Pump.}, publisher = {Advances in Experimental Medicine and Biology Eicosanoids and Other Bioactive Lipids in Cancer, Inflammation and Radiation Injury, Honn, K.V., Marnett, L.J., and Wong, P.Y. (eds.) Plenum Press, New York}, year = 1997, } @book{CTT100443771, author = {Ishikawa, T. and Akimaru, K.}, title = {Transport of Glutathione S-Conjugates from Cancer Cells: Function and Structure of GS-X Pump.}, publisher = {Vermeulen, N.P.E., Mulder, G.J., Nieuwenhuyse, H., Peters, W.H.M., van Bladeren, P.J. (eds.) Glutathione S-Transferases: Structure, function, and clinical implications. Taylor and Francis, London}, year = 1996, } @book{CTT100443772, author = {Ishikawa, T. and Ali-Osman, F.}, title = {Glutathione Conjugation and ATP-dependent Export of Anticancer Drugs.}, publisher = {Drug Transport in Antimicrobial and Anticancer DrugsGeorgopapadakou, N.H. (ed.), Marcel Dekker, New York}, year = 1994, } @book{CTT100443773, author = {Ishikawa, T.}, title = {Glutathione S-Conjugate Export Pump. }, publisher = {Structure and Function of Glutathione S-Transferases. Tew, K., Pickett, C.B., Mantle, T.J., Mannervik, B. and Hayes, J. (eds.), CRC Press, Boca Raton}, year = 1993, } @book{CTT100443774, author = {Keppler, D. and Muller, M. and Ishikawa, T.}, title = {Transport of Cysteinyl Leukotrienes.}, publisher = { Transport of Amino Acids. Haussinger, D. and Kilberg, M. (eds.) Academic Press, New York}, year = 1992, } @book{CTT100443775, author = {Sies, H. and Akerboom, T.P.M. and Ishikawa, T.}, title = {Glutathione Conjugates: Transport from the Cell and Intracellular Effects.}, publisher = {Sakamoto, Y., Higashi, T., Taniguchi, N. and Meister, A. (eds.) Glutathione Centennial: Molecular and Clinical Perspectives, Academic Press, New York}, year = 1989, } @article{CTT100397122, author = {Ishikawa, T. and Tamura, A. and Saito, S. and Wakabayashi, K. and Nakagawa, H.}, title = {Pharmacogenomics of the human ABC transporter ABCG2: from functional evaluation to drug molecular design.}, journal = {Naturwissenschaften}, year = 2005, } @article{CTT100387446, author = {石川智久}, title = {The 24th International Symposium of the Sapporo Cancer Seminar Foundation}, journal = {がん分子標的治療}, year = 2004, } @article{CTT100391625, author = {Ishikawa, T. and Sakurai, A. and Kanamori, Y. and Nagakura, M. and Hirano, H. and Takarada, Y. and Yamada, K. and Fukushima, K. and Kitajima, M.}, title = {High-speed screening of human ABC transporter function and genetic polymorphisms: New strategies in pharmacogenomics.}, journal = {Methods in Enzymol.}, year = 2005, } @article{CTT100387364, author = {石川智久}, title = {ゲノム創薬の新展開:薬物トランスポーターのファーマコゲノミクス 特集にあたって}, journal = {ゲノム医学}, year = 2004, } @article{CTT100391624, author = {Takahashi, T. and Nakai, K. and Doi, T. and Yasunaga, M. and Nakagawa, H. and Ishikawa, T.}, title = {Synthesis and Evaluation of 3D Templates Based on a Taxane Skeleton to Circumvent P-glycoprotein-associated Multidrug Resistance of Cancer.}, journal = {Bioorg. Med. Chem. Lett.}, year = 2005, } @article{CTT100387359, author = {石川智久}, title = {ABCB1(P-gp/MDR1)の遺伝子多型と機能解析高速スクリーニング}, journal = {ゲノム医学}, year = 2004, } @article{CTT100405688, author = {Sakurai, A. and Tamura, A. and Onishi Y. and Ishikawa, T.}, title = {Genetic polymorphisms of ATP-binding cassette transporters ABCB1 and ABCG2:therapeutic implications}, journal = {Expert Opin Pharmacother}, year = 2005, } @article{CTT100501029, author = {石川智久}, title = {ファーマコゲノミクスの新しい挑戦:SNPの機能的実体に迫る!}, journal = {ファルマシア}, year = 2004, } @article{CTT100501028, author = {石川智久}, title = {がん治療におけるPharmacogenomics -ABCトランスポーターの遺伝子多型と薬剤応答性}, journal = {がん分子標的治療}, year = 2004, } @article{CTT100501027, author = {石川智久}, title = {特集呼吸器のPharmacogenomics -ファーマコゲノミクス; overview}, journal = {THE LUNG perspectives}, year = 2004, } @article{CTT100501026, author = {石川智久}, title = {ABCトランスポーター遺伝子多型の機能解析から創薬への応用}, journal = {Pharma VISION NEWS Coll.}, year = 2004, } @article{CTT100501025, author = {石川智久}, title = {ヒトABCトランスポーターのファーマコゲノミクス:新規遺伝子の発見と遺伝子多型の機能解析}, journal = {血液・免疫・腫瘍}, year = 2004, } @article{CTT100501024, author = {石川智久}, title = {ヒトABCトランスポーターの遺伝子多型解析からバイオテクノロジークラスター形成へ}, journal = {日本農芸化学会誌}, year = 2004, } @article{CTT100501023, author = {石川智久}, title = {ヒト薬物トランスポーター遺伝子多型の機能解析からゲノム創薬と臨床診断への応用}, journal = {臨床検査}, year = 2004, } @article{CTT100501022, author = {中田國夫 and 大西裕子 and 櫻井亜季 and 平野弘之 and 樽井茂樹 and 石川智久}, title = {薬物トランスポーター機能に迫る -新しい創薬分子デザイン戦略}, journal = {化学}, year = 2004, } @article{CTT100501020, author = {石川智久}, title = {個の医療をめざして 薬物トランスポーターの遺伝子多型機能解析}, journal = {実験医学}, year = 2004, } @article{CTT100501019, author = {吉川恵美 and 伊藤明子 and 石川智久 and 池上洋二}, title = {ABCトランスポーターと薬剤応答性}, journal = {癌と化学療法}, year = 2004, } @article{CTT100387531, author = {Ishikawa, T.}, title = {The 24th International Symposium of Sapporo Cancer Seminar Pharmacogenomics in Cancer Chemotherapy: Recent Advancesin ABC Transporters and Genome Analyses}, journal = {Journal of Experimental Therapeutics and Oncology}, year = 2004, } @article{CTT100501011, author = {Takayanagi, S. and Kataoka, T. and Ohara, O. and Oishi, M. and Kuo, M.T. and Ishikawa, T.}, title = {Human ATP-binding cassette transporter ABCC10: expression profile and p53-dependent upregulation}, journal = {Journal of Experimantal Therapeutics and Oncology}, year = 2004, } @article{CTT100501012, author = {Ishikawa, T. and Onishi, Y. and Hirano, H. and Oosumi, K. and Nagakura, M. and Tarui, S.}, title = {Pharmacogenomics of Drug Transporters: A New Approach to Functional Analysis of the Genetic Polymorphisms of ABCB1 (P-Glycoprotein/MDR1)}, journal = {Biol. Pharm. Bull.}, year = 2004, } @article{CTT100501014, author = {Ishikawa, T. and Hirano, H. and Onishi, Y. and Sakurai, A. and Tarui, S.}, title = {Functional Evaluation of ABCB1 (P-Glycoprotein) Polymorphisms: High-Speed Screening and Structure-Activity Relationship Analyses.}, journal = {Drug Metabol. Pharmacokin.}, year = 2004, } @article{CTT100501021, author = {Ishikawa, T.}, title = {Pharmacogenomics in Drug Transporters: Functional Analysis of Genetic Polymorphisms}, journal = {Global Outsourcing Review}, year = 2004, } @article{CTT100501015, author = {Yoshikawa, M. and Ikegami, Y. and Sano, K. and Yoshida, H. and Mitomo, H. and Sawada, S. and Ishikawa, T.}, title = {Transport of SN-38 by the Wild Type of Human ABC Transporter ABCG2 and Its Inhibition by Quercetin, a Natural Flavonoid}, journal = {Journal of Experimental Therapeutics and Oncology}, year = 2004, } @article{CTT100501017, author = {Onishi, Y. and Hirano, H. and Nakata, K. and Oosumi, K. and Nagakura, M. and Tarui, S. and Ishikawa, T.}, title = {High-Speed Screening and Structure-Activity Relationship Analysis for the Substarte Specificity of P-Glycoprotein (ABCB1)}, journal = {Chem-Bio Informatics J.}, year = 2003, } @article{CTT100501018, author = {Satoh, T. and Baba, M. and Nakatsuka, D. and Ishikawa, Y. and Aburatani, H. and Furuta, K. and Ishikawa, T. and Hatanaka, H. and Suzuki, M. and Watanabe, Y.}, title = {Role of heme oxygenase-1 protein in the neuroprotective effects of cyclopentenone prostaglandin derivatives under oxidative stress.}, journal = {Eur. J. Nerosci.}, year = 2003, } @article{CTT100715684, author = {T. Ishikawa and A. Sakurai and H. Hirano and A. Lezhava and M. Sakurai}, title = {Emerging new technologies in pharamcogenomics: Rapid SNP detection, molecular dynamic simulation, and QSAR analysis methods to validate clinically importantgenetic variants of human ABC transporter ABCB1 (P-gp/MDR1)}, journal = {Pharmacology & Therapeutics}, year = 2010, } @article{CTT100525517, author = {Hiroshi Nakagawa and Hasumi, K. and Takami, M. and Aida-Hyugaji, S. and Woo, J. T. and Kazuo Nagai and Toshihisa Ishikawa and Masaaki Wachi}, title = {Identification of two biologically crucial hydroxyl groups of (-)-epigallocatechin gallate in osteoclast culture}, journal = {Biochem. Pharmacol.}, year = 2007, } @article{CTT100561991, author = {S. Aida-Hyugaji and H. Nakagawa and J. Nomura and M. Sakurai and U. Nagashima and T. Ishikawa}, title = {Theoretical Studies for Molecular Modeling of New Camptothecin Analogues}, journal = {Croatia Chemica Acta CCACAA}, year = 2007, } @article{CTT100561989, author = {A. Sakurai and Y. Onishi and H. Hirano and M. Seigneuret and K. Obanayama and G. Kim and E. L. Liew and T. Sakaeda and K. Yoshiura and N. Niikawa and M. Sakurai and T. Ishikawa}, title = {Quantitative Structure-Activity Relationship Analysis and Molecular Dynamics Simulation To Functionally Validate Nonsynonymous Polymorphisms of Human ABC Transporter ABCB}, journal = {Biochemistry}, year = 2007, } @article{CTT100532025, author = {Nakagawa H and Saito H and Ikegami Y and Aida-Hyugaji S and Sawada S and Ishikawa T}, title = {Molecular modeling of new camptothecin analogues to circumvent ABCG2-mediated drug resistance in cancer.}, journal = {Cancer Lett.}, year = 2006, } @article{CTT100532023, author = {Hirano H and Kurata A and Onishi Y and Sakurai A and Saito H and Nakagawa H and Nagakura M and Tarui S and Kanamori Y and Kitajima M and Ishikawa T}, title = {High-Speed Screening and QSAR Analysis of Human ATP-Binding Cassette Transporter ABCB11 (Bile Salt Export Pump) To Predict Drug-Induced Intrahepatic Cholestasis.}, journal = {Mol. Pharm.}, year = 2006, } @article{CTT100532024, author = {Ishikawa T and Ikegami Y and Sano K and Nakagawa H and Sawada S}, title = {Transport mechanism-based drug molecular design: novel camptothecin analogues to circumvent ABCG2-associated drug resistance of human tumor cells.}, journal = {Curr. Pharm. Des.}, year = 2006, } @article{CTT100532033, author = {Yoshiura K and Kinoshita A and Ishida T and Ninokata A and Ishikawa T and Kaname T and Bannai M and Tokunaga K and Sonoda S and Komaki R and Ihara M and Saenko VA and Alipov GK and Sekine I and Komatsu K and Takahashi H and Nakashima M and Sosonkina N and Mapendano CK and Ghadami M and Nomura M and Liang DS and Miwa N}, title = {A SNP in the ABCC11 gene is the determinant of human earwax type.}, journal = {Nat. Genet.}, year = 2006, } @article{CTT100532032, author = {Wakabayashi K and Tamura A and Saito H and Onishi Y and Ishikawa T}, title = {Human ABC transporter ABCG2 in xenobiotic protection and redox biology.}, journal = {Drug Metab. Rev.}, year = 2006, } @article{CTT100532031, author = {Wakabayashi K and Nakagawa H and Adachi T and Kii I and Kobatake E and Kudo A and Ishikawa T}, title = {Identification of cysteine residues critically involved in homodimer formation and protein expression of human ATP-binding cassette transporter ABCG2: a new approach using the flp recombinase system.}, journal = {J. Exp. Ther. Oncol.}, year = 2006, } @article{CTT100532030, author = {Tamura A and Watanabe M and Saito H and Nakagawa H and Kamachi T and Okura I and Ishikawa T}, title = {Functional validation of the genetic polymorphisms of human ATP-binding cassette (ABC) transporter ABCG2: identification of alleles that are defective in porphyrin transport.}, journal = {Mol. Pharmacol.}, year = 2006, } @article{CTT100532029, author = {Tamura A and Wakabayashi K and Onishi Y and Nakagawa H and Tsuji M and Matsuda Y and Ishikawa T}, title = {Genetic polymorphisms of human ABC transporter ABCG2: Development of the standard method for functional validation of SNPs by using the Flp recombinase system.}, journal = {J. Exp. Ther. Oncol.}, year = 2006, } @article{CTT100532028, author = {Shirasaka Y and Onishi Y and Sakurai A and Nakagawa H and Ishikawa T and Yamashita S}, title = {Evaluation of Human P-Glycoprotein (MDR1/ABCB1) ATPase Activity Assay Method by Comparing with in Vitro Transport Measurements: Michaelis-Menten Kinetic Analysis to Estimate the Affinity of P-Glycoprotein to Drugs.}, journal = {Biol. Pharm. Bull.}, year = 2006, } @article{CTT100532027, author = {Saito H and Hirano H and Nakagawa H and Fukami T and Oosumi K and Murakami K and Kimura H and Kouchi T and Konomi M and Tao E and Tsujikawa N and Tarui S and Nagakura M and Osumi M and Ishikawa T}, title = {A new strategy of high-speed screening and quantitative structure-activity relationship analysis to evaluate human ATP-binding cassette transporter ABCG2-drug interactions.}, journal = {J. Pharmacol. Exp. Ther.}, year = 2006, } @article{CTT100532026, author = {Nakata K and Tanaka Y and Nakano T and Adachi T and Tanaka H and Kaminuma T and Ishikawa T}, title = {Nuclear receptor-mediated xenobiotic procession loops in phase I, II, and III drug metabolizing systems.}, journal = {Drug Metab. Pharmacokinet.}, year = 2006, } @article{CTT100501030, author = {石川智久 and 遠藤仁 and 乾賢一 and 辻彰 and 和田守正 and 隅野靖弘}, title = {薬物トランスポーターのファーマコゲノミクス:SNPの機能的実体に迫る!}, journal = {蛋白質 核酸 酵素}, year = 2004, } @article{CTT100501013, author = {Yoshikawa, M. and Ikegami, Y. and Hayasaka, S. and Ishii, K. and Ito, A. and Sano, K. and Suzuki, T. and Togawa, T. and Yoshida, H. and Soda, H. and Oka, M. and Kohno, S. and Sawada and S. Ishikawa}, title = {Novel camptothecin analogues that circumvent ABCG2-associated drug resistance in human tumor cells}, journal = {Int. J. Cancer}, year = 2004, } @article{CTT100501016, author = {Ishikawa T. and Tsuji A. and Inui K. and Sai Y. and Anzai N. and Wada M. and Endou H.and Sumino Y.}, title = {The genetic polymorphism of drug transporters: functional analysis approaches}, journal = {Pharmacogenomics}, year = 2004, } @article{CTT100486762, author = {Sano, K. and Yoshikawa, M. and Hayakawa, S. and Ikegami, Y. and Yoshida, H. and Ishikawa, T. and Sawada, S. and Tanabe, S.}, title = {Simple non-ion-paired high performance liquid chromatograhic method for simultaneouse quantification of carboxylate and lactone forms of 14 new camptothecin derivatives}, journal = {J.Chromatogr.}, year = 2003, } @article{CTT100472155, author = {Mitomo, H. and Kato, R. and Ito, A. and Kasamatsu, S. and Ikegami, Y. and Kii, I. and Kudo, A. and Kobatake, E. and Sumino, Y. and Ishikawa, T.}, title = {A functional study on the polymorphism of ATP-binding cassette transporter ABCG2: critical role of arginine-482 in methotrexate transport.}, journal = {Biochem J.}, year = 2003, } @article{CTT100483360, author = {石川智久 and 清水秀忠 and 高柳晋一郎 and 北島正人}, title = {ヒトABCトランスポーター:新規遺伝子の探索とSNP機能解析}, journal = {Bioベンチャー }, year = 2003, } @article{CTT100483358, author = {Takayanagi, S. and Ishikawa, T.}, title = {Molecular identification and characterzation of rat Abcc1 cDNA: existence of two splicing variants and species difference in drug-resistance profile}, journal = {Journal of Experimental Therapeutics and Oncology}, year = 2003, } @article{CTT100483356, author = {Ishikawa, T. and Kasamatsu, S. and Hagiwara, Y. and Mitomo, H. and Kato, R. and Sumino, Y.}, title = {Expression and Functional Characterization of Human ABC Transporter ABCG2 Variants in Insect Cells.}, journal = {Drug Metabol. Pharmacokin. }, year = 2003, } @article{CTT100483354, author = {Shimizu, H. and Taniguchi, H. and Hippo, Y. and Hayashizaki, Y. and Aburatani, H. and Ishikawa, T.}, title = {Characterization of mouse Abcc12 gene and its transcript encoding an ATP-binding cassette transporter, an orthologue to human ABCC12.}, journal = {Gene}, year = 2003, } @article{CTT100472163, author = {Yabuuchi, H. and Takayanagi, S. and Yoshinaga, K. and Taniguchi, N. and Aburatani, H. and Ishikawa, T.}, title = {ABCC13, an unusual truncated ABC transporter, is highly expressed in fetal human liver}, journal = {Biochem. Biophys. Res. Commun.}, year = 2002, } @article{CTT100472136, author = {Yoshikawa, M. and Yabuuchi, H. and Kuroiwa, A. and Ikegami, Y. and Sai, Y. and Tamai, I. and Tsuji, A. and Matsuda, Y. and Yoshida, H. and Ishikawa, T.}, title = {Molecular and cytogenetic characterization of the mouse ATP-binding cassette transporter abcg4.}, journal = {Gene}, year = 2002, } @article{CTT100472055, author = {吉川恵美 and 池上洋二 and 藪内光 and 石川智久}, title = {ポストゲノム時代の挑戦;ABCトランスポーターに基づく創薬分子デザイン}, journal = {化学工業}, year = 2002, } @article{CTT100472063, author = {石川智久}, title = {わかりやすいゲノム創薬 第1回 新薬探索・毒性予測・遺伝子情報管理などを基本から}, journal = {ミクス}, year = 2002, } @article{CTT100472050, author = {Yoshikawa, M. and Kasamatsu, S. and Yasunaga, M. and Wang, G. and Ikegami, Y. and Yoshida, H. and Tarui, S. and Yabuuchi, H. and Ishikawa, T. }, title = {Dose ABCG2 need a heterodimer partner? Expression and functional evaluation of ABCG2 (Arg 482). }, journal = {Drug Metabolism and Pharmakokinetics}, year = 2002, } @article{CTT100453602, author = {Lin-Lee, Y.C. and Tatebe, S. and Savaraj, N. and Ishikawa, T and Kuo, M.T.}, title = { Differential sensitivities of the MRP gene family and γ-glutamylcysteine synthetase to prooxidants in human colorectal carcinoma cell lines with different p53 status.}, journal = {Biochem. Pharmacol.}, year = 2001, } @article{CTT100453603, author = {Stock, J.L. and Shinjo, K. and Burkhardt, J. and Roach, M. and Taniguchi, K. and Ishikawa, T. and Kim, H.S. and Flannery, P.J. and Coffman, T.M. and McNeish, J.D. and Audoly, L.P.}, title = {The prostaglandin E2 EP1 receptor mediates pain perception and regulates blood pressure}, journal = {J. Clin. Invest.}, year = 2001, } @article{CTT100453607, author = {石川智久 and 藪内光 and 池上洋二 and Kuo, M. T.}, title = {第Ⅲ相解毒系ABC トランスポーターファミリーと抗癌剤応答性}, journal = {Cancer Frontier}, year = 2001, } @article{CTT100453610, author = {石川智久}, title = {医薬品開発におけるヒト組織の利用:薬物代謝・トランスポート/ 個人差・相互作用(誘導・阻害)の評価}, journal = {Human & Animal Bridge NEWSLETTER}, year = 2001, } @article{CTT100453636, author = {Yabuuchi, H. and Shimizu, H. and Takayanagi, S. and Ishikawa, T.}, title = {Multiple splicing variants of two new human ATP-binding cassette transporters, ABCC11 and ABCC12}, journal = {Biochem. Biophys. Res. Commun.}, year = 2001, } @article{CTT100453637, author = {Nakatomi, K. and Yoshikawa, M. and Oka, M. and Ikegami, Y. and Hayasaka, S. and Sano, K. and Shiozawa, K. and Kawabata, S. and Soda, H. and Ishikawa, T. and Tanabe, S. and Kohno, S.}, title = {Transport of 7-ethyl-10-hydroxycamptothecin (SN-38) by breast cancer resistance protein (BCRP), ABCG2, in human lung cancer cells}, journal = {Biochem. Biophys. Res. Commun.}, year = 2001, } @article{CTT100443759, author = {Ishikawa, T. and Kuo, M.T. and Furuta, K. and Suzuki, M}, title = {The human multidrug resistance-associated protein (MRP) gene family: from biological function to drug molecular design}, journal = {Clin Chem Lab Med}, year = 2000, } @article{CTT100443760, author = {Ishikawa, T. and Priebe, W.}, title = {A New Challenge in the Post-Genome Era: Transport Mechanism-Based Drug Design Strategy.}, journal = {Global Outsourcing Review}, year = 2000, } @article{CTT100444504, author = {石川智久}, title = {薬物トランスポーターに基づく創薬分子デザイン:21世紀ゲノム創薬に向けた産学連携の提案}, journal = {バイオインダストリー}, year = 2000, } @article{CTT100443290, author = {Ikegami, Y. and Tatebe, S. and Lin-Lee and Y.-C. and Xie and Q.-W. and Ishikawa, T. and Kuo, M.T.}, title = {Induction of MRP1 and γ-Glutamylcystein Synthetase Gene Expression by Interleukin 1βis Mediated by Nitric Oxide-Related Signaling in Human Colorectal Cancer Cells.}, journal = {J. Cell. Physiol.}, year = 2000, } @article{CTT100443403, author = {Ogawa, K. and Suzuki, H. and Hirohashi, T. and Ishikawa, T. and Meier, P.J. and Hirose, K. and Akizawa, T. and Yoshioka, M. and Sugiyama, Y.}, title = {Characterization of inducible nature of MRP3 in rat liver.}, journal = {Am. J. Physiol. Gastrointest. Liver Physiol.}, year = 2000, } @article{CTT100443404, author = {Hosoya, T. and Tomokiyo, K. and Okuda, H. and Nakayama, H. and Ishikawa, T. and Furuta, K. and Suzuki, M.}, title = {[35S]S-[5-(4-benzoylphenyl)pentyl]glutathione: A Versatile Radio Ligand Targeting GS-X Pumps with the Ability of Photoaffinity Labeling.}, journal = {Bioorg. Medicin. Chem. Lett.}, year = 1999, } @article{CTT100443405, author = {Furuta, K. and Tomokiyo, K. and Kuo and M.T. Ishikawa, T. and Suzuki, M.}, title = {Molecular Design of Glutathione-derived Biochemical Probes targeting the GS-X Pump.}, journal = {Tetrahedron}, year = 1999, } @article{CTT100443406, author = {Yamane, Y. and Furuichi, M. and Song, R. and Van, N.T. and Mulchahy, T. and Ishikawa, T.}, title = {Expression of Multidrug Resitance Protein/GS-X pump and γ-Glutamylcysteine Synthetase Genes is Regulated by Oxidative Stress.}, journal = {J. Biol. Chem.}, year = 1998, } @article{CTT100443407, author = {Ishikawa, T. and Akimaru, K. and Nakanishi, M. and Suzuki, M. and Furuta, K. and Noyori, R.}, title = {Anticancer Prostaglandin-induced Cell Cycle Arrest and Its Modulation by a GS-X pump Inhibitor.}, journal = {Biochem. J.}, year = 1998, } @article{CTT100443408, author = {Priebe, W. and Krawczyk, M. and Kuo, M.T. and Yamane, Y. and Savaraj, N. and Ishikawa, T.}, title = {Doxorubicin- and Daunorubicin-Glutathione Conjugates, But Not Unconjugated Drugs, Competitively Inhibit Leukotriene C4 Transport Mediated by MRP/GS-X pump.}, journal = {Biochem. Biophys. Res. Commn.}, year = 1998, } @article{CTT100443409, author = {Kuo, M.T. and Bao and J.-J. and Yamane, Y. and Gomi, A. and Savaraj, N. and Masuzawa, T. and Ishikawa, T.}, title = {Coordinated Regulation of MRP/GS-X Pump and γ-Glutamylcysteine Synthetase Genes in Drug-Resistant Cells and in Tumor Cells.}, journal = {Biochem. Pharmacol.}, year = 1998, } @article{CTT100443410, author = {Ishikawa, T and Kuo, M.T. and Furuta, K. and Suzuki, M.}, title = {Glutathione-associated Biological Function of MRP/GS-X Pump and Its Gene Expression.}, journal = {Cytotechnology}, year = 1998, } @article{CTT100443411, author = {Schicho, R. and Kanai, Y. and Ishikawa, T. and Skofitsch, G. and Donnerer, J.}, title = {Involvement of NGF in the induction of increased noradrenergic innervation of the uretaer in neonatally capsaicin-treated rats.}, journal = {J. Autonomic Nerv. System}, year = 1998, } @article{CTT100444502, author = {石川智久}, title = {薬剤耐性機構とその克服}, journal = {化学療法の領域}, year = 1998, } @article{CTT100443415, author = {Suzuki, M. and Mori, M. and Niwa, T. and Hirata, K. and Furuta, T. and Ishikawa, T. and Noyori, R.}, title = {Chemical Implications for Anti-tumor and Anti-viral Prostaglandins: Reaction of D7-prostaglandin A1 and Prostaglandin A1 Methyl Esters with Thiols.}, journal = {J. Am. Chem. Soc.}, year = 1997, } @article{CTT100443412, author = {Taniguchi, K. and Shinjo, K. and Mizutani, M. and Shimada, K. and Menniti, F. and Ishikawa, T. and Nagahisa, A.}, title = {Antinociceptive Activity of CP-101,606, an NMDA Receptor NR2B Subunit Antagonist.}, journal = {Br. J. Pharmacol.}, year = 1997, } @article{CTT100443416, author = {Ishikawa, T. and Li and Z.-S. and Lu and Y.-P. and Rea, P.A.}, title = {The GS-X Pump in Plant, Yeast and Animal Cells: Structure, Function and Gene Expression.}, journal = {Bioscience Reports}, year = 1997, } @article{CTT100444501, author = {石川智久}, title = {GS-X ポンプファミリー: ATP依存型有機アニオントランスポーター}, journal = {蛋白質 核酸 酵素}, year = 1997, } @article{CTT100443414, author = {Gomi, A. and Shinoda, S. and Masuzawa, T. and Ishikawa, T. and Kuo, M.T.}, title = {Transient Co-induction of MRP/GS-X Pump and γ-Glutamylcysteine Synthetas by 1-(4-Amino-2-methyl-5-pyrimidinyl)methyl-3-(2-chloroethyl)-3-nitrosourea in Human Glioma Cells.}, journal = {Cancer Res.}, year = 1997, } @article{CTT100443413, author = {Gomi, A. and Masuzawa, T. and Ishikawa, T. and Kuo, M.T.}, title = {Posttranscriptional Regulation of MRP/GS-X Pump and γ-Glutamylcysteine Synthetase Expression by 1-(4-Aminp-2-methyl-5-pyridinyl)methyl-3-(2-chloroethyl)-3- nitrosourea and by Cycloheximide in Human Glioma Cells.}, journal = {Biochem. Biophys. Res. Commn.}, year = 1997, } @article{CTT100443418, author = {Ishikawa and T. Bao and J.-J. and Yamane, Y. and Akimaru, K. and Frindrich, K. and Wright, C.D. and Kuo, M.T.}, title = {Concerted Induction of MRP/GS-X pump and γ-Glutamylcysteine Synthetase by Heavy Metals in Human Leukemia Cells.}, journal = {J. Biol. Chem.}, year = 1996, } @article{CTT100443427, author = {Ishikawa, T. and Esterbauer, H. and Sies, H. }, title = {Role of Cardiac Glutathione S-Transferase and of the Glutathione S-Conjugate Export System in Biotransformation of 4-Hydroxynonenal in the Heart. }, journal = {J. Biol. Chem.}, year = 1996, } @article{CTT100443417, author = {Kuo, M.T. and Bao and J.-J. and Curley, S.A. and Ikeguchi, M. and Johnston, D.A. and Ishikawa, T.}, title = {Frequent Coordinated Overexpression of the MRP/GS-X pump and g-Glutamylcysteine Synthetase Genes in Human Colorectal Cancers.}, journal = {Cancer Res.}, year = 1996, } @article{CTT100443419, author = {Akimaru, K. and Kuo, M.T. and Suzuki, M. and Noyori and Ishikawa, T.}, title = {Induction of MRP/GS-X pump and Cellular Resiatance to Anticancer Prostaglandins.}, journal = {Cytotechnology}, year = 1996, } @article{CTT100443420, author = {Ishikawa, T. and Akimaru, K. and Kuo, M.T. and Priebe, W. and Suzuki, M.}, title = {How does the MRP/GS-X Pump Export Doxorubicin?}, journal = {J. Natl. Cancer Inst.}, year = 1995, } @article{CTT100444500, author = {石川智久 and Frindrich, K. and 秋丸国広}, title = {GS-X ポンプ:その生理機能と分子構造}, journal = {最新医学}, year = 1995, } @article{CTT100443421, author = {Ishikawa, T. and Wright, C.D. and Ishizuka, H.}, title = {Cisplatin-Resistant Human Leukemia HL-60 Cells and Downregulated by Cell Differentiation.}, journal = {J. Biol. Chem.}, year = 1994, } @article{CTT100443182, author = {Ishikawa, T.}, title = {Phase III Detoxification System.}, journal = {Trends Biochem. Sci.}, year = 1993, } @article{CTT100443183, author = {Kadmon, M. and Kluemann, C. and Bome, M. and Ishikawa, T.}, title = {Inhibition by Cyclosporin A of Adenosine triphosphate-dependent Transport from the Hepatocyte into Bile.}, journal = {Gastroenterology}, year = 1993, } @article{CTT100443422, author = {Ishikawa, T. and Ali-Osman, F.}, title = {Glutathione-associated cis-Diamminedichloroplatinum(II) Metabolism and ATP-dependent Efflux from Leukemia Cells: Molecular Characterization of Glutathione-Platinum Complex and Its Biological Significance.}, journal = {J. Biol. Chem.}, year = 1993, } @article{CTT100443185, author = {Bruing, A. and Ishikawa, T. and Kneusel, R.E. and Matern, U. and Lottspeich, F. and Wieland, F.}, title = {Brefeldin A Binds to Glutathione S-Transferase and Is Secreted as Glutathione and Cysteine Conjugates by Chinese Hamster Ovary Cells.}, journal = {J. Biol. Chem.}, year = 1992, } @article{CTT100443184, author = {Ishikawa, T.}, title = {The ATP-dependent Glutathione S-Conjugate Export Pump: Its Role in Detoxification, Signal Transmission, and Cell Growth Regulation.}, journal = {Trends Biochem. Sci.}, year = 1992, } @article{CTT100443186, author = {Muler, M. and Ishikawa, T. and Berger, U. and Kluemann, C. and Lucka, L. and Schreyer, A. and Reutter, W. and Kurz, G. and Keppler, D.}, title = {ATP-dependent Transport of Taurocholate across Hepatocyte Canalicular Membrane Mediated by a 110 kDa Glycoprotein Binding ATP and Bile Salt.}, journal = {J. Biol. Chem.}, year = 1991, } @article{CTT100443187, author = {Schaub, T. and Ishikawa, T. and Keppler, D.}, title = {ATP-dependent Leukotriene Export from Mastocytoma Cells.}, journal = {FEBS Lett.}, year = 1991, } @article{CTT100443188, author = {Ishikawa, T. and Muler, M. and Kluemann, C. and Schaub, T. and Keppler, D.}, title = {Primary Active Transport of Cysteinyl Leukotrienes across Rat Liver Canalicular Membrane: The Role of Glutathione S-Conjugate Carrier.}, journal = {J. Biol. Chem.}, year = 1990, } @article{CTT100443189, author = {Ishikawa, T.}, title = {Is the Glutathione S-Conjugate Carrier an mdr1 Gene Product?}, journal = {Trends in Biochem. Sci.}, year = 1990, } @article{CTT100444499, author = {石川智久}, title = {ATP依存性ロイコトリエンC4 の輸送}, journal = {生化学}, year = 1990, } @article{CTT100444402, author = {Ishikawa, T. and Sies, H. }, title = {Glutathione as an Antioxidant: Toxicological Aspects. }, journal = {Dolphin, D., Poulson, R. and Avramovic, O. (eds.) Coenzyme and Cofactors, John Wiley Publication, New York.}, year = 1989, } @article{CTT100443192, author = {Ishikawa, T.}, title = {ATP/Mg2+-dependent Cardiac Transport System for Glutathione S-Conjugates: A Study using Rat Heart Sarcolemma Vesicles.}, journal = {J. Biol. Chem.}, year = 1989, } @article{CTT100444404, author = {Kinoshita, N. and Tada, Y. and Arai, K. and Matsuda, Y. and Ishikawa, T. and Taniguchi, N. }, title = {Glycated Cu,Zn-Superoxide Dismutase in Streptozotocin-induced Diabetic Rats.}, journal = {Hayaishi, O., Niki, E., Kondo, M. and Yoshikawa, T. (eds.) Medical, Biochemical and Chemical Aspects of Free Radicals, Elsevier, Amsterdam.}, year = 1989, } @article{CTT100444403, author = {Matsuda Y. and Ishikawa, T. and Higashiyama, S. and Sugiyama, T. and Taniguchi, N. }, title = {An Acidic Variant Form of Mn-Superoxide Dismutase in Human Hepatocellular Carcinoma. }, journal = {Hayaishi, O., Niki, E., Kondo, M. and Yoshikawa, T. (eds.) Medical, Biochemical and Chemical Aspects of Free Radicals, Elsevier, Amsterdam.}, year = 1989, } @article{CTT100443190, author = {Ishikawa, T. and Kobayashi, K. and Sogame, Y. and Hayashi, K.}, title = {Evidence for Leukotriene C4 Transport Mediated by an ATP-dependent Glutathione S-Conjugate Carrier in Rat Heart and Liver Plasma Membranes.}, journal = {FEBS Lett.}, year = 1989, } @article{CTT100443191, author = {Ishikawa, T.}, title = {Leukotriene C4 Inhibits ATP-dependent Transport of Glutathione S-Conjugate across Rat Heart Sarcolemma: Implication for Leukotriene C4 Translocation Mediated by Glutathione S-Conjugate Carrier.}, journal = {FEBS Lett.}, year = 1989, } @article{CTT100444498, author = {石川智久 and 松田幸彦 }, title = {グルタチオンの輸送}, journal = {蛋白質 核酸 酵素}, year = 1988, } @article{CTT100444405, author = {Ishikawa, T. }, title = {Cardiac Defense System Associated with Glutathione. }, journal = {L'Abbate, A. and Ursini, F. (eds.) The Role of Oxygen Radicals in Cardiovascular Diseases, Kluwer Academic Publishers, Dordrecht.}, year = 1988, } @article{CTT100443193, author = {Dutta, C. and Muler, A. and Ishikawa, T. and Zimmer, M. and Sies, H.}, title = {Alkane Production by Isolated Rat Heart and Lung.}, journal = {Toxicology Letters}, year = 1988, } @article{CTT100506658, author = {Ishikawa, T. }, title = {Cardiac Defense Mechanisms Against Oxidative Damage: The Role of Superoxide Dismutase and Glutathione-related Enzymes. }, journal = {Singal, P.K. (ed.) Free Radicals in the Pathophysiology and Heart Disease, Kluwer Academic Publishers, Boston. }, year = 1988, } @article{CTT100443424, author = {Ishikawa, T. and Hunaiti, A.R. and Piechot, G. and Wolf, B.}, title = {Isolation and Characterization of Basic Superoxide Dismutase Consisting of Mr 25,000 Subunits in Rat Liver.}, journal = {Eur. J. Biochem.}, year = 1987, } @article{CTT100444418, author = {Ishikawa, T. }, title = {The Role of Cardiac Glutathione S-Transferases and Energy-linked Transport System for Glutathione S-Conjugates. }, journal = {Mantle, T.J., Pickett, C.B. and Hayes, J.D. (eds.) Glutathione S-transferases and Carcinogenesis, Taylor & Francis, London.}, year = 1987, } @article{CTT100444419, author = {Sies, H. and Akerboom, T.P.M. and Ishikawa, T. and Cadenas, E. and Graf, P. and Gabriel, H. and Muller, A. }, title = {Hepatic and Cardiac Hydroperoxide Metabolism: Role of Selenium. }, journal = {Comb, Jr., G.F., Spallholz, J.E., Levander, O.A., Oldfried, J.E. (eds.) Selenium in Biology and Medicine, Van Nostrand Reinhold Company Inc., New York.}, year = 1987, } @article{CTT100443425, author = {Ishikawa, T. and Hunaiti, A.R. and Piechot, G. and Wolf, B. }, title = {Isolation and Characterization of Basic Superoxide Dismutase Consisting of Mr 25,000 Subunits in Rat Liver. }, journal = {Eur. J. Biochem.}, year = 1987, } @article{CTT100443423, author = {Taniguchi, N. and Kondo, T. and Ishikawa, T.}, title = {Transport and Metabolism of Glutathione.}, journal = {Membrane}, year = 1987, } @article{CTT100444420, author = {Ishikawa, T.}, title = {Die Freisetzung von Glutathiondisulfid im Herzen: Ein hoch-Spezifischer Indikator fur die Beurteilung einer H2O2-Bildung in Herzzellen und der zugrundliegende Mechanismus.}, journal = {Elstner,E.F., Bors, W. und Wilmann, W. (eds.) Reactive Sauerstoffspezies in der Medizin, Springer-Verlag, Berlin.}, year = 1986, } @article{CTT100506659, author = {Ishikawa, T. and Akerboom, T.P.M. and Sies, H. }, title = {Role of Key Defense Systems in Target Organ Toxicity.}, journal = { Cohen, G.M. (ed.) Target Organ Toxicity, CRC Press, London. }, year = 1986, } @article{CTT100443428, author = {Ishikawa, T. and Milbert, U. and Oesch, F. and Sies, H.}, title = {The Major Isozyme of Rat Cardiac Glutathione Transferases: Its Correspondence to Hepatic Transferase X.}, journal = {Eur. J. Biochem.}, year = 1986, } @article{CTT100443426, author = {Ishikawa, T. and Zimmer, M. and Sies, H. }, title = {Energy-linked Cardiac Transport System for Glutathione Disulfide. }, journal = {FEBS Lett.}, year = 1986, } @article{CTT100444421, author = {Leibfritz, D. and Offermann, W. and Kuhn, W. and Ishikawa and T. Wolf, K.U. and Becker, J. }, title = {P-31-NMR Studies on Perfused Rat Organs (Heart, Diaphram, Gaster) and on Human Erythrocytes. }, journal = {Govil, Khetrapal and Saran (eds.) Magnetic Resonance in Biology and Medicine, Tata McGraw-Hill, New Delhi.}, year = 1985, } @article{CTT100443487, author = {Ishikawa, T. and Tamura, M. and Nakamura, S. and Ikeda, M. and Nagai, K. }, title = {Topographic Analysis of the Redox State of Rat Brain by NADH Fluorescence Photography of Cross Section. }, journal = {J. Biochem.}, year = 1984, } @article{CTT100443486, author = {Ishikawa, T. and Sies, H. }, title = {Cardiac Transport of Glutathione Disulfide and S-Conjugate: Studies with Isolated Perfused Rat Heart during Hydroperoxide Metabolism. }, journal = {J. Biol. Chem.}, year = 1984, } @article{CTT100443429, author = {Ishikawa, T. and Sies, H. }, title = {The Isozyme Pattern of Glutathione S-Transferases in Rat Heart. }, journal = {FEBS Lett.}, year = 1984, } @article{CTT100443557, author = {Tamura, M. and Ishikawa, T. and Tsubota, S. and Yamazaki, I. }, title = {Flash Photolysis Studies in Heterogeneous Systems. }, journal = {Sha'affi, R.I. and Fernandes, S.M. (eds.) Fast Methods in Physical Biochemistry and Cell Biology, Elsevier, Boston.}, year = 1983, } @article{CTT100443488, author = {Tsubota, S. and Ishikawa, T. and Tamura, M. and Yamazaki, I.}, title = {The Reaction of Carbon Monoxide with Myoglobin in Solution, in an Amorphous State and in Crystals.}, journal = {J. Biochem.}, year = 1983, } @article{CTT100443489, author = {Tamura, M. and Araki, R. and Ishikawa, T. and Sagisaka, K. and Yamazaki, I. }, title = {Direct Observation of Reduction of Met- and Ferrylmyoglobins in the Hemoglobin-free Perfused Rat Heart. }, journal = {J. Biochem.}, year = 1980, } @article{CTT100443490, author = {Ishikawa, T. }, title = {Topographic Analysis of the Redox Level on the Cross Section of Rat Brain by NADH Fluorescence Photography. }, journal = {Bulletin of the Research Institute of Applied Electricity }, year = 1980, } @article{CTT100444497, author = {石川智久 and 山崎勇夫}, title = {振動する化学反応:均一系および不均一系における。}, journal = {化学と工業}, year = 1980, } @article{CTT100443491, author = {Ishikawa, T. and Tamura, M. and Yamazaki, I.}, title = {A Kinetic Study on the Diffusion-coupled Reaction of a Basic Horseradish Peroxidase Adsorbed on the Carboxymethylcellulose Membrane.}, journal = {J. Biol. Chem.}, year = 1980, } @article{CTT100443558, author = {Yamazaki, I. and Ishikawa, T. and Nakamura, M. and Yokota, K. and Nakamura, S. }, title = {Metabolic Oscillations in Homogeneous and Heterogeneous Systems.}, journal = {Suda, M., Hayaishi, O. and Nakagawa, H. (eds.) Biological Rhythms and their Central Mechanism, Tokyo; Elsevier North-Holland Biochemical Ress.}, year = 1979, } @inproceedings{CTT100559381, author = {Toshihisa Ishikawa}, title = {Ubiquitin-mediated proteasomal degradation of non-synonymous SNP variants of human ABC transporter ABCG2}, booktitle = {Biochemical J.}, year = 2008, } @inproceedings{CTT100559384, author = {石川智久}, title = {Intramolecular disulfide bond is a critical checkpoint determining degradative fates of ABC transporter ABCG2 protein.}, booktitle = {J. Biol. Chem.}, year = 2007, } @misc{CTT100395614, author = {石川智久}, title = {展望 日本薬物動態学会賞を受賞して 薬物トランスポーター研究の23年間-波乱万丈の人生遍歴と孤独な挑戦-}, year = 2005, } @misc{CTT100395611, author = {石川智久}, title = {ヒトABCトランスポーターの遺伝子多型と薬物相互作用の解析:メンブレンを用いた高速スクリーニングシステムの開発}, year = 2005, } @misc{CTT100395609, author = {石川智久}, title = {薬物トランスポーターのファーマコゲノミクスと薬物相互作用}, year = 2005, } @misc{CTT100395605, author = {石川智久 and 櫻井亜季 and 大西裕子 and 中川大}, title = {癌の薬剤耐性機構解明から薬物トランスポーター遺伝子多型の臨床診断へ}, year = 2005, } @misc{CTT100405700, author = {石川智久}, title = {遺伝子診療学-遺伝子診断の進歩と遺伝子治療の展望-ファーマコゲノミクス:現状と将来展望}, year = 2005, } @misc{CTT100532111, author = {石川智久}, title = {OPINION 国立大学の常識は、社会の非常識!?}, year = 2006, } @misc{CTT100594350, author = {Toshihisa Ishikawa}, title = {Kinetic studies on immobilized horseradish peroxidase in vitro and myoglobin in vivo.}, year = 1982, } @misc{CTT100573091, author = {石川智久 and 中川大 and 渡邊 正人 and 齊藤 光}, title = {ABCタンパク質が輸送する基質のスクリーニング方法、及びABCタンパク質の輸送活性の測定法}, howpublished = {公開特許}, year = 2007, month = {}, note = {特願2005-353801(2005/12/07), 特開2007-151493(2007/06/21)} } @misc{CTT100573365, author = {石川智久 and 山田英彦 and 山本博保}, title = {薬物のスクリーニング方法}, howpublished = {公開特許}, year = 2007, month = {}, note = {特願2005-306956(2005/10/21), 特開2007-114091(2007/05/10)} } @misc{CTT100572851, author = {石川智久 and 櫻井 亜季 and 田村 藍}, title = {遺伝子多型の検出方法および薬物のスクリーニング方法}, howpublished = {公開特許}, year = 2007, month = {}, note = {特願2005-250084(2005/08/30), 特開2007-060967(2007/03/15)} } @phdthesis{CTT100594350, author = {Toshihisa Ishikawa}, title = {Kinetic studies on immobilized horseradish peroxidase in vitro and myoglobin in vivo.}, school = {北海道大学}, year = 1982, }