論文

• K.Ogiwara, M.Nagaoka, C-S.Cho, T.Akaike. Constraction of a novel extracellular matrix using a new genetically engineered epidermal growth factor fused to IgG-Fc, Biotechnology Letters, Vol. 27, pp. 1633-1637, 2005.
• E.H.Chowdhury, K.Kutsuzawa, T.Akaike. Designing smart nano-apatite composites: the emerging era of non-viral gene delivery, Gene Therapy and Molecular Biology, Vol. 9, pp. 301-315, 2005.
• E.H.Chowdhury, M.Nagaoka, K.Ogiwara, F.T.Zohra, K.Kutsuzawa, S.Tada, C.Kitamura, T.Akaike. Integrin-Supported Fast Rate Intracellular Delivery of Plasmid DNA by Extracellular Matrix Protein Embedded Calcium Phosphate Complexes, Biochemistry, Vol. 44, No. 37, pp. 12273-12278, 2005.
• E.H.Chowdhury, T.Akaike. Rapid isolation of high quality, multimeric plasmid DNA using zwitterionic detergent, J. Biotech., Vol. 119, pp. 343-347, 2005.
• F.T.Zohra, E.H.Chowdhury, M.Nagaoka, T.Akaike. Drastic effect of nanoapatite particles on liposome-mediated mRNA delivery to mammalian cells, Analytical Biochemistry, 345, 164-166, 2005.
• E.H.Chowdhury, T.Akaike. Advances in Fabrication of Calcium Phosphate Nano-composites for Smart Delivery of DNA and RNA to Mammalian Cells, Current Analytical Chemistry, Vol. 1, pp. 187-192, 2005.
• M.K.Yoo, H.K.Choi, T.H.Kim, Y.J.Choi, T.Akaike, M.shirakawa, C.S.Cho. Drug Release from Xyloglucan Beads Coated with Eudragit for Oral Drug Delivery., Arch.Pharm.Res., 28, No. 6, pp. 736-742, 2005.
• Y-I. Jeong, S-J.Seo, I-K.Park, H-C.Lee, I-C.Kang, T.Akaike, C-S.Cho. Cellular recognition of paclitaxel-loaded polymeric nanoparticles composed of poly(g-benzyl L-glutamate) and poly(ethylene glycol) diblock copolymer endcaped with galactose moiety., Inter.J.Pharmaceutics., 296, pp. 151-161, 2005.
• S.E.Cook, I.K.Park, E.M.Kim, H.J.Jeong, T.G.Park, Y.J.Choi, T.Akaike, C.S.Cho. Galactosylated polyethlenimine-graft-poly(vinyl pyrrolidone) as a hepatocyte-targeting gene carrier, J.Control.Release., Vol. 105, pp. 151-163, 2005.
• T.H.Kim, S.I.Kim, T.Akaike, C.S.Cho. Synergistic effect of poly(ethylenimine) on the transfection efficiency of galactosylated chitosan/DNA complexes., J.Control.Release., Vol. 105, pp. 354-366, 2005.
• J.S.Moon, H.M.Jeon, W.Meng, T.Akaike, I.K.Kang. Morphology and metabolism of hepatocytes microencapsulated with acrylic terpolymer-alginate using gelatin and poly(vinyl alcohol)as extracellular matrices., J.Biomater.Sci.Polymer Edn., Vol. 16, No. 10, pp. 1245-1259, 2005.
• C. Iitaka, K. Miyazaki, T. Akaike, N. Ishida. A Role for Glycogen Synthase Kinase-3b in the Mammalian Circadian Clock, J.Biol. Chem., Vol. 280, 29397-29402, 2005.
• J.S.Lee, S.H.Kim, Y.J.Kim, T. Akaike, S.C.Kim. Hepatocyte Adhesion on a Poly[N-p-vinylbenzyl-4-O-b-D-galactopyranosyl-D-glucoamide]-Coated Poly(L-lactic acid )Surface, Biomacromolecules, 6, 1906-1911, 2005.
• W. Meng, K.-H.Jung, I-K., Kang, O. H. Kwon, T. Akaike. Immobilization of Lactobionic Acid on Polyurethane Films and Their Interaction with Hepatocytes, Macromolecular Research, Vol. 13, pp. 257-264, 2005.
• K-H.Park, T.Akaike. Probing of Specific Binding of Synthetic Sulfonylurea with thte Insulinoma Cell Line MIN6, J.Biochem, Vol. 138, No. 1, pp. 21-25, 2005.
• E.H.Chowdhury, T.Akaike. A Bio-Recognition Device Developed Onto Nano-Crystals of Carbonate Apatite for Cell-Targeted Gene Delivery, Biotechnology and Bioengineering, Vol. 90, No. 4, pp. 414-419, 2005.
• S-J.Seo, T.Akaike, Y-J. Choi, M. Shirkawa, I-K. Kang, C-S.Cho. Alginate microcapsules prepared with xyloglucan as a synthetic extracellular matrix for hepatocyte attachment, Biomaterials, Vol. 26, pp. 3607-3615, 2005.
• Yu-ichi Sato, Yuki Kobayashi, Takayuki Kamiya, Hiromitsu Watanabe, Toshihiro Akaike, Kenichi Yoshikawa, Atsushi Maruyama. The effect of backbone structure on polycation comb-type copolymer/DNA interactions and the molecular assembly of DNA., Biomaterials, Vol. 26, No. 7, pp. 703-11, 2005.
• A. Higuchi, M. Kuriharaa, K. Kobayashi, C-S. Cho, T. Akaike, M. Hara. Albumin and urea production by hepatocytes cultured on extracellular matrix proteins-conjugated poly(vinyl alcohol) membranes, J. Biomat. Sci., Polym. Edn.,, Vol. 16, pp. 847-860, 2005.
• Kato R., Maeda T., Akaike, T., Tamai I.. Nucleoside Transport at the Blood-Testis Barrier Studied with Primary-Cultured Sertoli Cells., J. Pharmacol. Exp.Ther., 312, pp. 601-608, 2005.
• R.Takei, D.Suzuki, T.Hoshiba, M.Nagaoka, S.J.Seo, C.S.Cho, T. Akaike. Role of E-cadherin molcules in speroid formation of hepatocytes adhered on galactose-carring polymer as an artificial asialoglycoprotein model, Biotechnology Letters, Vol. 27, pp. 1149-1156,2005, 2005.
• R. Takei, S.J. Seo, C.S. Cho, Y. Okahata, T. Akaike. Adsorption behaviors of poly(N-p-vinylbenzyl-4-o-b-d-galactopyranosyl-[1→4]-d-gluconamide) by quartz-crystal microbalance, Colloids and Surfaces B: Biointerfaces, 42, No. 2, pp. 137-140, May 2005.
• Nihad Adnan, M. Mie, A. Hague, S. Hossain, Yasumasa Mashimo, Toshihiro Akaike, EIRY KOBATAKE. Construction of a Defined Biomimetic Matrix for Long-Term Maintenance of Mouse Induced Pluripotent Stem Cells, Bioconjugate Chemistry, Vol. 27, No. 7, pp. 1599-1605, July 2016.  公式リンク  
  
• Kakon Nag, Naznin Sultana, Akira Kato, A Dranik, Nobuhiro Nakamura, Koichi Kutsuzawa, Shigehisa Hirose, Toshihiro Akaike. Ligand-induced internalization, recycling, and resensitization of adrenomedullin receptors depend not on CLR or RAMP alone but on the receptor complex as a whole, Gen Comp Endocrinol, 212, 156-162, Feb. 2015.
• Dragomirka Jovic, Asako Sakaue-Sawano, Takaya Abe, Chong-Su Cho, Masato Nagaoka, Atsushi Miyawaki, Toshihiro Akaike. Direct observation of cell cycle progression in living mouse embryonic stem cells on an extracellular matrix of E-cadherin, SpringerPlus, Oct. 2013.
• Dragomirka Jovic, Amranul Haque, Bayar Hexig, Masato Nagaoka, Toshihiro Akaike. Control of Singular Cell Cycle Synchronization of Mouse ES Cells for Hepatocyte Differentiation on E-Cadherin Substratum, Journal of Biotechnology & Biomaterials, Aug. 2011.
• H-L.Jiang, Y-K.Kim, R.Arote, J-W. Nah, M-H.Cho, Y-J.Choi, T.Akaike. Chitosan-graft-polyethylenimine as a gene carrier, J.Controlled Release, Vol. 17, No. 2, pp. 273-280, 2007.
• Sung Won Choi, Akaike T, Maruyama A. Cationic comb-type copolymers for boosting DNA-fueled nanomachines., Nano Lett., vol. 7, no. 1, p. 172-8, 2007.
• Md. Ezharul Chowdhury, Toshihiro Akaike. pH-Sensitive Inorganic Nano-Particles and Their Precise Cell Targetibility: An Efficient Gene Delivery and Expression System., Current Chemical Biology, vol. 1, pp. 201-213, 2007.
• S-H Kim, 赤池敏宏. Epidermal growth factor signaling for matrix-dependent cell proliferation and differentiation in primary cultured hepatocyte., Tissue Engineering, Vol. 13, p. 601-609, 2007.
• Toshihiro Akaike. Primary hepatocyte survival on non-integrin-recognizable matrices without the activation of Akt signaling., Biomaterials, Vol. 28, pp. 1093-1104, 2007.
• H-L.Jian, I-K.Park, M-L.Kang, H-S.Yoo, Y-J.Choi, T.Akaike, C-S.Cho. Immune stimulating activity of an atrophic rhinitis vaccine associated to pegylated chitosan microspheres in vitro, Polym. Adv. Technol., pp. 18: 1-6, 2007.
• K.Kutsuzawa, E.H.Chowdhury, M.Nagaoka, K.Maruyama, Y.Akiyama, T.Akaike. Surface functionalization of inorganic nano-crystals with fibronectin and E-cadherin chimera synergistically accelerates trans-gene delivery into embryonic stem cells., Biochem.Biophys.Res.Commun., Vol. 350, 514-520, 2006.
• Toshihiro Akaike. Alginate/Galactosylated Chitosan]Heparin Scaffold As a New Synthetic Extracellular Matrix for Hepatocytes., Tissue Engineering, Vol. 12, No. 1, pp. 33-44, 2006.
• T.Hoshiba, C-S.Cho, A.Murakawa, Y.Okahata, T.Akaike. The effect of natural extracellular matrix deposited on synthetic polymers on cultured primary hepatocytes., Biomaterials, Vol. 27, pp. 4519-4528, 2006.
• K. Ogiwara, M. Nagaoka, C-S. Cho, T. Akaike. Effect of photo-immobilization of epidermal growth factor on the cellular behaviors., Biochem. Biophys. Res. Commun.,, Vol. 345, pp. 255-259, 2006.
• H.Zhang, M.Iwama, T.Akaike, D.W.Urry, A.Pattanaik, T.M.Parker, I.Konishi, T.Nikaido. Human amiotic cell sheet harvest uing a novel temperature-responsive culture surface coated with protein-based polymer., Tissue Engineering, Vol. 12, No. 2, pp. 391-401, 2006.
• S.J.Seo, H.S. Moon, D.D. Guo, S.H.Kim, T.Akaike, C.S.Cho. Receptor-mediated delivery of all-trans-retinoic acid (ATRA) to hepatocytes from ATRM-loaded poly(N-p-vinylbenzyl-4-o-b-D-garactopyranosyl-D-gluconamide)nanoparticles, Materials Science and Engineerig, Vol. 26, pp. 136-141, 2006.
• S.J.Seo, I.Y.Kim, S.H.Kim, Y.J.Choi, T.Akaike, C.S.Cho. Enhanced liver functions of Hepatocytes cocultured with NIH3T3 in the alignate/garactosylated chitosan scaffold, Biomaterials, Vol. 27, pp. 1487-1495, 2006.
• C.S.Cho, S.J.Seo, I.K.Park, S.H.Kim, T.H.Kim, T.Hoshiba, I.Harada, T.Akaike. Galactose-carrying polymers as extracelllular matrices for liver tissue engineering, Biomaterials, Vol. 27, pp. 576-585, 2006.
• M.Nagaoka, U.Koshimizu, S.Yuasa, F.Hattori, H.Chen, T.Tanaka, M.Okabe, K.Fukuda, T.Akaike.. E-cadherin-coated plates maintain pluripotent ES cells without colony formation, PLoS ONE, Vol. 1, pp. e15, 2006.
• E.H.Chowdhury, A.Maruyama. A.Kano, M. Nagaoka, S.Hirose, M. Kunou, T. Akaike. pH-sensing nano-crystals of cabonate apatite: Effects on intracellular delivery and release of DNA for efficient expression into mammalian cells., Gene, Vol. 376, 87-94, 2006.
• T.H.Kim, H-L.Jiang, I-Y.Park, Y-K.Kim, M.H.Cho, J.W.Nah, T.Akaike, C-S.Cho. Chemical Modifications of Chitosan as Gene Carriers, Biomaterials Research, Vol. 10, No. 3, pp. 110-116, 2006.
• K. Yamana, Y. Fukunaga, Y. Ohtania, S. Sato, M. Nakamura, W. J. Kim, T. Akaike, A. Maruyama. DNA mismatch detection using a pyrene–excimer-forming probe., Chem. Commun., Vol. 2005, pp. 2509-2511, 2005.
• I.K.Park, H.L.Jiang, C.H.Yun, Y.J.Choi, S.J.Kim, T.Akaike, S.I.Kim, C.S.Cho. Release of Newcastle Disease Virus Vaccine from Chitosan Microspheres In vitro and In vivo, Asian-Aust. J. Anim. Sci., Vol. 17, pp. 543-547, 2004.
• Chowdhury EH, Megumi K, Harada I, Kundu AK, Akaike T.. Dramatic effect of Mg(2+) on transfecting mammalian cells by DNA/calcium phosphate precipitates., Anal Biochem., Vol. 328, pp. 96-97, 2004.
• S. W. Choi, Y. Sato, T. Akaike, A. Maruyama. Preparation of Cationic Comb-Type Copolymer Having Guanidino Moieties and its Interaction with DNAs, J. Biomater. Sci. polymer Edn., Vol. 15, pp. 1099-1110, 2004.
• K.H.Park, T.Akaike. Visualization of theSpecific Interaction of Sulfonylurea-Incorporated Polymer with Insulinoma Cell Line MIN6 , J. Biochem., Vol. 135, pp. 179-183, 2004.
• S.Takashima, H. Ise, P. Zhao, T. Akaike, T. Nikaido. Human Amniotic Epithelial Cells Possess Hepatocyte-like Characteristics and Functions, Cell Structure and Function , Vol. 29, pp. 73-84, 2004.
• H-L. Jiang, I-K.Park, N-R.Shin, S-G.Kang, H-S.Yoo, S-I.Kim, S-B.Suh, T.Akaike, C-S.Cho. In vitro study of the immune stimulating activity of an athrophic rhinitis vaccine associated to chitosan microspheres, European J. of Pharmaceutics and Biopharmaceutics , Vol. 58, pp. 471-476, 2004.
• Sung Won Choi, Yuichi Sato, Toshihiro Akaike, Atsushi Maruyama. Evaluation of comb-type copolymers with different cationic groups as artificial nucleic acid chaperones, Nucleic acids symposium series , Vol. 48, pp. 273, 2004.
• Kazuya Hirata, Yuichi Sato, Kano Arihiro, Toshihiro Akaike, Atsushi Maruyama. Nucleation-synchronized strand displacement for highly sensitive DNA analysis, Nucleic Acids Res. Suppl., Vol. 48, pp. 267-268, 2004.
• Y.Takei, A.Maruyama, T.Akaike, et al. Targeted gene delivery to sinusoidal endothelial cells: DNA nanoassociate bearing hyaluronan-glycocalyx, FASEB J., Vol. 18, pp. 699-701, 2004.
• E.H.Chowdury, F.T.Zohra, S.Tada, C.Kitamura, T.Akaike. Fibronectin in collaboration with Mg2+ enhances transgene expression by calcioum phosphate coprecipitates, Anal. Biochem., Vol. 335, pp. 162-164, 2004.
• Jiang HL, Park IK, Shin NR, Yoo HS, Akaike T, Cho CS.. Controlled release of Bordetella bronchiseptica dermonecrotoxin (BBD) vaccine from BBD-loaded chitosan microspheres in vitro., Arch Pharm Res. 20, Vol. 27, pp. 346-350, 2004.
• S.J.Seo, I-K. Park, M-K. Yoo, M. Shirakawa, T.Akaike, C.S.Cho. Xyloglucan as a synthetic extracellular matrix for hepatocyte attachment, J. Biomater. Sci. Polymer Edn., Vol. 15, pp. 1375-87, 2004.
• T-W. Chung, K-Y. Cho, H-C. Lee, J-W. Nah, J-H. Yeo, T. Akaike, C-S. Cho. Novel micelle-forming block copolymer composed of poly (e-caprolactone) and poly (vinyl pyrroridone), Polymer , Vol. 45, pp. 1591-1597, 2004.
• 原田伊知郎, 長岡正人, 金相憲, 笹川忠, 赤池敏宏. 再生医療今後の課題と生命理工学との交流, 学会新報　, Vol. 25, No. 20, pp. 5-15, 2004.
• 望月慎一, 狩野有宏, 赤池敏宏, 丸山厚. バイオナノマテリアルとしての多糖コンジュゲート, 高分子論文集, Vol. 61, pp. 601-605, 2004.
• I-K. Park, H-L. Jiang, S-E. Cook, M-H. Cho, S-I. Kim, H-J. Jeong, T.Akaike, C-S.Cho. Galactosylated chitosan(GC)-graft-poly(vinyl pyrrolidone)(PVP) as hepatocyte-targeting DNA carrier: in vitro transfection, Arch. Pharm. Res., Vol. 27, pp. 1284-9, 2004.
• S-J.Seo, T.Akaike, Y.J. Choi, M. Shirkawa, I-K. Kang, C-S.Cho. Alginate microcapsules prepared with xyloglucan as a synthetic extracellular matrix for hepatocyte attachment, Biomaterials, Vol. 26, pp. 3607-3615, 2004.
• H. Ise, T. Nikaido, N. Negishi, N. Sugihara, F. Suzuki, T. Akaike, U. Ikeda. Effective Hepatocyte Transplantation Using Rat Hepatocytes with Low Asialoglycoprotein Receptor Expression., Am. J. Pathol., Vol. 165, pp. 501-510, 2004.
• E.H. Chowdhury, M. Kunou, M. Nagaoka, A.K. Kundu, T. Hoshiba, T.Akaike. High-efficiency gene delivery for expression in mammalian cells by nanoprecipitates of Ca-Mg phosphate, Gene, Vol. 341, pp. 77-82, 2004.
• S-H.Kim, T.Hoshiba, T.Akaike. Hepatocyte behavior on synthetic glycopolymer matrix: inhibitory effect of receptor-ligand binding on hepatocyte spreading, Biomaterials, Vol. 25, pp. 1813-1823, 2004.
• S.J.Seo, S.H.Kim, T.Sasagawa, Y.J.Choi, T.Akaike, C.S.Cho. Delivery of all trans-retinoic acid (RA) to hepatocyte cell line from RA/galactosyl α-cyclodextrin i nclusion complex, European J. of Pharmaceutics and Biopharmaceutics, Vol. 58, pp. 681-687, 2004.
• S-H.Kim, T.Hoshiba, T.Akaike. Effect of carbohydrates attached to polystyrene on hepatocyte morphology on sugar-derivated polystyrene matrices., J.Biomaterial Mater.Res. , pp. in press, 2003.
• I-K. Park, T-H. Kim, S-I. Kim, T.Akaike, C-S.Cho. Chemical Modification of Chitosan for Gene Delivery, J.of Disp. Sci. a nd Tech., Vol. 24, pp. 489-498, 2003.
• 赤池敏宏. 基盤的再生医療研究としての生命理工学の発展をめざして, 再生医療, Vol. 2, No. 3, pp. 9, 2003.
• H.Nonaka, H.Ise, N.Suhihara, S.Hirose, N.Negishi, Y.Kondo, T.Akaike. Development of Highly Functional Long-Term Culture Method of Liver Slice Embeded in Agarose Gel for Bioartificial Liver, Cell Transplantation, Vol. 12, pp. 491-498, 2003.
• S.Shimojo, C-S.Cho, I-K.Park, M.Kunou, M.Goto, T.Akaike. Helical Structure of Sugar-carrying Polystyrene in Aqueous Solution by Circular Dichroism, Carbohydrate Research , Vol. 338, No. 26, pp. 2129-2133, 2003.
• S-H.Kim, J-H.Kim, T.Akaike. Regulation of cell adhesion signaling by synthetic glycopolymer matrix in primary cultured hepatocyte, FEBS Letters, Vol. 553, pp. 433-9, 2003.
• I-K.Park, S-J.Seo, M.Akashi, T.Akaike, C-S.Cho. Controlled Release of Epidermal Growth Factor (EGF) from EGF-loaded Polymeric Nanoparticles Composed of Polystyrene as Core and Poly(methacrylic acid) as Corona in vitro, Arch Pharm Res , Vol. 26, No. 8, pp. 649-652,, 2003.
• I-K. Park, D-W. Kang, T.Akaike, M-Y.Chang, C-S.Cho. Contact Angle of Water on langmuir-Blodgett Films of Poly(g-benzyl L-glutamate)/Poly(ethylene glycol)/poly(g-benzyl L-glutamate) Block Copolymer, Biomaterials Research, Vol. 7, No. 2, pp. 101-105, 2003.
• I-K.Kang, D.W.Lee, S.K.Lee, T.Akaike. Grafting of lactose-carrying styrene onto polystrene dishes using plasma glow discharge and their interaction with hepatocytes, J.Materials Science: Materials in Medicine , Vol. 14, pp. 611-616, 2003.
• 石原義久　後藤光昭　赤池敏宏. バイオハイブリッド型人工肝臓：肝組織の再構築化とバイオハイブリッド型人工肝臓, 最新医学6月増刊号　”現代医療の最前線ー人工臓器とメディカル・エンジニアリングの進歩ー”, No. 6月増刊, pp. 147-157, 2003.
• K.Ishida, H.Nagahara, T.Kogiso, T.Aso, N.Hayashi, T.Akaike. Cell adhesion aside from integrin system can abrogate anoikis in rat liver cells by down-regulation of FasL expression, not by activation of PI-3K/Akt and ERK signaling pathway, Biochem.Biophys.Res.Commun., Vol. 300, pp. 201-208, 2003.
• 赤池敏宏. バイオマテリアルから再生医療への期待, 未来材料, Vol. 3, No. 7, pp. 1, 2003.
• A. Higuchi, Y. Takanashi, N. Tsuzuki, T.Asakura, C-S. Cho, T.Akaike, M.Hara. Production of interferon-b by fibroblast cells on membranes prepared with RGD-containing peptide, J. Biomed. Mater.Res. , Vol. 65A, pp. 369-378, 2003.
• 笹川忠, 伊勢裕彦, 赤池敏宏. 特集　バイオマテリアルと再生医療　肝再生　肝細胞の増殖・分化・組織化を目指して, バイオマテリアルー生体材料, Vol. 21, No. 3, pp. 200-202, 2003.
• I-K.Park, J.Yang, H-J.Jeong, H-S.Bom, I.Harada, T.Akaike, S-I.Kim, C-S.Cho. Galactosylated chiotosan as a synthetic extracellular matrix for hepatocytes attachment, Biomaterials, Vol. 24, pp. 2331-2337, 2003.
• I-K.Park, T-H.Kim. S-I.Kim, Y-H.Park, W-J.Kim, T.akaike, C-S.Cho. Visualization of transfectionof hepatocytes by galactosylated chitosan-graft-poly(ethylene glycol)/DNA complexes by confocal laser scanning microscopy, Internaional Journal of Pharmaceutics, Vol. 257, pp. 103-110, 2003.
• M.Nagaoka, T.Akaike. Single amino acid substitution in the mouse IgG1 Fc region induces drastic enhancement of the affinity to protein A, Protein Engineering, Vol. 16, pp. 243-245, 2003.
• Y.Watanabe, O.Suzuki, T.Haruyama, T.Akaike. Interferon-γ Induces Reactive Oxygen Species and Endoplasmic Reticulum Stress at the Hepatic Apoptosis, J.Cell.Biochem., Vol. 89, pp. 244-253, 2003.
• Y.Watanabe, T.Haruyama, T.Akaike. Liver-Derived Matrix Metalloproteinase-9(Gelatinase B) Recruits Progenitor Cells from Bone Marrow into the Blood Circulation, Biol.Pharm.Bull., Vol. 26, pp. 564-568, 2003.
• 赤池敏宏, 長岡正人. 再生・発生医工学ー新しい細胞マトリックス工学への期待ー, 化学装置, No. 4月, 2003.
• E.H.Chowdhury, T.Sasagawa, M.Nagaoka, A.K.Kundu, T.Akaike. Transfecting mammalian cells by DNA/calcium phosphate precipitates:Effect of temperature and pH on precipitation, Analytical Biochemistry, Vol. 314, pp. 316-318, 2003.
• H-Y.Kweon, M-K.Yoo, In-Kyu Park, T-H.Kim, H-C.Lee, H-S.Lee, J-S.Oh, T.Akaike, C-S.Cho. A novel degradable polycaprolactone networks for tissue engineering, Biomaterials, Vol. 24, pp. 801-808, 2003.
• 伊勢裕彦, 高島誠司, 趙鵬, 赤池敏宏, 二階堂敏雄. 肝前駆様細胞の探索と単離－生体肝臓と胎盤付着物である羊膜組織中の肝前駆細胞を中心に－, 肝胆膵, Vol. 46, pp. 345-353, 2003.
• C.S. Cho, I.K.Park, J.W.Nah, T.Akaike. Preparation of Polymeric Self-assembly and Its Application to Biomaterial, Macromolecular Reseach,, Vol. 11, pp. 2-8,, 2003.
• I.K.Park, J.E.Ihm, Y.H.Park, Y.J.Choi, S.I.Kim, W.J.Kim, T.Akaike, C.S.Cho. Galactosylated chitosan (GC)-graft-poly(vinyl pyrrolidone) (PVP) as hepatocyte-targeting DNA carrier Preparetion physicochemical charactarization of GC-graft-PVP/DNA complex(1), J. Control. Release, Vol. 84, pp. 349-359, 2003.
• A.K.Kundu, M.Nagaoa, E.H.Chowdhury, S.Hirose, T.Sasagawa, T.Akaike. IGF-Indeuces Growth, Survival and Morphological Change of Primary Hepatocytes on a Galactose-bared Polymer through both MAPK and b-catenin Pathways, Cell Structure and Function, Vol. 28, pp. 255-263, 2003.
• J.Yang, M.Goto, H.Ise, C-S.Cho, T.Akaike. Galactosylated Alginate as a Scaffold for Hepatocytes Entrapment, Biomaterials, Vol. 23, pp. 471-479, 2002.
• R. Nishio, T. Akaike, M. Ikekita, K.Ishibashi, M. Obinata, Y.Watanebe. Establishment of different types of immortalized liver containing cell lines from temperature-sensitive SV40 large., Research Communications in Biochemistry, Cell & Molecular Biology, , Vol. 6, NOS. 1&2,, 57-69, 2002.
• M.Nagaoka, H.Ise, T.Akaike. Immobilized E-cadherin Model Can Enhance the Cell Attachment and Differentiation of Primary Hepatocytes but not Proliferation., Biotech.Lett., pp. in press, 2002.
• T-W.Chung, J.Yang, T.Akaike, K-Y.Cho, J-W.Nah, S-I.Kim, C-S.Cho. Preparation of alginate/galactosylated chitosan scaffold for hepatocyte attachment, biomaterials, Vol. 23, pp. 2827-2834, 2002.
• 赤池敏宏　後藤光昭. 肝再生医療の現状と将来展開, 再生医療, Vol. 1, No. 2, pp. 15-22, 2002.
• 伊勢裕彦, 赤池敏宏. 再生医療のための細胞分離と工学装置, 医科器械学, Vol. 72, No. 7, pp. 310-315, 2002.
• G. Khan, H. B. Lee 訳：赤池敏宏, 入山俊介. 韓国における再生医療研究の近況, 再生医療, Vol. 1, No. 2, pp. 114-117, 2002.
• I.Ajioka, T.Akaike, Y.Watanabe. Ethanolamine is a co-mitogenic factor for proliferation of primary hepatocytes., J.Cell.Biochem., Vol. 84, pp. 249-263, 2002.
• K-H.Park, K.Na, T.Akaike. Probe of specific interaction between a dsimplified synthetic glycopolymer and erythrocytes as mediated by a glucose transporter (GLUT) on a cell membrane, J. of Biomedical Materials Research, Vol. 59, pp. 591-594, 2002.
• A.Higuchi, T.Takanashi, T.Ohno, T.Asakura, C-S.Cho, T.Akaike, M.Hara. Pruduction of interferon-βby fibroblast cells on membranes prepared by extracellular matrix proteins., Cytotechnology, Vol. 39, pp. 131-137, 2002.
• N.Sugihara, H.Ise, N.Negishi, T.Nikaido, T. Akaike. Drug metabolic activity of cultured hepatocytes can synchronize with bile acid concentration in the medium, Cell Biochem.Funct., Vol. 20, 11-17, 2002.
• 渡辺恵史, 赤池敏宏. 再生医学へのアプローチ：第２の肝臓を作る, ファルマシア　社団法人日本薬学会, Vol. 33, 2002.
• K-H.Park, S.C.Song, T.Akaike. Determination of specific Interaction between Sulfonylurea-Incorporated Polymer and rat Islet, J. Biochem., Vol. 131, pp. 359-364, 2002.
• M.Mikawa, T.Yokawa, N.Miwa, M.Brautigam, T.Akaike, A.Maruyama. An Intelligent MRI Contrst Agent for Tumor Sensing, Acad. Radial., Vol. 9, pp. 109-111, 2002.
• S.Shimojo, T.Akaike, M.Harra, A.Higuchi, I-K.Park, C-S.Cho. Difference in the attachment of hepatocytes between a poly(g-benzyl L-glutamate) (PBLG)/poly(N-isopropylacrylamide)(PNIPAAm)diblock copolymer cast surface and a PBLG/PNIPAAm Langmuir-Blodgett one, J.Biomater.Sci.Polymer Edn, Vol. 13, pp. 829-841, 2002.
• 伊勢裕彦, 赤池敏宏. 再生医療のための細胞分離と工学装置, 医科器械学　, Vol. 72, No. 7, pp. 310-315, 2002.
• 杉原伸宏, 根岸直樹, 赤池敏宏. 臓器別の現状と工学技術の必要性ー肝臓の再生医療に必要な工学的視点ー, 医科器械学, Vol. 72, No. 7, pp. 338-341, 2002.
• T. W. Chung, K.Y. Cho, J.W. Nah, T. Akaike, C.S. Cho. Chiral Recognition of Bilirubin by Polymeric Nanoparticles, Langmuir, Vol. 18, pp. 6462-6464, 2002.
• S-G. Kim, T.Akaike, T.Sasagawa, Y.Atomi, H.Kurosawa. Gene Expression of Type I and Type III Collagen by Mechanical Stretch in Anterior Cruciate Ligament Cells, Cell Structure and Function, Vol. 27, pp. 139-144, 2002.
• 赤池　敏宏. 再生医療の発展のためには理工学との連携が必要不可欠である　　, 炎症・再生, Vol. 22, pp. 443-444, 2002.
• W.J.Kim, T.Akeike, A.Maruyama. DNA Strand Exchange Stimulated by Spontaneous Complex Formation with Cationic Comb-Type Copolymer, J.AM.CHEM.SOC., Vol. 124, pp. 12676-12677, 2002.
• J.H.Kim, S.H.Kim, H.K.Kim, T.Akaike, S.C.Kim. Adhesion and Growth of Endothelial Cell on Amphiphilic PU/PS IPN Surface: Effect of Amphiphilic Balance and Immobilized Collagen, J.Biomed.Mater.Res., Vol. 62, pp. 613-621, 2002.
• I.Ajioka, T.Akaike, Y.Watanabe. Ethanolamine is a Co-Mitogenic Factor for Proliferation of Primary Hepatocytes., J.Cell.Bioche., in press, 2001.
• Y.Watanabe, k.Hirakawa, T.Haruyama, T.Akaike. Direct Production of an Activatedmatrix Metalloproteinase-9 (gelatinase B) from Mammalian Cells., FEBS Lett., Vol. 502, pp. 63-67, 2001.
• 渡辺恵史, 渋谷功, 赤池敏宏. DDSによる肝疾患治療, Drug Delivery System, Vol. 16, pp. 39-49, 2001.
• I.Ajioka, R.Nishio, T.Akaike, M.Sasaki, J.Enami, Y.Watanabe. Establishment of Heterotropic Liver Tissue Mass with Direct Link to the Host Liver Following Implantation of Hepatocytes Transfected with Vascular Endothelial Growth Factor Gene in Mice., Tissue Engineering, Vol. 7, pp. 335-344, 2001.
• M.Goto, K.Kobayashi, A.Hachikawa, K.Saito, C-S.Cho, T.Akaike. Micellar Behavior of Sugar-Carrying Polystyrene in Aqueous Solution, Macromol. Chem. Phys., pp. 1161-1165, 2001.
• S-H.Kim, M.Goto, C-S.Cho, T.Akaike. Specific Binding of Glucose-derivatized Polymers to the Asialoglycoprotein Receptor Mouse Primary Hepatocytes, J. Biol. Chem., Vol. 276, No. 38, pp. 35312-35319, 2001.
• H.Ise, A.Ferdous, N.Sugihara, T.Nikaido N.Negishi, T.Akaike. Separation of mouse hepatocytes of distinct biological phenotypes on their asialogycoprotein receptor-mediated binding affinity to an artificial ligand, J.Artif.Organs, Vol. 4, pp. 342-347, 2001.
• C-S.Cho, K-Y.Cho, I-K.Park, S-H.Kim, T.Sasagawa, M.Uchiyama, T.Akaike. Receptor-mediated delivery of all trans-retinoic acid to hepatocyte using poly(L-lactic acid) nanoparticles coated with galactose-carrying polystyrene., J.Cont. Rel., Vol. 77, No. 1-2, pp. 7-15, 2001.
• 根岸直樹, 赤池敏宏. 代用臓器の開発・臨床応用と血栓形成の制御　d人工肝臓（特集　代用臓器と血栓）, 血栓と循環(Thrombosis and Circulation), Vol. 9, No. 2, 2001.
• 根岸直樹, 赤池敏宏. 特集　代用臓器と血栓　3.代用臓器の開発・臨床応用と血栓形成の制御　d 人工肝臓, 血栓と循環　（株）メディカル　レビュー社, Vol. 9, No. 2, pp. 40(146)-43(149), 2001.
• C-S.Cho, T-W.Chung, T.Akaike. Self-Assembled Polymeric Nanoparticles., Macromol. Chem. Symp., Vol. 14, No. 2, pp. 227-236, 2001.
• W.J.Kim, T.Ishihara, T.Akaike, A.Maruyama. Comb-Type Cationic Copolymer Expedites DNA Strand Exchange while Stabilizing DNA Duplex, Chem.Eur., Vol. 7, No. 1, pp. 176-180, 2001.
• M.Nogawa, T.Ishihara, T.Akaike, A.Maruyama. Polyethylenimine/Arabinogalactan Conjugate as a Hepatocyte Specific Gene Carrier, S.T.P.Pharma Sciences, Vol. 11, No. 1, pp. 97-102, 2001.
• 杉原伸宏, 赤池敏宏. 再生医工学としての細胞マトリックス工学, Biotherapy, Vol. 15, No. 2, pp. 133-140, 2001.
• 赤池敏宏. 高分子のここが面白いー細胞を認識し機能制御する高分子の魅力, 高分子　, Vol. 50, No. 3, pp. 129-130, 2001.
• 杉原伸宏, 長岡正人, 赤池敏宏. 細胞機能制御を目指すマトリックス工学, 化学フロンテイア３　再生医療工学　２部　再生医療のための基礎工学技術　化学同人, 2001.
• C-S.Cho, A.Kobayashi, R.Takei, T.Ishihara, A.Maruyama, T.Akaike. Receptor-Mediated Cell Modulator Delivery to Hepatocyte Using Nanoparticles Coated with Carbohydrate-Carrying Polymers, Biomaterials, Vol. 22, pp. 45-51, 2001.
• 赤池敏宏, 根岸直樹. 生命科学と材料科学との融合　新しい治療法の開発をめざして, 実験医学, Vol. 19, No. 1, pp. 23-27, 2001.
• T.Sato, A.Kotake, M.Miura, T.Aota, Y.Ishikawa, M.Sato, K.Imai, N.Kojima, C.Mukai-Tateno, T.Akaike, R.Hata, K.Yoshizato, H.Senoo. Enhancement of Glucose utilization in isolated-liver cells by the rotary culture system, Molecular Biology of The Cell, 2001.
• S.Suzuki, A-J.Li, A.Ishisaki, X.Hou, M.Hasegawa, M.Fukumura, T.Akaike, T.Imamura. Feeding Suppression by Fibroblast Growth Factor-1 is Accompanied by Selective Induction of Heat Shock Protein 27 in Hypothalamic Astrocytes, European J. Neurosci. , Vol. 13, pp. 2299-2308, 2001.
• 赤池敏宏, 根岸直樹. 生命科学と材料科学との融合　新しい治療法を開発をめざして, 実験医学, Vol. 19, No. １, pp. 23-27, 2001.
• C-S.Cho, A.Kobayashi, R.Takei, T.Ishihara, A.Maruyama, T.Akaike. Receptor-mediated cell modulator delivery to hepatocyte using nanoparticles coated with carbohydrate-carrying polymers, Biomaterials, Vol. 22, pp. 45-51, 2001.
• 伊勢裕彦, 高島誠司, 赤池敏宏. 人工肝臓研究ー最近の進歩・各装置の工夫　４．肝細胞スフェロイドと人工肝臓, 臨床雑誌「外科」　南江堂, Vol. 63, No. 5, pp. 528-532, 2001.
• K.Na, H-K.Choi, T.Akaike, K-H.Park. Conjugation of Arg-Gly-Asp (RGD) Sequence in Copolymer Bearing Sugar Moiety for Insulinoma Cell Line (MIN6) Culture, Biosci. Biotechnol. Biochem., Vol. 65, No. 6, pp. 1284-1289, 2001.
• K-H. Park, M.Goto, J.Miyazaki, C-S.Cho, T.Akaike. Incorporation of Sulfonylrea into Sugar-Carrying Polymers and Their Effects on Insulin Secretion from MIN6 Cells in a Solution State, J.Biomater.Sci., Vol. 12, No. 8, pp. 911-920, 2001.
• S.Suzuki, A-J. Li, T.Akaike, T.Imamura. Intracerebroventricular Infusion of Fibroblast Growth Factor-1 Increases Fos Immuoreactivity in Periventricular Astrocytes in Rat Hypothalamus., Neuroscience Letters, Vol. 300, pp. 29-32, 2001.
• S.Hirose, H.Ise, M.Uchiyama, C-S.Cho, T.Akaike. Regulation of Asialoglycoprotein Receptor Expression in the Proliferative States of Hepatocytes, Biochem. Biophys. Res. Commun., Vol. 287, pp. 675-681, 2001.
• T.Uchida, T.Serizawa, H.Ise, T.Akaike, M.Akashi. Graft Copolymer Having Hydrophobic Backbone and Hydrophilic Branches.34.Interaction of Hepatocytes and Polystyrene Nanospheres Having Lactose-Immobilized Hydrophilic Polymers on Their Surfaces, Biomacromolecules, pp. in press, 2001.
• M.Goto, Y.Makino, K.Kobayashi, C-S.Cho, T.Akaike. Hepatocyte Attachment onto Thermosensitive Poly(N-isopropylacrylamide-co-N-p-vinylbenzyl-O-β-D-galactopyranosyl-(1→4)-D-gluconamide), J.Biomater.Sci.Polymer Edn., Vol. 12, No. 7, pp. 755-768, 2001.
• N.Sugihara, H.ise, N.Negishi, T.Nikaido, T.Akaike. Drug Metabolic Activity of Cultured Hepatocytes can Synchronize with Bile Acid Concentration in the Medium, Cell Biochemistry and Function, pp. in press, 2001.
• K.Na, H-K.Choi, D-W, Kim, T.Akaike, K.H.Park. Incorporation of Sulfonylurea into N-Isopropylacrylamide as an Extracellular Matrix for an Artificial Pancreas, Biosci. Biotechnol. Biochem., Vol. 65, No. 9, pp. 2016-2020, 2001.
• J.Yang, T.W.Chung, M.Nagaoka, M.Goto, C-S.Cho, T.Akaike. Hepatocyte-Specific Porous Polymer-Scaffolds of Alginate/Galactosylated Chitosan Sponge for Liver-Tissue Engineering, Biotech. Letters, Vol. 23, pp. 1385-1389, 2001.
• I-K.Park, T-H.Kim, Y-H.Park, B-A.Shin, E-S.Choi, E-H.Chowdhury, T.Akaike, C-S.Cho. Galactosylated chitosan-graft-poly(ethylene glycol) as hepatocyte-targeting DNA carrier., J.Control Release., Vol. 76, No. 3, pp. 349-362, 2001.
• H.Ise, N.Sugihara, N.Negishi, T.Nikaido, T.Akaike. Low Asialoglycoprotein Receptor Expression as Markers for Highly Proliferative Potential Hepatocytes, Biochem. Biophys. Res. Commun., Vol. 285, pp. 172-182, 2001.
• 朝山章一郎, 赤池敏宏, 丸山厚. エンドソーム内pHに応答するDNAに応答するキャリヤーとしての異種塩基性セグメントを持つポリカチオングラフト共重合体, 高分子加工, Vol. 50, pp. 106-111, 2001.
• T.Takei, A.Maruyama, T.Akaike, S.Sato. Site-specific Gene Transfer with Polylysinecomb-type Copolymers, in Non-viral Vectors for Gene Therapy, Methods in Molecular Medicine, M.A.Findeis,Ed., Humana Press Inc., pp. 123-129, 2001.
• A.Maruyama, M.Ueda, W.J.Kim, T.Akaike. Design of Polymer Materials Enhancing Nucleotide Hybridization for Anti-gene Technology, Advance in Drug Delivery Systems, in press, 2001.
• H.Torigoe, T.Akaike, A.Maruyama. Synergistic Stabilization of Triplex by Combination of Comb-type Cationic Copolymer and Oligo-N3'->P5' Phospharamidat, Nucleic. Acids. Sym. Ser. in press, 2001.
• W.J.Kim, T.Akaike, A.Maruyama. Polycation Graft Copolymers Accelerating DNA Strand Exchange: Involvement of Ionic Interaction, Nucleic Acids Sym. Ser. in press, 2001.
• K.Obara, T.Ishihara, T.Akaike, A.Maruyama. Protein/Oligonucleotide Conjugates as a Cell Specific PNA Carrier, Nucleic Acids Sym. Ser., in press, 2001.
• S.Asayama, T.Akaike, A.Maruyama. Bi-Phaseic Polycation for the DNA Carrier Responding to Endosomal pH, Colloids Surf. B., Vol. 22, pp. 183-191, 2001.
• Taek Woong Chung, Beom Jun Kim, Soo Youg Park, Toshihiro Akaike, Jae Woon Nah, Chong Su Cho. Induced Circular Dichroism of Disperse Red Dye in the Self-Assembled Nanoparticles Composed of Poly(γ-benzyl L-gulutamate )and Poly(N-Isopropylacrylamide) and Its Phase Transition by Temperature, Macromolecules, Vol. 33, No. 24, pp. 8921-8923, 2000.
• Y.Watanabe, X.Liu, I.Shibuya, T.Akaike. Functonal Evaluation of Poly-(N-p-vinylbenzyl-O-β-D-galactopyranosyl-[1-4]D-gluconamide)(PVLA) as a Liver Specific Carrier, J.Biomater.Sci. Polymer Edn., Vol. 11, No. 8, pp. 833-848, 2000.
• 雨宮　浩, 赤池敏宏, 福田恵一. 移植と再生医学ー21世紀を占うー, カレントテラピー, Vol. 18, No. 10, 2000.
• 石原務, 丸山厚, 赤池敏宏. 遺伝子キャリヤーとバイオマテリアル, Drug Delivery System (日本DDS学会編) , Vol. 15, No. 2, pp. 106-112, 2000.
• A.Maruyama, W.J.Kim, T.Ishihara, M.Ueda, H.Torigoe, A.Ferdous, T.Akaike. Regulation of DNA Function by Cationic Graft Copolymers, Biomaterials and Drug Delivery toward New Mellenium, Eds.K., 2000.
• M.Ueda, M.Saito, T.Ishihara, T.Akaike, A.Maruyama. Triplex formation Using ODN Conjugates with Polycation Comb-Type Copolymer, Nucleic Acids Sys.Ser., Vol. 44, pp. 289-290, 2000.
• I.Ajioka, T.Akaike, Y.Watanabe. Ethanolamine Regulates the Transition from G2 to M Phase of Primary Cultured Hepatocytes by Inducing Cyclin B Expression via Cytoskeletal Rearrangement., Mol.Biol.Cell, Vol. 11, pp. 342a, 2000.
• T.W.Chung, J.W.Nah, T.Akaike, Y.H.Park, C-S.Cho. Induced Circular Dichroism of Merocyanine Dye in the Self-Assembled Polymeric Nanoparticles, Polymer, Vol. 41, pp. 6415-6419, 2000.
• 渡辺恵史, 味岡逸樹, 赤池敏宏. 遺伝子操作と新素材を用いた臓器工学, 蛋白質核酸酵素, Vol. 45, No. 8, pp. 1376-1382, 2000.
• I.Shibuya, T.Akaike, Y.Watanabe. Suppression of Fas-Mediated Hepaticd Apoptosis by Caspase Inhibitor-Encapsulated Nanoparticles Bearing Poly-(N-p-vinylbenzyl-O-β-D-galactopyranosyl-[1-4]-D-gluconamide)., Biotech.Letters, Vol. 22, pp. 1855-1859, 2000.
• I.Shibuya, T.Akaike, Y.Watanabe. Design of Temporally and Spatially Controlled Drug Delivery System for the Treatment of Liver Diseases in Mice, Hepatology, Vol. 32, No. 6, pp. 1300-1308, 2000.
• T.Haruyama, I.Ajioka, T.Akaike, Y.Watanabe. Regulation and Significance of Hepatocyte-Derived Matrix Metalloproteinases (MMP) in Liver Remodeling, Biochem.Biophys.Res.Commun., Vol. 272, pp. 681-686, 2000.
• Y.Watanabe, X. Liu, I. Shibuya, T.Akaike. Functional Evaluation of Poly-N-Vinylbenzyl-D-Lactonamide(PVLA) as a Liver Specific Carrier, J. Biomaterials Sci., Polymer Edn., Vol. 11, No. 8, pp. 833-848, 2000.
• M.Mikawa, N.Miwa, M.Brautigam, T.Akaike. Gd3+-loaded Polyion Complex for pH Depicition with Magnetic Resonance Imaging, J.Biomed.Mater.Res., Vol. 49, pp. 390-395, 2000.
• A.Ferdous, T.Akaike, A.Maruyama. Inhibition of Sequence-Specific Protein-DNA Interaction and Restricition Endonuclease Cleavage via Triplex Stabilization by Poly(L-Lysine)-Graft-Dextran Copolymer, Biomacromolecules, Vol. 1, No. 2, pp. 186-193, 2000.
• 赤池敏宏. さまざまな高分子基盤上におけるPC12細胞の形態観察ー培養基盤表面の物理的特性との相関ー, 日本化学会誌, Vol. 4, pp. 257-265, 2000.
• M. Ishihara, K. Ono, K. Ishikawa, H. Hattori, Y. Saito, H. Yura, T. Akaikke, Y. Ozeki, S. Tanaka, H. Mochizuki, A. Kurita. Enhanced Ability of Heparin-CarringPolystyrene (HCPS) to Bind to Heparin-Binding Growth Factors and to Inhibit Growth Factor-Induced Endothelial Cell Growth, J. Biochem., Vol. 127, pp. 797-803, 2000.
• 赤池敏宏. 再生医療をめざす組織工学ー肝臓でのケーススタデイー, 診療と新薬, Vol. 37, No. 9, pp. 1018-1020, 2000.
• S.H.Kim, M. Goto, C.S.Cho, T.Akaike. Specific adhesion of primary hepatocytes to a novel glucose-carrying polymer, Biotechnology Letters, No. 22, pp. 1049-1057, 2000.
• Ferdous A, Akaike T, Maruyama A.. Mechanism of intermolecular purine-purine-pyrimidine triple helix stabilization by comb-type polylysine graft copolymer at physiologic potassium concentration, Bioconjug Chem., Vol. 11, No. 4, pp. 520-6, 2000.
• T.Sasagawa, M.Hlaing, T.Akaike. Synergistic Induction of Apoptosis in Murine Hepatoma Hepa1-6 cells by IFN-gamma and TNF-alpha, Biochem. Biophys. Res. Commun., Vol. 272, pp. 674-680, 2000.
• Higuchi A, Tamiya S, Tsubomura T, Katoh A, Cho CS, Akaike T, Hara M. Growth of L929 cells on polymeric films prepared by Langmuir-Blodgett and casting methods, J. Biomater Sci. Polym. Edn., Vol. 11, No. 2, pp. 149-68, 2000.
• Mayer J, Karamuk E, Akaike T, Wintermantel E. Matrices for tissue engineering-scaffold structure for a bioartificial liver support system., J Control Release., Vol. 14, No. 64(1-3), pp. 81-90, 2000.
• K-H. Park, M. Goto, R.Takei, A. Maruyama, K. Kobayashi, J. Miyazaki, C-S. Cho, T.Akaike. Enhanced effect of sulfoyurea (SU) in copolymer comprising a sugar moiety and SU derivative as double Ligands insulin secretion from MIN6 Cells, J. Biomater.Sci.Polymer Edn, Vol. 11, No. 9, pp. 903-913, 2000.
• Y.K. Park, Y.H. Park, B.A. Shin, E.S. Choi, Y.R. Park, T. Akaike, C-S.Cho. Galactosylated Chitosan-Graft-Dextran as Hepatocyte-Targeting DNA Carrier, J. Contr. Rel., Vol. 69, pp. 97-108, 2000.
• W.J.Kim, T.Ishihara, T.Akaike, A.Maruyama. Accelaration of DNA Strand Exchange by Polycation Comb-Type Copolymer, Nucleic Acids Sym. Ser., Vol. 44, pp. 289-290, 2000.
• A.Higuchi, S.Uchiyama, M.Demura, T.Asakura, C-S.Cho, T.Akaike, H.Takarada, M.Hara. Enhanced CEA Production Associated with Aspirin in a Culture of CW-2 Cells on Some Polymeric Films, Cytotechnology, Vol. 31, pp. 233-242, 1999.
• Tatsuki Shinoda, Atsushi Maeda, Seiki Kojima, Seiya Kagatani, Yutaka Konno, Takashi Sonobe, Toshihiro Akaike. Nanosphere Coated with Lactosyl-Polystyrene Polymer as a Targeting Carrier to Hepatocytes, Drug Delivery, Vol. 6, pp. 147-151, 1999.
• 赤池敏宏, 伊勢裕彦, 味岡逸樹, 渡辺恵史. 　先端科学技術と人工臓器　―新しいマトリックス工学と遺伝子工学の導入, 医学の歩み, Vol. 188, No. 6, 1999.
• Hirohiko ISE, Seiji TAKASHIMA, Masato NAGAOKA, Anwarul FERDOUS, Toshihiro AKAIKE. Analysis of Cell Viability and Differential Activity of Mouse Hepatocytes under 3D and 2D Culture in Agarose Gel, Biotechnology Letters, Vol. 21, pp. 209-213, 1999.
• 赤池敏宏, 丸山　厚. 新しい材料システム構築のための分子シンクロナイゼーショム, 化学, Vol. 28, No. 6, 1999.
• M.Kamijou, H.Uchiyama, Y.Hoshi, T.Akaike. Flow Cytometric Analysis of the Binding Pattern of Various Carbohydrates to Leukemic Cells, Jikeikai Medical Journal, Vol. 45, No. 4, pp. 177-189, 1998.
• Toshihiro Akaike. Receptor-mediated Regulation of Differentiation and Proliferation of Hepatocyte by Synthetic Polymer Model of Asaloglycoproteon, J. Biomater. Sci., Polymer Edn., Vol. 6, pp. 325-342, 1994.

著書

• 赤池敏宏. バイオテクノロジー教科書シリーズ12　生体機能材料学－人工臓器・組織工学・再生医療の基礎－, コロナ社, 2005.
• 伊勢裕彦, 中森修子, 赤池敏宏. バイオ人工肝臓, 現代化学増刊　　再生医学・再生医療　東京化学同人, 現代化学増刊　　再生医学・再生医療　東京化学同人, Vol. 41, 2002.
• 赤池敏宏. ハイブリッド人工臓器（バイオ人工臓器）設計の基礎, 現代医学の基礎　岩波書店, 現代医学の基礎　岩波書店, Vol. 14, pp. 1-12, 2001.
• 荻原一隆, 長岡正人, 赤池敏宏. ティッシュエンジニアリング2005・材料表面修飾とティッシュエンジニアリング－キメラタンパク質を用いた細胞接着応答の制御, 日本医学館, pp. 77-83, 2005.
• 赤池敏宏. 再生医療の基礎シリーズ4 再生医療のためのバイオエンジニアリング, コロナ社, 2007.
• 赤池敏宏　後藤光昭. 先端医療シリーズ３７「人工臓器・再生医療の最先端」人工肝臓, 先端医療技術研究所, 2005.
• 赤池敏宏. 特集「細胞の狩人と錬金術からの脱却をめざして」, 日本再生医療学会雑誌, 日本再生医療学会雑誌, Vol. 3, No. 1, pp. 77, 2004.
• 丸山厚, 赤池敏宏. ナノバイオエンジニアリング　生命と物質の融合をめざして　II部ナノバイオで解析する　７章人工核酸シャペロン, 化学フロンティア１３　杉本直巳編　化学同人, 化学フロンティア１３　杉本直巳編　化学同人, 2004.
• 赤池敏宏. 再生医療と人工臓器, 「日本産業の推進力『先端技術』」一橋フォーラム, 「日本産業の推進力『先端技術』」一橋フォーラム, 2003.
• T.Akaike, M.Nagaoka, S-H.Kim. Synthetically-and Genetically-Engineered Extracellular Matrices for Tissue Engineering., Advanced in Biomaterials and Drub Delivery Systems,Princeton International Publishing Co.Ltd., Advanced in Biomaterials and Drub Delivery Systems,Princeton International Publishing Co.Ltd., pp. 21-34, 2002.
• 赤池敏宏. 細胞における受容体シンクロナイゼーション, バイオミメテイックスハンドブック　第８節 , バイオミメテイックスハンドブック　第８節 , pp. 355-362, 2000.
• 赤池敏宏, 伊勢裕彦. 再生医療、人工臓器開発と幹細胞システム－応用の鍵を握るバイオマテリアル, 現代化学, 現代化学, Vol. 356, No. 11, pp. 64-69, 2000.
• Masayuki Ishihara, Yoshio Saito, Hirohumi Yuta, Katsuaki Ono, Keiichi Ishikawa, Hidemi Hattori, Toshiro Akaike, Akira Kurita. Heparin-Carrying Polystyrene to Mediate Cellular Attachment and Growth via Interaction with Growth Factors, HCP to Cellular Attachment and Growth, HCP to Cellular Attachment and Growth, pp. 144-152, 2000.
• 赤池敏宏, 渡辺恵史, 伊勢裕彦, 味岡逸樹. 人工肝臓 再生医学―基礎と治療への応用 西川伸，中村敏一編, 日本医学会, 日本医学会, pp. 13-23, 1999.
• 赤池敏宏, 渡辺恵史, 伊勢裕彦, 味岡逸樹. ティッシュ・エンジニアリング　人工肝臓　　上田実編, 名大出版会, 名大出版会, pp. 206-215, 1999.
• Kazukiyo KOBAYASHI, Akira KOBAYASHI, Toshihiro AKAIKE. Culturing Hepatocytes on Lactose-Carrying Polystyrene Layer via Asialoglycoprotein Receptor-Mediated Interations, Methods in Enzymology, Methods in Enzymology, Vol. 247, No. 30, pp. 409-418, 1994.
• Kazukiyo Kobayashi, Akira Kobayashi, Seishiro Tobe, Toshihiro Akaike. Neoglycoconjugates Carbohydrate-Containing Polystyrenes in Neoglycoconjugates-preparation and Applications(分担), Academic Press, Academic Press, 1994.

国際会議発表 (査読有り)

• Dragomirka Jovic, Asako Sakaue-Sawano, Atsushi Miyawaki, Toshihiro Akaike. Direct Observation of Mouse ES cells on extracellular E-cadherin matrix, ISSCR 10th Annual Meeting, June 2012.
• Dragomirka Jovic, Asako Sakaue-Sawano, Atsushi Miyawaki, Toshihiro Akaike. Visualization of Mouse Embryonic Stem Cell Cycle with Fucci Proteins on E-cadherin Engineered matrix, Single Cell Analysis Meeting, Cold Spring Harbor Laboratory, July 2011.
• Jovic Dragomirka, Akaike Toshihiro. Synchronization of mES cells on E-cad-Fc Matrix using drug to establish efficient cell differentiation, Tissue Engineering International & Regenerative Medicine Society 2nd World Congress, Sept. 2009.
• Jovic Dragomirka, Akaike Toshihiro. Synchronization of mES cells on E-Cad-Fc matrix by drug treatment to establish efficient cell differentiation, 1st International Graduate Symposium on Biotechnology, Bioengineering and Biomedical Science, Mar. 2009.

国内会議発表 (査読有り)

• Dragomirka Jovic, Asako Sakaue-Sawano, Atsushi Miyawaki, Toshihiro Akaike. Visualization of Mouse Embryonic Stem Cell Cycle with Fucci Proteins on E-cadherin Engineered matrix., GCOE Symposium, Oct. 2011.
• Jovic Dragomirka, Akaike Toshihiro. Mouse ES cell cycle regulation on Cadherin Engineered Matrix for Regenerative Medicine, 第10回日本再生医療学会総会, 2011.
• Jovic Dragomirka, Akaike Toshihiro. Regulation of mES cells cycles on E-cad-Fc protein to Induce differentiation of Hepatocytes, 第62回日本細胞生物学会大会, May 2010.
• Jovic Dragomirka, Akaike Toshihiro. The mES Cycles Synchronization for Regenerative Medicine, 9th Congress of the Japanese Society for Regenerative Medicine, Mar. 2010.
• Jovic Dragomirka, Akaike Toshihiro. Synchronization of mES cell cycles on E-cadherin using drugs for efficient cell differentiation, Teijin 21c Forum, Jan. 2010.
• Jovic Dragomirka, Akaike Toshihiro. Synchronization of mES cells on E-cad-Fc Matrix using drug to establish efficient cell differentiation, Japanese Society for Biomaterials, Nov. 2009.
• Jovic Dragomirka, Akaike Toshihiro. Mouse ES cells differentiation using drug for cell differentiation, The 61st Annual Meeting of the Japanese Society for Cell Biology, June 2009.

その他の論文・著書など

• 赤池敏宏, 荻原一隆, 長岡正人. バイオハイブリッド工学の新展開ー再生医療をめざす細胞マトリックス工学, Bio Industry, Vol. 22, No. 3, pp. 25-33, 2005.
• 赤池敏宏, 長岡正人, 村上哲平, 赤野恭子, 太田宗宏, 後藤光昭, 石原義久. バイオ人工肝臓をめざす細胞マトリックス工学－肝細胞機能の制御, 細胞, Vol. 37, No. 2, pp. 13-17, 2005.
• 赤池敏宏, 杉山雄一. 医薬品開発における薬工連携への展望, Pharm Tech Japan, Vol. 21, No. 1, pp. 47-60, 2005.
• E.H.Chowdhury, T.Akaike. Mammalian integrin-targeted gene delivery: A common approach for advanced viral and non-viral vectors, Gene.Ther.Mol.Biol., Vol. 9, pp. 431-444, 2005.
• Sultana N, Nobuhiro Nakamura, Hirose Shige, Kutsuzawa K, Akaike T, Nag K. Congenital heart disease and biotechnology: Connecting by connexin, Vol. 995, 85-112, July 2014.
• 赤池敏宏, 長岡正人. 細胞とナノファイバー （展望 特集 ナノファイバー）, 高分子, Vol. 55, pp. 142-145, Mar. 2006.
• 赤池敏宏. 巻頭言　若者よ、バイオマテリアル研究の変革期をたくましく、かつオリジナルに生き抜け！, バイオマテリアルー生体材料, Vol. 24, No. 3, pp. 145-146,, 2006.
• Chong-Su Cho, Toshihiro Akaike. Nanothechnology in synthetic glycopolymers, Nanothechnology in Cabohydrate Chemistry, TransWorld Research Network, pp. 103-125, 2006.
• 長岡正人, 赤池敏宏. 再生医療・組織工学のためのバイオマテリアル, SEN'I GAKKAISI（繊維と工業）, Vol. 61, No. 6, pp. 139-141, 2005.
• 田川陽一, 赤池敏宏. ES細胞から肝臓の発生・再構築を目指して、その薬理学的応用, Pharm Tech Japan, 21, (12),119(2051)-122(2054), Vol. 21, No. 12, pp. 2051-2054, 2005.
• 長岡正人, 赤池敏宏. マトリックス工学による幹細胞の分化増殖制御, 日本再生医療学会雑誌　Vol.3 No.2、47-54, Vol. 3, No. 2, pp. 47-54, 2004.

特許など

• 赤池敏宏, 石井　浩介, 荒巻　博, 上野　俊一郎, 大原　宏明, 成相　健太郎, 森　美栄, 山村　隼志. 細胞培養装置. 特許. 登録. 国立大学法人東京工業大学, 株式会社ＩＨＩ. 2013/12/27. 特願2013-273602. 2015/07/09. 特開2015-126719. 特許第6247932号. 2017/11/24 2017.
• 赤池敏宏, 石井　浩介, 村本　知哉. 細胞培養方法および細胞培養装置. 特許. 公開. 国立大学法人東京工業大学, 株式会社ＩＨＩ. 2013/12/27. 特願2013-273605. 2015/07/09. 特開2015-126720. 2015.
• 赤池敏宏, 石井　浩介, 森　美栄, 山村　隼志. 幹細胞培養装置、幹細胞培養方法. 特許. 登録. 国立大学法人東京工業大学, 株式会社ＩＨＩ. 2013/03/22. 特願2013-060669. 2014/10/02. 特開2014-183770. 特許第6054223号. 2016/12/09 2016.
• 赤池敏宏, 篠田　さやか, 後藤　光昭. 組織撮像用MRI造影剤. 特許. 公開. 国立大学法人東京工業大学, 有限会社セラジックス. 2009/03/09. 特願2009-055656. 2010/09/24. 特開2010-208979. 2010.
• 赤池敏宏, 賀喜　白乙, 佐竹　真, 福井　三由紀, 兼子　博章. 細胞培養用基材. 特許. 公開. 国立大学法人東京工業大学, 帝人株式会社. 2008/09/11. 特願2008-233322. 2010/03/25. 特開2010-063411. 2010.
• 赤池敏宏, Ezharul Hoque Choudh, Fatema Tuj Zohra. 物質導入担体、物質導入方法及び物質導入用キット. 特許. 公開. 国立大学法人東京工業大学. 2005/08/31. 特願2005-252057. 2007/03/15. 特開2007-063194. 2007.
• 赤池敏宏, Ezharul Hoque Chowdh. アパタイト粒子及びその作製方法、遺伝子－アパタイト粒子複合体及びその作製方法、並びに遺伝子導入方法及び遺伝子導入用キット. 特許. 公開. 国立大学法人東京工業大学. 2005/08/10. 特願2005-232504. 2007/02/22. 特開2007-043972. 2007.
• 赤池敏宏, Ezharul Hoque CHOWDH. プラスミドＤＮＡの精製方法及びプラスミドＤＮＡ精製用キット. 特許. 公開. 国立大学法人東京工業大学. 2005/06/30. 特願2005-192605. 2007/01/18. 特開2007-006799. 2007.

学位論文

• The Stereochemistry of the Polymerization of N-Carboxy α-Amino Acids Anhydrides,  本文,  Doctor of Engineering,  The University of Tokyo,  1975/--/--, 

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