論文

• Haruka Kono, Satoshi Hara, Tadaomi Furuta, Hiroshi Ichinose. Binding profile of quinonoid-dihydrobiopterin to quinonoid-dihydropteridine reductase examined by in silico and in vitro analyses, J Biochem, vol. 174, no. 5, pp. 441-450, Aug. 2023.
• Yuka Nago-Iwashita, Moriya Y, Hara S, Ogawa R, Aida R, Miyajima K, Shimura T, Muramatsu SI, Ide S, Ikeda K, Ichinose H. Overexpression of tyrosine hydroxylase in dopaminergic neurons increased sensitivity to methamphetamine, Neurochemistry International, Vol. 164, pp. 105491, Apr. 2023.
• Madokoro Y, Kamikokuryo C, Niiyama S, Ito T, Hara S, Ichinose H, Kakihana Y. Early ascorbic acid administration prevents vascular endothelial cell damage in septic mice, Front Pharmacol, Vol. 13, 929448, Oct. 2022.
• Miyajima K, Sudo Y, Sanechika S, Hara Y, Horiguchi M, Xu F, Suzuki M, Hara S, Tanda K, Inoue KI, Takada M, Yoshioka N, Takebayashi H, Mori-Kojima M, Sugimoto M, Sumi-Ichinose C, Kondo K, Takao K, Miyakawa T, Ichinose H.. Perturbation of monoamine metabolism and enhanced fear responses in mice defective in the regeneration of tetrahydrobiopterin, Journal of neurochemistry, Volume 161, Issue 2, Page 129-145, May 2022.
• Hara S, Sanatani T, Tachikawa N, Yoshimura Y, Miyata N, Sasaki H, Kuroda R, Kamikokuryo C, Eguchi T, Niiyama S, Kakihana Y, Ichinose H.. Comparison of the levels of neopterin, CRP, and IL-6 in patients infected with and without SARS-CoV-2., Heliyon, Volume 8, Issue 5, e09371, May 2022.
• Inukai S, Hara S, Ichinose H.. Tyrosine hydroxylase activity is regulated through the modification of the 176th cysteine residue, Biochem Biophys Res Commun., Volume 589, Page 209-214, Jan. 2022.
• Miyajima K, Kawamoto C, Hara S, Mori-Kojima M, Ohye T, Sumi-Ichinose C, Saito N, Sasaoka T, Metzger D, Ichinose H. Tyrosine hydroxylase conditional knockout mice reveal peripheral tissue-dependent differences in dopamine biosynthetic pathways, Vol. 296, Page 100544, May 2021.
• hirokazu arai, rina takahashi, yoshiaki sakamoto, tatsuya kitano, okishi mashita, satoshi hara, satoru yoshikawa, koh kawasaki, hiroshi ichinose. Peripheral tetrahydrobiopterin is involved in the pathogenesis of mechanical hypersensitivity in a rodent postsurgical pain model, Pain, June 2020.
• Zhang L, Hara S, Ichinose H, Nagashima D, Morita K, Sakurai T, Ichihara S, Ichihara G.. Exposure to acrylamide decreases noradrenergic axons in rat brain., NEUROTOXICOLOGY, May 2020.
• Takeshita N, Kawade N, Suzuki W, Hara S, Horio F, Ichinose H. Deficiency of ascorbic acid decreases the contents of tetrahydrobiopterin in the liver and the brain of ODS rats., Neuroscience letters, Jan. 2020.
• Yokochi Y, Sugiura K, Takemura K, Yoshida K, Hara S, Wakabayashi KI, Kitao A, Hisabori T. Impact of key residues within chloroplast thioredoxin-f on recognition for reduction and oxidation of target proteins., J BIOL CHEM, 294, 46, 17437, Nov. 2019.
• Yoshida K, Uchikoshi E, Hara S, Hisabori T.. Thioredoxin-like2/2-Cys peroxiredoxin redox cascade acts as oxidative activator of glucose-6-phosphate dehydrogenase in chloroplasts., Biochemical Journal, Vol. 476, No. 12, pp. 1781-1790, June 2019.  公式リンク  
  
• Kurosaki H, Yamaguchi K, Man-Yoshi K, Muramatsu SI, Hara S, Ichinose H. Administration of tetrahydrobiopterin restored the decline of dopamine in the striatum induced by an acute action of MPTP., Neurochemistry International, Vol. 125, Page 16-24, May 2019.
• Hara S, Fukumura S, Ichinose H. Reversible S-glutathionylation of human 6-pyruvoyl tetrahydropterin synthase protects its enzymatic activity, Journal of Biological Chemistry, Vol. 394, No. 4, Page 1420-1427, Jan. 2019.
• 宮嶋克也, 原怜, 一瀬宏. 葉酸代謝はオリゴデンドロサイトの分化や生存を制御している, Vol. 92, No. 10, p. 464-465, Oct. 2018.
• Murakami Satoshi, Kondo K, Katayama S, Satoshi Hara, sunamura EI, Yamashita E, Groth G, TORU HISABORI. Structure of the γ-ε complex of cyanobacterial F1-ATPase reveals a suppression mechanism of the γ subunit on ATP-hydrolysis in phototrophs, Biochemical Journal, Vol. 475, pp. 2925-2939, Sept. 2018.  公式リンク  
  
• 竹下直輝, 原怜, 一瀬宏. キサンツレン酸はビオプテリン生合成酵素の阻害作用を持つ, ビタミン, Vol. 91, No. 5, 6, p. 361-362, June 2017.
• Seta, Atsushi, Tabara, Midori, Nishibori, Yuki, Hiraguri, Akihiro, Ohkama-Ohtsu, Naoko, Yokoyama, Tadashi, Satoshi Hara, Yoshida, Keisuke, TORU HISABORI, Fukudome, Akihito, Koiwa, Hisashi, Moriyama, Hiromitsu, Takahashi, Nobuhiro, Fukuhara, Toshiyuki. Post-translational regulation of the dicing activities of Arabidopsis DICER-LIKE 3 and 4 by inorganic phosphate and the redox state, Plant and Cell Physiology, Vol. 58, No. 3, pp. 485-495, Mar. 2017.  公式リンク  
  
• Keiko Imamura, Takayuki Kondo, Yasushi Koshiba, Satoshi Hara, Hiroshi Ichinose, Mahoko Furujo, Masako Kinoshita, Tomoko Oeda, Jun Takahashi, Ryosuke Takahashi, Haruhisa Inoue. Genetic and pharmacological correction of aberrant dopamine synthesis using patient iPSCs with BH4 metabolism disorders., Human Molecular Genetics, Vol. 25, No. 23, pp. 5188-5197, Dec. 2016.  公式リンク  
  
• 加藤北都, 原怜, 一瀬宏. パーキンソン病動物モデルにおけるイソチオシアネートの神経保護作用について, ビタミン, vol. 90, No. 7, pp. 350-352, July 2016.
• Yoshida K, Satoshi Hara, Hisabori T. Thioredoxin Selectivity for Thiol-Based Redox Regulation of Target Proteins in Chloroplasts, J Biol Chem., 290, 23, 14278-14288, June 2015.  公式リンク  
  
• Satoshi Hara, Y. Tatenaka, Y. Ohuchi, T. Hisabori. Direct determination of the redox status of cysteine residues in proteins in vivo, Biochem Biophys Res Commun, Vol. 456, pp. 339-43, Jan. 2015.  公式リンク  
  
• 原怜, 久堀徹. タンパク質中のチオール基の酸化還元状態を可視化・定量するDNAマレイミドの開発, 生物物理化学, 58, 2, 83-86, Oct. 2014.
• Keisuke Yoshida, Yuta Matsuoka, Satoshi Hara, Hiroki Konno, Toru Hisabori. Distinct Redox Behaviors of Chloroplast Thiol Enzymes and their Relationships with Photosynthetic Electron Transport in Arabidopsis thaliana., Plant and Cell Physiology, Vol. 55, pp. 1415-1425, May 2014.  公式リンク  
  
• Satoshi Hara, T. Hisabori. Kinetic analysis of the interactions between plant thioredoxin and target proteins, Front Plant Sci, Vol. 4, pp. 508, Dec. 2013.  公式リンク  
  
• Y. Tsukamoto, Y. Fukushima, Satoshi Hara, T. Hisabori. Redox control of the activity of phosphoglycerate kinase in Synechocystis sp. PCC6803., Plant Cell Physiol, Vol. 54, pp. 484-91, Jan. 2013.  公式リンク  
  
• Satoshi Hara, T. Nojima, KOHJI SEIO, MASASUKE YOSHIDA, TORU HISABORI. DNA-maleimide: An improved maleimide compound for electrophoresis-based titration of reactive thiols in a specific protein, Biochimica Et Biophysica Acta-General Subjects, Vol. 1830, pp. 3077-3081, Jan. 2013.  公式リンク  
  
• S. Kikutani, R. Tanaka, Y. Yamazaki, Satoshi Hara, T. Hisabori, P. G. Kroth, Y. Matsuda. Redox regulation of carbonic anhydrases via thioredoxin in the chloroplast of the marine diatom Phaeodactylum tricornutum., J Biol Chem, Vol. 287, pp. 20689-700, June 2012.  公式リンク  
  
• H. Konno, T. Nakane, M. Yoshida, H. Ueoka-Nakanishi, Satoshi Hara, T. Hisabori. Thiol modulation of the chloroplast ATP synthase dependent on the membrane energization of thylakoid membranes., Plant Cell Physiol, Vol. 53, pp. 626-34, Feb. 2012.  公式リンク  
  
• Satoshi Hara, Motohashi K, Arisaka F, Romano PG, Hosoya-Matsuda N, Kikuchi N, Fusada N, Hisabori T. Thioredoxin-h1 reduces and reactivates the oxidized cytosolic malate dehydrogenase dimer in higher plants., Journal of Biological Chemistry, Vol. 281, No. 43, pp. 320065-32071, Oct. 2006.  公式リンク  
  
• Hisabori, T., Satoshi Hara, Fujii, T., Yamazaki, D., Hosoya-Matsuda, N., Motohashi, K.. Thioredoxin affinity chromatography: a useful method for further understanding the thioredoxin network., Journal of Experimental Botany, Vol. 56, No. 416, pp. 1463,1468, June 2005.

著書

• 原怜, 久堀徹. 植物におけるチオレドキシンを介したタンパク質のレドックス制御, 化学工業, Vol. 69, No. 11, p. 32-36, Nov. 2018.

国内会議発表 (査読有り)

• Haruka Kono, Satoshi Hara, Tadaomi Furuta, Hiroshi Ichinose. Analysis of the binding profile of quinonoid-form of dihydropteridine to quinonoid-dihydropteridine reductase, CBI Annual Meeting 2023, Oct. 2023.

国内会議発表 (査読なし・不明)

• 河野はるか, 原怜, 古田忠臣, 一瀬宏. 葉酸代謝とビオプテリン代謝の接点, 第472回ビタミンB研究協議会, Sept. 2023.
• 河野はるか, 原怜, 古田忠臣, 一瀬宏. 分子シミュレーションによるキノノイドジヒドロプテリジン還元酵素の基質認識機構の解析, 2019年度日本生化学会関東支部例会, June 2019.
• 河野はるか, 古田忠臣, 原怜, 一瀬宏. キノノイドジヒドロプテリジン還元酵素の基質認識機構の解析, 日本ビタミン学会第71回大会, June 2019.

特許など

• 一瀬宏, 原怜, 吉田　勇輝, 村松　慎一, 加藤　節子. ＳＰＲをコードするポリヌクレオチドを含む組み換えベクター、及びそれを含む組成物. 特許. 公開. 国立大学法人東京工業大学, 学校法人自治医科大学, 加藤　節子. 2018/11/01. 特願2018-206643. 2020/05/07. 特開2020-068734. 2020.
• 久堀徹, 原怜, 野島達也. タンパク質のチオール基の酸化還元状態を検出する方法、並びにそれに用いられる試薬及びキット . 特許. 登録. 国立大学法人東京工業大学, 株式会社同仁化学研究所. 2013/08/09. 特願2013-166448. 2014/05/08. 特開2014-081360. 特許第6146742号. 2017/05/26 2017.

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