論文

• Lestari B, Fukushima T, Utomo RY, Wahyuningsih MSH. Apoptotic and non-apoptotic roles of caspases in placenta physiology and pathology., Placenta, Vol. 151, Page 37-47, June 2024.
• 遠藤彬則, 福嶋俊明, 高橋ちかげ, 土屋光, 大竹史明, Sayaka Ono, Ly Tony, 吉田雪子, 田中啓二, 佐伯泰, 駒田雅之. USP8 prevents aberrant NF-kappaB and Nrf2 activation by counteracting ubiquitin signals from endosomes., Journal of Cell Biology, Vol. 223, No. 3, Page e202306013, Mar. 2024.
• Junya Adachi, Haruka Oda, Toshiaki Fukushima, Beni Lestari, Hiroshi Kimura, Hiroka Sugai, Kentaro Shiraki, Rei Hamaguchi, Kohei Sato, Kazushi Kinbara. Dense and Acidic Organelle-Targeted Visualization in Living Cells: Application of Viscosity-Responsive Fluorescence Utilizing Restricted Access to Minimum Energy Conical Intersection, Analytical Chemistry, 95, 5196–5204, Mar. 2023.
• Yomogita H, Ito H, Hashimoto K, Kudo A, Fukushima T, Endo T, Hirate Y, Akimoto Y, Komada M, Kanai Y, Miyasaka N, Kanai-Azuma M. A possible function of Nik-related kinase in the labyrinth layer of delayed delivery mouse placentas, J Reprod Dev Mol, Vol. 69, No. 1, Page 32-40, Dec. 2022.
• Beni Lestari, Satomi Naito, Akinori Endo, Hidenori Nishihara, Akira Kato, Erika Watanabe, Kimitoshi Denda, Masayuki Komada, Toshiaki Fukushima. Placental Mammals Acquired Functional Sequences in NRK for Regulating the CK2–PTEN–AKT Pathway and Placental Cell Proliferation, Molecular Biology and Evolution, Vol. 39, No. 2, p. msab371, Feb. 2022.
• Keijun Kakihara, Kengo Asamizu, Kei Moritsugu, Masahide Kubo, Tetsuya Kitaguchi, Akinori Endo, Akinori Kidera, Mitsunori Ikeguchi, Akira Kato, Masayuki Komada, Toshiaki Fukushima.. Molecular basis of ubiquitin-specific protease 8 autoinhibition by the WW-like domain., Commun Biol, 4, 1272, Nov. 2021.
• Béziat V, Rapaport F, Hu J, Titeux M, Bonnet des Claustres M, Bourgey M, Griffin H, Bandet É, Ma CS, Sherkat R, Rokni-Zadeh H, Louis DM, Changi-Ashtiani M, Delmonte OM, Fukushima T, Guennoun A, Khan T, Bender N, Rahman M, About F, Yang R, Rao G, Rouzaud C, Li J, Shearer D, Balogh K, Al Ali F, Ata M, Dabiri S, Momenilandi M, Nammour J, Alyanakian MA, Leruez-Ville M, Guenat D, Materna M, Marcot L, Vladikine N, Soret C, Vahidnezhad H, Youssefian L, Saeidian AH, Uitto J, Catherinot É, Navabi SS, Zarhrate M, Woodley DT, Jeljeli M, Abraham T, Belkaya S, Lorenzo L, Rosain J, Bayat M, Lanternier F, Lortholary O, Zakavi F, Gros P, Orth G, Abel L, Prétet JL, Fraitag S, Jouanguy E, Davis MM, Tangye SG, Notarangelo LD, Marr N, Waterboer T, Langlais D, Doorbar J, Hovnanian A, Christensen N, Bossuyt X, Shahrooei M, Casanova JL.. Humans with inherited T cell CD28 deficiency are susceptible to skin papillomaviruses but are otherwise healthy., Cell, Vol. 184, No. 14, pp. 3812-3828, July 2021.
• Satomi Naito, Toshiaki Fukushima, Akinori Endo, Kimitoshi Denda, Masayuki Komada. Nik-related kinase is targeted for proteasomal degradation by the chaperone-dependent ubiquitin ligase CHIP, FEBS Letters, 594, 11, 1778-1786, Mar. 2020.
• WH. Chan, M. Komada, T. Fukushima, EM. Southard-Smith, CR. Anderson. MJ. Wakefield. RNA-seq of Isolated Chromaffin Cells Highlights the Role of Sex-Linked and Imprinted Genes in Adrenal Medulla Development, Scientific Reports, Vol. 9, No. 1, Page 3929, Mar. 2019.
• Ryohei Sakai, Ryosuke Fukuda, Shin Unida, Misaki Aki, Yuji Ono, Akinori Endo, Satoshi Kusumi, Daisuke Koga, Toshiaki Fukushima, Masayuki Komada, Tsukasa Okiyoneda. The integral function of the endocytic recycling compartment is regulated by RFFL-mediated ubiquitylation of Rab11 effectors, Journal of cell science, Vol. 132, No. 3, pp. 228007, Feb. 2019.
• Ryohei Sakai, Ryosuke Fukuda, Shin Unida, Misaki Aki, Yuji Ono, Akinori Endo, Satoshi Kusumi, Daisuke Koga, Toshiaki Fukushima, Masayuki Komada, Tsukasa Okiyoneda. The integral function of the endocytic recycling compartment is regulated by RFFL-mediated ubiquitylation of Rab11 effectors, Journal of cell science, Vol. 132, No. 3, pp. 228007, Feb. 2019.
• R. Sakai, R. Fukuda, S. Unida, M. Aki, Y. Ono, A. Endo, S. Kusumi, D. Koga, T. Fukushima, M. Komada, T. Okiyoneda. The integral function of endocytic recycling compartment is regulated by RFFL-mediated ubiquitination of Rab11 effectors, J Cell Sci, Jan. 2019.  公式リンク  
  
• H. Furuta, H. Yoshihara, T. Fukushima, Y. Yoneyama, A. Ito, C. Worrall, A. Girnita, L. Girnita, M. Yoshida, T. Asano, M. Komada, N. Kataoka, K. Chida, F. Hakuno, SI. Takahashi. IRS-2 deubiquitination by USP9X maintains anchorage-independent cell growth via Erk1/2 activation in prostate carcinoma cell line, Oncotarget, Vol. 9, No. 74, Page 33871-33883, Sept. 2018.
• K. Kawaguchi, A. Endo, T. Fukushima, Y. Madoka, T. Tanaka, M. Komada. Ubiquitin-specific protease 8 deubiquitinates Sec31A and decreases large COPII carriers and collagen IV secretion, Biochem Biophys Res Commun, Vol. 499, No. 3, pp. 635-641, May 2018.  公式リンク  
  
• X. Xie, S. Matsumoto, A. Endo, T. Fukushima, H. Kawahara, Y. Saeki, M. Komada. Deubiquitinases USP5 and USP13 are recruited to and regulate heat-induced stress granules by deubiquitinating activities, J Cell Sci, Mar. 2018.  公式リンク  
  
• M. Ariga, Y. Yoneyama, T. Fukushima, Y. Ishiuchi, T. Ishii, H. Sato, F. Hakuno, T. Nedachi, S. I. Takahashi. Glucose deprivation attenuates sortilin levels in skeletal muscle cells, Endocr J, Vol. 64, No. 3, pp. 255-268, Mar. 2017.  公式リンク  
  
• T. Fukushima, H. Yoshihara, H. Furuta, F. Hakuno, S. I. Iemura, T. Natsume, Y. Nakatsu, H. Kamata, T. Asano, M. Komada, S. I. Takahashi. USP15 attenuates IGF-I signaling by antagonizing Nedd4-induced IRS-2 ubiquitination, Biochem Biophys Res Commun, Vol. 484, No. 3, pp. 522-528, Mar. 2017.  公式リンク  
  
• T. Yamamotoya, Y. Nakatsu, Y. Matsunaga, T. Fukushima, H. Yamazaki, S. Kaneko, M. Fujishiro, T. Kikuchi, A. Kushiyama, F. Tokunaga, T. Asano, H. Sakoda. Reduced SHARPIN and LUBAC Formation May Contribute to CCl(4)- or Acetaminophen-Induced Liver Cirrhosis in Mice, Int J Mol Sci, Vol. 18, No. 2, Feb. 2017.  公式リンク  
  
• T. Yanagawa, K. Denda, T. Inatani, T. Fukushima, T. Tanaka, N. Kumaki, Y. Inagaki, M. Komada. Deficiency of X-Linked Protein Kinase Nrk during Pregnancy Triggers Breast Tumor in Mice, Am J Pathol, Vol. 186, No. 10, pp. 2751-60, Oct. 2016.  公式リンク  
  
• L. Girnita, S. I. Takahashi, C. Crudden, T. Fukushima, C. Worrall, H. Furuta, H. Yoshihara, F. Hakuno, A. Girnita. Chapter Seven - When Phosphorylation Encounters Ubiquitination: A Balanced Perspective on IGF-1R Signaling, Prog Mol Biol Transl Sci, Vol. 141, pp. 277-311, Apr. 2016.  公式リンク  
  
• H. Okubo, A. Kushiyama, H. Sakoda, Y. Nakatsu, M. Iizuka, N. Taki, M. Fujishiro, T. Fukushima, H. Kamata, A. Nagamachi, T. Inaba, F. Nishimura, H. Katagiri, T. Asahara, Y. Yoshida, O. Chonan, J. Encinas, T. Asano. Involvement of resistin-like molecule beta in the development of methionine-choline deficient diet-induced non-alcoholic steatohepatitis in mice, Sci Rep, Vol. 6, pp. 20157, 2016.  公式リンク  
  
• Y. Nakatsu, M. Iwashita, H. Sakoda, H. Ono, K. Nagata, Y. Matsunaga, T. Fukushima, M. Fujishiro, A. Kushiyama, H. Kamata, S. Takahashi, H. Katagiri, H. Honda, H. Kiyonari, T. Uchida, T. Asano. Prolyl isomerase Pin1 negatively regulates AMP-activated protein kinase (AMPK) by associating with the CBS domain in the gamma subunit, J Biol Chem, Vol. 290, No. 40, pp. 24255-66, Oct. 2015.  公式リンク  
  
• T. Shinjo, Y. Nakatsu, M. Iwashita, T. Sano, H. Sakoda, H. Ishihara, A. Kushiyama, M. Fujishiro, T. Fukushima, Y. Tsuchiya, H. Kamata, F. Nishimura, T. Asano. DPP-IV inhibitor anagliptin exerts anti-inflammatory effects on macrophages, adipocytes, and mouse livers by suppressing NF-kappaB activation, Am J Physiol Endocrinol Metab, Vol. 309, No. 3, pp. E214-23, Aug. 2015.  公式リンク  
  
• T. Fukushima, H. Yoshihara, H. Furuta, H. Kamei, F. Hakuno, J. Luan, C. Duan, Y. Saeki, K. Tanaka, S. Iemura, T. Natsume, K. Chida, Y. Nakatsu, H. Kamata, T. Asano, S. Takahashi. Nedd4-induced monoubiquitination of IRS-2 enhances IGF signalling and mitogenic activity, Nat Commun, Vol. 6, pp. 6780, Apr. 2015.  公式リンク  
  
• H. Okubo, Y. Nakatsu, H. Sakoda, A. Kushiyama, M. Fujishiro, T. Fukushima, Y. Matsunaga, H. Ohno, M. Yoneda, H. Kamata, T. Shinjo, M. Iwashita, F. Nishimura, T. Asano. Mosapride citrate improves nonalcoholic steatohepatitis with increased fecal lactic acid bacteria and plasma glucagon-like peptide-1 level in a rodent model, Am J Physiol Gastrointest Liver Physiol, Vol. 308, No. 2, pp. G151-8, Jan. 2015.  公式リンク  
  
• Y. Matsunaga, Y. Nakatsu, T. Fukushima, H. Okubo, M. Iwashita, H. Sakoda, M. Fujishiro, T. Yamamotoya, A. Kushiyama, S. Takahashi, Y. Tsuchiya, H. Kamata, F. Tokunaga, K. Iwai, T. Asano. LUBAC Formation Is Impaired in the Livers of Mice with MCD-Dependent Nonalcoholic Steatohepatitis, Mediators Inflamm, Vol. 2015, pp. 125380, 2015.  公式リンク  
  
• F. Hakuno, T. Fukushima, Y. Yoneyama, H. Kamei, A. Ozoe, H. Yoshihara, D. Yamanaka, T. Shibano, M. Sone-Yonezawa, B. C. Yu, K. Chida, S. Takahashi. The Novel Functions of High-Molecular-Mass Complexes Containing Insulin Receptor Substrates in Mediation and Modulation of Insulin-Like Activities: Emerging Concept of Diverse Functions by IRS-Associated Proteins, Front Endocrinol (Lausanne), Vol. 6, pp. 73, 2015.  公式リンク  
  
• R. Kanaoka, A. Kushiyama, Y. Seno, Y. Nakatsu, Y. Matsunaga, T. Fukushima, Y. Tsuchiya, H. Sakoda, M. Fujishiro, T. Yamamotoya, H. Kamata, A. Matsubara, T. Asano. Pin1 Inhibitor Juglone Exerts Anti-Oncogenic Effects on LNCaP and DU145 Cells despite the Patterns of Gene Regulation by Pin1 Differing between These Cell Lines, PLoS One, Vol. 10, No. 6, pp. e0127467, 2015.  公式リンク  
  
• Y. Kawashima, F. Hakuno, S. Okada, T. Hotsubo, T. Kinoshita, M. Fujimoto, R. Nishimura, T. Fukushima, K. Hanaki, S. Takahashi, S. Kanzaki. Familial short stature is associated with a novel dominant-negative heterozygous insulin-like growth factor 1 receptor (IGF1R) mutation, Clin Endocrinol (Oxf), Vol. 81, No. 2, pp. 312-4, Aug. 2014.  公式リンク  
  
• A. Ozoe, M. Sone, T. Fukushima, N. Kataoka, K. Chida, T. Asano, F. Hakuno, S. Takahashi. Insulin receptor substrate-1 associates with small nucleolar RNA which contributes to ribosome biogenesis, Front Endocrinol (Lausanne), Vol. 5, pp. 24, Mar. 2014.  公式リンク  
  
• M. Iwashita, Y. Nakatsu, H. Sakoda, M. Fujishiro, A. Kushiyama, T. Fukushima, S. Kumamoto, T. Shinjo, H. Kamata, F. Nishimura, T. Asano. Valsartan restores inflammatory response by macrophages in adipose and hepatic tissues of LPS-infused mice, Adipocyte, Vol. 2, No. 1, pp. 28-32, Jan. 2014.  公式リンク  
  
• H. Okubo, H. Sakoda, A. Kushiyama, M. Fujishiro, Y. Nakatsu, T. Fukushima, Y. Matsunaga, H. Kamata, T. Asahara, Y. Yoshida, O. Chonan, M. Iwashita, F. Nishimura, T. Asano. Lactobacillus casei strain Shirota protects against nonalcoholic steatohepatitis development in a rodent model, Am J Physiol Gastrointest Liver Physiol, Vol. 305, No. 12, pp. G911-8, Nov. 2013.  公式リンク  
  
• A. Ozoe, M. Sone, T. Fukushima, N. Kataoka, T. Arai, K. Chida, T. Asano, F. Hakuno, S. Takahashi. Insulin receptor substrate-1 (IRS-1) forms a ribonucleoprotein complex associated with polysomes, FEBS Lett, Vol. 587, No. 15, pp. 2319-24, Aug. 2013.  公式リンク  
  
• A. Kushiyama, H. Sakoda, N. Oue, M. Okubo, Y. Nakatsu, H. Ono, T. Fukushima, H. Kamata, F. Nishimura, T. Kikuchi, M. Fujishiro, K. Nishiyama, H. Aburatani, S. Kushiyama, M. Iizuka, N. Taki, J. Encinas, K. Sentani, N. Ogonuki, A. Ogura, S. Kawazu, W. Yasui, Y. Higashi, H. Kurihara, H. Katagiri, T. Asano. Resistin-like molecule beta is abundantly expressed in foam cells and is involved in atherosclerosis development, Arterioscler Thromb Vasc Biol, Vol. 33, No. 8, pp. 1986-93, Aug. 2013.  公式リンク  
  
• J. Zhang, Y. Nakatsu, T. Shinjo, Y. Guo, H. Sakoda, T. Yamamotoya, Y. Otani, H. Okubo, A. Kushiyama, M. Fujishiro, T. Fukushima, Y. Tsuchiya, H. Kamata, M. Iwashita, F. Nishimura, H. Katagiri, S. Takahashi, H. Kurihara, T. Uchida, T. Asano. Par14 protein associates with insulin receptor substrate 1 (IRS-1), thereby enhancing insulin-induced IRS-1 phosphorylation and metabolic actions, J Biol Chem, Vol. 288, No. 28, pp. 20692-701, July 2013.  公式リンク  
  
• Y. Otani, Y. Nakatsu, H. Sakoda, T. Fukushima, M. Fujishiro, A. Kushiyama, H. Okubo, Y. Tsuchiya, H. Ohno, S. Takahashi, F. Nishimura, H. Kamata, H. Katagiri, T. Asano. Integrator complex plays an essential role in adipose differentiation, Biochem Biophys Res Commun, Vol. 434, No. 2, pp. 197-202, May 2013.  公式リンク  
  
• Y. Nakatsu, Y. Otani, H. Sakoda, J. Zhang, Y. Guo, H. Okubo, A. Kushiyama, M. Fujishiro, T. Kikuch, T. Fukushima, H. Ohno, Y. Tsuchiya, H. Kamata, A. Nagamachi, T. Inaba, F. Nishimura, H. Katagiri, S. Takahashi, H. Kurihara, T. Uchida, T. Asano. Role of Pin1 protein in the pathogenesis of nonalcoholic steatohepatitis in a rodent model, J Biol Chem, Vol. 287, No. 53, pp. 44526-35, Nov. 2012.  公式リンク  
  
• T. Fukushima, Y. Nakamura, D. Yamanaka, T. Shibano, K. Chida, S. Minami, T. Asano, F. Hakuno, S. Takahashi. Phosphatidylinositol 3-kinase (PI3K) activity bound to insulin-like growth factor-I (IGF-I) receptor, which is continuously sustained by IGF-I stimulation, is required for IGF-I-induced cell proliferation, J Biol Chem, Vol. 287, No. 35, pp. 29713-21, Aug. 2012.  公式リンク  
  
• Y. Kawashima, K. Higaki, T. Fukushima, F. Hakuno, J. Nagaishi, K. Hanaki, E. Nanba, S. Takahashi, S. Kanzaki. Novel missense mutation in the IGF-I receptor L2 domain results in intrauterine and postnatal growth retardation, Clin Endocrinol (Oxf), Vol. 77, No. 2, pp. 246-54, Aug. 2012.  公式リンク  
  
• H. Yoshihara, T. Fukushima, F. Hakuno, Y. Saeki, K. Tanaka, A. Ito, M. Yoshida, S. Iemura, T. Natsume, T. Asano, K. Chida, L. Girnita, S. Takahashi. Insulin/insulin-like growth factor (IGF) stimulation abrogates an association between a deubiquitinating enzyme USP7 and insulin receptor substrates (IRSs) followed by proteasomal degradation of IRSs, Biochem Biophys Res Commun, Vol. 423, No. 1, pp. 122-7, June 2012.  公式リンク  
  
• D. Yamanaka, T. Akama, T. Fukushima, T. Nedachi, C. Kawasaki, K. Chida, S. Minami, K. Suzuki, F. Hakuno, S. Takahashi. Phosphatidylinositol 3-kinase-binding protein, PI3KAP/XB130, is required for cAMP-induced amplification of IGF mitogenic activity in FRTL-5 thyroid cells, Mol Endocrinol, Vol. 26, No. 6, pp. 1043-55, June 2012.  公式リンク  
  
• M. Iwashita, H. Sakoda, A. Kushiyama, M. Fujishiro, H. Ohno, Y. Nakatsu, T. Fukushima, S. Kumamoto, Y. Tsuchiya, T. Kikuchi, H. Kurihara, H. Akazawa, I. Komuro, H. Kamata, F. Nishimura, T. Asano. Valsartan, independently of AT1 receptor or PPARgamma, suppresses LPS-induced macrophage activation and improves insulin resistance in cocultured adipocytes, Am J Physiol Endocrinol Metab, Vol. 302, No. 3, pp. E286-96, Feb. 2012.  公式リンク  
  
• A. Kushiyama, H. Okubo, H. Sakoda, T. Kikuchi, M. Fujishiro, H. Sato, S. Kushiyama, M. Iwashita, F. Nishimura, T. Fukushima, Y. Nakatsu, H. Kamata, S. Kawazu, Y. Higashi, H. Kurihara, T. Asano. Xanthine oxidoreductase is involved in macrophage foam cell formation and atherosclerosis development, Arterioscler Thromb Vasc Biol, Vol. 32, No. 2, pp. 291-8, Feb. 2012.  公式リンク  
  
• T. Fukushima, H. Okajima, D. Yamanaka, M. Ariga, S. Nagata, A. Ito, M. Yoshida, T. Asano, K. Chida, F. Hakuno, S. Takahashi. HSP90 interacting with IRS-2 is involved in cAMP-dependent potentiation of IGF-I signals in FRTL-5 cells, Mol Cell Endocrinol, Vol. 344, No. 1-2, pp. 81-9, Sept. 2011.  公式リンク  
  
• Y. Nakatsu, H. Sakoda, A. Kushiyama, J. Zhang, H. Ono, M. Fujishiro, T. Kikuchi, T. Fukushima, M. Yoneda, H. Ohno, N. Horike, M. Kanna, Y. Tsuchiya, H. Kamata, F. Nishimura, T. Isobe, T. Ogihara, H. Katagiri, Y. Oka, S. Takahashi, H. Kurihara, T. Uchida, T. Asano. Peptidyl-prolyl cis/trans isomerase NIMA-interacting 1 associates with insulin receptor substrate-1 and enhances insulin actions and adipogenesis, J Biol Chem, Vol. 286, No. 23, pp. 20812-22, June 2011.  公式リンク  
  
• H. Ohno, Y. Nakatsu, H. Sakoda, A. Kushiyama, H. Ono, M. Fujishiro, Y. Otani, H. Okubo, M. Yoneda, T. Fukushima, Y. Tsuchiya, H. Kamata, F. Nishimura, H. Kurihara, H. Katagiri, Y. Oka, T. Asano. 4F2hc stabilizes GLUT1 protein and increases glucose transport activity, Am J Physiol Cell Physiol, Vol. 300, No. 5, pp. C1047-54, May 2011.  公式リンク  
  
• T. Fukushima, T. Arai, M. Ariga-Nedachi, H. Okajima, Y. Ooi, Y. Iijima, M. Sone, Y. Cho, Y. Ando, K. Kasahara, A. Ozoe, H. Yoshihara, K. Chida, S. Okada, J. J. Kopchick, T. Asano, F. Hakuno, S. Takahashi. Insulin receptor substrates form high-molecular-mass complexes that modulate their availability to insulin/insulin-like growth factor-I receptor tyrosine kinases, Biochem Biophys Res Commun, Vol. 404, No. 3, pp. 767-73, Jan. 2011.  公式リンク  
  
• Y. Nakatsu, H. Sakoda, A. Kushiyama, H. Ono, M. Fujishiro, N. Horike, M. Yoneda, H. Ohno, Y. Tsuchiya, H. Kamata, H. Tahara, T. Isobe, F. Nishimura, H. Katagiri, Y. Oka, T. Fukushima, S. Takahashi, H. Kurihara, T. Uchida, T. Asano. Pin1 associates with and induces translocation of CRTC2 to the cytosol, thereby suppressing cAMP-responsive element transcriptional activity, J Biol Chem, Vol. 285, No. 43, pp. 33018-27, Oct. 2010.  公式リンク  
  
• M. Shibata, F. Hakuno, D. Yamanaka, H. Okajima, T. Fukushima, T. Hasegawa, T. Ogata, Y. Toyoshima, K. Chida, K. Kimura, H. Sakoda, A. Takenaka, T. Asano, S. Takahashi. Paraquat-induced oxidative stress represses phosphatidylinositol 3-kinase activities leading to impaired glucose uptake in 3T3-L1 adipocytes, J Biol Chem, Vol. 285, No. 27, pp. 20915-25, July 2010.  公式リンク  
  
• T. Fukushima, T. Nedachi, H. Akizawa, M. Akahori, F. Hakuno, S. Takahashi. Distinct modes of activation of phosphatidylinositol 3-kinase in response to cyclic adenosine 3', 5'-monophosphate or insulin-like growth factor I play different roles in regulation of cyclin D1 and p27Kip1 in FRTL-5 cells, Endocrinology, Vol. 149, No. 7, pp. 3729-42, July 2008.  公式リンク  
  
• Y. Kawashima, S. Kanzaki, F. Yang, T. Kinoshita, K. Hanaki, J. Nagaishi, Y. Ohtsuka, I. Hisatome, H. Ninomoya, E. Nanba, T. Fukushima, S. Takahashi. Mutation at cleavage site of insulin-like growth factor receptor in a short-stature child born with intrauterine growth retardation, J Clin Endocrinol Metab, Vol. 90, No. 8, pp. 4679-87, Aug. 2005.  公式リンク  
  
• Y. Okubo, K. Siddle, H. Firth, S. O'Rahilly, L. C. Wilson, L. Willatt, T. Fukushima, S. Takahashi, C. J. Petry, T. Saukkonen, R. Stanhope, D. B. Dunger. Cell proliferation activities on skin fibroblasts from a short child with absence of one copy of the type 1 insulin-like growth factor receptor (IGF1R) gene and a tall child with three copies of the IGF1R gene, J Clin Endocrinol Metab, Vol. 88, No. 12, pp. 5981-8, Nov. 2003.  公式リンク  
  
• S. I. Takahashi, T. Nedachi, T. Fukushima, K. Umesaki, Y. Ito, F. Hakuno, J. J. Van Wyk, M. Conti. Long-term hormonal regulation of the cAMP-specific phosphodiesterases in cultured FRTL-5 thyroid cells, Biochim Biophys Acta, Vol. 1540, No. 1, pp. 68-81, July 2001.  公式リンク  
  

国際会議発表 (査読有り)

• Keijun Kakihara, Masayuki Komada, Toshiaki Fukushima. Caspase-dependent STAMBPL1 cleavage promotes cell death through its C-terminal fragment with hyperactive deubiquitinating activity, The International Symposium in Tokyo 2022 “Ubiquitin New Frontier “from Neo-Biology to Target Protein Degradation”, Dec. 2023.
• Gai Ando, Keijun Kakihara, Masayuki Komada, Toshiaki Fukushima. Molecular mechanisms underlying the over-activation of USP8 and USP48 by Cushing’s disease-associated mutations, The International Symposium in Tokyo 2022 “Ubiquitin New Frontier “from Neo-Biology to Target Protein Degradation”, Dec. 2022.
• Keijun Kakihara, Masayuki Komada, Toshiaki Fukushima. Cis-activity regulation of USP8 and STAMBPL1, two endosomal deubiquitinating enzymes, and role of dysregulation in disease onset, TMiMS国際シンポジウム「New Frontiers in Ubiquitin Proteasome System」, Dec. 2022.
• Keijun Kakihara, Kei Moritsugu, Tetsuya Kitaguchi, Akinori Endo, Masayuki Komada, Toshiaki Fukushima. Autoinhibition of USP8 by WW-like domain and the dysregulation in Cushing’s disease, EMBO Workshop “Ubiquitin and ubiquitin-like proteins in health and disease”, EMBO Workshop “Ubiquitin and ubiquitin-like proteins in health and disease”, Sept. 2022.
• Junya Adachi, Toshiaki Fukushima, Haruka Oda, Hiroka Sugai, Kohei Sato, Hiroshi Kimura, Kazushi Kinbara. Development of Anthracene-Based Fluorescent Probes for Application in Cellular Systems, The 19th International Symposium on Novel Aromatic Compounds, July 2022.
• Toshiaki Fukushima, Yuka Madoka, Akinori Endo, Kohei Kawaguchi, Saki Arakaki, Masayuki Komada. Constitutive formation of USP8-STAM1 complex plays an important role in the onset of Cushing’s disease, The 2019 joint meeting of the American Society for Cell Biology (ASCB) and European Molecular Biology Organization (EMBO), Dec. 2019.
• Keijun Kakihara, Kengo Asamizu, Akinori Endo, Masayuki Komada, Toshiaki Fukushima. A novel autoinhibitory mechanism of ubiquitin-specific protease 8 activity via the intramolecular interaction, The 2019 joint meeting of the American Society for Cell Biology (ASCB) and European Molecular Biology Organization (EMBO), Dec. 2019.
• Satomi Naito, Akinori Endo, Kimitoshi Denda, Yuka Madoka, Akira Kato, Masayuki Komada, Toshiaki Fukushima. Nrk prevents hyperplasia by modulating CK2-PTEN-Akt signaling pathway, The 2019 joint meeting of the American Society for Cell Biology (ASCB) and European Molecular Biology Organization (EMBO), Dec. 2019.
• Xie Xuan, Shunsuke Matsumoto, Akinori Endo, Toshiaki Fukushima, Hiroyuki Kawahara, Yasushi Saeki, Masayuki Komada. Deubiquitinases USP5 and USP13 are recruited to and regulate heat-induced stress granules by deubiquitinating activities., Cold Spring Harbor Asia Conferences, Ubiquitin Family, Autophagy and Diseases, Apr. 2018.

国内会議発表 (査読有り)

• 辻本 泰貴, 山本 直希, 福嶋 俊明, 駒田 雅之, 大町 侑香, 本村 悠馬, 大井 佑夏, 佐々木 百合子, 鈴木正暉, 浦井 伸, 坂東 弘教, 山本 雅昭, 井口 元三, 西岡 宏, 山田 正三, 小川 渉, 福岡 秀規. ACTH産生下垂体腫瘍におけるWW-like領域を含めたUSP8体細胞変異の解析, 第97回日本内分泌学会総会, June 2024.
• 倉持 七海, 駒田 雅之, 福嶋 俊明. 活性型ユビキチンプローブを用いたプロファイリングによる細胞老化関連DUBの同定, 第46回日本分子生物学会年会, Dec. 2023.
• Marsya Nurrachma, Beni Lestari, Masayuki Komada, Toshiaki Fukushima. Development of a new method for identifying ubiquitin-binding proteins based on the Split-TurboID technology, 第46回日本分子生物学会年会, Dec. 2023.
• 安藤 凱, 森次 圭, 木寺 詔紀, 柿原 慧遵, 駒田 雅之, 福嶋 俊明. 脱ユビキチン化酵素USP48の活性制御機構とクッシング病関連変異による制御異常, 第46回日本分子生物学会年会, Dec. 2023.
• 萩生田 健太, 氷見 雄哉, 柿原 慧遵, 駒田 雅之, 福嶋 俊明. ユビキチン化依存的なGagとALIXの相互作用によってレンチウイルスRNAのウイルス粒子への取り込みが促進される, 第46回日本分子生物学会年会, Dec. 2023.
• 西岡 柚香, 遠藤 彬則, 駒田 雅之, 福嶋 俊明. SNAREタンパク質VAMP8・STX17のユビキチン化がオートファジーの進行に果たす役割, 第46回日本分子生物学会年会, Dec. 2023.
• 傳田 公紀, 清田 雅哉, Wong Sing Ying, 伏見 海, 加藤 明, Beni Lestari, 福嶋 俊明, 駒田 雅之, 林 宣宏. 卵巣プロテオミクスによるプロテインキナーゼ NRKの機能解明, 第46回日本分子生物学会年会, Dec. 2023.
• 吉村 玲奈, Beni Lestari, 福嶋 俊明, 森次 圭. NRKによるCK2活性制御の構造モデリングと解析, 第61回日本生物物理学会, Nov. 2023.
• 福嶋 俊明, 柿原 慧遵, 浅水 謙吾, 森次 圭, 北口 哲也, 駒田 雅之. クッシング病を引き起こすUSP8の過剰活性化機構, 第95回 日本生化学会大会シンポジウム「ユビキチンワールドを制御する脱ユビキチン化酵素の疾患、創薬における重要性」, 第95回日本生化学会大会要旨集, Nov. 2022.
• Marsya Yonna Nurrachma, Beni Lestari, 駒田 雅之, 福嶋 俊明. Ubiquitination-mediated activation of AKT and its cancer-associated mutants, 第45回 日本分子生物学会年会, Nov. 2022.
• 西岡 柚香, 柿原 慧遵, 遠藤 彬則, 駒田 雅之, 福嶋 俊明. 脱ユビキチン化酵素USP8によるVAMP8の制御とその細胞質分裂における意義の解明, 第45回 日本分子生物学会年会, Nov. 2022.
• 福嶋 俊明, 柿原 慧遵, 駒田 雅之. 脱ユビキチン化酵素USP8の遺伝子変異を介したクッシング病の発症メカニズム, 第27回 日本病態プロテアーゼ学会学術集会, Aug. 2022.
• 蓬田裕, 高峰愛幸, 伊藤日加瑠, 平手良和, 福嶋俊明, 駒田雅之, 金井克晃, 宮坂尚幸, 金井正美. マウス、ヒト胎盤におけるNrk下流遺伝子群と分娩遅延の関連について, 日本分子生物学会年会, Dec. 2021.
• BENI Lestari, 内藤 聡美, 遠藤 彬則, 西原 秀典, 加藤 明, 渡邊 恵理香, 傳田 公紀, 駒田 雅之, 福嶋 俊明. Comparative Phylogenetic Analysis and Molecular Characterization Reveal Eutherian-Specific Role of NRK in Regulating Placenta Development, 日本分子生物学会年会, Dec. 2021.
• 氷見 雄哉, 柿原 慧遵, 加藤 明, 駒田 雅之, 福嶋 俊明. 脱ユビキチン酵素USP8はレンチウイルス粒子へのウイルスRNAの動員を阻害することによってウイルスの増殖を防ぐ, 日本分子生物学会年会, Dec. 2021.
• Keijun Kakihara, Kengo Asamizu, Akinori Endo, Masayuki Komada, Toshiaki Fukushima. A novel autoinhibitory mechanism of ubiquitin-specific protease 8 activity via the intramolecular interaction, The 92nd Annual Meeting of the Japanease Biochemical Society, Sept. 2019.
• 柿原 慧遵, 浅水 謙吾, 遠藤 彬則, 駒田 雅之, 福嶋 俊明. 脱ユビキチン化酵素 USP8 の自己活性抑制機構, 2019年度日本生化学会関東支部例会, June 2019.
• Satomi Naito, Akinori Endo, Toshiaki Fukushima, Kimitoshi Denda, Akira Kato, Masayuki Komada. Molecular mechanisms underlying the control of Nrk protein levels and Nrk-mediated anti-proliferation effects, Annual Meeting of the Molecular Biology Society of Japan, Nov. 2018.
• Akinori Endo, Toshiaki Fukushima, Masayuki Komada. A deubiquitinase USP8, a master regulator of endosome-centered membrane traffic, controls inter-cellular signal transduction., Annual Meeting of the Molecular Biology Society of Japan, Nov. 2018.
• Takahiro Sawada, Kazuya Inoko, Kohei Kawaguchi, Akinori Endo, Yasushi Saeki, Keiji Tanaka, Toshiaki Fukushima, Masayuki Komada. Nuclear localization mechanism of deubiquitinating enzyme USP8 in Cushing’s disease, Annual Meeting of the Molecular Biology Society of Japan, Nov. 2018.
• 福嶋俊明, 澤田崇広, 猪子和也, 待鳥卓, 遠藤彬則, 駒田雅之. 脱ユビキチン化酵素USP8の遺伝子変異に起因するACTH過剰産生の分子機構, 第２回 ＰＯＭＣ研究者の集い, Sept. 2018.
• 待鳥 卓, 猪子 和也, 川口 紘平, 遠藤 彬則, 福嶋 俊明, 駒田 雅之. USP8 遺伝子のゲノム編集によるCushing 病モデル細胞の作製と解析, 第３３回日本下垂体研究会学術集会, Aug. 2018.
• Kohei Kawaguchi, Akinori Endo, Toshiaki Fukushima, Masayuki Komada. Ubiquitin-specific protease 8 suppresses collagen secretion by deubiquitinating Sec31, Cell and Developmental Biology Meeting, June 2018.

国際会議発表 (査読なし・不明)

• Toshiaki Fukushima. Deubiquitinating enzyme USP8 controls proliferative signals and cell division, and its constitutive activation causes neoplastic diseases, International Symposium on “Signals for Human, Animal and Planetary Health: From Metabolites To Biological Interactions”, Mar. 2024.
• Toshiaki Fukushima. USP8-STAM1 deubiquitinating enzyme complex is a novel drug target for Cushing's disease, Targeted Protein Degradation Forum in Japan, Aug. 2019.
• Toshiaki Fukushima. USP8, a deubiquitinating enzyme in the endocytic pathway, plays roles in proteostasis in the secretory pathway., Tokyo Tech WRHI-Cell Biology Center Mini-Symposium on Proteostasis in the Cell, Aug. 2018.

国内会議発表 (査読なし・不明)

• 足立 惇弥, 福嶋 俊明, 小田 春佳, 菅井 祥加, 佐藤 浩平, 木村 宏, 金原 数. 粘度応答性蛍光プローブの開発と生細胞内における応答性, 第17回バイオ関連化学シンポジウム, Sept. 2023.
• 足立 惇弥, 小田 春佳, 福嶋 俊明, 菅井 祥加, 佐藤 浩平, 木村 宏, 金原 数. 水溶性蛍光プローブの生細胞内における粘度応答性とメラノソームの可視化, 日本化学会第103春季年会, Mar. 2023.
• 足立惇弥, 福嶋 俊明, 小田 春佳, 菅井 祥加, 佐藤 浩平, 木村 宏, 金原 数. 非TICT型粘度応答性蛍光プローブの開発と生細胞イメージングへの適用, 2022年光化学討論会, Sept. 2022.
• 福嶋俊明. USP8 の機能異常は様々な疾患の発症・増悪に関与する, 新学術領域「ケモユビキチン」第6回班会議（オンライン）, Feb. 2022.
• 柿原慧遵, 浅水謙吾, 森次圭, 北口哲也, 遠藤彬則, 木寺詔記, 池口満徳, 駒田雅之, 福嶋俊明. 脱ユビキチン化酵素USP8の自己阻害機構とクッシング病関連変異によるその解除, 第44回日本分子生物学会年会, 第44回日本分子生物学会年会要旨集, Dec. 2021.
• 福嶋俊明. USP8の自己阻害機構の理解に基づく阻害剤開発とクッシング病治療への応用, 新学術領域「ケモユビキチン」第5回領域班会議, June 2021.
• 福嶋俊明, 遠藤彬則, 川口紘平, 円由香, 駒田雅之. クッシング病の治療薬開発を目指したUSP8-STAM1複合体を作用点とするACTH分泌制御物質の開発, 第6回橋渡し研究戦略的推進プログラムシンポジウム, Mar. 2021.
• 福嶋俊明. ケモテクノロジーによって明らかとなった脱ユビキチン化酵素USP8の作用機構, 新学術領域研究「ケモユビキチン」第4回領域班会議, Feb. 2021.
• Satomi Naito, Akinori Endo, Kimitoshi Denda, Akira Kato, Masayuki Komada, Toshiaki Fukushima. Nik-related kinase is regulated by quality control ubiquitin ligase CHIP, 新学術領域「ケモユビキチン」第3回班会議, Dec. 2019.
• Toshiaki Fukushima. The mechanism of action of wild-type and Cushing's disease-associated mutant USP8, 新学術領域「ケモユビキチン」第3回班会議, Dec. 2019.
• Keijun Kakihara, Kengo Asamizu, Akinori Endo, Kei Moritsugu, Akira Kato, Masayuki Komada, Toshiaki Fukushima. The enzyme activity of USP8 is regulated by the intramolecular interaction of the USP domain and the WW domain, 新学術領域「ケモユビキチン」第3回班会議, Dec. 2019.
• Arakaki Saki, Toshiaki Fukushima. 14-3-3 protein regulates USP8-STAM1 complex formation and the subcellular localization, 新学術領域「ケモユビキチン」第3回班会議, Dec. 2019.
• Toshiaki Fukushima. The mechanism of action of deubiquitinating enzyme USP8 revealed by chemo-technologies, 新学術領域「ケモユビキチン」第２回班会議, June 2019.
• 柿原慧遵, 浅水謙吾, 遠藤彬則, 駒田雅之, 福嶋俊明. 脱ユビキチン化酵素USP8の自己活性抑制機構, 第2回ユビキチン研究会, Jan. 2019.
• 福嶋 俊明. USP8遺伝子変異によるクッシング病発症機構解明の新展開, 第2回ユビキチン研究会, Jan. 2019.
• 伝田 公紀, 二口 充, 丹野 正隆, 福嶋 俊明, 田邉 暢子, 林 宣宏. 胎盤特異的な新規プロテインキナーゼNRKは乳腺組織における細胞増殖制御を司る, Jan. 2018.  公式リンク  
  

その他の論文・著書など

• Keijun Kakihara, Kengo Asamizu, Kei Moritsugu, Masahide Kubo, Tetsuya Kitaguchi, Akinori Endo, Akinori Kidera, Mitsunori Ikeguchi, Akira Kato, Masayuki Komada, Toshiaki Fukushima. The molecular basis of ubiquitin-specific protease 8 autoinhibition by the WW-like domain, bioRxiv, May 2021.
• 福嶋俊明, 川口紘平. コラーゲンの細胞内輸送の分子機構 -脱ユビキチン化酵素 USP8 による輸送制御-, フレグランスジャーナル, フレグランスジャーナル社, Aug. 2020.
• 柳川 享世, 傳田 公紀, 稲谷 卓也, 田中 利明, 福嶋 俊明, Nobue Kumaki, 稲垣 豊, 駒田 雅之. 乳がんを抑制する新たな遺伝子を発見, 大学ジャーナル, Sept. 2016.  公式リンク  
  
• 柳川 享世, 傳田 公紀, 稲谷 卓也, 田中 利明, 福嶋 俊明, Nobue Kumaki, 稲垣 豊, 駒田 雅之. 乳がんを抑制する新たな遺伝子を発見―ヒト乳がんの診断・治療への応用に期待―, 東工大ニュース, Sept. 2016.

特許など

• 福嶋俊明. クッシング病治療剤のスクリーニング方法. 特許. 公開. 国立大学法人東京工業大学. 2018/12/27. 特願2018-244180. 2020/07/09. 特開2020-106356. 2020. July

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