論文

• Kadokura H, Harada N, Yamaki S, Hirai N, Tsukuda R, Azuma K, Amagai Y, Nakamura D, Yanagitani K, Taguchi H, Kohno K, Inaba K. Development of luciferase-based highly sensitive reporters that detect ER-associated protein biogenesis abnormalities., iScience, Oct. 2024.  公式リンク  
  
• Zhang, Y., Watanabe, S., Tsutsumi, A., Kadokura, H., Kikkawa, M., Inaba, K., Hiroshi Kadokura. Cryo-EM analysis provides new mechanistic insight into ATP binding to Ca²⁺-ATPase SERCA2b, EMBO Journal, Vol. 40, No. 19, 2021.  公式リンク  
  
• Kadokura, H., Dazai, Y., Fukuda, Y., Hirai, N., Nakamura, O., Inaba, K., Hiroshi Kadokura. Observing the nonvectorial yet cotranslational folding of a multidomain protein, LDL receptor, in the ER of mammalian cells, Proceedings of the National Academy of Sciences of the United States of America, Vol. 117, No. 28, pp. 16401-16408, 2020.  公式リンク  
  
• Kanemura, S., Sofia, E.F., Hirai, N., Okumura, M., Kadokura, H., Inaba, K., Hiroshi Kadokura. Characterization of the endoplasmic reticulum–resident peroxidases GPx7 and GPx8 shows the higher oxidative activity of GPx7 and its linkage to oxidative protein folding, Journal of Biological Chemistry, Vol. 295, No. 36, pp. 12772-12785, 2020.  公式リンク  
  
• Fujimoto, T., Inaba, K., Kadokura, H., Hiroshi Kadokura. Methods to identify the substrates of thiol-disulfide oxidoreductases, Protein Science, Vol. 28, No. 1, pp. 30-40, 2019.  公式リンク  
  
• Fujimoto, T., Nakamura, O., Saito, M., Tsuru, A., Matsumoto, M., Kohno, K., Inaba, K., Kadokura, H., Hiroshi Kadokura. Identification of the physiological substrates of PDIp, a pancreas-specific protein-disulfide isomerase family member, Journal of Biological Chemistry, Vol. 293, No. 48, pp. 18421-18433, 2018.  公式リンク  
  
• Tsuchiya, Y., Saito, M., Kadokura, H., Miyazaki, J., Tashiro, F., Imagawa, Y., Iwawaki, T., Kohno, K., Hiroshi Kadokura. IRE1-XBP1 pathway regulates oxidative proinsulin folding in pancreatic β cells, Journal of Cell Biology, Vol. 217, No. 4, pp. 1287-1301, 2018.  公式リンク  
  
• Okumura, M., Kadokura, H., Inaba, K., Hiroshi Kadokura. Structures and functions of protein disulfide isomerase family members involved in proteostasis in the endoplasmic reticulum, Free Radical Biology and Medicine, Vol. 83, pp. 314-322, 2015.  公式リンク  
  
• Okumura, M., Kadokura, H., Hashimoto, S., Yutani, K., Kanemura, S., Hikima, T., Hidaka, Y., Ito, L., Shiba, K., Masui, S., Imai, D., Imaoka, S., Yamaguchi, H., Inaba, K., Hiroshi Kadokura. Inhibition of the functional interplay between endoplasmic reticulum (ER) Oxidoreduclin-1α (Ero1α) and protein-disulfide isomerase (PDI) by the endocrine disruptor bisphenol A, Journal of Biological Chemistry, Vol. 289, No. 39, pp. 27004-27018, 2014.  公式リンク  
  
• Tsuru, A., Fujimoto, N., Takahashi, S., Saito, M., Nakamura, D., Iwano, M., Iwawaki, T., Kadokura, H., Ron, D., Kohno, K., Hiroshi Kadokura. Negative feedback by IRE1β optimizes mucin production in goblet cells, Proceedings of the National Academy of Sciences of the United States of America, Vol. 110, No. 8, pp. 2864-2869, 2013.  公式リンク  
  
• Nakayashiki, T., Saito, N., Takeuchi, R., Kadokura, H., Nakahigashi, K., Wanner, B.L., Mori, H., Hiroshi Kadokura. The tRNA thiolation pathway modulates the intracellular redox state in Escherichia coli, Journal of Bacteriology, Vol. 195, No. 9, pp. 2039-2049, 2013.  公式リンク  
  
• Kadokura, H., Saito, M., Tsuru, A., Hosoda, A., Iwawaki, T., Inaba, K., Kohno, K., Hiroshi Kadokura. Identification of the redox partners of ERdj5/JPDI, a PDI family member, from an animal tissue, Biochemical and Biophysical Research Communications, Vol. 440, No. 2, pp. 245-250, 2013.  公式リンク  
  
• Chng, S.-S., Xue, M., Garner, R.A., Kadokura, H., Boyd, D., Beckwith, J., Kahne, D., Hiroshi Kadokura. Disulfide rearrangement triggered by translocon assembly controls lipopolysaccharide export, Science, Vol. 337, No. 6102, pp. 1665-1668, 2012.  公式リンク  
  
• Chng, S.-S., Dutton, R.J., Denoncin, K., Vertommen, D., Collet, J.-F., Kadokura, H., Beckwith, J., Hiroshi Kadokura. Overexpression of the rhodanese PspE, a single cysteine-containing protein, restores disulphide bond formation to an Escherichia coli strain lacking DsbA, Molecular Microbiology, Vol. 85, No. 5, pp. 996-1006, 2012.  公式リンク  
  
• Sopha, P., Kadokura, H., Yamamoto, Y.H., Takeuchi, M., Saito, M., Tsuru, A., Kohno, K., Hiroshi Kadokura. A novel mammalian ER-located J-protein, DNAJB14, can accelerate ERAD of misfolded membrane proteins., Cell structure and function, Vol. 37, No. 2, pp. 177-187, 2012.  公式リンク  
  
• Yanagitani, K., Kimata, Y., Kadokura, H., Kohno, K., Hiroshi Kadokura. Translational pausing ensures membrane targeting and cytoplasmic splicing of XBP1u mRNA, Science, Vol. 331, No. 6017, pp. 586-589, 2011.  公式リンク  
  
• Shinya, S., Kadokura, H., Imagawa, Y., Inoue, M., Yanagitani, K., Kohno, K., Hiroshi Kadokura. Reconstitution and characterization of the unconventional splicing of XBP1u mRNA in vitro, Nucleic Acids Research, Vol. 39, No. 12, pp. 5245-5254, 2011.  公式リンク  
  
• Kadokura, H., Beckwith, J., Hiroshi Kadokura. Mechanisms of oxidative protein folding in the bacterial cell envelope, Antioxidants and Redox Signaling, Vol. 13, No. 8, pp. 1231-1246, 2010.  公式リンク  
  
• Ohtsu, I., Wiriyathanawudhiwong, N., Morigasaki, S., Nakatani, T., Kadokura, H., Takagi, H., Hiroshi Kadokura. The L-cysteine/L-cystine shuttle system provides reducing equivalents to the periplasm in Escherichia coli, Journal of Biological Chemistry, Vol. 285, No. 23, pp. 17479-17487, 2010.  公式リンク  
  
• Yamamoto, Y.H., Kimura, T., Momohara, S., Takeuchi, M., Tani, T., Kimata, Y., Kadokura, H., Kohno, K., Hiroshi Kadokura. A novel ER J-protein DNAJB12 accelerates ER-associated degradation of membrane proteins including CFTR., Cell structure and function, Vol. 35, No. 2, pp. 107-116, 2010.  公式リンク  
  
• Eser, M., Masip, L., Kadokura, H., Georgiou, G., Beckwith, J., Hiroshi Kadokura. Disulfide bond formation by exported glutaredoxin indicates glutathione's presence in the E. coli periplasm, Proceedings of the National Academy of Sciences of the United States of America, Vol. 106, No. 5, pp. 1572-1577, 2009.  公式リンク  
  
• Kadokura, H., Beckwith, J., Hiroshi Kadokura. Detecting Folding Intermediates of a Protein as It Passes through the Bacterial Translocation Channel, Cell, Vol. 138, No. 6, pp. 1164-1173, 2009.  公式リンク  
  
• Zhou, Y., Cierpicki, T., Jimenez, R.H.F., Lukasik, S.M., Ellena, J.F., Cafiso, D.S., Kadokura, H., Beckwith, J., Bushweller, J.H., Hiroshi Kadokura. NMR Solution Structure of the Integral Membrane Enzyme DsbB: Functional Insights into DsbB-Catalyzed Disulfide Bond Formation, Molecular Cell, Vol. 31, No. 6, pp. 896-908, 2008.  公式リンク  
  
• Kadokura, H., Hiroshi Kadokura. Oxidative protein folding: Many different ways to introduce bisulfide bonds, Antioxidants and Redox Signaling, Vol. 8, No. 5-6, pp. 731-733, 2006.  公式リンク  
  
• Segatori, L., Murphy, L., Arredondo, S., Kadokura, H., Gilbert, H., Beckwith, J., Georgiou, G., Hiroshi Kadokura. Conserved role of the linker α-helix of the bacterial disulfide isomerase DsbC in the avoidance of misoxidation by DsbB, Journal of Biological Chemistry, Vol. 281, No. 8, pp. 4911-4919, 2006.  公式リンク  
  
• Sevier, C.S., Kadokura, H., Tam, V.C., Beckwith, J., Fass, D., Kaiser, C.A., Hiroshi Kadokura. The prokaryotic enzyme DsbB may share key structural features with eukaryotic disulfide bond forming oxidoreductases, Protein Science, Vol. 14, No. 6, pp. 1630-1642, 2005.  公式リンク  
  
• Kadokura, H., Nichols II, L., Beckwith, J., Hiroshi Kadokura. Mutational alterations of the key cis proline residue that cause accumulation of enzymatic reaction intermediates of DsbA, a member of the thioredoxin superfamily, Journal of Bacteriology, Vol. 187, No. 4, pp. 1519-1522, 2005.  公式リンク  
  
• Kadokura, H., Tian, H., Zander, T., Bardwell, J.C.A., Beckwith, J., Hiroshi Kadokura. Snapshots of DsbA in Action: Detection of Proteins in the Process of Oxidative Folding, Science, Vol. 303, No. 5657, pp. 534-537, 2004.  公式リンク  
  
• Kadokura, H., Hiroshi Kadokura. Protein disulfide bond formation in vivo, Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme, Vol. 48, No. 10, pp. 1386-1393, 2003.  公式リンク  
  
• Kadokura, H., Beckwith, J., Hiroshi Kadokura. Four cysteines of the membrane protein DsbB act in concert to oxidize its substrate DsbA, EMBO Journal, Vol. 21, No. 10, pp. 2354-2363, 2002.  公式リンク  
  
• Suzuki, K., Sami, M., Kadokura, H., Nakajima, H., Kitamoto, K., Hiroshi Kadokura. Biochemical characterization of horA-independent hop resistance mechanism in Lactobacillus brevis, International Journal of Food Microbiology, Vol. 76, No. 3, pp. 223-230, 2002.  公式リンク  
  
• Kadokura, H., Kawasaki, H., Yoda, K., Yamasaki, M., Kitamoto, K., Hiroshi Kadokura. Efficient export of alkaline phosphatase overexpressed from a multicopy plasmid requires degP, a gene encoding a periplasmic protease of Escherichia coli, Journal of General and Applied Microbiology, Vol. 47, No. 3, pp. 133-141, 2001.  公式リンク  
  
• Kadokura, H., Beckwith, J., Hiroshi Kadokura. The expanding world of oxidative protein folding, Nature Cell Biology, Vol. 3, No. 11, pp. E247-E249, 2001.  公式リンク  
  
• Xu, X.Y., Kadokura, H., Okubo, A., Kitamoto, K., Yamazaki, S., Hiroshi Kadokura. Cloning and sequencing of a gene encoding a novel salt stress-induced membrane protein from Rhodobacter sphaeroides f. sp. denitrificans, Applied Microbiology and Biotechnology, Vol. 56, No. 3-4, pp. 442-447, 2001.  公式リンク  
  
• Kadokura, H., Bader, M., Tian, H., Bardwell, J.C.A., Beckwith, J., Hiroshi Kadokura. Roles of a conserved arginine residue of DsbB in linking protein disulfide-bond-formation pathway to the respiratory chain of Escherichia coli, Proceedings of the National Academy of Sciences of the United States of America, Vol. 97, No. 20, pp. 10884-10889, 2000.  公式リンク  
  
• Maruyama, J.-I., Ohnuma, H., Yoshikawa, A., Kadokura, H., Nakajima, H., Kitamoto, K., Hiroshi Kadokura. Production and product quality assessment of human hepatitis B virus pre-S2 antigen in submerged and solid-state cultures of Aspergillus oryzae, Journal of Bioscience and Bioengineering, Vol. 90, No. 1, pp. 118-120, 2000.  公式リンク  
  
• Haruta, M., Murata, M., Kadokura, H., Homma, S., Hiroshi Kadokura. Immunological and molecular comparison of polyphenol oxidase in Rosaceae fruit trees, Phytochemistry, Vol. 50, No. 6, pp. 1021-1025, 1999.  公式リンク  
  
• Haruta, M., Murata, M., Hiraide, A., Kadokura, H., Yamasaki, M., Sakuta, M., Shimizu, S., Kadokura, H., Hiroshi Kadokura. Cloning genomic dna encoding apple polyphenol oxidase and comparison of the gene product in escherichia coli and in apple, Bioscience, Biotechnology and Biochemistry, Vol. 62, No. 2, pp. 358-362, 1998.  公式リンク  
  
• Wang, T., Kadokura, H., Yada, K., Yamasaki, M., Hiroshi Kadokura. Identification of a sulfhydryl-reducing agent-inducible protein highly homologous to protein synthesis elongation factor Tu in Bacillus subtilis, Wei sheng wu xue bao = Acta microbiologica Sinica, Vol. 38, No. 1, pp. 6-12, 1998.  公式リンク  
  
• Sami, M., Suzuki, K., Sakamoto, K., Kadokura, H., Kitamoto, K., Yoda, K., Hiroshi Kadokura. A plasmid pRH45 of Lactobacillus brevis confers hop resistance, Journal of General and Applied Microbiology, Vol. 44, No. 5, pp. 361-363, 1998.  公式リンク  
  
• Sami, M., Yamashita, H., Hirono, T., Kadokura, H., Kitamoto, K., Yoda, K., Yamasaki, M., Hiroshi Kadokura. Hop-resistant Lactobacillus brevis contains a novel plasmid harboring a multidrug resistance-like gene, Journal of Fermentation and Bioengineering, Vol. 84, No. 1, pp. 1-6, 1997.  公式リンク  
  
• Wang, T., Hiroshi, K., Makari, Y., Hiroshi Kadokura. Identification of a disulfide bonded protein from cytoplasm of Bacillus subtilis, Chinese Science Bulletin, Vol. 42, No. 20, pp. 1756-1760, 1997.  公式リンク  
  
• Wang, T., Kadokura, H., Yoda, K., Yamasaki, M., Hiroshi Kadokura. Internal amino acid sequence analysis of proteins after limited proteolytic cleavage, Progress in Biochemistry and Biophysics, Vol. 24, No. 1, pp. 68-71, 1997.  公式リンク  
  
• Sami, M., Yamashita, H., Kadokura, H., Kitamoto, K., Yoda, K., Yamasaki, M., Hiroshi Kadokura. A new and rapid method for determination of beer-spoilage ability of lactobacilli, Journal of the American Society of Brewing Chemists, Vol. 55, No. 4, pp. 137-140, 1997.  公式リンク  
  
• Chang, Y.-C., Kadokura, H., Yoda, K., Yamasaki, M., Hiroshi Kadokura. Secretion of active subtilisin YaB by a simultaneous expression of separate pre-pro and pre-mature polypeptides in Bacillus subtilis, Biochemical and Biophysical Research Communications, Vol. 219, No. 2, pp. 463-468, 1996.  公式リンク  
  
• Nagao, K., Taguchi, Y., Arioka, M., Kadokura, H., Takatsuki, A., Yoda, K., Yamasaki, M., Hiroshi Kadokura. bfr1⁺, a novel gene of Schizosaccharomyces pombe which confers brefeldin A resistance, is structurally related to the ATP-binding cassette superfamily, Journal of Bacteriology, Vol. 177, No. 6, pp. 1536-1543, 1995.  公式リンク  
  
• Kadokura, H., Watanabe, K., Tsuneizumi, K., Yoda, K., Yamasaki, M., Hiroshi Kadokura. Physiological and biochemical analysis of the effects of alkaline phosphatase overproduction in Escherichia coli, Journal of Bacteriology, Vol. 177, No. 12, pp. 3596-3600, 1995.  公式リンク  
  
• Kadokura, H., Yoda, K., Watanabe, S., Kikuchi, Y., Tamura, G., Yamasaki, M., Hiroshi Kadokura. Enhancement of protein secretion by optimizing protein synthesis: isolation and characterization of Escherichia coli mutants with increased secretion ability of alkaline phosphatase, Applied Microbiology and Biotechnology, Vol. 41, No. 2, pp. 163-169, 1994.  公式リンク  
  
• Noda, Y., Nishikawa, S., Shiozuka, K.-I., Kadokura, H., Nakajima, H., Yoda, K., Katayama, Y., Morohoshi, N., Haraguchi, T., Yamasaki, M., Hiroshi Kadokura. Molecular cloning of the protocatechuate 4,5-dioxygenase genes of Pseudomonas paucimobilis, Journal of Bacteriology, Vol. 172, No. 5, pp. 2704-2709, 1990.  公式リンク  
  
• Kadokura, H., Yoda, K., Imai, M., Yamasaki, M., Hiroshi Kadokura. Production and secretion in Escherichia coli of hepatitis b virus pre-S2 antigen as fusion proteins with β-lactamase, Applied and Environmental Microbiology, Vol. 56, No. 9, pp. 2742-2747, 1990.  公式リンク  
  
• Tachibana, K.-I., Yoda, K., Watanabe, S., Kadokura, H., Katayama, Y., Yamane, K., Yamasaki, M., Tamura, G., Hiroshi Kadokura. Secretion of Bacillus subtilis α-amylase in the periplasmic space of Escherichia coli, Journal of General Microbiology, Vol. 133, No. 7, pp. 1775-1782, 1987.  公式リンク  
  
• Tachibana, K., Imai, M., Okamoto, H., Yoda, K., Kadokura, H., Katayama, Y., Yamasaki, M., Hiroshi Kadokura. Expression of the pre-S(2) gene of hepatitis B virus in Escherichia coli, Biotechnology Letters, Vol. 8, No. 10, pp. 677-682, 1986.  公式リンク  
  

著書

• Kadokura, H., Katzen, F., Beckwith, J., Hiroshi Kadokura. Protein disulfide bond formation in prokaryotes, Annual Review of Biochemistry, Vol. 72, pp. 111-135, 2003.  公式リンク  

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