論文

• Nobuyuki Shimizu, Tomoko Asatsuma-Okumura, Junichi Yamamoto, Yuki Yamaguchi, Hiroshi Handa, Takumi Ito. PLZF and its fusion proteins are pomalidomide-dependent CRBN neosubstrates, Commun. Biol., 4, 1, 1277, Nov. 2021.
• Junichi Yamamoto, Tetsufumi Suwa, Yuki Murase, Shunpei Tateno, Hirotaka Mizutome, Tomoko Asatsuma-Okumura, Nobuyuki Shimizu, Tsutomu Kishi, Shuji Momose, Masahiro Kizaki, Takumi Ito, Yuki Yamaguchi, Hiroshi Handa. ARID2 is a pomalidomide-dependent CRL4CRBN substrate in multiple myeloma cells, Nature Chemical Biology, Sept. 2020.
• Shunpei Tateno, Midori Iida, Satoshi Fujii, Miki Katayama, Haruka Tokuyama, Junichi Yamamoto, Takumi Ito, Satoshi Sakamoto, Hiroshi Handa, Yuki Yamaguchi. Genome-wide screening reveals a role for subcellular localization of CRBN in the anti-myeloma activity of pomalidomide , Scientific Reports, Volume 10, Number 4012, Mar. 2020.
• Asatsuma-Okumura T, Ando H, De Simone M, Yamamoto J, Sato T, Shimizu N, Asakawa K, Yamaguchi Y, Takumi Ito, Guerrini L, Hiroshi Handa. p63 is a cereblon substrate involved in thalidomide teratogenicity, Nature Chemical Biology, 15, Page 1077–1084, Oct. 2019.

著書

• Junichi Yamamoto, Tomoko Asatsuma-Okumura, Takumi Ito, Yuki Yamaguchi, Hiroshi Handa. History of IMiDs and Protein Degradation as a Pharmacological Modality, Protein Homeostasis in Drug Discovery: A Chemical Biology Perspective, John Wiley & Sons, Nov. 2022.

国内会議発表 (査読なし・不明)

• 山口 雄輝, 伊藤拓水, 山本淳一, 半田宏. サリドマイドの多様な薬理作用の分子メカニズム, 新学術領域研究「転写サイクル」冬の若手ワークショップ2016, Feb. 2016.
• 片山 美樹, 伊藤拓水, 安藤 秀樹, 山口 雄輝, 半田宏. E3ユビキチンリガーゼの基質認識レセプター CRBNとポマリドマイド依存的な基質Aiolosの生化学的解析, 第３７回日本分子生物学会年会, Nov. 2014.

その他の論文・著書など

• Junichi Yamamoto, Takumi Ito, Yuki Yamaguchi, Hiroshi Handa. Discovery of CRBN as a target of thalidomide: a breakthrough for progress in the development of protein degraders., CHEM. SOC. REV., 51, 6234-6250, July 2022.
• Takumi Ito, Yuki Yamaguchi, Hiroshi Handa. Exploiting ubiquitin ligase cereblon as a target for small-molecule compounds in medicine and chemical biology, Cell Chem. Biol., 28, 7, 987-999, July 2021.

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