論文

• R. Sonobe, P. Yang, M.M. Suzuki, K. Shinjo, K. Iijima, N. Nishiyama, K. Miyata, K. Kataoka, H. Kajiyama, Y. Kondo. Long noncoding RNA TUG1 promotes cisplatin resistance in ovarian cancer via upregulation of DNA polymerase eta, Cancer Science, Vol. 115, No. 6, pp. 1910-1923, Apr. 2024.
• Jing Liu, Cabral Horacio, Bing Song, Ichio Aoki, Zhouyun Chen, Nobuhiro Nishiyama, Yuan Huang, Kazunori Kataoka, Peng Mi. Nanoprobe-based magnetic resonance imaging of hypoxia predicts responses to radiotherapy, immunotherapy, and sensitizing treatments in pancreatic tumors, ACS Nano, Vol. 15, No. 8, pp. 13526–13538, Aug. 2021.
• Tsukasa Chida, Yutaka Miura, Cabral Horacio, Takahiro Nomoto, Kazunori Kataoka, Nobuhiro Nishiyama. Epirubicin-loaded polymeric micelles effectively treat axillary lymph nodes metastasis of breast cancer through selective accumulation and pH-triggered drug release, J. Control. Release, Vol. 292, pp. 130-140, Dec. 2018.
• M. Maeda, Y. Muragaki, J. Okamoto, S. Yoshizawa, N. Abe, H. Nakamoto, H. Ishii, K. Kawabata, S. Umemura, N. Nishiyama, K. Kataoka, H. Iseki. Sonodynamic therapy based on combined use of low dose administration of epirubicin-incorporating drug delivery system and focused ultrasound, Ultrasound Med. Biol., Vol. 43, No. 10, pp. 2295-2301, Oct. 2017.
• Y. Anraku, H. Kuwahara, Y. Fukusato, A. Mizoguchi, T. Ishii, K. Nitta, Y. Matsumoto, K. Toh, K. Miyata, S. Uchida, K. Nishina, K. Osada, K. Itaka, N. Nishiyama, H. Mizusawa, T. Yamasoba, T. Yokota, K. Kataoka. Glycaemic control boosts glucosylated nanocarrier crossing the BBB into the brain, Nature Communications, Vol. 8, pp. 1001, Oct. 2017.
• P. Mi, H. Yanagie, N. Dewi, H.-C. Yen, X. Liu, M. Suzuki, Y. Sakurai, K. Ono, H. Takahashi, H. Cabral, K. Kataoka, N. Nishiyama. Block copolymer-boron cluster conjugate for effective boron neutron capture therapy of solid tumors, J. Control. Release, Vol. 254, pp. 1-9, May 2017.
• H. Taniguchi, D. Hoshino, C. Moriya, H. Zembutsu, N. Nishiyama, H. Yamamoto, K. Kataoka, K. Imai. Silencing PRDM14 expression by an innovative RNAi therapy inhibits stemness, tumorigenicity, and metastasis of breast cancer, Oncotarget, Vol. 8, No. 29, pp. 46856-46874, Apr. 2017.
• Mitsuru Naito, Ryota Azuma, Hiroyasu Takemoto, Mao Hori, Naoto Yoshinaga, Shigehito Osawa, Rimpei Kamegawa, Hyun Jin Kim, Takehiko Ishii, Nobuhiro Nishiyama, Kanjiro Miyata, Kazunori. Multilayered Polyion Complexes with Dissolvable Silica Layer Covered by Controlling Densities of cRGD-conjugated PEG Chains for Cancer-targeted siRNA Delivery, Journal of Biomaterials Science, Polymer Edition, Vol. 28, pp. 1109-1123, Mar. 2017.  公式リンク  
  
• Shigehito Osawa, Takehiko Ishii, Hiroyasu Takemoto, Kensuke Osada, Kazunori Kataoka. A facile amino-functionalization of poly(2-oxazoline)s’ distal end through sequential azido end-capping and Staudinger reactions, European Polymer Journal, Vol. 88, pp. 553-561, Feb. 2017.
• C. Moriya, H. Taniguchi, K. Miyata, N. Nishiyama, K. Kataoka, K. Imai. Inhibition of PRDM14 expression in pancreatic cancer suppresses cancer stem-like properties and liver metastasis in mice, Carcinogenesis, Vol. 38, No. 6, pp. 638-648, Jan. 2017.
• Yi Yu, Hyun Jin Kim, Peng Mi, Meng Zheng, Hiroyasu Takemoto, Kazuko Toh, Kim Beob Soo, Kotaro Hayashi, Mitsuru Naito, Yu Matsumoto, Kanjiro Miyata, Kazunori Kataoka. Targeted systemic delivery of siRNA to cervical cancer model using cyclic RGD-installed unimer polyion complex-assembled gold nanoparticles., Journal of Controlled Release, Elsevier, Sept. 2016.
• H. Hino, M. Kamiya, K. Kitano, K. Mizuno, S. Tanaka, N. Nishiyama, K. Kataoka, Y. Urano, J. Nakajima. Rapid cancer fluorescence imaging using a γ-glutamyltranspeptidase-specific probe for primary lung cancer, Translational Oncology, Vol. 9, No. 3, pp. 203-210, June 2016.
• Nobuhiro Nishiyama, Yasuhiro Matsumura, Kazunori Kataoka. Development of polymeric micelles for targeting intractable cancers., Cancer science, Vol. 107, No. 7, pp. 867-74, June 2016.  公式リンク  
  
• Peng Mi, Daisuke Kokuryo, Cabral Horacio, Hailiang Wu, Yasuko Terada, Tsuneo Saga, Ichio Aoki, Nobuhiro Nishiyama, Kazunori Kataoka. A pH-activatable nanoparticle with signal-amplification capabilities for non-invasive imaging of tumour malignancy, Nature Nanotechnology, Vol. 11, No. 8, pp. 724-+, May 2016.  公式リンク  
  
• Yoko Matsumoto, Miyamoto Yuichiro, Cabral Horacio, Yu Mastumoto, Kazunori Nagasawa, Shunsuke Nakagawa, Tetsu Yano, Daichi Maeda, Katsutoshi Oda, Kei Kawana, Nobuhiro Nishiyama, Kazunori Kataoka, Tomoyuki Fujii. Enhanced efficacy against cervical carcinomas through polymeric micelles physically incorporating the proteasome inhibitor MG132, Cancer Science, Vol. 107, No. 6, pp. 773-781, Apr. 2016.  公式リンク  
  
• Takahiro Nomoto, Shigeto Fukushima, Michiaki Kumagai, Kozo Miyazaki, Aki Inoue, Peng Mi, Yoshinori Maeda, Kazuko Toh, Yu Mastumoto, Yuji Morimoto, Akihiro Kishimura, Nobuhiro Nishiyama, Kazunori Kataoka. Calcium phosphate-based organic-inorganic hybrid nanocarriers with pH-responsive on/off switch for photodynamic therapy., Biomaterials science, Vol. 4, No. 5, pp. 826-838, Mar. 2016.  公式リンク  
  
• Haruka Nishida, Yoko Matsumoto, Kei Kawana, Christie James, Mitsuru Naito, Kim Beob Soo, Kazuko Toh, Hyun Su Min, Yi Yu, Yu Mastumoto, Hyun Jin Kim, Kanjiro Miyata, Ayumi Taguchi, Kensuke Tomio, Aki Yamashita, Tomoko Inoue, Hiroe Nakamura, Asaha Fujimoto, Masakazu Sato, Mitsuyo Yoshida, Katsuyuki Adachi, Takahide Arimoto, Osamu Wada-Hiraike, Katsutoshi Oda, Takeshi Nagamatsu, Nobuhiro Nishiyama, Kazunori Kataoka, Yutaka Osuga, Tomoyuki Fujii. Systemic delivery of siRNA by actively targeted polyion complex micelles for silencing the E6 and E7 human papillomavirus oncogenes, Journal of Controlled Release, Vol. 231, pp. 29-37, Mar. 2016.  公式リンク  
  
• Hirokuni Uchida, Keiji Itaka, Satoshi Uchida, Takehiko Ishii, Tomoya Suma, Kanjiro Miyata, Makoto Oba, Nobuhiro Nishiyama, Kazunori Kataoka. Synthetic Polyamines to Regulate mRNA Translation through the Preservative Binding of Eukaryotic Initiation Factor 4E to the Cap Structure, Journal of the American Chemical Society, Vol. 138, No. 5, pp. 1478-1481, Jan. 2016.  公式リンク  
  
• Kotaro Hayashi, Hiroyuki Chaya, Shigeto Fukushima, Sumiyo Watanabe, Hiroyasu Takemoto, Kensuke Osada, Nobuhiro Nishiyama, Kanjiro Miyata, Kazunori Kataoka. Macromol. Rapid Commun. 6/2016., Macromolecular rapid communications, Vol. 37, No. 6, pp. 560, Jan. 2016.  公式リンク  
  
• Kotaro Hayashi, Hiroyuki Chaya, Shigeto Fukushima, Sumiyo Watanabe, Hiroyasu Takemoto, Kensuke Osada, Nobuhiro Nishiyama, Kanjiro Miyata, Kazunori Kataoka. Influence of RNA Strand Rigidity on Polyion Complex Formation with Block Catiomers, Macromolecular Rapid Communications, Vol. 37, No. 6, pp. 486-493, Jan. 2016.  公式リンク  
  
• Novriana Dewi, Peng Mi, Hironobu Yanagie, Yuriko Sakurai, Yasuyuki Morishita, Masashi Yanagawa, Takayuki Nakagawa, Atsuko Shinohara, Takehisa Mastukawa, Kazuhito Yokoyama, Cabral Horacio, Minoru Suzuki, Yoshinori Sakurai, Hiroki Tanaka, Koji Ono, Nobuhiro Nishiyama, Kazunori Kataoka, Hiroyuki Takahashi. In vivo evaluation of neutron capture therapy effectivity using calcium phosphate-based nanoparticles as Gd-DTPA delivery agent, Journal of Cancer Research and Clinical Oncology, Vol. 142, No. 4, pp. 767-775, Dec. 2015.  公式リンク  
  
• Masahiro Murakami, Kazutaka Nishina, Chie Watanabe, Kie Yoshida-Tanaka, Wenying Piao, Hiroya Kuwahara, Yuji Horikiri, Kanjiro Miyata, Nobuhiro Nishiyama, Kazunori Kataoka, Masayuki Yoshida, Hidehiro Mizusawa, Takanori Yokota. Enteral siRNA delivery technique for therapeutic gene silencing in the liver via the lymphatic route, Scientific Reports, Vol. 5, Nov. 2015.  公式リンク  
  
• Kumiko Sakai-Kato, Kunie Nanjo, Hiroyuki Kusuhara, Nobuhiro Nishiyama, Kazunori Kataoka, Toru Kawanishi, Haruhiko Okuda, Yukihiro Goda. Effect of Knockout of Mdr1a and Mdr1b ABCB1 Genes on the Systemic Exposure of a Doxorubicin-Conjugated Block Copolymer in Mice, Molecular Pharmaceutics, Vol. 12, No. 9, pp. 3175-3183, July 2015.  公式リンク  
  
• Kumiko Sakai-Kato, Nobuhiro Nishiyama, Masato Kozaki, Takeshi Nakanishi, Yoshihiro Matsuda, Mai Hirano, Hiroyuki Hanada, Shigeru HIsada, Hiroshi Onodera, Hideyoshi Harashima, Yasuhiro Matsumura, Kazunori Kataoka, Yukihiro Goda, Haruhiko Okuda, Toru Kawanishi. General considerations regarding the in vitro and in vivo properties of block copolymer micelle products and their evaluation, Journal of Controlled Release, Vol. 210, pp. 76-83, July 2015.  公式リンク  
  
• Peng Mi, Novriana Dewi, Hironobu Yanagie, Daisuke Kokuryo, Minoru Suzuki, Yoshinori Sakurai, Yanmin Li, Ichio Aoki, Koji Ono, Hiroyuki Takahashi, Cabral Horacio, Nobuhiro Nishiyama, Kazunori Kataoka. Hybrid Calcium Phosphate-Polymeric Micelles Incorporating Gadolinium Chelates for Imaging-Guided Gadolinium Neutron Capture Tumor Therapy, Acs Nano, Vol. 9, No. 6, pp. 5913-5921, June 2015.  公式リンク  
  
• Peng Mi, Hironobu Yanagie, Daisuke Kokuryo, Novriana Dewi, Ichio Aoki, Nobuhiro Nishiyama, Kazunori Kataoka. Block copolymer hybrid calcium phosphate micelles for cancer diagnosis and neutron capture therapy, Journal of Controlled Release, Vol. 213, pp. E88, May 2015.  公式リンク  
  
• Hui Gao, Hiroyasu Takemoto, Qixian Chen, Mitsuru Naito, Hirokuni Uchida, Xueying Liu, Kanjiro Miyata, Kazunori Kataoka. Regulated protonation of polyaspartamide derivatives bearing repeated aminoethylene side chains for efficient intracellular siRNA delivery with minimal cytotoxicity, Chemical Communications, Vol. 51, No. 15, pp. 3158-3161, 2015.  公式リンク  
  
• Meng Zheng, Hyun Jin Kim, Hiroyasu Takemoto, Kanjiro Miyata, Kazunori Kataoka. Precisely regulated nanoarchitecture comprised of gold nanotemplate and unimer polyion complex for systemic delivery of siRNA, Journal of Controlled Release, Vol. 213, pp. E75-E76, 2015.  公式リンク  
  
• Yoshinori Maeda, Frederico Pittella, Takahiro Nomoto, Hiroyasu Takemoto, Nobuhiro Nishiyama, Kanjiro Miyata, Kazunori Kataoka. Fine-Tuning of Charge-Conversion Polymer Structure for Efficient Endosomal Escape of siRNA-Loaded Calcium Phosphate Hybrid Micelles, Macromolecular Rapid Communications, Vol. 35, No. 13, pp. 1211-1215, 2014.  公式リンク  
  
• Frederico Pittella, Cabral Horacio, Yoshinori Maeda, Peng Mi, Sumiyo Watanabe, Hiroyasu Takemoto, Hyun Jin Kim, Nobuhiro Nishiyama, Kanjiro Miyata, Kazunori Kataoka. Systemic siRNA delivery to a spontaneous pancreatic tumor model in transgenic mice by PEGylated calcium phosphate hybrid micelles, Journal of Controlled Release, Vol. 178, pp. 18-24, 2014.  公式リンク  
  
• Hyun Jin Kim, Hiroyasu Takemoto, Yi Yu, Meng Zheng, Yoshinori Maeda, Hiroyuki Chaya, Kotaro Hayashi, Peng Mi, Frederico Pittella, Christie James, Kazuko Toh, Yu Mastumoto, Nobuhiro Nishiyama, Kanjiro Miyata, Kazunori Kataoka. Precise Engineering of siRNA Delivery Vehicles to Tumors Using Polyion Complexes and Gold Nanoparticles, Acs Nano, Vol. 8, No. 9, pp. 8979-8991, 2014.  公式リンク  
  
• Shigehito Osawa, Kensuke Osada, Shigehiro Hiki, Anjaneyulu Dirisala, Hiroyasu Takemoto, Takehiko Ishii, Kazunori Kataoka. Design of poly(oxazoline) based triblock copolymer for polyplex micelles with core protective parisade, Abstracts of Papers of the American Chemical Society, Vol. 248, 2014.  公式リンク  
  
• Hiroyasu Takemoto, Kanjiro Miyata, Shota Hattori, Takehiko Ishii, Tomoya Suma, Satoshi Uchida, Nobuhiro Nishiyama, Kazunori Kataoka. Acidic pH-Responsive siRNA Conjugate for Reversible Carrier Stability and Accelerated Endosomal Escape with Reduced IFN alpha-Associated Immune Response, Angewandte Chemie-International Edition, Vol. 52, No. 24, pp. 6218-6221, 2013.  公式リンク  
  
• Kanjiro Miyata, Christie James, Tomoya Suma, Hiroyasu Takemoto, Hirokuni Uchida, Nobuhiro Nishiyama, Kazunori Kataoka. Fine-Tuning of Repeating Aminoethyelene Units in Poly(aspartamide) Side Chains for Enhanced siRNA Delivery, Tailored Polymer Architectures For Pharmaceutical and Biomedical Applications, Vol. 1135, pp. 189-196, 2013.  公式リンク  
  
• Hiroyasu Takemoto, Kanjiro Miyata, Nobuhiro Nishiyama, Kazunori Kataoka. siRNA-grafted polymer for efficient siRNA delivery system, Abstracts of Papers of the American Chemical Society, Vol. 243, 2012.  公式リンク  
  
• Hiroyasu Takemoto, Kanjiro Miyata, Takehiko Ishii, Shota Hattori, Shigehito Osawa, Nobuhiro Nishiyama, Kazunori Kataoka. Accelerated Polymer-Polymer Click Conjugation by Freeze-Thaw Treatment, Bioconjugate Chemistry, Vol. 23, No. 8, pp. 1503-1506, 2012.  公式リンク  
  
• Tomoya Suma, Kanjiro Miyata, Yasutaka Anraku, Sumiyo Watanabe, Christie James, Hiroyasu Takemoto, Momoko Shioyama, Noha Gouda, Takehiko Ishii, Nobuhiro Nishiyama, Kazunori Kataoka. Smart Multilayered Assembly for Biocompatible siRNA Delivery Featuring Dissolvable Silica, Endosome-Disrupting Polycation, and Detachable PEG, Acs Nano, Vol. 6, No. 8, pp. 6693-6705, 2012.  公式リンク  
  
• Kanjiro Miyata, Noha Gouda, Hiroyasu Takemoto, Makoto Oba, Yan Lee, Hiroyuki Koyama, Yuichi Yamasaki, Keiji Itaka, Nobuhiro Nishiyama, Kazunori Kataoka. Enhanced transfection with silica-coated polyplexes loading plasmid DNA, Biomaterials, Vol. 31, No. 17, pp. 4764-4770, 2010.  公式リンク  
  
• Hiroyasu Takemoto, Atsushi Ishii, Kanjiro Miyata, Masataka Nakanishi, Makoto Oba, Takehiko Ishii, Yuichi Yamasaki, Nobuhiro Nishiyama, Kazunori Kataoka. Polyion complex stability and gene silencing efficiency with a siRNA-grafted polymer delivery system, Biomaterials, Vol. 31, No. 31, pp. 8097-8105, 2010.  公式リンク  
  
• Kanjiro Miyata, Takahiro Nomoto, Hiroyasu Takemoto, Hyun Jin Kim, Yu Matsumoto, Makoto Oba, Nobuhiro Nishiyama, Kazunori Kataoka. Development of advanced polymer-based nanodevices for nucleic acids delivery, Abstracts of Papers of the American Chemical Society, Vol. 240, 2010.  公式リンク  
  

著書

• Hiroyasu Takemoto, Kanjiro Miyata, Nobuhiro Nishiyama, Kazunori Kataoka. Bioresponsive Polymer-Based Nucleic Acid Carriers, Nonviral Vectors For Gene Therapy Lipid- and Polymer-Based Gene Transfer, Vol. 88, pp. 289-323, 2014.  公式リンク  
• 武元宏泰, 西山伸宏, 片岡一則. 凍結濃縮現象によるClick反応加速, クリックケミストリー–基礎から実用まで-（ファインケミカルシリーズ）, 184-191, 2014.

国際会議発表 (査読有り)

• Takahiro Nomoto, Shigeto Fukushima, Michiaki Kumagai, Kaori Machitani, Kanjiro Miyata, Makoto Oba, Yu Matsumoto, Kensuke Osada, Nobuhiro Nishiyama, Kazunori Kataoka. Three-layered polyplex micelle for light-induced gene transfer, The 13th US-Japan DDS symposium, Dec. 2015.

国内会議発表 (査読有り)

• 本田雄士, 長尾周平, 喜納宏昭, 野本貴大, Liu Xueying, Dirisala Anjaneyulu, 松井誠, 三浦裕, 片岡一則, 西山伸宏. アデノ随伴ウイルス（AAV）の中和抗体回避および活性を向上させるAAV内包三元系複合体, 日本薬学会第142回年会, Mar. 2022.
• 長尾周平, 本田雄士, 喜納宏昭, 野本貴大, Liu Xueying, Dirisala Anjaneyulu, 松井誠, 三浦裕, 片岡一則, 西山伸宏. アデノ随伴ウイルス(AAV)中和抗体回避を可能にする全身投与型AAV搭載三元系複合体の開発, 第43回日本バイオマテリアル学会大会, Nov. 2021.
• 長尾周平, 本田雄士, 喜納宏昭, 野本貴大, Liu Xueying, Dirisala Anjaneyulu, 松井誠, 三浦裕, 片岡一則, 西山伸宏. アデノ随伴ウイルス(AAV)ベクターの中和抗体および副作用を克服するAAV/タンニン酸/ボロン酸導入高分子三元系複合体の構築, 第37回日本DDS学会学術集会, June 2021.
• 1. 野本貴大, 福島重人, 熊谷康顕, 宮崎幸造, 井上明季, Mi Peng, 前田芳周, 籐加珠子, 松本有, 守本祐司, 岸村顕広, 西山伸宏, 片岡一則, 野本貴大. 効率的な光線力学療法を指向したハイブリッド型光増感剤送達システム, 日本薬学会 第138年会, Mar. 2018.
• 武元宏泰, キム ヒュンジン, 宮田完二郎, 西山伸宏, 片岡一則. 単分子siRNA内包型小会合体を要素とするsiRNAキャリアの構築と全身投与による腫瘍組織への送達, 日本薬学会第137年会, Mar. 2017.
• 武元宏泰, 宮田完二郎, 林光太朗, 持田祐希, 片岡一則, 西山伸宏. シロキサンネットワークにて形成されるsiRNA内包有機-無機ハイブリッドナノ粒子の開発, 日本バイオマテリアル学会シンポジウム 2016, Nov. 2016.
• 越後真梨那, 武元 宏泰, 林 光太朗, 宮田 完二郎, 金澤秀子, 片岡 一則, 西山 伸宏. がん細胞内にて特異的に切断される Linker を利用した siRNA 送達キャリアの開発, 日本バイオマテリアル学会シンポジウム 2016, Nov. 2016.

国内会議発表 (査読なし・不明)

• 本田雄士, 長尾周平, 喜納宏昭, 松平望, Xueying Liu, 野本貴大, Anjaneyulu Dirisala, 三浦裕, 片岡一則, 西山伸宏. 集束超音波と高分子複合体を組み合わせた脳選択的AAV送達システムの構築, 第４４回日本バイオマテリアル学会大会, Nov. 2023.
• 松平望, 本田雄士, 長尾周平, 喜納宏昭, 野本貴大, Xueying Liu, Anjaneyulu Dirisala, 三浦裕, 片岡一則, 西山伸宏. 腫瘍細胞標的機能を備えた全身投与型アデノ随伴ウイルス(AAV)三元系複合体の開発, Nov. 2022.
• Yoshihiro Tachihara, 中川 泰宏, Anqi Tao, Huang George, Takuya Miyazaki, Kazunori Igarashi, Quader Sabina, 安楽 泰孝, 片岡 一則, Horacio Cabral. 難治性膵臓癌を標的としたホストゲスト相互作用を介した環状中分子担持型pH応答性高分子ミセルの開発, 日本バイオマテリアル学会 2020 年度関東ブロック発表会, Jan. 2021.
• Hiroyasu Takemoto, Kanjiro Miyata, Nobuhiro Nishiyama, Kazunori Kataoka. Size-regulated siRNA carriers from small complex loading single siRNA molecule for systemic delivery to tumor tissue, 第77回日本癌学会学術総会, Sept. 2018.

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