@book{CTT100827137, author = {武元宏泰}, title = {抗体とDDS}, publisher = {丸善出版}, year = 2019, } @book{CTT100827138, author = {武元宏泰}, title = {バイオシグナルに応答する高分子の設計と薬物送達キャリアへの展開}, publisher = {丸善出版}, year = 2019, } @book{CTT100720812, author = {武元宏泰 and 西山伸宏}, title = {ジブロックコポリマーを基盤とする高分子ミセル型制がん剤送達キャリア}, publisher = {}, year = 2015, } @book{CTT100720814, author = {武元宏泰 and 西山伸宏 and 片岡一則}, title = {凍結濃縮現象によるClick反応加速}, publisher = {}, year = 2014, } @book{CTT100720783, author = {Nobuhiro Nishiyama and Hiroyasu Takemoto}, title = {Polymeric Micelles}, publisher = {}, year = 2014, } @book{CTT100720778, author = {Hiroyasu Takemoto and Kanjiro Miyata and Nobuhiro Nishiyama and Kazunori Kataoka}, title = {Bioresponsive Polymer-Based Nucleic Acid Carriers}, publisher = {}, year = 2014, } @book{CTT100720815, author = {武元宏泰 and 宮田完二郎}, title = {生体内還元環境とそれに応答する薬剤キャリア設計}, publisher = {}, year = 2013, } @article{CTT100920585, author = {Keitaro Homma and Y. Miura* and M. Kobayashi and W. Chintrakulchai and M. Toyoda and K. Ogi and J. Michinishi and T. Ohtake and Y. Honda and T. Nomoto and H. Takemoto and N. Nishiyama}, title = {Fine tuning of the net charge alternation of polyzwitterion surfaced lipid nanoparticles to enhance cellular uptake and membrane fusion potential}, journal = {Sci. Technol. Adv. Mater.}, year = 2024, } @article{CTT100920580, author = {Xin Shen and A. Dirisala and M. Toyoda and Yao Xiao and H. Guo and Y. Honda and T. Nomoto and H. Takemoto and Y. Miura and N. Nishiyama}, title = {pH-Responsive polyzwitterion covered nanocarriers for DNA delivery}, journal = {J. Control. Release}, year = 2023, } @article{CTT100900226, author = {Haochen Guo and Xu Wen and Takahiro Nomoto and Kaito Kanamori and Yan Ming Voon and Yuto Honda and Naoki Yamada and Hiroyasu Takemoto and Makoto Matsui and Nobuhiro Nishiyama}, title = {Polymeric ligands comprising sulfur-containing amino acids for targeting tumor-associated amino acid transporters.}, journal = {Biomaterials}, year = 2023, } @article{CTT100900205, author = {Yijung Sung and Haochen Guo and Aria Ghasemizadeh and Xin Shen and Wanphiwat Chintrakulchai and Motoaki Kobayashi and Masahiro Toyoda and Koichi Ogi and Junya Michinishi and Tokoyuki Ohtake and Makoto Matsui and Yuto Honda and Takahiro Nomoto and Hiroyasu Takemoto and Yutaka Miura and Nobuhiro Nishiyama}, title = {Cancerous pH-responsive polycarboxybetaine-coated lipid nanoparticle for smart delivery of siRNA against subcutaneous tumor model}, journal = {Cancer Science}, year = 2022, } @article{CTT100900217, author = {Yuto Honda and Sayaka Onodera and Hiroyasu Takemoto and Faizah Noor and Takahiro Nomoto and Makoto Matsui and Keishiro Tomoda and Yudi Sun and Yutaka Miura and Nobuhiro Nishiyama}, title = {Thermo-responsive polymer-siRNA conjugates enabling artificial control of gene silencing around body temperature}, journal = {Pharmaceutical Research}, year = 2022, } @article{CTT100876895, author = {Aziz Awaad and Hiroyasu Takemoto and Muneaki Iizuka and Koichi Ogi and Yuki Mochida and Abdul-Hackam Ranneh and Masahiro Toyoda and Makoto Matsui and Takahiro Nomoto and Yuto Honda and Kotaro Hayashi and Keishiro Tomoda and Tomoyuki Ohtake and Yutaka Miura and Nobuhiro Nishiyama}, title = {Changeable net charge on nanoparticles facilitates intratumor accumulation and penetration}, journal = {Journal of Controlled Release}, year = 2022, } @article{CTT100863940, author = {Yuto Honda* and Takahiro Nomoto and Makoto Matsui and Hiroyasu Takemoto and Yutaka Miura and Nobuhiro Nishiyama*}, title = {Sequentially Self-Assembled Nanoreactor Comprising Tannic Acid and Phenylboronic Acid-Conjugated Polymers Inducing Tumor-Selective Enzymatic Activity}, journal = {ACS Applied Materials and Interfaces}, year = 2021, } @article{CTT100863939, author = {Yuto Honda* and Takahiro Nomoto and Hiroyasu Takemoto and Makoto Matsui and Kaori Taniwaki and Haochen Guo and Yutaka Miura and Nobuhiro Nishiyama*}, title = {Systemically Applicable Glutamine-Functionalized Polymer Exerting Multivalent Interaction with Tumors Overexpressing ASCT2.}, journal = {ACS Applied Bio Materials}, year = 2021, } @article{CTT100853182, author = {Takahiro Nomoto and Ying Yao and Yukiya Inoue and Minoru Suzuki and Kaito Kanamori and Hiroyasu Takemoto and Makoto Matsui and Keishiro Tomoda and Nobuhiro Nishiyama}, title = {Fructose-functionalized polymers to enhance therapeutic potential of p-boronophenylalanine for neutron capture therapy}, journal = {Journal of Controlled Release}, year = 2021, } @article{CTT100853184, author = {Komoto Kana and Takahiro Nomoto and Muttaqien S. and Takemoto Hiroyasu and Matsui Makoto and Miura Yutaka and Nishiyama Nobuhiro}, title = {Iron chelation cancer therapy using hydrophilic block copolymers conjugated with deferoxamine}, journal = {Cancer Science}, year = 2021, } @article{CTT100835412, author = {S Muttaqien and Takahiro Nomoto and Xuebo Dou and Hiroyasu Takemoto and Makoto Matsui and Nobuhiro Nishiyama}, title = {Photodynamic therapy using LCST polymers exerting pH-responsive isothermal phase transition}, journal = {Journal of Controlled Release}, year = 2020, } @article{CTT100835413, author = {Xiaohang Sun and Takahiro Nomoto and Hiroyasu Takemoto and Makoto Matsui and Haochen Guo and Yudi Sun and Yutaka Miura and Nobuhiro Nishiyama}, title = {Potential urinary monitoring of the enhanced permeability and retention effect using MMP-2-responsive poly(ethylene glycol) derivatives}, journal = {Journal of Controlled Release}, year = 2020, } @article{CTT100835414, author = {Yuto Honda and Takahiro Nomoto and Makoto Matsui and Hiroyasu Takemoto and Yuka Kaihara and Yutaka Miura and Nobuhiro Nishiyama}, title = {Sequential Self-Assembly Using Tannic Acid and Phenylboronic Acid-Modified Copolymers for Potential Protein Delivery}, journal = {Biomacromolecules}, year = 2020, } @article{CTT100836394, author = {Takahiro Nomoto and Yukiya Inoue and Ying Yao and M Suzuki and Kaito Kanamori and Hiroyasu Takemoto and Makoto Matsui and Keishiro Tomoda and Nobuhiro Nishiyama}, title = {Poly(vinyl alcohol) boosting therapeutic potential of p-boronophenylalanine in neutron capture therapy by modulating metabolism}, journal = {Science Advances}, year = 2020, } @article{CTT100827009, author = {Hiroyasu Takemoto and Takanori Inaba and Takahiro Nomoto and Makoto Matsui and Gyomon Ryu and Masahiro Toyoda and Yuto Honda and Kaori Taniwaki and Naoki Yamada and Junhyun Kim and Keishiro Tomoda and Nobuhiro Nishiyama}, title = {Polymeric modification of gemcitabine via cyclic acetal linkage for enhanced anticancer potency with negligible side effects}, journal = {Biomaterials}, year = 2020, } @article{CTT100813287, author = {Hiroyasu Takemoto and Wang, Chih-Ling and Takahiro Nomoto and Matsui, Makoto and Tomoda, Keishiro and Nobuhiro Nishiyama}, title = {Pyruvate responsiveness based on α-oxohydrazone formation for intracellular siRNA release from polyion complex-based carriers}, journal = {Biomacromolecules}, year = 2019, } @article{CTT100813276, author = {Watanabe, Sumiyo and Hayashi, Kotaro and Toh, Kazuko and Kim Hyun Jin and Liu, Xueying and Chaya, Hiroyuki and Fukushima, Shigeto and Katsushima, Keisuke and Kondo, Yutaka and Uchida, Satoshi and Ogura, Satomi and Takahiro Nomoto and Hiroyasu Takemoto and Cabral, Horacio and Kinoh, Hiroaki and Tanaka, Hiroyoshi and Kano, Mitsunobu and Matsumoto, Yu and Fukuhama, Hiroshi and Uchida, Shyunya and Nagaku, Masaomi and Osada, Kensuke and Nobuhiro Nishiyama and Miyata, Kanjiro and Kataoka, Kazunori}, title = {In vivo rendezvous of small nucleic acid drugs with charge-matched block catiomers to target cancers}, journal = {Nature Communications}, year = 2019, } @article{CTT100836396, author = {Muttaqien and Takahiro Nomoto and Hiroyasu Takemoto and Makoto Matsui and Keishiro Tomoda and Nobuhiro Nishiyama}, title = {Poly(N-isopropylacrylamide)-based polymer inducing isothermal hydrophilic-to-hydrophobic phase transition via detachment of hydrophilic acid-labile moiety}, journal = {BIOMACROMOLECULES}, year = 2018, } @article{CTT100773954, author = {R. Toshiyama R and M. Konno and H. Eguchi and H. Takemoto and T. Noda and A. Asai and J. Koseki and N. Haraguchi and Y. Ueda and K. Matsushita and K. Asukai and T. Ohashi and Y. Iwagami and D. Yamada and D. Sakai and T. Asaoka and T. Kudo and K. Kawamoto and K. Gotoh and S. Kobayashi and T. Satoh and Y. Doki and N. Nishiyama and M. Mori and H. Ishii}, title = {Poly(ethylene glycol)-poly(lysine) block copolymer-ubenimex conjugate targets aminopeptidase N and exerts an antitumor effect in hepatocellular carcinoma stem cells}, journal = {Oncogene}, year = 2018, } @article{CTT100773952, author = {X. Dou and T. Nomoto and H. Takemoto and M. Matsui and K. Tomoda and N. Nishiyama}, title = {Effect of multiple cyclic RGD peptides on tumor accumulation and intratumoral distribution of IRDye 700DX-conjugated polymers}, journal = {Scientific Reports}, year = 2018, } @article{CTT100773951, author = {A.-H. Ranneh and H. Takemoto and S. Sakuma and A. Awaad and T. Nomoto and Y. Mochida and M. Matsui and K. Tomoda and M. Naito and N. Nishiyama}, title = {An ethylenediamine-based switch to control the polyzwitterion charge at tumorous pH for effective tumor accumulation of coated nanomaterials}, journal = {Angewandte Chemie International Edition}, year = 2018, } @article{CTT100773956, author = {H. Takemoto and N. Nishiyama}, title = {Functional polymer-based siRNA delivery carrier that recognizes site- specific biosignals}, journal = {Journal of Controlled Release}, year = 2017, } @article{CTT100811952, author = {N. Yamada and Y. Honda and H. Takemoto and T. Nomoto and M. Matsui and K. Tomoda and M. Konno and H. Ishii and M. Mori and N. Nishiyama}, title = {Engineering tumour cell-binding synthetic polymers with sensing dense transporters associated with aberrant glutamine metabolism}, journal = {Scientific Reports}, year = 2017, } @article{CTT100752056, author = {Mitsuru Naito and Ryota Azuma and Hiroyasu Takemoto and Mao Hori and Naoto Yoshinaga and Shigehito Osawa and Rimpei Kamegawa and Hyun Jin Kim and Takehiko Ishii and Nobuhiro Nishiyama and Kanjiro Miyata and Kazunori}, title = {Multilayered Polyion Complexes with Dissolvable Silica Layer Covered by Controlling Densities of cRGD-conjugated PEG Chains for Cancer-targeted siRNA Delivery}, journal = {Journal of Biomaterials Science, Polymer Edition}, year = 2017, } @article{CTT100752051, author = {Shigehito Osawa and Takehiko Ishii and Hiroyasu Takemoto and Kensuke Osada and Kazunori Kataoka}, title = {A facile amino-functionalization of poly(2-oxazoline)s’ distal end through sequential azido end-capping and Staudinger reactions}, journal = {European Polymer Journal}, year = 2017, } @article{CTT100752048, author = {Chih-Hao Huang and Hiroyasu Takemoto and Takahiro Nomoto and Keishiro Tomoda and Makoto Matsui and Nobuhiro Nishiyama}, title = {Utility of 2-Nitrobenzenesulfonamide Group as a Chemical Linker for Enhanced Extracellular Stability and Cytosolic Cleavage in siRNA-conjugated Polymer System}, journal = {ChemMedChem}, year = 2017, } @article{CTT100720807, author = {Yi Yu and Hyun Jin Kim and Peng Mi and Meng Zheng and Hiroyasu Takemoto and Kazuko Toh and Kim Beob Soo and Kotaro Hayashi and Mitsuru Naito and Yu Matsumoto and Kanjiro Miyata and Kazunori Kataoka}, title = {Targeted systemic delivery of siRNA to cervical cancer model using cyclic RGD-installed unimer polyion complex-assembled gold nanoparticles.}, journal = {Journal of Controlled Release}, year = 2016, } @article{CTT100714121, author = {Faizah Noor and Hiroyasu Takemoto and Takahiro Nomoto and Keishiro Tomoda and Makoto Matsui and Nobuhiro Nishiyama}, title = {Artificial Control of Gene Silencing Activity Based on siRNA Conjugation with Polymeric Molecule Having Coil–Globule Transition Behavior}, journal = {Bioconjugate Chemistry}, year = 2016, } @article{CTT100720773, author = {Kotaro Hayashi and Hiroyuki Chaya and Shigeto Fukushima and Sumiyo Watanabe and Hiroyasu Takemoto and Kensuke Osada and Nobuhiro Nishiyama and Kanjiro Miyata and Kazunori Kataoka}, title = {Influence of RNA Strand Rigidity on Polyion Complex Formation with Block Catiomers}, journal = {Macromolecular Rapid Communications}, year = 2016, } @article{CTT100720774, author = {Kotaro Hayashi and Hiroyuki Chaya and Shigeto Fukushima and Sumiyo Watanabe and Hiroyasu Takemoto and Kensuke Osada and Nobuhiro Nishiyama and Kanjiro Miyata and Kazunori Kataoka}, title = {Macromol. Rapid Commun. 6/2016.}, journal = {Macromolecular rapid communications}, year = 2016, } @article{CTT100720776, author = {Meng Zheng and Hyun Jin Kim and Hiroyasu Takemoto and Kanjiro Miyata and Kazunori Kataoka}, title = {Precisely regulated nanoarchitecture comprised of gold nanotemplate and unimer polyion complex for systemic delivery of siRNA}, journal = {Journal of Controlled Release}, year = 2015, } @article{CTT100720777, author = {Hui Gao and Hiroyasu Takemoto and Qixian Chen and Mitsuru Naito and Hirokuni Uchida and Xueying Liu and Kanjiro Miyata and Kazunori Kataoka}, title = {Regulated protonation of polyaspartamide derivatives bearing repeated aminoethylene side chains for efficient intracellular siRNA delivery with minimal cytotoxicity}, journal = {Chemical Communications}, year = 2015, } @article{CTT100720781, author = {Shigehito Osawa and Kensuke Osada and Shigehiro Hiki and Anjaneyulu Dirisala and Hiroyasu Takemoto and Takehiko Ishii and Kazunori Kataoka}, title = {Design of poly(oxazoline) based triblock copolymer for polyplex micelles with core protective parisade}, journal = {Abstracts of Papers of the American Chemical Society}, year = 2014, } @article{CTT100720779, author = {Hiroyasu Takemoto and Nobuhiro Nishiyama}, title = {Design of Functional Polymers for Intracellular Nucleic Acids Delivery}, journal = {Intracellular Delivery Ii: Fundamentals and Applications}, year = 2014, } @article{CTT100723941, author = {Yoshinori Maeda and Frederico Pittella and Takahiro Nomoto and Hiroyasu Takemoto and Nobuhiro Nishiyama and Kanjiro Miyata and Kazunori Kataoka}, title = {Fine-Tuning of Charge-Conversion Polymer Structure for Efficient Endosomal Escape of siRNA-Loaded Calcium Phosphate Hybrid Micelles}, journal = {Macromolecular Rapid Communications}, year = 2014, } @article{CTT100720785, author = {Frederico Pittella and Cabral Horacio and Yoshinori Maeda and Peng Mi and Sumiyo Watanabe and Hiroyasu Takemoto and Hyun Jin Kim and Nobuhiro Nishiyama and Kanjiro Miyata and Kazunori Kataoka}, title = {Systemic siRNA delivery to a spontaneous pancreatic tumor model in transgenic mice by PEGylated calcium phosphate hybrid micelles}, journal = {Journal of Controlled Release}, year = 2014, } @article{CTT100720784, author = {Hyun Jin Kim and Hiroyasu Takemoto and Yi Yu and Meng Zheng and Yoshinori Maeda and Hiroyuki Chaya and Kotaro Hayashi and Peng Mi and Frederico Pittella and Christie James and Kazuko Toh and Yu Mastumoto and Nobuhiro Nishiyama and Kanjiro Miyata and Kazunori Kataoka}, title = {Precise Engineering of siRNA Delivery Vehicles to Tumors Using Polyion Complexes and Gold Nanoparticles}, journal = {Acs Nano}, year = 2014, } @article{CTT100720789, author = {Kanjiro Miyata and Christie James and Tomoya Suma and Hiroyasu Takemoto and Hirokuni Uchida and Nobuhiro Nishiyama and Kazunori Kataoka}, title = {Fine-Tuning of Repeating Aminoethyelene Units in Poly(aspartamide) Side Chains for Enhanced siRNA Delivery}, journal = {Tailored Polymer Architectures For Pharmaceutical and Biomedical Applications}, year = 2013, } @article{CTT100720786, author = {Hiroyasu Takemoto and Kanjiro Miyata and Shota Hattori and Takehiko Ishii and Tomoya Suma and Satoshi Uchida and Nobuhiro Nishiyama and Kazunori Kataoka}, title = {Acidic pH-Responsive siRNA Conjugate for Reversible Carrier Stability and Accelerated Endosomal Escape with Reduced IFN alpha-Associated Immune Response}, journal = {Angewandte Chemie-International Edition}, year = 2013, } @article{CTT100720791, author = {Tomoya Suma and Kanjiro Miyata and Yasutaka Anraku and Sumiyo Watanabe and Christie James and Hiroyasu Takemoto and Momoko Shioyama and Noha Gouda and Takehiko Ishii and Nobuhiro Nishiyama and Kazunori Kataoka}, title = {Smart Multilayered Assembly for Biocompatible siRNA Delivery Featuring Dissolvable Silica, Endosome-Disrupting Polycation, and Detachable PEG}, journal = {Acs Nano}, year = 2012, } @article{CTT100720793, author = {Hiroyasu Takemoto and Kanjiro Miyata and Nobuhiro Nishiyama and Kazunori Kataoka}, title = {siRNA-grafted polymer for efficient siRNA delivery system}, journal = {Abstracts of Papers of the American Chemical Society}, year = 2012, } @article{CTT100720790, author = {Hiroyasu Takemoto and Kanjiro Miyata and Takehiko Ishii and Shota Hattori and Shigehito Osawa and Nobuhiro Nishiyama and Kazunori Kataoka}, title = {Accelerated Polymer-Polymer Click Conjugation by Freeze-Thaw Treatment}, journal = {Bioconjugate Chemistry}, year = 2012, } @article{CTT100720798, author = {Kanjiro Miyata and Noha Gouda and Hiroyasu Takemoto and Makoto Oba and Yan Lee and Hiroyuki Koyama and Yuichi Yamasaki and Keiji Itaka and Nobuhiro Nishiyama and Kazunori Kataoka}, title = {Enhanced transfection with silica-coated polyplexes loading plasmid DNA}, journal = {Biomaterials}, year = 2010, } @article{CTT100720796, author = {Kanjiro Miyata and Takahiro Nomoto and Hiroyasu Takemoto and Hyun Jin Kim and Yu Matsumoto and Makoto Oba and Nobuhiro Nishiyama and Kazunori Kataoka}, title = {Development of advanced polymer-based nanodevices for nucleic acids delivery}, journal = {Abstracts of Papers of the American Chemical Society}, year = 2010, } @article{CTT100720799, author = {Hiroyasu Takemoto and Atsushi Ishii and Kanjiro Miyata and Masataka Nakanishi and Makoto Oba and Takehiko Ishii and Yuichi Yamasaki and Nobuhiro Nishiyama and Kazunori Kataoka}, title = {Polyion complex stability and gene silencing efficiency with a siRNA-grafted polymer delivery system}, journal = {Biomaterials}, year = 2010, } @inproceedings{CTT100835423, author = {野本貴大 and Dou Xuebo and 武元宏泰 and 西山伸宏}, title = {多価環状RGDペプチド担持高分子型光増感剤によるphotochemical internalizationの検討}, booktitle = {}, year = 2020, } @inproceedings{CTT100836387, author = {ムツタキンシャイクリザルエル and Yutaka Miura and Haochen Guo and Takahiro Nomoto and Kana Komoto and S Muttaqien and Xiaohang Sun and Hiroyasu Takemoto and Makoto Matsui and Yutaka Miura and Nobuhiro Nishiyama}, title = {Polymeric iron-chelators for improving high- dose vitamin C therapy}, booktitle = {}, year = 2020, } @inproceedings{CTT100836392, author = {豊田真広 and 武元宏泰 and 野本貴大 and 松井誠 and 三浦裕 and 西山伸宏}, title = {腫瘍内pH応答性の獲得を目指した高分子ベタイン内の両イオン性基の種類・間隔の検討}, booktitle = {}, year = 2020, } @inproceedings{CTT100836391, author = {SUNYudi and 武元宏泰 and 野本貴大 and 松井誠 and 三浦裕 and 西山伸宏}, title = {ASO-分岐PEG結合体を内包する小分子キャリアの開発および機能評価}, booktitle = {}, year = 2020, } @inproceedings{CTT100836390, author = {Takahiro Nomoto and Yukiya Inoue and Ying Yao and Minoru Suzuki and Kaito Kanamori and Kakeru Konarita and Hiroyasu Takemoto and Makoto Matsui and Nobuhiro Nishiyama}, title = {Development of functional polymers to boost therapeutic potential of boronophenylalanine in neutron capture therapy}, booktitle = {}, year = 2020, } @inproceedings{CTT100836389, author = {河本花奈 and 野本貴大 and Sjaikhurrizal El Muttaqien and 武元宏泰 and 松井誠 and 三浦裕 and 西山伸宏}, title = {がん鉄キレート療法のための効率的な除鉄を実現する機能性高分子の開発}, booktitle = {}, year = 2020, } @inproceedings{CTT100836388, author = {I Dewa Agung Panji Dwipayana and Yuto Honda and Takahiro Nomoto and Hiroyasu Takemoto and Makoto Matsui and Yutaka Miura and Nobuhiro Nishiyama}, title = {Development of a versatile drug delivery system using tannic acid and boronic acid-conjugated polymer}, booktitle = {}, year = 2020, } @inproceedings{CTT100836393, author = {武元宏泰 and 野本貴大 and 松井誠 and 三浦裕 and 西山伸宏}, title = {高分子修飾によるsiRNA周囲の空間支配と薬理機構制御}, booktitle = {}, year = 2020, } @inproceedings{CTT100835429, author = {Guo Haochen and 野本貴大 and 河本花奈 and ElMuttaqien S. and Sun Xiaohang and 武元宏泰 and 松井誠 and 三浦裕 and 西山伸宏}, title = {Effect of polymeric iron-chelators on high-dose vitamin C therapy}, booktitle = {}, year = 2020, } @inproceedings{CTT100835432, author = {武元宏泰 and 稲葉高徳 and 野本貴大 and 松井誠 and 三浦裕 and 西山伸宏}, title = {"環状アセタール構造に基づくゲムシタビン担持型高分子の開発とその機能評価 および副作用低減"}, booktitle = {}, year = 2020, } @inproceedings{CTT100835424, author = {野本貴大 and 本田雄士 and 海原悠可 and 喜納宏昭 and 武元宏泰 and 松井誠 and 西山伸宏}, title = {タンニン酸とボロン酸ケミストリーを利用した高分子複合体の簡便調製法}, booktitle = {}, year = 2020, } @inproceedings{CTT100835426, author = {Guo Haochen and Takahiro Nomoto and Kana Komoto and Sun Xiaohang and Hiroyasu Takemoto and Makoto Matsui and Yutaka Miura and Nobuhiro Nishiyama}, title = {Development of polymeric iron-chelators for enhancing high-dose vitamin C therapy}, booktitle = {}, year = 2020, } @inproceedings{CTT100835419, author = {Takahiro Nomoto and Sjaikhurrizal El Muttaqien and Hiroyasu Takemoto and Makoto Matsui and Nobuhiro Nishiyama}, title = {Photodynamic therapy utilizing functional polymers that exert pH-responsive isothermal phase transition}, booktitle = {}, year = 2020, } @inproceedings{CTT100835428, author = {武元宏泰 and 野本貴大 and 松井誠 and 三浦裕 and 西山伸宏}, title = {"環状アセタール構造を介したゲムシタビンのポリアミノ酸への導入と薬効増大 および副作用低減"}, booktitle = {}, year = 2020, } @inproceedings{CTT100835427, author = {豊田真広 and 武元 宏泰 and 野本 貴大 and 松井 誠 and 三浦 裕 and 西山 伸宏}, title = {高分子ベタイン内のイオン性基の種類・間隔の制御と腫瘍内pH応答性への展開}, booktitle = {}, year = 2020, } @inproceedings{CTT100835417, author = {Yuto Honda and Takahiro NOMOTO and Makoto MATSUI and Hiroyasu TAKEMOTO and Yuka KAIHARA and Yutaka MIURA and Nobuhiro NISHIYAMA}, title = {Development of intracellular pH- responsive protein delivery system utilizing boronic acid-conjugated polymer and tannic acid}, booktitle = {}, year = 2020, } @inproceedings{CTT100835418, author = {Kana Komoto and Takahiro Nomoto and Hiroyasu Takemoto and Makoto Matsui and Yutaka Miura and Nobuhiro Nishiyama}, title = {Iron chelation cancer therapy using functional polymers targeting tumors}, booktitle = {}, year = 2020, } @inproceedings{CTT100835416, author = {Takahiro Nomoto and Yukiya Inoue and Ying Yao and Minoru Suzuki and Kaito Kanamori and Hiroyasu Takemoto and Makoto Matsui and Keishiro Tomoda and Nobuhiro Nishiyama}, title = {Poly(vinyl alcohol) for enhancing therapeutic effects of p-boronophenylalanine in neutron capture therapy}, booktitle = {}, year = 2020, } @inproceedings{CTT100813362, author = {Takahiro Nomoto and Xuebo Dou and Hiroyasu Takemoto and Makoto Matsui and Keishiro Tomoda and Nobuhiro Nishiyama}, title = {Photosensitizer delivery to tumor cells and tumor-associated vasculature using functional polymers}, booktitle = {}, year = 2019, } @inproceedings{CTT100813359, author = {野本貴大 and 松井誠 and 武元宏泰 and 海原悠可 and 三浦裕 and 西山伸宏}, title = {ボロン酸導入高分子とタンニン酸を用いた細胞内環境応答タンパク質送達システムの構築}, booktitle = {}, year = 2019, } @inproceedings{CTT100813624, author = {武元宏泰 and 稲葉高徳 and 野本貴大 and 松井誠 and 三浦裕 and 西山伸宏}, title = {環状アセタール構造に基づくゲムシタビンの高分子修飾と制がん効果増大及び副作用低減}, booktitle = {}, year = 2019, } @inproceedings{CTT100813361, author = {野本貴大 and 井上透矢 and YAOYing and 金盛開人 and 鈴木実 and 武元宏泰 and 松井誠 and 西山伸宏}, title = {生体適合性高分子とボロノフェニルアラニンから構成される中性子捕捉療法用代謝制御型ホウ素送達システム}, booktitle = {}, year = 2019, } @inproceedings{CTT100813360, author = {河本花奈 and 野本貴大 and 武元宏泰 and 松井誠 and 三浦裕 and 西山伸宏}, title = {がん治療のための効率的な生体内の除鉄を実現する機能性高分子の開発}, booktitle = {}, year = 2019, } @inproceedings{CTT100813356, author = {野本貴大 and ElMuttaqien S. and 武元宏泰 and 松井誠 and 西山伸宏}, title = {腫瘍内低pH環境に応答して親水-疎水相転移挙動を示す高分子コンジュゲート型光増感剤}, booktitle = {}, year = 2019, } @inproceedings{CTT100813357, author = {Takahiro Nomoto and Yukiya Inoue and Ying Yao and Minoru Suzuki and Kaito Kanamori and Makoto Matsui and Hiroyasu Takemoto and Nobuhiro Nishiyama}, title = {Boosting Therapeutic Potential of p-Boronophenylalanine Using Biocompatible Polymers}, booktitle = {}, year = 2019, } @inproceedings{CTT100813353, author = {本田雄士 and 山田直生 and 武元宏泰 and 野本貴大 and 松井誠 and 友田敬士郎 and 西山伸宏}, title = {がん細胞の高密度グルタミントランスポーターと選 択的な相互作用を示す機能性高分子の開発}, booktitle = {}, year = 2019, } @inproceedings{CTT100813352, author = {野本貴大 and 井上透矢 and YAOYing and 金盛開人 and 鈴木実 and 武元宏泰 and 松井誠 and 友田敬士郎 and 西山伸宏}, title = {生体適合性高分子とp-boronophenylalanineから構成されるホウ素送達システムの開発と構成高分子の物性が体内動態と治療効果に与える影響に関する考察}, booktitle = {}, year = 2019, } @inproceedings{CTT100813355, author = {武元宏泰 and AZIZMUHAMMAD and RannehA-Hackam and 野本貴大 and 松井誠 and 三浦裕 and 西山伸宏}, title = {腫瘍内pH応答性高分子ベタインの設計と被覆ナノ粒子への展開}, booktitle = {}, year = 2019, } @inproceedings{CTT100813354, author = {小野寺彩 and 武元宏泰 and 野本貴大 and 松井誠 and 三浦裕 and 西山伸宏}, title = {温度応答性高分子-siRNA結合体の合成と外部刺激によるsiRNAの生物活性制御}, booktitle = {}, year = 2019, } @inproceedings{CTT100813358, author = {Kaito Kanamori and Takahiro Nomoto and Hiroyasu Takemoto and Makoto Matsui and Nobuhiro Nishiyama}, title = {BPA delivery system utilizing sugar-modified polymers forming stable boronate esters}, booktitle = {The 10th Young Member’s Boron Neutron Capture Therapy (10th YBNCT)}, year = 2019, } @inproceedings{CTT100813348, author = {河本花奈 and 野本貴大 and 武元宏泰 and 松井誠 and 西山伸宏}, title = {がん治療を指向した生体内鉄イオンをキレートする機能性高分子の開発}, booktitle = {}, year = 2019, } @inproceedings{CTT100813351, author = {Nobuhiro Nishiyama and Kana Komoto and Takahiro Nomoto and Hiroyasu Takemoto and Makoto Matsui}, title = {Development of polymeric iron chelator for cancer therapy}, booktitle = {}, year = 2019, } @inproceedings{CTT100813349, author = {小野寺彩 and 武元宏泰 and 野本貴大 and 友田敬士郎 and 松井誠 and 西山伸宏}, title = {温度応答性高分子-siRNA結合体とのポリイオンコンプレックス形成と外部刺激によるsiRNA の薬効制御}, booktitle = {}, year = 2019, } @inproceedings{CTT100813347, author = {金盛開人 and 野本貴大 and 鈴木実 and 武元宏泰 and 松井誠 and 西山伸宏}, title = {ボロン酸エステルを利用したホウ素薬物送達キャリアの開発}, booktitle = {}, year = 2019, } @inproceedings{CTT100813346, author = {松井誠 and 海原悠可 and 武元宏泰 and 野本貴大 and 西山伸宏}, title = {薬物送達技術を応用した新規骨折治療法の開発}, booktitle = {}, year = 2019, } @inproceedings{CTT100813345, author = {武元宏泰 and AZIZMUHAMMAD and 野本貴大 and 松井誠 and 西山伸宏}, title = {腫瘍 pH 応答性高分子ベタインの開発とナノ粒子のがん送達への展開}, booktitle = {}, year = 2019, } @inproceedings{CTT100813344, author = {本田雄士 and 山田直生 and 武元宏泰 and 野本貴大 and 松井誠 and 友田敬士郎 and 西山伸宏}, title = {がん細胞の高密度グルタミントランスポーターを標的として選択的な相互作用を示す機能性高分子の開発}, booktitle = {}, year = 2019, } @inproceedings{CTT100813342, author = {豊田真広 and 武元宏泰 and 野本貴大 and 松井誠 and 西山伸宏}, title = {腫瘍内pH応答性高分子ベタイン内のイオン性基間距離の検討}, booktitle = {}, year = 2019, } @inproceedings{CTT100813339, author = {小野寺彩 and 武元宏泰 and 野本貴大 and 友田敬士郎 and 松井誠 and 西山伸宏}, title = {ポリイオンコンプレックスを利用した温度応答性高分子-siRNA結合体の細胞内導入と外部刺激によるsiRNAの生物活性制御}, booktitle = {}, year = 2019, } @inproceedings{CTT100813338, author = {金盛開人 and 野本貴大 and 鈴木実 and 武元宏泰 and 松井誠 and 西山伸宏}, title = {糖修飾高分子とホウ素薬物から構成される薬物送達システムの開発}, booktitle = {}, year = 2019, } @inproceedings{CTT100813337, author = {野本貴大 and 井上透矢 and YAOYing and 鈴木実 and 金盛開人 and 武元宏泰 and 松井誠 and 友田敬士郎 and 西山伸宏}, title = {Metabolism-controlled boron delivery systems composed of biocompatible polymers and boronophenylalanine for neutron capture therapy}, booktitle = {Abstracts of Papers of the American Chemical Society}, year = 2019, } @inproceedings{CTT100813350, author = {Kaito Kanamori and Takahiro Nomoto and Minoru Suzuki and Hiroyasu Takemoto and Makoto Matsui and Nobuhiro Nishiyama}, title = {Boron Delivery Using Sugar-Modified Polymers for Neutron Capture Therapy}, booktitle = {}, year = 2019, } @inproceedings{CTT100783090, author = {Sjaikhurrizal El Muttaqien and 松井 誠 and 武元 宏泰 and 野本 貴 大 and 友田 敬士郎 and 西山 伸宏}, title = {Poly(N-isopropylacrylamide) derivatives exering remarkable LCST shift in response to slight pH chnge via detachment of hydrophilic acid-labile moiety}, booktitle = {}, year = 2018, } @inproceedings{CTT100783086, author = {Yuka Kaihara and Makoto Matsui and Hiroyasu Takemoto and Takahiro Nomoto and Keishiro Tomoda and Nobuhiro Nishiyama}, title = {Development of novel drug delivery system for enhancing bone regeneration in bone fracture model mouse}, booktitle = {}, year = 2018, } @inproceedings{CTT100783087, author = {Sayaka Onodera and Hiroyasu Takemoto and Takahiro Nomoto and Keishiro Tomoda and Makoto Matsui and Nobuhiro Nishiyama}, title = {Conjugation of siRNA and a polymer with coil-globule transition property for control of siRNA activity around body temperature}, booktitle = {}, year = 2018, } @inproceedings{CTT100783088, author = {Gyomon Ryu and Hiroyasu Takemoto and Takahiro Nomoto and Makoto Matsui and Keishiro Tomoda and Nobuhiro Nishiyama}, title = {Development of poly(amino acid)-based carrier that loads gemcitabine via reversible linkage and its evaluation using pancreatic cancer model}, booktitle = {}, year = 2018, } @inproceedings{CTT100783089, author = {Sun Xiaohang and Taknaori Inaba and Kazuki Ohsakama and Mika Shishido and Hiroki Yoshioka and 武元宏泰 and 野本貴大 and 松井誠 and 友田敬士郎 and 西山伸宏}, title = {Development of degradable poly(ethylene glycol)(PEG) derivatives for suppressing cellular vacuolations}, booktitle = {}, year = 2018, } @inproceedings{CTT100783091, author = {Hiroyasu Takemoto and Abdul-Hackam Ranneh and Takahiro Nomoto and Makoto Matsui and Nobuhiro Nishiyama}, title = {Ethylenediamine-based polyzwitterion that becomes cationic at tumorous pH for effective tumor accumulation of the coated nanomaterials}, booktitle = {}, year = 2018, } @inproceedings{CTT100811939, author = {Yuto Honda and Naoki Yamada and Takahiro Nomoto and Yukiya Inoue and Ying Yao and Minoru Suzuki and Kaito Kanamori and Hiroyasu Takemoto and Makoto Matsui and Keishiro Tomoda and Nobuhiro Nishiyama}, title = {Tumor cell-targeting glutamine-derived polymer that can interact with high density glutamine transporter based on aberrant glutamine metabolism.}, booktitle = {}, year = 2018, } @inproceedings{CTT100783083, author = {Ying Yao and Takahiro Nomoto and Yukiya Inoue and Minoru Suzuki and Makoto Matsui and Hiroyasu Takemoto and Keishiro Tomoda and Nobuhiro Nishiyama}, title = {Enhanced tumor-targeted delivery of p-boronophenylalanine using fructose-functionalized polymers for boron neutron capture therapy}, booktitle = {}, year = 2018, } @inproceedings{CTT100783082, author = {Takahiro Nomoto and Yukiya Inoue and Ying Yao and Minoru Suzuki and Hiroyasu Takemoto and Makoto Matsui and Keishiro Tomoda and Nobuhiro Nishiyama}, title = {Metabolism-controlled boron delivery systems composed of p-boronophenylalanine and poly(vinyl alcohol)}, booktitle = {}, year = 2018, } @inproceedings{CTT100774003, author = {Takahiro Nomoto and Xuebo Dou and Hiroyasu Takemoto and Makoto Matsui and Keishiro Tomoda and Nobuhiro Nishiyama}, title = {Multiple cyclic RGD-conjugated functional polymers controlling intratumoral distribution of IRDye 700DX}, booktitle = {}, year = 2018, } @inproceedings{CTT100773999, author = {野本 貴大 and 井上 透矢 and Yao Ying and 鈴木 実 and 金盛 開人 and 武元 宏泰 and 松井 誠 and 友田 敬士郎 and 西山 伸宏}, title = {生体適合性機能性高分子によるボロノフェニルアラニンの代謝制御と治療効果の向上}, booktitle = {}, year = 2018, } @inproceedings{CTT100774000, author = {本田雄士 and 山田 直生 and 武元 宏泰 and 野本 貴 大 and 松井 誠 and 友田 敬士郎 and 西山 伸宏}, title = {グルタミン代謝が亢進したがん細胞の高密度グルタ ミントランスポーターを認識してアフィニティを示す機能性高 分子}, booktitle = {}, year = 2018, } @inproceedings{CTT100774001, author = {Gyomon Ryu and Hiroyasu Takemoto and Takahiro Nomoto and Makoto Matsui and Keishiro Tomoda and Nobuhiro Nishiyama}, title = {Development of gemcitabine-conjugated poly(amino acid) and its evaluation using pancreatic tumor model}, booktitle = {}, year = 2018, } @inproceedings{CTT100774002, author = {Hiroyasu Takemoto and Kanjiro Miyata and Nobuhiro Nishiyama and Kazunori Kataoka}, title = {Size-regulated siRNA carriers from small complex loading single siRNA molecule for systemic delivery to tumor tissue}, booktitle = {}, year = 2018, } @inproceedings{CTT100773997, author = {Hiroyasu Takemoto and Abduhl Hackam Ranneh and Takahiro Nomoto and Makoto Matsui and Keishiro Tomoda and Nobuhiro Nishiyama}, title = {Ethylenediamine-based betaine structure switches the neutral net charge of polyzwitterion into cationic at tumorous pH toward effective tumor accumulation of the coated nanomaterials}, booktitle = {}, year = 2018, } @inproceedings{CTT100773998, author = {Sjaikhurrizal El Muttaqien and Takahiro Nomoto and Hiroyasu Takemoto and Makoto Matsui and Keishiro Tomoda and Nobuhiro Nishiyama}, title = {Novel design of pH-responsive polymer for targeting acidic microenvironment of tumor}, booktitle = {}, year = 2018, } @inproceedings{CTT100773995, author = {野本貴大 and Dou Xuebo and 武元宏泰 and 松井誠 and 友田敬士郎 and 西山伸宏}, title = {IRDye 700DXの腫瘍内分布を制御する環状RGD担持高分子コンジュゲートによる光線力学効果の検討}, booktitle = {}, year = 2018, } @inproceedings{CTT100774004, author = {Hiroyasu Takemoto}, title = {Bioresponsive Polyzwitterion that Recognizes Tumorous pH for a Construction of Tumor-Targeted Carriers}, booktitle = {}, year = 2018, } @inproceedings{CTT100773996, author = {Hiroyasu Takemoto}, title = {Development of polyzwitterion that recognizes tumorous pH for effective delivery of the coated nanoparticles}, booktitle = {}, year = 2018, } @inproceedings{CTT100773994, author = {yao ying and 野本貴大 and 井上透矢 and 鈴木実 and 松井誠 and 武元宏泰 and 友田敬士郎 and 西山伸宏}, title = {Tumor-targeted delivery of BPA using functional polymers for boron neutron capture therapy}, booktitle = {}, year = 2018, } @inproceedings{CTT100773993, author = {武元宏泰 and Ranneh Abdul-Hackam and 野本貴大 and 松井誠 and 友田敬士郎 and 持田祐希 and 内藤瑞 and 西山伸宏}, title = {腫瘍内環境を認識する高分子ベタインの開発とナノ粒子の効率的な腫瘍集積への展開}, booktitle = {}, year = 2018, } @inproceedings{CTT100773992, author = {小野寺彩 and 武元宏泰 and 野本貴大 and 友田敬士郎 and 松井誠 and 西山伸宏}, title = {siRNAへのCoil-globule挙動を有する高分子の結合と生体温度付近での遺伝子発現抑制能の精密制御}, booktitle = {}, year = 2018, } @inproceedings{CTT100773990, author = {劉暁夢 and 武元宏泰 and 野本貴大 and 松井誠 and 友田敬士郎 and 西山伸宏}, title = {可逆的にゲムシタビンを担持するポリアミノ酸型キャリアの開発とすい臓がんモデルでの機能評価}, booktitle = {}, year = 2018, } @inproceedings{CTT100773989, author = {Naoki Yamada and Yuto Honda and Hiroyasu Takemoto and Takahiro Nomoto and Makoto Matsui and Keishiro Tomoda and Nobuhiro Nishiyama}, title = {Glutamine-Functionalized Polymer for Tumor-Selective High Affinity by Sensing Dense Glutamine Transporters Associated with Aberrant Metabolism}, booktitle = {}, year = 2017, } @inproceedings{CTT100773988, author = {Hiroyasu Takemoto and Takahiro Nomoto and Keishiro Tomoda and Makoto Matsui and Nobuhiro Nishiyama}, title = {2-nitrobenzenesulfonamide group that allows highly selective cleavage in intracellular redox system and the application for a construction of siRNA-polymer conjugate}, booktitle = {}, year = 2017, } @inproceedings{CTT100773986, author = {Hiroyasu Takemoto and Nobuhiro Nishiyama}, title = {Construction of siRNA-polymer conjugate and its biological application}, booktitle = {}, year = 2017, } @inproceedings{CTT100773987, author = {山田直生 and 本田雄士 and 武元宏泰 and 野本貴大 and 松井 誠 and 友田敬士郎 and 西山伸宏}, title = {がん選択的に相互作用するグルタミン担持高分子の創製と機能評価}, booktitle = {}, year = 2017, } @inproceedings{CTT100773983, author = {左久間隼矢 and Abdul-Hackam RANNEH and 武元宏泰 and 野本貴大 and 松井誠 and 友田敬士郎 and 西山伸宏}, title = {腫瘍指向性ステルス高分子の開発とDDSへの応 用-ベタイン構造内アニオン性基の影響-}, booktitle = {}, year = 2017, } @inproceedings{CTT100773985, author = {武元宏泰 and 稲葉 高徳 and 野本 貴大 and 松井 誠 and 友田 敬士郎 and 西山 伸宏}, title = {糖骨格を有する制がん剤のポリアミノ酸への可逆的担持と薬効向上及び消化器毒性低減}, booktitle = {}, year = 2017, } @inproceedings{CTT100773982, author = {真貝 太規 and 山田直生 and 武元宏泰 and 野本貴大 and 松井誠 and 友田敬士郎 and 西山伸宏}, title = {がん代謝に着想した表層にグルタミンを有する高分子ミセル型薬物送達システムの開発}, booktitle = {}, year = 2017, } @inproceedings{CTT100773984, author = {Dou Xuebo and 野本 貴大 and 武元 宏泰 and 松井 誠 and 友田 敬士郎 and 西山 伸宏}, title = {光増感剤結合型高分子における多岐環状RGDペプチドの腫瘍集積性と腫瘍内分布への効果の検討}, booktitle = {}, year = 2017, } @inproceedings{CTT100752117, author = {武元 宏泰 and 稲葉 高徳 and 野本 貴大 and 松井 誠 and 友田 敬士郎 and 西山 伸宏}, title = {ゲムシタビンのポリアミノ酸への可逆的担持に基づく消化器毒性低減及び制がん効果向上}, booktitle = {}, year = 2017, } @inproceedings{CTT100752165, author = {Hiroyasu Takemoto and Huang Chih-Hao and Takahiro Nomoto and Keishiro Tomoda and Makoto Matsui and Nobuhiro Nishiyama}, title = {2-Nitrobenzenesulfonamide Group that Responds to Intracellular Redox Potential with Enhanced Photostability for a Construction of Polymer-siRNA Conjugate System}, booktitle = {}, year = 2017, } @inproceedings{CTT100752096, author = {Hiroyasu Takemoto and Chih Hao Huang and Takahiro Nomoto and Keishiro Tomoda and Makoto Matsui and Nobuhiro Nishiyama}, title = {2-nitrobenzenesulfonamide group as a redox-sensitive linker for a construction of polymer-siRNA conjugate system}, booktitle = {}, year = 2017, } @inproceedings{CTT100752091, author = {真貝太規 and 山田直生 and 武元宏泰 and 野本貴大 and 松井誠 and 友田敬士郎 and 西山伸宏}, title = {がん特異的代謝に着想した外殻にグルタミンを有する高分子ミセルの開発}, booktitle = {}, year = 2017, } @inproceedings{CTT100752093, author = {劉暁夢 and 武元宏泰 and 野本貴大 and 松井誠 and 友田敬士郎 and 西山伸宏}, title = {ミトコンドリア呼吸鎖阻害剤を腫瘍組織に送達するための高分子ミセルの開発}, booktitle = {}, year = 2017, } @inproceedings{CTT100752095, author = {左久間隼矢 and RannehA-Hackam and 武元宏泰 and 野本貴大 and 松井誠 and 友田敬士郎 and 西山伸宏}, title = {腫瘍内pHに応答する双性イオン型ポリマーの設計とDDS応用-ベタイン内アニオン性基の影響-}, booktitle = {}, year = 2017, } @inproceedings{CTT100752097, author = {Naoki Yamada and Yuto Honda and Hiroyasu Takemoto and Takahiro Nomoto and Makoto Matsui and Keishiro Tomoda and Nobuhiro Nishiyama}, title = {Design of synthetic polymer toward achieving a selective high affinity to tumor cells by interacting with dense glutaminolysis-related transporters}, booktitle = {}, year = 2017, } @inproceedings{CTT100752161, author = {Yuto Honda and Naoki Yamada and Hiroyasu Takemoto and Takahiro Nomoto and Makoto Matsui and Keishiro Tomoda and Nobuhiro Nishiyama}, title = {Novel design of glutamine-derived polymer with a high affinity to cancer cells based on aberrant glutamine metabolism.}, booktitle = {}, year = 2017, } @inproceedings{CTT100752159, author = {Hiroyasu Takemoto and Huang Chih-Hao and Takahiro Nomoto and Keishiro Tomoda and Makoto Matsui and Nobuhiro Nishiyama}, title = {2-Nitrobenzenesulfonamide group as a chemical linker with highly selective cleavability in response to intracellular redox system for a construction of siRNA-polymer conjugate.}, booktitle = {}, year = 2017, } @inproceedings{CTT100752150, author = { Tsukasa Nishimori and Naoki Yamada and Hiroyasu Takemoto and Kentaro Suina and Juntaro Yamasaki and Takahiro Nomoto and Makoto Matsui and Keishiro Tomoda and Osamu Nagano and Hideyuki Saya and Nobuhiro Nishiyama}, title = {Development of intravenously injectable sulfasalazine derivatives to treat stem-like cancer cells}, booktitle = {}, year = 2017, } @inproceedings{CTT100752154, author = {武元宏泰 and キム ヒュンジン and 宮田完二郎 and 西山伸宏 and 片岡一則}, title = {単分子siRNA内包型小会合体を要素とするsiRNAキャリアの構築と全身投与による腫瘍組織への送達}, booktitle = {}, year = 2017, } @inproceedings{CTT100752152, author = {Takanori Inaba and Hiroyasu Takemoto and Makoto Matsui and Takahiro Nomoto and Keishiro Tomoda and Nobuhiro Nishiyama}, title = {Enhanced antitumor activity and reduced gastrointestinal toxicity of gemcitabine based on conjugation with biocompatible polymer via acetal linker}, booktitle = {}, year = 2017, } @inproceedings{CTT100752155, author = {Ranneh Hackam and Hiroyasu Takemoto and Takahiro Nomoto and Makoto Matsui and Keishiro Tomoda and Nobuhiro Nishiyama}, title = {Development of stealth shell based on polycarboxybetaine structure tuned to selectively interact with cells in tumor extracellular acidic pH}, booktitle = {}, year = 2017, } @inproceedings{CTT100752149, author = {Chi-Hao Huang and Hiroyasu Takemoto and Takahiro Nomoto and Keishiro Tomoda and Makoto Matsui and Nobuhiro Nishiyama}, title = {2-nitrobenzenesulfonamide group as a new chemical linker with redox sensitivity for siRNA-conjugated polymer system}, booktitle = {}, year = 2017, } @inproceedings{CTT100752148, author = {Faizah Noor and Hiroyasu Takemoto and Takahiro Nomoto and Keishiro Tomoda and Makoto Matsui and Nobuhiro Nishiyama}, title = {Artificial control of siRNA bioactivity based on the phase transition behavior of the conjugated polymeric molecule}, booktitle = {}, year = 2016, } @inproceedings{CTT100752147, author = {Chihhao Huang and Hiroyasu Takemoto and Takahiro Nomoto and Keishiro Tomoda and Makoto Matsui and Nobuhiro Nishiyama}, title = {2-nitrobenzensulfonamide groups as a chemical linker with enhanced extracellular stability and redox-sensitive cleavability for siRNA-conjugated polymer system}, booktitle = {}, year = 2016, } @inproceedings{CTT100752144, author = {Naoki Yamada and Yuto Honda and Hiroyasu Takemoto and Takahiro Nomoto and Makoto Matsui and Keishiro Tomoda and Nobuhiro Nishiyama}, title = {Novel glutamine-based polymeric ligand for transporter-mediated tumor targeting}, booktitle = {}, year = 2016, } @inproceedings{CTT100752141, author = {武元宏泰 and 宮田完二郎 and 林光太朗 and 持田祐希 and 片岡一則 and 西山伸宏}, title = {シロキサンネットワークにて形成されるsiRNA内包有機-無機ハイブリッドナノ粒子の開発}, booktitle = {}, year = 2016, } @inproceedings{CTT100752143, author = {越後真梨那 and 武元 宏泰 and 林 光太朗 and 宮田 完二郎 and 金澤秀子 and 片岡 一則 and 西山 伸宏}, title = {がん細胞内にて特異的に切断される Linker を利用した siRNA 送達キャリアの開発}, booktitle = {}, year = 2016, } @inproceedings{CTT100752131, author = {Faizah Noor and Hiroyasu Takemoto and Takahiro Nomoto and Keishiro Tomoda and Makoto Matsui and Nobuhiro Nishiyama}, title = {Development of siRNA-conjugated polymer with coil-globule transition behavior for an artificially controlled gene silencing activity}, booktitle = {}, year = 2016, } @inproceedings{CTT100752136, author = {KimJunhyun and 武元 宏 泰 and 野本 貴大 and 松井 誠 and 友田 敬士郎 and 西山 伸宏}, title = {高分子ミセルにおける内核構造の安定性の差異がもたらす腫瘍集積性に関する考察}, booktitle = {}, year = 2016, } @inproceedings{CTT100752139, author = {SunXiaohang and 武元 宏 泰 and 野本 貴大 and 友田 敬士郎 and 松井 誠 and 西山 伸宏}, title = {がんへの薬剤の集積状態をレポートするナノメディシンの開 発}, booktitle = {}, year = 2016, } @inproceedings{CTT100752135, author = {Chih Ling Wang and Hiroyasu Takemoto and Takahiro Nomoto and Keishiro Tomoda and Makoto Matsui and Nobuhiro Nishiyama}, title = {A Novel Design of Polyion Complex (PIC) with The Pyruvate-Reactive Function toward Enhanced Cytosolic Release of siRNA}, booktitle = {}, year = 2016, } @inproceedings{CTT100752130, author = {NOOR and Hiroyasu Takemoto and Takahiro Nomoto and Nobuhiro Nishiyama}, title = {Development of thermoresponsive polymer-siRNA conjugates for controlled RNAi activity}, booktitle = {}, year = 2016, } @inproceedings{CTT100752128, author = {Chih-Ling and Hiroyasu Takemoto and Nobuhiro Nishiyama}, title = {Programmed siRNA Release based on α-Oxohydrazone Chemistry for Polyion complex-based siRNA Delivery System}, booktitle = {}, year = 2016, } @misc{CTT100827136, author = {武元宏泰}, title = {がん組織内環境を認識する機能性高分子の開発と被覆ナノ粒子への展開}, year = 2020, } @misc{CTT100791435, author = {武元宏泰}, title = {第33回日本DDS学会学術集会}, year = 2017, } @misc{CTT100892274, author = {西山伸宏 and 武元宏泰 and 三浦裕 and 野本貴大 and 松井誠 and SUNG, Yi-Jung and 豊田真広 and GhasemizadehAria and 尾木 公一 and 道西 准也  and 飯塚 宗明   and 大嶽 知之 }, title = {高純度pH応答性ポリマー及びその製造方法}, howpublished = {公開特許}, year = 2023, month = {}, note = {PCT/JP2022/026864(2022/07/06), WO 2023/282297(2023/01/12)} } @misc{CTT100892275, author = {西山伸宏 and 武元宏泰 and 三浦裕 and 野本貴大 and 松井誠 and SUNG, Yi-Jung and 豊田真広 and GhasemizadehAria and 尾木 公一 and 道西 准也   and 大嶽 知之}, title = {pH応答性脂質誘導体}, howpublished = {公開特許}, year = 2023, month = {}, note = {PCT/JP2022/026863(2022/07/06), WO 2023/282296(2023/01/12)} } @misc{CTT100909661, author = {西山伸宏 and 野本貴大 and GUOHaochen and Voon Yan Ming and Wen Xu and 金盛開人 and 山田直生 and 松井誠 and 武元宏泰 and 萩山 朋子}, title = {L型アミノ酸トランスポーター1を標的とした高分子}, howpublished = {公開特許}, year = 2023, month = {}, note = {特願2022-075447(2022/04/28), 特開2023-164109(2023/11/10)} } @misc{CTT100869592, author = {西山伸宏 and 本田雄士 and 野本貴大 and 武元宏泰 and 松井誠 and 喜納 宏昭 and 片岡 一則 and 劉 学蛍 and Dirisala, Anjaneyulu}, title = {複合体、医薬、癌治療剤、キット及び結合体}, howpublished = {公開特許}, year = 2020, month = {}, note = {PCT/JP2020/021301(2020/05/29), WO 2020/241819(2020/12/03)} } @misc{CTT100927751, author = {西山伸宏 and 本田雄士 and 野本貴大 and 武元宏泰 and 松井誠 and 喜納 宏昭 and 片岡 一則 and 劉 学蛍 and ディリサラ アンジャネユル}, title = {複合体、医薬、癌治療剤、キット及び結合体}, howpublished = {登録特許}, year = 2024, month = {}, note = {特願2021-522894(2020/05/29), WO 2020/241819(2020/12/03), 特許第7536258号(2024/08/09)} } @misc{CTT100869610, author = {西山伸宏 and 野本貴大 and 河本花奈 and 武元宏泰 and 松井誠}, title = {結合体、及び癌治療剤}, howpublished = {公開特許}, year = 2020, month = {}, note = {PCT/JP2020/017421(2020/04/23), WO 2020/218390(2020/10/29)} } @misc{CTT100843278, author = {西山伸宏 and 松井誠 and 武元宏泰 and 野本貴大 and SunXiaohang and 吉岡 宏樹  and 大坂間 順規  and 羽村 美華 and 稲葉 高徳 }, title = {分岐型分解性ポリエチレングリコール誘導体}, howpublished = {登録特許}, year = 2023, month = {}, note = {特願2020-055411(2020/03/26), 特開2020-164855(2020/10/08), 特許第7411188号(2023/12/27)} } @misc{CTT100843292, author = {西山伸宏 and 松井誠 and 武元宏泰 and 野本貴大 and SunXiaohang and 吉岡 宏樹  and 大坂間 順規  and 羽村 美華 and 稲葉 高徳 }, title = {分岐型分解性ポリエチレングリコール結合体}, howpublished = {登録特許}, year = 2023, month = {}, note = {特願2020-055412(2020/03/26), 特開2020-164856(2020/10/08), 特許第7411189号(2023/12/27)} } @misc{CTT100815581, author = {西山伸宏 and 松井誠 and 武元宏泰 and 宮内和輝 and 野本貴大 and 友田敬士郎 and 山本 裕二 and 吉岡 宏樹 and 神谷 昌樹 and 平居 翠  and 佐々木 明子}, title = {分解性ポリエチレングリコール誘導体}, howpublished = {登録特許}, year = 2023, month = {}, note = {特願2019-068350(2019/03/29), 特開2019-173014(2019/10/10), 特許第7205827号(2023/01/06)} } @misc{CTT100815578, author = {西山伸宏 and 松井誠 and 武元宏泰 and 宮内和輝 and 野本貴大 and 友田敬士郎 and 吉岡 宏樹  and 神谷 昌樹 and 山本 裕二 and 平居 翠 and 佐々木 明子 }, title = {分解性ポリエチレングリコール結合体}, howpublished = {登録特許}, year = 2023, month = {}, note = {特願2019-068351(2019/03/29), 特開2019-172673(2019/10/10), 特許第7249591号(2023/03/23)} } @misc{CTT100845913, author = {西山伸宏 and 野本貴大 and 井上透矢 and YAOYing and 金盛開人 and 武元宏泰 and 松井誠 and 友田敬士郎}, title = {p-ボロノフェニルアラニン誘導体及びそれを含む組成物、並びにそれらを製造するためのキット}, howpublished = {登録特許}, year = 2023, month = {}, note = {特願2020-500974(2019/02/19), 再表2019/163790(2021/02/12), 特許第7219925号(2023/02/01)} } @misc{CTT100845885, author = {西山伸宏 and 武元宏泰 and 森 正樹  and 石井 秀始 and 今野 雅允 and 江口 英利   and 原口 直紹 and 俊山 礼志 }, title = {抗がん剤}, howpublished = {登録特許}, year = 2023, month = {}, note = {特願2019-569175(2019/01/30), 再表2019/151320(2021/01/14), 特許第7267609号(2023/04/24)} } @misc{CTT100815579, author = {西山伸宏 and 武元宏泰 and Abdul-Hackam RANNEH and 友田敬士郎 and 野本貴大 and 松井誠}, title = {pH応答性ポリマー及び薬物送達システム}, howpublished = {登録特許}, year = 2021, month = {}, note = {特願2018-556597(2017/12/05), 再表2018/110366(2019/10/24), 特許第6995375号(2021/12/17)} } @misc{CTT100806614, author = {西山伸宏 and El Muttaqien SJAIKHURRIZAL and 野本貴大 and 武元宏泰 and 松井誠 and 友田敬士郎}, title = {温度応答性ポリマー及びそれを含む組成物}, howpublished = {公開特許}, year = 2019, month = {}, note = {特願2017-211893(2017/11/01), 特開2019-085438(2019/06/06)} } @misc{CTT100806622, author = {西山伸宏 and 武元宏泰 and 野本貴大 and 友田敬士郎 and 松井誠 and 山田直生 and 本田雄士 and 森 正樹 and 石井 秀始 and 今野 雅允}, title = {グルタミントランスポーターと多価結合することができるリガンド、及び当該リガンドを含む組成物}, howpublished = {登録特許}, year = 2022, month = {}, note = {特願2018-535630(2017/08/17), 特開(再表)2018-037996(2019/06/20), 特許第7076104号(2022/05/19)} } @misc{CTT100808501, author = {西山伸宏 and 中村浩之 and 武元宏泰 and 野本貴大 and 片岡 一則  and Mi Peng  and Horacio Cabral  and 柳衛 宏宣 and Novriana Dewi  and 黒澤 渉 and 姥貝 吏紗 and 北原 吉朗  and 須賀 泰世 }, title = {ホウ素クラスター結合ペプチド化合物}, howpublished = {公開特許}, year = 2019, month = {}, note = {特願2018-507416(2017/03/23), 再表2017/164334(2019/02/28)} } @misc{CTT100830142, author = {西山伸宏 and 武元宏泰 and 稲葉高徳 and 野本貴大 and 松井誠 and 友田敬士郎}, title = {薬物送達用担体及び薬物送達システム}, howpublished = {公開特許}, year = 2020, month = {}, note = {特願2017-029264(2017/02/20), 特開2020-063191(2020/04/23)} } @misc{CTT100789761, author = {西山伸宏 and 武元宏泰 and 野本貴大 and 松井誠 and 友田敬士郎 and 山田直生 and 西森司 and 佐谷 秀行 and 永野 修  and 土橋 賢司 and 推名 健太郎}, title = {抗腫瘍剤}, howpublished = {登録特許}, year = 2020, month = {}, note = {特願2017-560416(2017/01/05), 再表2017/119462(2018/11/01), 特許第6803589号(2020/12/03)} } @misc{CTT100761475, author = {西山伸宏 and 武元宏泰 and Chih-Hao HUANG  and 野本貴大 and 友田敬士郎 and 松井誠}, title = {結合体}, howpublished = {公開特許}, year = 2017, month = {}, note = {特願2016-113664(2016/06/07), 特開2017-218408(2017/12/14)} }