論文

• Hung Wei Lai, Kiwamu Takahashi, Motowo Nakajima, Tohru Tanaka, Shun-ichiro Ogura. Efficiency of aminolevulinic acid (ALA)-photodynamic therapy based on ALA uptake transporters in a cell density-dependent malignancy model, Journal of Photochemistry and Photobiology B: Biology, Vol. 218, May 2021.
• Taku Nakayama, Tatsuya Kobayashi, Otsuka Shinpei, Hideo Fukuhara, Tsutomu Namikawa, Keiji Inoue, Kazuhiro Hanazaki, Kiwamu Takahashi, Motowo Nakajima, Tohru Tanaka, Shun-ichiro Ogura. Photoirradiation after aminolevulinic acid treatment suppresses cancer cell proliferation through the HO-1/p21 pathway, Photodiagnosis and photodynamic therapy, Vol. 28, pp. 10-17, Dec. 2019.
• Hung Wei Lai, Ryuta Sasaki, Shiro Usuki, Motowo Nakajima, Tohru Tanaka, Shun-ichiro Ogura. Novel Strategy to Increase Specificity of ALA-Induced PpIX Accumulation through Inhibition of Transporters Involved in ALA Uptake, Photodiagnosis and photodynamic therapy, Vol. 27, pp. 327-335, June 2019.
• Yuta Sugiyama, Yukari Hiraiwa, Yuichiro Hagiya, Motowo Nakajima, Tohru Tanaka, Shun-ichiro Ogura. 5-Aminolevulinic acid regulates the immune response in LPS-stimulated RAW 264.7 macrophages, BMC immunology, Vol. 19, pp. 41, Dec. 2018.
• Yusei Shinohara, Yoshio Endo, Chiaki Abe, Ikkyu Shiba, Masahiro Ishizuka, Tohru Tanaka, Yutaka Yonemura, Shun-ichiro Ogura, Masahide Tominaga, Hisatsugu Yamada, Yoshihiro Uto. Development of a novel Schiff base derivative for enhancing the anticancer potential of 5-aminolevulinic acid-based photodynamic therapy, Photodiagnosis and Photodynamic Therapy, Vol. 20, 182-188, Dec. 2017.
• Junkoh Yamamoto, Shingo Kaneda, Tetsuya Yoneda, Shun-ichiro Ogura, Shohei Shimajiri, Tohru Tanaka, Yukinori Korogi, Shigeru Nishizawa. 5-aminolevulinic acid–induced protoporphyrin IX for high-grade gliomas: A prospective case study and clinical implications, Oncology Letters, Vol. 13, pp. 1269-1275, Dec. 2016.
• Taku Nakayama, Shinpei Otsuka, Tatsuya Kobayashi, Hodaka Okajima, Kentaro Matsumoto, Yuichiro Hagiya, Keiji Inoue, Taro Shuin, Motowo Nakajima, Tohru Tanaka, Shun-ichiro Ogura. Dormant cancer cells accumulate high protoporphyrin IX levels and are sensitive to 5-aminolevulinic acid-based photodynamic therapy, Scientific Reports, Vol. 6, No. 36478, Nov. 2016.
• Tomohiro Osaki, Inoru Yokoe, Shun-ichiro Ogura, Kiwamu Takahashi, Kiyotaka Murakami, Katsushi Inoue, Masahiro Ishizuka, Tohru Tanaka, Liming Li, Akihiko Sugiyama, Kazuo Azuma, Yusuke Murahata, Takeshi Tsuka, Norihiko Ito, Tomohiro Imagawa, Yoshiharu Okamoto. Photodynamic detection of canine mammary gland tumours after oral administration of 5-aminolevulinic acid, Veterinary and Comparative Oncology, Jan. 2016.
• Shinpei Otsuka, Kentaro Matsumoto, Motowo Nakajima, Tohru Tanaka, Shun-ichiro Ogura. Oxygen availability for porphyrin biosynthesis enzymes determines the production of protoporphyrin IX (PpIX) during hypoxia, PLOS ONE, 10, e0146026, Dec. 2015.
• Urara Ota, Hideo Fukuhara, Masahiro Ishizuka, Fuminori Abe, Chiaki Kawada, Kenji Tamura, Tohru Tanaka, Keiji Inoue, Shun-ichiro Ogura, Taro Shuin. Plasma protoporphyrin IX following administration of 5-aminolevulinic acid as a potential tumor marker, Molecular and Clinical Oncology, 11, 1813-1819, July 2015.
• Mai Miura, Kensuke Ito, Maiko Hayashi, Motowo Nakajima, Tohru Tanaka, Shun-ichiro Ogura. The effect of 5-aminolevulinic acid on cytochrome P450-mediated prodrug activation, PLOS ONE, 10, e0131793, July 2015.
• Junkoh Yamamoto, Shun-ichiro Ogura, Shohei Shimajiri, Yoshiteru Nakano, Daisuke Akiba, Takehiro Kitagawa, Kunihiro Ueta, Tohru Tanaka, Shigeru Nishizawa. 5-Aminolevulinic acid-induced protoporphyrin IX with multi-dose ionizing irradiation enhances host antitumor response and strongly inhibits tumor growth in experimental glioma in vivo, Molecular Medicine Reports, 11, 1813-1819, Mar. 2015.
• Maiko Hayashi, Hideo Fukuhara, Keiji Inoue, Taro Shuin, Yuichiro Hagiya, Motowo Nakajima, Tohru Tanaka, Shun-ichiro Ogura. The effect of iron ion on the specificity of photodynamic therapy with 5-aminolevulinic acid, PLOS ONE, 10, e0122351, Mar. 2015.
• Kentarou Matsumoto, Yuichiro Hagiya, Yoshio Endo, Motowo Nakajima, Masahiro Ishizuka, Tohru Tanaka, Shun-ichiro Ogura. Effects of plasma membrane ABCB6 on 5-aminolevulinic acid (ALA)-induced porphyrin accumulation in vitro: Tumor cell response to hypoxia, Photodiagnosis and Photodynamic Therapy, 12, 45-51, Mar. 2015.
• Taku Chibazakura, Yui Toriyabe, Hiroshi Fujii, Kiwamu Takahashi, Mariko Kawakami, Haruna Kuwamura, Hazuki Haga, Shun-ichiro OGURA, Fuminori Abe, Motowo Nakajima, Hirofumi Yoshikawa, Tohru Tanaka. 5-aminolevulinic acid enhances cell death under thermal stress in certain cancer cell lines, Bioscience Biotechnology and Biochemistry, 79, 422-431, Mar. 2015.

国際会議発表 (査読有り)

• Taku Nakayama, Shinpei Otsuka, Kazuhiro Hanazaki, Keiji Inoue, Taro Shuin, Motowo Nakajima, Tohru Tanaka, Shun-ichiro Ogura. Dormant Cancer Cells Accumulate High Protoporphyrin IX Levels And Are Sensitive To 5-aminolevulinic Acid-based Photodynamic Therapy, 17th International Photodynamic Association World Congress, June 2019.

国際会議発表 (査読なし・不明)

• Hung Wei Lai, Ryota Sasaki, Shiro Usuki, Kiwamu Takahashi, Motowo Nakajima, Tohru Tanaka, Shun-ichiro Ogura. Novel strategy to increase specificity of ALA-induced PpIX accumulation through inhibition of transporters involved in ALA uptake, The 7 th International ALA and Porphyrin Symposium, Dec. 2019.
• Arif Suprihadi, Kiwamu Takahashi, Motowo Nakajima, Tohru Tanaka, Shun-ichiro Ogura. The effect of heme biosynthesis on the mitochondrial functions in C2C12 cell line, 17th International Photodynamic Association World Congress, June 2019.
• Hung Wei Lai, Ryota Sasaki, Shiro Usuki, Kiwamu Takahashi, Motowo Nakajima, Tohru Tanaka, Shun-ichiro Ogura. Novel strategy to increase specificity of ALA-induced PpIX accumulation through inhibition of transporters involved in ALA uptake, 17th International Photodynamic Association World Congress, June 2019.
• Arif Suprihadi, Lai Hung Wei, Tan Hui Sin, Motowo Nakajima, Tohru Tanaka, Shun-ichiro Ogura. The Effect of Heme Biosynthesis on the Electron Transport Chain in C2C12 cell line, Nov. 2018.
• Daiki Yamaoka, Kentaro Matsumoto, Shimpei Otsuka, Tohru Tanaka, Shun-ichiro Ogura. Analysis of transporter which effects porphyrin metabolism in cancer cell line under treated hypoxic condition, Nov. 2018.
• Taku Nakayama, Shimpei Otsuka, Kazuhiro Hanazaki, Keiji Inoue, Taro Shuin, Motowo Nakajima, Tohru Tanaka, Shun-ichiro Ogura. Dormant Cancer Cells Accumulate High Protoporphyrin IX Levels And Are Sensitive To 5-aminolevulinic Acid-based Photodynamic Therapy, 6th International ALA and Porphyrin Symposium, Oct. 2018.
• Shun-ichiro Ogura, Taku Nakayama, Keiji Inoue, Motowo Nakajima, Tohru Tanaka. Applications of Aminolevulinic acid in tumor – From Diagnosis and Therapy to Screening, Photodynamic Therapy and Photodiagnosis Update 2018, Sept. 2018.
• Shun-ichiro Ogura, Keiji Inoue, Hideo Fukuhara, Motowo Nakajima, Tohru Tanaka. Porphyrins as urinary biomarkers for bladder cancer after 5-aminolevulinic acid administration: The potential of photodynamic screening for tumors, The 5th International ALA and Porphyrin Symposium, Dec. 2017.

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