@book{CTT100720778, author = {Hiroyasu Takemoto and Kanjiro Miyata and Nobuhiro Nishiyama and Kazunori Kataoka}, title = {Bioresponsive Polymer-Based Nucleic Acid Carriers}, publisher = {}, year = 2014, } @book{CTT100720814, author = {武元宏泰 and 西山伸宏 and 片岡一則}, title = {凍結濃縮現象によるClick反応加速}, publisher = {}, year = 2014, } @article{CTT100920584, author = {R. Sonobe and P. Yang and M.M. Suzuki and K. Shinjo and K. Iijima and N. Nishiyama and K. Miyata and K. Kataoka and H. Kajiyama and Y. Kondo}, title = {Long noncoding RNA TUG1 promotes cisplatin resistance in ovarian cancer via upregulation of DNA polymerase eta}, journal = {Cancer Science}, year = 2024, } @article{CTT100877325, author = {Jing Liu and Cabral Horacio and Bing Song and Ichio Aoki and Zhouyun Chen and Nobuhiro Nishiyama and Yuan Huang and Kazunori Kataoka and Peng Mi}, title = {Nanoprobe-based magnetic resonance imaging of hypoxia predicts responses to radiotherapy, immunotherapy, and sensitizing treatments in pancreatic tumors}, journal = {ACS Nano}, year = 2021, } @article{CTT100837910, author = {Tsukasa Chida and Yutaka Miura and Cabral Horacio and Takahiro Nomoto and Kazunori Kataoka and Nobuhiro Nishiyama}, title = {Epirubicin-loaded polymeric micelles effectively treat axillary lymph nodes metastasis of breast cancer through selective accumulation and pH-triggered drug release}, journal = {J. Control. Release}, year = 2018, } @article{CTT100752146, author = {M. Maeda and Y. Muragaki and J. Okamoto and S. Yoshizawa and N. Abe and H. Nakamoto and H. Ishii and K. Kawabata and S. Umemura and N. Nishiyama and K. Kataoka and H. Iseki}, title = {Sonodynamic therapy based on combined use of low dose administration of epirubicin-incorporating drug delivery system and focused ultrasound}, journal = {Ultrasound Med. Biol.}, year = 2017, } @article{CTT100773950, author = {Y. Anraku and H. Kuwahara and Y. Fukusato and A. Mizoguchi and T. Ishii and K. Nitta and Y. Matsumoto and K. Toh and K. Miyata and S. Uchida and K. Nishina and K. Osada and K. Itaka and N. Nishiyama and H. Mizusawa and T. Yamasoba and T. Yokota and K. Kataoka}, title = {Glycaemic control boosts glucosylated nanocarrier crossing the BBB into the brain}, journal = {Nature Communications}, year = 2017, } @article{CTT100752115, author = {P. Mi and H. Yanagie and N. Dewi and H.-C. Yen and X. Liu and M. Suzuki and Y. Sakurai and K. Ono and H. Takahashi and H. Cabral and K. Kataoka and N. Nishiyama}, title = {Block copolymer-boron cluster conjugate for effective boron neutron capture therapy of solid tumors}, journal = {J. Control. Release}, year = 2017, } @article{CTT100752123, author = {H. Taniguchi and D. Hoshino and C. Moriya and H. Zembutsu and N. Nishiyama and H. Yamamoto and K. Kataoka and K. Imai}, title = {Silencing PRDM14 expression by an innovative RNAi therapy inhibits stemness, tumorigenicity, and metastasis of breast cancer}, journal = {Oncotarget}, year = 2017, } @article{CTT100752056, author = {Mitsuru Naito and Ryota Azuma and Hiroyasu Takemoto and Mao Hori and Naoto Yoshinaga and Shigehito Osawa and Rimpei Kamegawa and Hyun Jin Kim and Takehiko Ishii and Nobuhiro Nishiyama and Kanjiro Miyata and Kazunori}, title = {Multilayered Polyion Complexes with Dissolvable Silica Layer Covered by Controlling Densities of cRGD-conjugated PEG Chains for Cancer-targeted siRNA Delivery}, journal = {Journal of Biomaterials Science, Polymer Edition}, year = 2017, } @article{CTT100752051, author = {Shigehito Osawa and Takehiko Ishii and Hiroyasu Takemoto and Kensuke Osada and Kazunori Kataoka}, title = {A facile amino-functionalization of poly(2-oxazoline)s’ distal end through sequential azido end-capping and Staudinger reactions}, journal = {European Polymer Journal}, year = 2017, } @article{CTT100752111, author = {C. Moriya and H. Taniguchi and K. Miyata and N. Nishiyama and K. Kataoka and K. Imai}, title = {Inhibition of PRDM14 expression in pancreatic cancer suppresses cancer stem-like properties and liver metastasis in mice}, journal = {Carcinogenesis}, year = 2017, } @article{CTT100720807, author = {Yi Yu and Hyun Jin Kim and Peng Mi and Meng Zheng and Hiroyasu Takemoto and Kazuko Toh and Kim Beob Soo and Kotaro Hayashi and Mitsuru Naito and Yu Matsumoto and Kanjiro Miyata and Kazunori Kataoka}, title = {Targeted systemic delivery of siRNA to cervical cancer model using cyclic RGD-installed unimer polyion complex-assembled gold nanoparticles.}, journal = {Journal of Controlled Release}, year = 2016, } @article{CTT100752062, author = {H. Hino and M. Kamiya and K. Kitano and K. Mizuno and S. Tanaka and N. Nishiyama and K. Kataoka and Y. Urano and J. Nakajima}, title = {Rapid cancer fluorescence imaging using a γ-glutamyltranspeptidase-specific probe for primary lung cancer}, journal = {Translational Oncology}, year = 2016, } @article{CTT100714252, author = {Nobuhiro Nishiyama and Yasuhiro Matsumura and Kazunori Kataoka}, title = {Development of polymeric micelles for targeting intractable cancers.}, journal = {Cancer science}, year = 2016, } @article{CTT100714250, author = {Peng Mi and Daisuke Kokuryo and Cabral Horacio and Hailiang Wu and Yasuko Terada and Tsuneo Saga and Ichio Aoki and Nobuhiro Nishiyama and Kazunori Kataoka}, title = {A pH-activatable nanoparticle with signal-amplification capabilities for non-invasive imaging of tumour malignancy}, journal = {Nature Nanotechnology}, year = 2016, } @article{CTT100714253, author = {Yoko Matsumoto and Miyamoto Yuichiro and Cabral Horacio and Yu Mastumoto and Kazunori Nagasawa and Shunsuke Nakagawa and Tetsu Yano and Daichi Maeda and Katsutoshi Oda and Kei Kawana and Nobuhiro Nishiyama and Kazunori Kataoka and Tomoyuki Fujii}, title = {Enhanced efficacy against cervical carcinomas through polymeric micelles physically incorporating the proteasome inhibitor MG132}, journal = {Cancer Science}, year = 2016, } @article{CTT100723937, author = {Takahiro Nomoto and Shigeto Fukushima and Michiaki Kumagai and Kozo Miyazaki and Aki Inoue and Peng Mi and Yoshinori Maeda and Kazuko Toh and Yu Mastumoto and Yuji Morimoto and Akihiro Kishimura and Nobuhiro Nishiyama and Kazunori Kataoka}, title = {Calcium phosphate-based organic-inorganic hybrid nanocarriers with pH-responsive on/off switch for photodynamic therapy.}, journal = {Biomaterials science}, year = 2016, } @article{CTT100714260, author = {Haruka Nishida and Yoko Matsumoto and Kei Kawana and Christie James and Mitsuru Naito and Kim Beob Soo and Kazuko Toh and Hyun Su Min and Yi Yu and Yu Mastumoto and Hyun Jin Kim and Kanjiro Miyata and Ayumi Taguchi and Kensuke Tomio and Aki Yamashita and Tomoko Inoue and Hiroe Nakamura and Asaha Fujimoto and Masakazu Sato and Mitsuyo Yoshida and Katsuyuki Adachi and Takahide Arimoto and Osamu Wada-Hiraike and Katsutoshi Oda and Takeshi Nagamatsu and Nobuhiro Nishiyama and Kazunori Kataoka and Yutaka Osuga and Tomoyuki Fujii}, title = {Systemic delivery of siRNA by actively targeted polyion complex micelles for silencing the E6 and E7 human papillomavirus oncogenes}, journal = {Journal of Controlled Release}, year = 2016, } @article{CTT100714258, author = {Hirokuni Uchida and Keiji Itaka and Satoshi Uchida and Takehiko Ishii and Tomoya Suma and Kanjiro Miyata and Makoto Oba and Nobuhiro Nishiyama and Kazunori Kataoka}, title = {Synthetic Polyamines to Regulate mRNA Translation through the Preservative Binding of Eukaryotic Initiation Factor 4E to the Cap Structure}, journal = {Journal of the American Chemical Society}, year = 2016, } @article{CTT100720774, author = {Kotaro Hayashi and Hiroyuki Chaya and Shigeto Fukushima and Sumiyo Watanabe and Hiroyasu Takemoto and Kensuke Osada and Nobuhiro Nishiyama and Kanjiro Miyata and Kazunori Kataoka}, title = {Macromol. Rapid Commun. 6/2016.}, journal = {Macromolecular rapid communications}, year = 2016, } @article{CTT100720773, author = {Kotaro Hayashi and Hiroyuki Chaya and Shigeto Fukushima and Sumiyo Watanabe and Hiroyasu Takemoto and Kensuke Osada and Nobuhiro Nishiyama and Kanjiro Miyata and Kazunori Kataoka}, title = {Influence of RNA Strand Rigidity on Polyion Complex Formation with Block Catiomers}, journal = {Macromolecular Rapid Communications}, year = 2016, } @article{CTT100714255, author = {Novriana Dewi and Peng Mi and Hironobu Yanagie and Yuriko Sakurai and Yasuyuki Morishita and Masashi Yanagawa and Takayuki Nakagawa and Atsuko Shinohara and Takehisa Mastukawa and Kazuhito Yokoyama and Cabral Horacio and Minoru Suzuki and Yoshinori Sakurai and Hiroki Tanaka and Koji Ono and Nobuhiro Nishiyama and Kazunori Kataoka and Hiroyuki Takahashi}, title = {In vivo evaluation of neutron capture therapy effectivity using calcium phosphate-based nanoparticles as Gd-DTPA delivery agent}, journal = {Journal of Cancer Research and Clinical Oncology}, year = 2015, } @article{CTT100714351, author = {Masahiro Murakami and Kazutaka Nishina and Chie Watanabe and Kie Yoshida-Tanaka and Wenying Piao and Hiroya Kuwahara and Yuji Horikiri and Kanjiro Miyata and Nobuhiro Nishiyama and Kazunori Kataoka and Masayuki Yoshida and Hidehiro Mizusawa and Takanori Yokota}, title = {Enteral siRNA delivery technique for therapeutic gene silencing in the liver via the lymphatic route}, journal = {Scientific Reports}, year = 2015, } @article{CTT100714350, author = {Kumiko Sakai-Kato and Kunie Nanjo and Hiroyuki Kusuhara and Nobuhiro Nishiyama and Kazunori Kataoka and Toru Kawanishi and Haruhiko Okuda and Yukihiro Goda}, title = {Effect of Knockout of Mdr1a and Mdr1b ABCB1 Genes on the Systemic Exposure of a Doxorubicin-Conjugated Block Copolymer in Mice}, journal = {Molecular Pharmaceutics}, year = 2015, } @article{CTT100714352, author = {Kumiko Sakai-Kato and Nobuhiro Nishiyama and Masato Kozaki and Takeshi Nakanishi and Yoshihiro Matsuda and Mai Hirano and Hiroyuki Hanada and Shigeru HIsada and Hiroshi Onodera and Hideyoshi Harashima and Yasuhiro Matsumura and Kazunori Kataoka and Yukihiro Goda and Haruhiko Okuda and Toru Kawanishi}, title = {General considerations regarding the in vitro and in vivo properties of block copolymer micelle products and their evaluation}, journal = {Journal of Controlled Release}, year = 2015, } @article{CTT100714353, author = {Peng Mi and Novriana Dewi and Hironobu Yanagie and Daisuke Kokuryo and Minoru Suzuki and Yoshinori Sakurai and Yanmin Li and Ichio Aoki and Koji Ono and Hiroyuki Takahashi and Cabral Horacio and Nobuhiro Nishiyama and Kazunori Kataoka}, title = {Hybrid Calcium Phosphate-Polymeric Micelles Incorporating Gadolinium Chelates for Imaging-Guided Gadolinium Neutron Capture Tumor Therapy}, journal = {Acs Nano}, year = 2015, } @article{CTT100714348, author = {Peng Mi and Hironobu Yanagie and Daisuke Kokuryo and Novriana Dewi and Ichio Aoki and Nobuhiro Nishiyama and Kazunori Kataoka}, title = {Block copolymer hybrid calcium phosphate micelles for cancer diagnosis and neutron capture therapy}, journal = {Journal of Controlled Release}, year = 2015, } @article{CTT100720777, author = {Hui Gao and Hiroyasu Takemoto and Qixian Chen and Mitsuru Naito and Hirokuni Uchida and Xueying Liu and Kanjiro Miyata and Kazunori Kataoka}, title = {Regulated protonation of polyaspartamide derivatives bearing repeated aminoethylene side chains for efficient intracellular siRNA delivery with minimal cytotoxicity}, journal = {Chemical Communications}, year = 2015, } @article{CTT100720776, author = {Meng Zheng and Hyun Jin Kim and Hiroyasu Takemoto and Kanjiro Miyata and Kazunori Kataoka}, title = {Precisely regulated nanoarchitecture comprised of gold nanotemplate and unimer polyion complex for systemic delivery of siRNA}, journal = {Journal of Controlled Release}, year = 2015, } @article{CTT100723941, author = {Yoshinori Maeda and Frederico Pittella and Takahiro Nomoto and Hiroyasu Takemoto and Nobuhiro Nishiyama and Kanjiro Miyata and Kazunori Kataoka}, title = {Fine-Tuning of Charge-Conversion Polymer Structure for Efficient Endosomal Escape of siRNA-Loaded Calcium Phosphate Hybrid Micelles}, journal = {Macromolecular Rapid Communications}, year = 2014, } @article{CTT100720785, author = {Frederico Pittella and Cabral Horacio and Yoshinori Maeda and Peng Mi and Sumiyo Watanabe and Hiroyasu Takemoto and Hyun Jin Kim and Nobuhiro Nishiyama and Kanjiro Miyata and Kazunori Kataoka}, title = {Systemic siRNA delivery to a spontaneous pancreatic tumor model in transgenic mice by PEGylated calcium phosphate hybrid micelles}, journal = {Journal of Controlled Release}, year = 2014, } @article{CTT100720784, author = {Hyun Jin Kim and Hiroyasu Takemoto and Yi Yu and Meng Zheng and Yoshinori Maeda and Hiroyuki Chaya and Kotaro Hayashi and Peng Mi and Frederico Pittella and Christie James and Kazuko Toh and Yu Mastumoto and Nobuhiro Nishiyama and Kanjiro Miyata and Kazunori Kataoka}, title = {Precise Engineering of siRNA Delivery Vehicles to Tumors Using Polyion Complexes and Gold Nanoparticles}, journal = {Acs Nano}, year = 2014, } @article{CTT100720781, author = {Shigehito Osawa and Kensuke Osada and Shigehiro Hiki and Anjaneyulu Dirisala and Hiroyasu Takemoto and Takehiko Ishii and Kazunori Kataoka}, title = {Design of poly(oxazoline) based triblock copolymer for polyplex micelles with core protective parisade}, journal = {Abstracts of Papers of the American Chemical Society}, year = 2014, } @article{CTT100720786, author = {Hiroyasu Takemoto and Kanjiro Miyata and Shota Hattori and Takehiko Ishii and Tomoya Suma and Satoshi Uchida and Nobuhiro Nishiyama and Kazunori Kataoka}, title = {Acidic pH-Responsive siRNA Conjugate for Reversible Carrier Stability and Accelerated Endosomal Escape with Reduced IFN alpha-Associated Immune Response}, journal = {Angewandte Chemie-International Edition}, year = 2013, } @article{CTT100720789, author = {Kanjiro Miyata and Christie James and Tomoya Suma and Hiroyasu Takemoto and Hirokuni Uchida and Nobuhiro Nishiyama and Kazunori Kataoka}, title = {Fine-Tuning of Repeating Aminoethyelene Units in Poly(aspartamide) Side Chains for Enhanced siRNA Delivery}, journal = {Tailored Polymer Architectures For Pharmaceutical and Biomedical Applications}, year = 2013, } @article{CTT100720793, author = {Hiroyasu Takemoto and Kanjiro Miyata and Nobuhiro Nishiyama and Kazunori Kataoka}, title = {siRNA-grafted polymer for efficient siRNA delivery system}, journal = {Abstracts of Papers of the American Chemical Society}, year = 2012, } @article{CTT100720790, author = {Hiroyasu Takemoto and Kanjiro Miyata and Takehiko Ishii and Shota Hattori and Shigehito Osawa and Nobuhiro Nishiyama and Kazunori Kataoka}, title = {Accelerated Polymer-Polymer Click Conjugation by Freeze-Thaw Treatment}, journal = {Bioconjugate Chemistry}, year = 2012, } @article{CTT100720791, author = {Tomoya Suma and Kanjiro Miyata and Yasutaka Anraku and Sumiyo Watanabe and Christie James and Hiroyasu Takemoto and Momoko Shioyama and Noha Gouda and Takehiko Ishii and Nobuhiro Nishiyama and Kazunori Kataoka}, title = {Smart Multilayered Assembly for Biocompatible siRNA Delivery Featuring Dissolvable Silica, Endosome-Disrupting Polycation, and Detachable PEG}, journal = {Acs Nano}, year = 2012, } @article{CTT100720798, author = {Kanjiro Miyata and Noha Gouda and Hiroyasu Takemoto and Makoto Oba and Yan Lee and Hiroyuki Koyama and Yuichi Yamasaki and Keiji Itaka and Nobuhiro Nishiyama and Kazunori Kataoka}, title = {Enhanced transfection with silica-coated polyplexes loading plasmid DNA}, journal = {Biomaterials}, year = 2010, } @article{CTT100720799, author = {Hiroyasu Takemoto and Atsushi Ishii and Kanjiro Miyata and Masataka Nakanishi and Makoto Oba and Takehiko Ishii and Yuichi Yamasaki and Nobuhiro Nishiyama and Kazunori Kataoka}, title = {Polyion complex stability and gene silencing efficiency with a siRNA-grafted polymer delivery system}, journal = {Biomaterials}, year = 2010, } @article{CTT100720796, author = {Kanjiro Miyata and Takahiro Nomoto and Hiroyasu Takemoto and Hyun Jin Kim and Yu Matsumoto and Makoto Oba and Nobuhiro Nishiyama and Kazunori Kataoka}, title = {Development of advanced polymer-based nanodevices for nucleic acids delivery}, journal = {Abstracts of Papers of the American Chemical Society}, year = 2010, } @inproceedings{CTT100900269, author = {本田雄士 and 長尾周平 and 喜納宏昭 and 松平望 and Xueying Liu and 野本貴大 and Anjaneyulu Dirisala and 三浦裕 and 片岡一則 and 西山伸宏}, title = {集束超音波と高分子複合体を組み合わせた脳選択的AAV送達システムの構築}, booktitle = {}, year = 2023, } @inproceedings{CTT100900272, author = {松平望 and 本田雄士 and 長尾周平 and 喜納宏昭 and 野本貴大 and Xueying Liu and Anjaneyulu Dirisala and 三浦裕 and 片岡一則 and 西山伸宏}, title = {腫瘍細胞標的機能を備えた全身投与型アデノ随伴ウイルス(AAV)三元系複合体の開発}, booktitle = {}, year = 2022, } @inproceedings{CTT100876897, author = {本田雄士 and 長尾周平 and 喜納宏昭 and 野本貴大 and Liu Xueying and Dirisala Anjaneyulu and 松井誠 and 三浦裕 and 片岡一則 and 西山伸宏}, title = {アデノ随伴ウイルス(AAV)の中和抗体回避および活性を向上させるAAV内包三元系複合体}, booktitle = {}, year = 2022, } @inproceedings{CTT100863942, author = {長尾周平 and 本田雄士 and 喜納宏昭 and 野本貴大 and Liu Xueying and Dirisala Anjaneyulu and 松井誠 and 三浦裕 and 片岡一則 and 西山伸宏}, title = {アデノ随伴ウイルス(AAV)中和抗体回避を可能にする全身投与型AAV搭載三元系複合体の開発}, booktitle = {}, year = 2021, } @inproceedings{CTT100857506, author = {長尾周平 and 本田雄士 and 喜納宏昭 and 野本貴大 and Liu Xueying and Dirisala Anjaneyulu and 松井誠 and 三浦裕 and 片岡一則 and 西山伸宏}, title = {アデノ随伴ウイルス(AAV)ベクターの中和抗体および副作用を克服するAAV/タンニン酸/ボロン酸導入高分子三元系複合体の構築}, booktitle = {}, year = 2021, } @inproceedings{CTT100843336, author = {Yoshihiro Tachihara and 中川 泰宏 and Anqi Tao and Huang George and Takuya Miyazaki and Kazunori Igarashi and Quader Sabina and 安楽 泰孝 and 片岡 一則 and Horacio Cabral}, title = {難治性膵臓癌を標的としたホストゲスト相互作用を介した環状中分子担持型pH応答性高分子ミセルの開発}, booktitle = {}, year = 2021, } @inproceedings{CTT100774002, author = {Hiroyasu Takemoto and Kanjiro Miyata and Nobuhiro Nishiyama and Kazunori Kataoka}, title = {Size-regulated siRNA carriers from small complex loading single siRNA molecule for systemic delivery to tumor tissue}, booktitle = {}, year = 2018, } @inproceedings{CTT100768254, author = {1. 野本貴大 and 福島重人 and 熊谷康顕 and 宮崎幸造 and 井上明季 and Mi Peng and 前田芳周 and 籐加珠子 and 松本有 and 守本祐司 and 岸村顕広 and 西山伸宏 and 片岡一則 and 野本貴大}, title = {効率的な光線力学療法を指向したハイブリッド型光増感剤送達システム}, booktitle = {}, year = 2018, } @inproceedings{CTT100752154, author = {武元宏泰 and キム ヒュンジン and 宮田完二郎 and 西山伸宏 and 片岡一則}, title = {単分子siRNA内包型小会合体を要素とするsiRNAキャリアの構築と全身投与による腫瘍組織への送達}, booktitle = {}, year = 2017, } @inproceedings{CTT100752141, author = {武元宏泰 and 宮田完二郎 and 林光太朗 and 持田祐希 and 片岡一則 and 西山伸宏}, title = {シロキサンネットワークにて形成されるsiRNA内包有機-無機ハイブリッドナノ粒子の開発}, booktitle = {}, year = 2016, } @inproceedings{CTT100752143, author = {越後真梨那 and 武元 宏泰 and 林 光太朗 and 宮田 完二郎 and 金澤秀子 and 片岡 一則 and 西山 伸宏}, title = {がん細胞内にて特異的に切断される Linker を利用した siRNA 送達キャリアの開発}, booktitle = {}, year = 2016, } @inproceedings{CTT100768256, author = {Takahiro Nomoto and Shigeto Fukushima and Michiaki Kumagai and Kaori Machitani and Kanjiro Miyata and Makoto Oba and Yu Matsumoto and Kensuke Osada and Nobuhiro Nishiyama and Kazunori Kataoka}, title = {Three-layered polyplex micelle for light-induced gene transfer}, booktitle = {}, year = 2015, }