@article{CTT100782291, author = {Kimura A. and Kitajima, M. and Nishida, K. and Serada, S. and Fujimoto, M. and Naka, T. and Fujii-Kuriyama, Y. and Satoshi Sakamoto and Takumi Ito and HIROSHI HANDA and Tanaka, T. and Yoshimura, A and Suzuki, H.}, title = {NQO1 inhibits TLR-dependent production of selective cytokines by promoting PDLIM2-mediated degradation of IkB-z}, journal = {J. Exp. Med.}, year = 2018, } @article{CTT100779857, author = {Tomoyuki Mori and Takumi Ito and Shujie Liu and Hideki Ando and Satoshi Sakamoto and Yuki Yamaguchi and Etsuko Tokunaga and Norio Shibata and Hiroshi Handa}, title = {Structural basis of thalidomide enantiomer binding to cereblon}, journal = {Scientific Reports}, year = 2018, } @article{CTT100691780, author = {Kentaro Hotta and Akihiro Nashimoto and Eiji Yasumura and Masafumi Suzuki and Motoki Azuma and Yosuke Iizumi and Daisuke Shima and Ryusuke Nabeshima and Masaki Hiramoto and Akira Okada and Kumiko Sakata-Sogawa and Makio Tokunaga and Takumi Ito and Hideki Ando and Satoshi Sakamoto and Yasuaki Kabe and Shinichi Aizawa and Takeshi Imai and Yuki Yamaguchi and Hajime Watanabe and Hiroshi Handa}, title = {Vesnarinone suppresses TNFα mRNA expression by inhibiting valosin-containing protein}, journal = {Mol. Pharmacol.}, year = 2013, } @article{CTT100748892, author = {Yuki Ito and Takumi Ito and Satoki Karasawa and Teruya Enomoto and Nashimoto, Akihiro and Hase, Yasuyoshi and Sakamoto, Satoshi and Mimori, Tsuneyo and Yoshihisa Matsumoto and Yuki Yamaguchi and HIROSHI HANDA}, title = {Identification of DNA-Dependent Protein Kinase Catalytic Subunit (DNA-PKcs) as a Novel Target of Bisphenol A}, journal = {Plos One}, year = 2012, } @article{CTT100691791, author = {Satoshi Sakamoto and Mamoru Hatakeyama and Takumi Ito and Hiroshi Handa}, title = {Tools and methodologies capable of isolating and identifying a target molecule for a bioactive compound}, journal = {Bioorganic & Medicinal Chemistry}, year = 2012, } @article{CTT100691789, author = {HIROSHI HANDA and Takumi Ito}, title = {Deciphering the mystery of thalidomide teratogenicity}, journal = {Congenital Anomalies}, year = 2012, } @article{CTT100691805, author = {Naoya Maekawa and Masaki Hiramoto and Satoshi Sakamoto and Motoki Azuma and Takumi Ito and Marie Ikeda and Michitaka Naitou and Hukum P. Acharya and Yuichi Kobayashi and Makoto Suematsu and Hiroshi Handa and Takeshi Imai}, title = {High-performance affinity purification for identification of 15-deoxy-Δ12,14-PGJ2 interacting factors using magnetic nanobeads}, journal = {Biomedical Chromatography}, year = 2011, } @article{CTT100691801, author = {Miho Aizawa and Yuichi Abe and Takumi Ito and Hiroshi Handa and Hiroyuki Nawa}, title = {mRNA distribution of the thalidomide binding protein cereblon in adult mouse brain}, journal = {Neuroscience Research}, year = 2011, } @article{CTT100691799, author = {Takumi Ito and Hideki Ando and Hiroshi Handa}, title = {Teratogenic effects of thalidomide: molecular mechanisms}, journal = {Cellular and Molecular Life Sciences}, year = 2011, } @article{CTT100614753, author = {Takumi Ito and Hideki Ando and Takayuki Suzuki and Toshihiko Ogura and Kentaro Hotta and Yoshimasa Imamura and Yuki Yamaguchi and Hiroshi Handa}, title = {Identification of a primary target of thalidomide teratogenicity}, journal = {Science}, year = 2010, } @inproceedings{CTT100779844, author = {坂本 聡 and 伊藤 拓水 and 森 智行 and 安藤 秀樹 and 山口 雄輝 and 箱嶋 敏雄 and 半田 宏}, title = {CRBNに対するサリドマイド光学異性体の結合基盤解析}, booktitle = {}, year = 2016, } @inproceedings{CTT100779846, author = {伊藤 拓水 and 朝妻 知子 and 山本 淳一 and 安藤 秀樹 and 佐藤 智美 and 山口 雄輝 and 半田 宏}, title = {リガンド依存的ユビキチンリガーゼCRBNの制御機構}, booktitle = {}, year = 2016, } @inproceedings{CTT100777831, author = {Satoshi Sakamoto and Yuki Yamaguchi and Takumi Ito and Hiroshi Handa}, title = {Elucidation of the molecular mechanisms of action of bioactive natural products using high performance affinity beads}, booktitle = {}, year = 2015, } @inproceedings{CTT100777832, author = {Satoshi Sakamoto and Takumi Ito and Yuki Yamaguchi and Hideki Ando and Hiroshi Handa}, title = {Biochemical analyses of CRBN, the target protein for immunomodulatory drugs (IMiDs)}, booktitle = {}, year = 2015, } @inproceedings{CTT100777828, author = {坂本 聡 and 伊藤 拓水 and 安藤 秀樹 and 山口 雄輝 and 半田 宏}, title = {IMiDs標的タンパク質CRBNの生化学的解析}, booktitle = {}, year = 2015, } @inproceedings{CTT100799917, author = {飯田 結 and 伊藤 拓水 and 安藤 秀樹 and 山口 雄輝 and 半田 宏}, title = {サリドマイドターゲット分子CRBN の生化学的解析}, booktitle = {}, year = 2013, } @inproceedings{CTT100799919, author = {舩造 正英 and 伊藤 拓水 and 安藤 秀樹 and 山口 雄輝 and 半田 宏}, title = {多発性骨髄腫におけるCRBN 結合因子の探索及び解析}, booktitle = {}, year = 2013, } @misc{CTT100658248, author = {半田宏 and 安藤秀樹 and 伊藤拓水 and 堀田 健太郎}, title = {サリドマイド標的因子を利用したスクリーニング方法}, howpublished = {登録特許}, year = 2014, month = {}, note = {特願2011-537238(2010/10/18), 特開(再表)2011/049043(2013/03/14), 特許第5660578号(2014/12/12)} } @misc{CTT100649193, author = {半田宏 and 安藤秀樹 and 伊藤拓水 and 堀田 健太郎}, title = {中枢神経細胞の増殖及び分化に係る中核因子を含む医薬組成物}, howpublished = {公開特許}, year = 2012, month = {}, note = {特願2011-516008(2010/05/24), 特開(再表)2010-137547(2012/11/15)} } @misc{CTT100683282, author = {半田宏 and 安藤秀樹 and 伊藤拓水 and 堀田 健太郎}, title = {中枢神経細胞の増殖及び分化に係る中核因子を含む医薬組成物}, howpublished = {登録特許}, year = 2014, month = {}, note = {特願2011-516008(2010/05/24), 特開2010-137547(2012/11/15), 特許第5645816号(2014/11/14)} }